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The Approach to Increase the Bioavailability of Drug(s)
Hydrophobicity is an inherent problem for making a successful formulation using water insoluble drug and/or drugs with poor water solubility.
By A H M Saifuddin
Jun. 4, 2016

Hydrophobicity is an inherent problem for making a successful formulation using water insoluble drug and/or drugs with poor water solubility. Therefore, various approaches such as miceller solubilization, chemical conversion, size reduction, complexation, use of co-solvent, solid dispersion etc are taken to improve the bioavailability of low aqueous soluble drug(s).

In a recent book by author A H M Saifuddin, gliclazide capsules were subjected to solid dispersion technology to improve the bioabailavility of gliclazide which is a type 2 anti-diabetic drug with limited (or poor) water solubility. This book therefore provides information on formulation and preparation of gliclazide capsule by solid dispersion method using polyethylene glycol – a well established non ionic surfactant in different ratios followed by in vitro evaluation of physical and chemical properties.

According to Dr. Sakina Sultana, professor of Department of Pharmacy, Jahangirnagar University, Bangladesh “surfactants plays an important role in enhancing aqueous solubility of hydrophobic drug through solubilisation technique. Such enhancement in solubility may be caused by increasing wettability, dispersibility or may be due to the alteration of surface. In other cases it may be due to the formation of micelles beyond critical micellar concentration where micelles act like micro-containers to carry the hydrophobic drug molecule(s) across the hostile water media and make them bio-available for action. Solid dispersion has become a promising approach in exhibiting a considerable effect for improving solubility of hydrophobic drugs and can be conducted by several methods. In recent years surfactants have been included for betterment of formulation to potentiate solubility”.

In the book, Saifuddin describes Fusion method for preparing solid dispersion followed by encpsulation. Capsules were chosen in this case. This is because; capsules have some advantages over other dosage forms. For instances capsules offer high dose accuracy with minimum excipients and prolong shelf life of drug. Again capsules are tasteless, odorless and can be administered easily. Capsules are attractive in appearance. At last it can be stated that, it is possible to formulate and prepare gliclazide capsule by solid dispersion with success in the laboratory and it would be a remarkable addition to the formulation of Pharmaceutical field indeed.

Saifuddin goes on to suggest that “depending upon the large number of patients, medication has to be up-dated. Again, the number of diabetic patients in this world is increasing day by day. Therefore preparations containing anti-diabetic drug(s) should be investigated with more effort for the benefit(s) of mankind”.

Author:
A H M Saifuddin, B. Pharm, M. Pharm student at department of Pharmacy, Jahangirnagar University, Bangladesh.

Paper Link:
http://article.sciencepublishinggroup.com/html/10.11648.j.ajbls.20160403.15.html

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