Determinants of First Line Anti-Retroviral Treatment Failure Among Adult Human Immunodeficiency Virus Infected Patients in Western Oromia Public Hospitals, West Ethiopia
American Journal of Health Research
Volume 7, Issue 5, September 2019, Pages: 71-78
Received: Jul. 1, 2019; Accepted: Jul. 25, 2019; Published: Sep. 2, 2019
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Fraol Jaleta, Oromia Regional Health Bureau, Adama Public Health Research and Referral Laboratory Center, Adama, Ethiopia
Alemayehu Getahun, Department of Public Health, College of Medical and Health Science, Wollega University, Nekemte, Ethiopia
Getu Bayissa, Department of Pharmacy, College of Medical and Health Science, Wollega University, Nekemte, Ethiopia
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Back ground: First line antiretroviral treatment failure has led to increased HIV associated mortality especially in resource limited setting. A determinant of First line antiretroviral treatment failure is not well studied in Ethiopia. The objective of the study was to identify determinants of first line treatment failure among adults living with HIV in western Oromia public hospitals, West Ethiopia. Method: Unmatched case control study was conducted at public hospitals of West Oromia using medical record review. Cases were adult HIV patients on ART in selected hospitals who were switched to second line ART regimen because of first line treatment failure in the past ten years (2005-2015) and Controls were adult HIV patients on ART in selected hospitals who were on first line ART for greater or equal to six month in the same years (2005-2015).Data was collected by trained nurses (counselors) using checklists developed from Ministry of Health ART follow up form and entered to EPi data version 3.1 and transferred to SPSS version 20.0 for analysis. To identify determinants of first line anti-retroviral treatment failure, multivariate analysis with P-value <0.05 was done. Results: A total of 115 cases and 345 controls were included in the study. Baseline CD4 measure (AOR [95% CI] = 3.96 [1.84, 8.54]), regimen change due to drug stock out (AOR [95% CI] = 2.54 [1.38, 4.66]), treatment interruption (AOR [95% CI] = 5.09 [2.39, 10.82]), adverse effect of drug (AOR [95% CI] = 8.49 [1.87, 38.42]) and History of opportunistic infection (AOR [95% CI] = 2.15 [1.28, 3.64] were independently associated with first line antiretroviral treatment failure. Conclusion: Intervention for First line antiretroviral treatment failure needs to emphasize on regimen change due to drug stock out, treatment interruption, history of opportunistic infection, adverse effect of drug and base line CD4 <50cell/µ.
Treatment Failure, Antiretroviral Therapy, Case Control
To cite this article
Fraol Jaleta, Alemayehu Getahun, Getu Bayissa, Determinants of First Line Anti-Retroviral Treatment Failure Among Adult Human Immunodeficiency Virus Infected Patients in Western Oromia Public Hospitals, West Ethiopia, American Journal of Health Research. Vol. 7, No. 5, 2019, pp. 71-78. doi: 10.11648/j.ajhr.20190705.13
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