American Journal of Health Research
Volume 4, Issue 3, May 2016, Pages: 70-74
Received: Apr. 25, 2016;
Accepted: May 11, 2016;
Published: May 28, 2016
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Zhihai Deng, Department of Urology, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, People’s Republic of China
Yude Hong, Department of Urology, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, People’s Republic of China
Baiwei Tang, Department of Urology, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, People’s Republic of China
Weibo Liang, Department of Urology, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, People’s Republic of China
Electrical and electronic waste (e-waste) contains multiple toxic materials. However, there is currently a lack of exposure data on workers in formal recycling plants. This study aims to observe the influence of electronic waste (e-waste) on male’s reproductive health and to provide a theoretical foundation for improving the occupational safety. A survey and sample collections were performed based on 210 workers in e-waste recycling plant as the exposure group and 210 residents who worked at the same area but not exposed to e-waste (other jobs) as the control group. Semen sperm analysis and TUNEL assay were applied to detect the apoptotic rate and single comet assay to detect DNA damage. The survey results showed that infertility rate of e-waste recycling workers was significantly higher than that of non-occupationally exposed workers (P < 0.05); e-waste occupationally exposed workers showed markedly higher rate of prostatitis, urethritis, abortion and preterm birth of their spouses (P < 0.05). The percentage of sperm concentration, motile sperm, ‘a’ level sperm, ‘a+b’ level sperm and live sperm of the exposure group were higher than control group (P < 0.05). TUNEL assay revealed that the apoptotic rate of sperms in the exposure group was higher too (P < 0.05). Further, the sperm comet length, tail length, tail DNA %, Olive tail moment were significantly different between the two groups (P < 0.05). In general, we concluded that occupational exposure to e-waste led to asthenospermia and increased male infertility. Occupational exposure to e-waste increased the sperm apoptosis rate and sperm DNA damage.
The Impact of E-waste Occupational Exposure on Male Reproductive Health, American Journal of Health Research.
Vol. 4, No. 3,
2016, pp. 70-74.
Chan, J. K. and M. H. Wong, A review of environmental fate, body burdens, and human health risk assessment of PCDD/Fs at two typical electronic waste recycling sites in China. Sci Total Environ, 2013, 463-464: 1111-23.
Directive 2001/20/EC of the European Parliament and of the Council of 4 April 2001 on the approximation of the laws, regulations and administrative provisions of the member states relating to the implementation of good clinical practice in the conduct of clinical trials on medicinal products for human use. Med Etika Bioet, 2002, 9(1-2): 12-9.
Sthiannopkao, S. and M. H. Wong, Handling e-waste in developed and developing countries: initiatives, practices, and consequences. Sci Total Environ, 2013, 463-464: 1147-53.
Xu, X., Y. Zhang, T. A. Yekeen, Y. Li, B. Zhuang, and X. Huo, Increase male genital diseases morbidity linked to informal electronic waste recycling in Guiyu, China. Environ Sci Pollut Res Int, 2014, 21(5): 3540-5.
Chi, X., M. Streicher-Porte, M. Y. Wang, and M. A. Reuter, Informal electronic waste recycling: a sector review with special focus on China. Waste Manag, 2011, 31(4): 731-42.
Ongondo, F. O., I. D. Williams, and T. J. Cherrett, How are WEEE doing? A global review of the management of electrical and electronic wastes. Waste Manag, 2011, 31(4): 714-30.
Wong, C. S., S. C. Wu, N. S. Duzgoren-Aydin, A. Aydin, and M.H. Wong, Trace metal contamination of sediments in an e-waste processing village in China. Environ Pollut, 2007, 145(2): 434-42.
Yu, X. Z., Y. Gao, S. C. Wu, H. B. Zhang, K. C. Cheung, and M.H. Wong, Distribution of polycyclic aromatic hydrocarbons in soils at Guiyu area of China, affected by recycling of electronic waste using primitive technologies. Chemosphere, 2006, 65(9): 1500-9.
Song, Q. and J. Li, A review on human health consequences of metals exposure to e-waste in China. Environ Pollut, 2015, 196: 450-61.
Jurasovic, J., P. Cvitkovic, A. Pizent, B. Colak, and S. Telisman, Semen quality and reproductive endocrine function with regard to blood cadmium in Croatian male subjects. Biometals, 2004, 17(6): 735-43.
Haines, G. A., J. H. Hendry, C. P. Daniel, and I. D. Morris, Germ cell and dose-dependent DNA damage measured by the comet assay in murine spermatozoaa after testicular X-irradiation. Biol Reprod, 2002, 67(3): 854-61.
Kushwaha, S. and G. B. Jena, Enalapril reduces germ cell toxicity in streptozotocin-induced diabetic rat: investigation on possible mechanisms. Naunyn Schmiedebergs Arch Pharmacol, 2012, 385(2): 111-24.
Xu, B., S. E. Chia, M. Tsakok, and C. N. Ong, Trace elements in blood and seminal plasma and their relationship to sperm quality. Reprod Toxicol, 1993, 7(6): 613-8.
Agarwal, A. and T. M. Said, Role of sperm chromatin abnormalities and DNA damage in male infertility. Hum Reprod Update, 2003, 9(4): 331-45.
Ghobish, A. A., Quantitative and qualitative assessment of flowmetrograms in patients with prostatodynia. Eur Urol, 2000, 38(5): 576-83.
Khalili, M. A., F. Aghaie-Maybodi, M. Anvari, and A. R. Talebi, Sperm nuclear DNA in ejaculates of fertile and infertile men: correlation with semen parameters. Urol J, 2006, 3(3): 154-9.
Giwercman, A., L. Lindstedt, M. Larsson, M. Bungum, M. Spano, R. J. Levine, and L. Rylander, Sperm chromatin structure assay as an independent predictor of fertility in vivo: a case-control study. Int J Androl, 2010, 33(1): e221-7.
Cocuzza, M., S. C. Sikka, K. S. Athayde, and A. Agarwal, Clinical relevance of oxidative stress and sperm chromatin damage in male infertility: an evidence based analysis. Int Braz J Urol, 2007, 33(5): 603-21.
Erenpreiss, J., S. Elzanaty, and A. Giwercman, Sperm DNA damage in men from infertile couples. Asian J Androl, 2008, 10(5): 786-90.
Zeng, X., X. Xu, H. M. Boezen, and X. Huo, Children with health impairments by heavy metals in an e-waste recycling area. Chemosphere, 2016, 148: 408-15.
Xu, X., X. Zeng, H.M. Boezen, and X. Huo, E-waste environmental contamination and harm to public health in China. Front Med, 2015, 9(2): 220-8.
De Franciscis, P., R. Ianniello, D. Labriola, D. Ambrosio, P. Vagnetti, G. Mainini, C. Trotta, D. Mele, M. R. Campitiello, and F. Caprio, Environmental pollution due to cadmium: measure of semen quality as a marker of exposure and correlation with reproductive potential. Clin Exp Obstet Gynecol, 2015, 42(6): 767-70.
Li, Y., Q. Gao, M. Li, M. Li, and X. Gao, Cadmium, Chromium, and Copper Concentration plus Semen-Quality in Environmental Pollution Site, China. Iran J Public Health, 2014, 43(1): 35-41.