The Research Status of Class II Histone Deace-tylases Physiological Function

Jianyu Wang; Songpo Yao; Xingzhou Li; Xiaoxia Xu; Ruidi Zhang; Ye Lu; Liangchen Liu; Baosheng Guan; Xianglin Yin

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The Research Status of Class II Histone Deace-tylases Physiological Function

Jianyu Wang, Songpo Yao, Xingzhou Li, Xiaoxia Xu, Ruidi Zhang, Ye Lu, Liangchen Liu, Baosheng Guan, Xianglin Yin

Received: 29 November 2019 Accepted: 19 February 2020 Published: 6 March 2020

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Abstract

Histone deace-tylases (HDACs) are proteases, The main function of HDACs are to modify the structure of chromosomes and regulate gene expression in organisms. HDACs can catalyze the deacetylation of histones, regulate histone acetylation process and deacetylation process in the nucleus, and maintain its dynamic balance state, which is closely related to the occurrence of cell apoptosis, oxidative stress and with it inflammatory response, metabolic disorders, senescence, tumor and other processes in living things. There are many members of the HDACs family, as many as 18 of which have been discovered so far, was divided into classesI, classesIIa, classesIIb, classesIII and classesIV, The structure, function, subcellular localization and expression patterns of each enzyme are not the same. In recent years, the physiological function of classII HDACs is more widespread attention by researchers, In this paper, we will review the physiological function of classII HDACs in the regulation of bone formation, skeletal muscle regulation, cardiovascular growth and formation, endothelial cells, cytoskeletal dynamics and so on, It also gives a brief description of possible research directions of HDACs, so that it can be widely used in clinical treatment and play a positive therapeutic role.

Published in	Asia-Pacific Journal of Medicine (Volume 3, Issue 1, March 2020)
Page(s)	1-4
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Histone Deace-tylases, HDAC, HAT, Dach2, RUNX2

References

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APA Style

Jianyu Wang, Songpo Yao, Xingzhou Li, Xiaoxia Xu, Ruidi Zhang, et al. (2020). The Research Status of Class II Histone Deace-tylases Physiological Function. Asia-Pacific Journal of Medicine, 3(1), 1-4.

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ACS Style

Jianyu Wang; Songpo Yao; Xingzhou Li; Xiaoxia Xu; Ruidi Zhang, et al. The Research Status of Class II Histone Deace-tylases Physiological Function. Asia-Pac. J. Med. 2020, 3(1), 1-4.

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AMA Style

Jianyu Wang, Songpo Yao, Xingzhou Li, Xiaoxia Xu, Ruidi Zhang, et al. The Research Status of Class II Histone Deace-tylases Physiological Function. Asia-Pac J Med. 2020;3(1):1-4.

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@article{10045225,
  author = {Jianyu Wang and Songpo Yao and Xingzhou Li and Xiaoxia Xu and Ruidi Zhang and Ye Lu and Liangchen Liu and Baosheng Guan and Xianglin Yin},
  title = {The Research Status of Class II Histone Deace-tylases Physiological Function},
  journal = {Asia-Pacific Journal of Medicine},
  volume = {3},
  number = {1},
  pages = {1-4},
  url = {https://www.sciencepublishinggroup.com/article/10045225},
  abstract = {Histone deace-tylases (HDACs) are proteases, The main function of HDACs are to modify the structure of chromosomes and regulate gene expression in organisms. HDACs can catalyze the deacetylation of histones, regulate histone acetylation process and deacetylation process in the nucleus, and maintain its dynamic balance state, which is closely related to the occurrence of cell apoptosis, oxidative stress and with it inflammatory response, metabolic disorders, senescence, tumor and other processes in living things. There are many members of the HDACs family, as many as 18 of which have been discovered so far, was divided into classesI, classesIIa, classesIIb, classesIII and classesIV, The structure, function, subcellular localization and expression patterns of each enzyme are not the same. In recent years, the physiological function of classII HDACs is more widespread attention by researchers, In this paper, we will review the physiological function of classII HDACs in the regulation of bone formation, skeletal muscle regulation, cardiovascular growth and formation, endothelial cells, cytoskeletal dynamics and so on, It also gives a brief description of possible research directions of HDACs, so that it can be widely used in clinical treatment and play a positive therapeutic role.},
 year = {2020}
}

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TY  - JOUR
T1  - The Research Status of Class II Histone Deace-tylases Physiological Function
AU  - Jianyu Wang
AU  - Songpo Yao
AU  - Xingzhou Li
AU  - Xiaoxia Xu
AU  - Ruidi Zhang
AU  - Ye Lu
AU  - Liangchen Liu
AU  - Baosheng Guan
AU  - Xianglin Yin
Y1  - 2020/03/06
PY  - 2020
T2  - Asia-Pacific Journal of Medicine
JF  - Asia-Pacific Journal of Medicine
JO  - Asia-Pacific Journal of Medicine
SP  - 1
EP  - 4
PB  - Science Publishing Group
UR  - http://www.sciencepg.com/article/10045225
AB  - Histone deace-tylases (HDACs) are proteases, The main function of HDACs are to modify the structure of chromosomes and regulate gene expression in organisms. HDACs can catalyze the deacetylation of histones, regulate histone acetylation process and deacetylation process in the nucleus, and maintain its dynamic balance state, which is closely related to the occurrence of cell apoptosis, oxidative stress and with it inflammatory response, metabolic disorders, senescence, tumor and other processes in living things. There are many members of the HDACs family, as many as 18 of which have been discovered so far, was divided into classesI, classesIIa, classesIIb, classesIII and classesIV, The structure, function, subcellular localization and expression patterns of each enzyme are not the same. In recent years, the physiological function of classII HDACs is more widespread attention by researchers, In this paper, we will review the physiological function of classII HDACs in the regulation of bone formation, skeletal muscle regulation, cardiovascular growth and formation, endothelial cells, cytoskeletal dynamics and so on, It also gives a brief description of possible research directions of HDACs, so that it can be widely used in clinical treatment and play a positive therapeutic role.
VL  - 3
IS  - 1
ER  -

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Author Information

Jianyu Wang

School of Public Health, Jiamusi University, Jiamusi, China
Songpo Yao

School of Public Health, Jiamusi University, Jiamusi, China; Heilongjiang Key Laboratory of Gout Research, Jiamusi, China
Xingzhou Li

School of Public Health, Jiamusi University, Jiamusi, China; Heilongjiang Key Laboratory of Gout Research, Jiamusi, China
Xiaoxia Xu

School of Stomatology, Jiamusi University, Jiamusi, China
Ruidi Zhang

School of Public Health, Jiamusi University, Jiamusi, China
Ye Lu

School of Public Health, Jiamusi University, Jiamusi, China
Liangchen Liu

School of Public Health, Jiamusi University, Jiamusi, China
Baosheng Guan

School of Public Health, Jiamusi University, Jiamusi, China; Heilongjiang Key Laboratory of Gout Research, Jiamusi, China
Xianglin Yin

School of Public Health, Jiamusi University, Jiamusi, China; Heilongjiang Key Laboratory of Gout Research, Jiamusi, China

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APA Style

Jianyu Wang, Songpo Yao, Xingzhou Li, Xiaoxia Xu, Ruidi Zhang, et al. (2020). The Research Status of Class II Histone Deace-tylases Physiological Function. Asia-Pacific Journal of Medicine, 3(1), 1-4.

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ACS Style

Jianyu Wang; Songpo Yao; Xingzhou Li; Xiaoxia Xu; Ruidi Zhang, et al. The Research Status of Class II Histone Deace-tylases Physiological Function. Asia-Pac. J. Med. 2020, 3(1), 1-4.

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AMA Style

Jianyu Wang, Songpo Yao, Xingzhou Li, Xiaoxia Xu, Ruidi Zhang, et al. The Research Status of Class II Histone Deace-tylases Physiological Function. Asia-Pac J Med. 2020;3(1):1-4.

Copy | Download

@article{10045225,
  author = {Jianyu Wang and Songpo Yao and Xingzhou Li and Xiaoxia Xu and Ruidi Zhang and Ye Lu and Liangchen Liu and Baosheng Guan and Xianglin Yin},
  title = {The Research Status of Class II Histone Deace-tylases Physiological Function},
  journal = {Asia-Pacific Journal of Medicine},
  volume = {3},
  number = {1},
  pages = {1-4},
  url = {https://www.sciencepublishinggroup.com/article/10045225},
  abstract = {Histone deace-tylases (HDACs) are proteases, The main function of HDACs are to modify the structure of chromosomes and regulate gene expression in organisms. HDACs can catalyze the deacetylation of histones, regulate histone acetylation process and deacetylation process in the nucleus, and maintain its dynamic balance state, which is closely related to the occurrence of cell apoptosis, oxidative stress and with it inflammatory response, metabolic disorders, senescence, tumor and other processes in living things. There are many members of the HDACs family, as many as 18 of which have been discovered so far, was divided into classesI, classesIIa, classesIIb, classesIII and classesIV, The structure, function, subcellular localization and expression patterns of each enzyme are not the same. In recent years, the physiological function of classII HDACs is more widespread attention by researchers, In this paper, we will review the physiological function of classII HDACs in the regulation of bone formation, skeletal muscle regulation, cardiovascular growth and formation, endothelial cells, cytoskeletal dynamics and so on, It also gives a brief description of possible research directions of HDACs, so that it can be widely used in clinical treatment and play a positive therapeutic role.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - The Research Status of Class II Histone Deace-tylases Physiological Function
AU  - Jianyu Wang
AU  - Songpo Yao
AU  - Xingzhou Li
AU  - Xiaoxia Xu
AU  - Ruidi Zhang
AU  - Ye Lu
AU  - Liangchen Liu
AU  - Baosheng Guan
AU  - Xianglin Yin
Y1  - 2020/03/06
PY  - 2020
T2  - Asia-Pacific Journal of Medicine
JF  - Asia-Pacific Journal of Medicine
JO  - Asia-Pacific Journal of Medicine
SP  - 1
EP  - 4
PB  - Science Publishing Group
UR  - http://www.sciencepg.com/article/10045225
AB  - Histone deace-tylases (HDACs) are proteases, The main function of HDACs are to modify the structure of chromosomes and regulate gene expression in organisms. HDACs can catalyze the deacetylation of histones, regulate histone acetylation process and deacetylation process in the nucleus, and maintain its dynamic balance state, which is closely related to the occurrence of cell apoptosis, oxidative stress and with it inflammatory response, metabolic disorders, senescence, tumor and other processes in living things. There are many members of the HDACs family, as many as 18 of which have been discovered so far, was divided into classesI, classesIIa, classesIIb, classesIII and classesIV, The structure, function, subcellular localization and expression patterns of each enzyme are not the same. In recent years, the physiological function of classII HDACs is more widespread attention by researchers, In this paper, we will review the physiological function of classII HDACs in the regulation of bone formation, skeletal muscle regulation, cardiovascular growth and formation, endothelial cells, cytoskeletal dynamics and so on, It also gives a brief description of possible research directions of HDACs, so that it can be widely used in clinical treatment and play a positive therapeutic role.
VL  - 3
IS  - 1
ER  -

Copy | Download