Hepato-Renal Toxicity of Gongronema latifolium Extracts on Streptozocin Induced Diabetes in Rats
American Journal of Health Research
Volume 4, Issue 3, May 2016, Pages: 62-69
Received: Apr. 22, 2016; Accepted: May 7, 2016; Published: May 14, 2016
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Authors
Brown Holy, Dept. of Medical Laboratory Science Rivers State University of Science and Technology, Npkolu, Port Harcourt, Nigeria
Tamunoemine Davies, Dept. of Medical Laboratory Science Rivers State University of Science and Technology, Npkolu, Port Harcourt, Nigeria
Thompson N. Imomoemi, Dept. of Medical Laboratory Science Rivers State University of Science and Technology, Npkolu, Port Harcourt, Nigeria
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Abstract
This study evaluated the effect of methanolic, ethanolic, aqueous and crude extracts of Gongronema latifolium leaves on some nephrotoxic and hepatotoxic parameters in streptozocin induced diabetic rats. Thirty albino rats divided into six experimental groups were used. Two groups served as control were fed normal saline and glibenclamide. Four groups were fed methanolic, ethanolic, crude and aqueous extracts of Gongronema latifolium leaves respectively. Treatment lasted four 14 days after which the rats were sacrificed and blood collected for biochemical evaluation. The results showed that treatment with all the various extracts of Gongronema latifolium leave did not cause any significant increase in the nephrotoxic and hepatotoxic parameters. Treatment with methanolic extract caused a significant decrease in the serum glutamate pyruvate transaminase activity (P<0.001). The histological analysis revealed a recovery from inflammatory phase of the cells of the kidney and liver from the toxic effect of the streptozocin.
Keywords
Hepatoxicity, Nephrotoxicity, Gongronema latifolium, Diabetes, Plant Extracts, Phytochemicals
To cite this article
Brown Holy, Tamunoemine Davies, Thompson N. Imomoemi, Hepato-Renal Toxicity of Gongronema latifolium Extracts on Streptozocin Induced Diabetes in Rats, American Journal of Health Research. Vol. 4, No. 3, 2016, pp. 62-69. doi: 10.11648/j.ajhr.20160403.15
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Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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