Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children
American Journal of Health Research
Volume 5, Issue 1, January 2017, Pages: 7-10
Received: Jan. 24, 2016; Accepted: Feb. 4, 2016; Published: Feb. 15, 2017
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Wildana Azikin, Department of Pediatrics, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi, Indonesia
Amiruddin Laompo, Department of Pediatrics, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi, Indonesia
Husein Albar, Department of Pediatrics, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi, Indonesia
Dasril Daud, Department of Pediatrics, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi, Indonesia
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Background: Lung Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (M. Tb). Excessive body's immune response to M. Tb will contribute to the host tissue damage. M. Tb infection stimulates gene expression and MMP-9 secretion from monocyte which is infected by M. Tb. M. Tb molecular mechanisms inducing granuloma formation which is the ESAT-6 protein that stimulates the production of matrix metalloproteinase-9 (MMP-9) from epithelial cells near the infected macrophages. Objective: To evaluate the levels of Matrix Metalloproteinase-9 (MMP-9) in children who lived in the same house with a tuberculosis person. Methods: A cross sectional study was conducted at the Lung Health Community Center (BBKPM) Makassar, from May to July 2015. The study population was children aged 3 months to 18 years. Results: Levels of MMP-9 were examined in 55 samples of the study, 29 samples infected with TB (52.7%), and 26 samples exposed to TB (47.3%). There is no significant difference in the levels of MMP-9 and genders, age, nutritional status, status of BCG, as well as the levels of MMP-9 in the group of exposed and infected to TB (p>0.05). Conclusion: There was no significant differences between the levels of MMP-9 in the group of exposed and infected to TB.
Matrix Metalloproteinase-9 (MMP-9), Tuberculosis Exposed Children, Tuberculosis Infected Children
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Wildana Azikin, Amiruddin Laompo, Husein Albar, Dasril Daud, Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children, American Journal of Health Research. Vol. 5, No. 1, 2017, pp. 7-10. doi: 10.11648/j.ajhr.20170501.12
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