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Review on DNA Micro Array Technologyand Its Application

Received: 9 September 2019     Accepted: 16 October 2019     Published: 6 January 2020
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Abstract

DNA microarrays are technology that measure the expression level of thousands of genes at the same time. They need become avital tool for a good kind of biological experiments. one among the most common goals of polymer microarray experiments is to spot genes related to biological processes of interest. DNA Microarray is one such technology that allows the researchers to analyze and address problems that were once thought to be non traceable. This technology has scepter the scientific community to manage the elemental aspects underlining the expansion and development of life, additionally on explore the genetic causes of anomalies occurring within the functioning of organisms. Microarrays area unit vital as a result of they possess a large variety of genes and additionally owingto their transportable size. An important implication of the fundamental dogma of molecular biology is that there should be a strong association between the presence of a given protein in a cell and the presence of the mRNA sequence that is transcribed to build that protein. If a protein is active in a given cell, there should be a large number of copies of the mRNA sequence corresponding to that protein. Conversely, if a protein is not active in a cell, there should be few copies of the corresponding mRNA sequence. Thus, DNA microarrays attempt to evaluate the presence or absence of proteins in a cell and their relative abundance by measuring the relative abundance of the corresponding mRNA sequences. This review addresses the potential uses of DNA microarray technology, principle of the technology, its application and limitation of the technology.

Published in American Journal of Zoology (Volume 2, Issue 4)
DOI 10.11648/j.ajz.20190204.11
Page(s) 44-50
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

DNA Microarray, Protein Microarray, Hybridization, cDNA

References
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    Takale Worku, Demessa Negassu. (2020). Review on DNA Micro Array Technologyand Its Application. American Journal of Zoology, 2(4), 44-50. https://doi.org/10.11648/j.ajz.20190204.11

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    Takale Worku; Demessa Negassu. Review on DNA Micro Array Technologyand Its Application. Am. J. Zool. 2020, 2(4), 44-50. doi: 10.11648/j.ajz.20190204.11

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    AMA Style

    Takale Worku, Demessa Negassu. Review on DNA Micro Array Technologyand Its Application. Am J Zool. 2020;2(4):44-50. doi: 10.11648/j.ajz.20190204.11

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  • @article{10.11648/j.ajz.20190204.11,
      author = {Takale Worku and Demessa Negassu},
      title = {Review on DNA Micro Array Technologyand Its Application},
      journal = {American Journal of Zoology},
      volume = {2},
      number = {4},
      pages = {44-50},
      doi = {10.11648/j.ajz.20190204.11},
      url = {https://doi.org/10.11648/j.ajz.20190204.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajz.20190204.11},
      abstract = {DNA microarrays are technology that measure the expression level of thousands of genes at the same time. They need become avital tool for a good kind of biological experiments. one among the most common goals of polymer microarray experiments is to spot genes related to biological processes of interest. DNA Microarray is one such technology that allows the researchers to analyze and address problems that were once thought to be non traceable. This technology has scepter the scientific community to manage the elemental aspects underlining the expansion and development of life, additionally on explore the genetic causes of anomalies occurring within the functioning of organisms. Microarrays area unit vital as a result of they possess a large variety of genes and additionally owingto their transportable size. An important implication of the fundamental dogma of molecular biology is that there should be a strong association between the presence of a given protein in a cell and the presence of the mRNA sequence that is transcribed to build that protein. If a protein is active in a given cell, there should be a large number of copies of the mRNA sequence corresponding to that protein. Conversely, if a protein is not active in a cell, there should be few copies of the corresponding mRNA sequence. Thus, DNA microarrays attempt to evaluate the presence or absence of proteins in a cell and their relative abundance by measuring the relative abundance of the corresponding mRNA sequences. This review addresses the potential uses of DNA microarray technology, principle of the technology, its application and limitation of the technology.},
     year = {2020}
    }
    

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    T2  - American Journal of Zoology
    JF  - American Journal of Zoology
    JO  - American Journal of Zoology
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    AB  - DNA microarrays are technology that measure the expression level of thousands of genes at the same time. They need become avital tool for a good kind of biological experiments. one among the most common goals of polymer microarray experiments is to spot genes related to biological processes of interest. DNA Microarray is one such technology that allows the researchers to analyze and address problems that were once thought to be non traceable. This technology has scepter the scientific community to manage the elemental aspects underlining the expansion and development of life, additionally on explore the genetic causes of anomalies occurring within the functioning of organisms. Microarrays area unit vital as a result of they possess a large variety of genes and additionally owingto their transportable size. An important implication of the fundamental dogma of molecular biology is that there should be a strong association between the presence of a given protein in a cell and the presence of the mRNA sequence that is transcribed to build that protein. If a protein is active in a given cell, there should be a large number of copies of the mRNA sequence corresponding to that protein. Conversely, if a protein is not active in a cell, there should be few copies of the corresponding mRNA sequence. Thus, DNA microarrays attempt to evaluate the presence or absence of proteins in a cell and their relative abundance by measuring the relative abundance of the corresponding mRNA sequences. This review addresses the potential uses of DNA microarray technology, principle of the technology, its application and limitation of the technology.
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Author Information
  • Department of Veterinary Laboratory, Ambo University, Ambo, Ethiopia

  • Department of Veterinary Laboratory, Ambo University, Ambo, Ethiopia

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