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Volume 3, Issue 2-1
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Feb. 28, 2015
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Home / Journals / Cell Biology / Mitochondria: Implications in Human Health and Diseases
Mitochondria: Implications in Human Health and Diseases
Lead Guest Editor:
Lokendra Sharma
Center for Biological Sciences, Central University of Bihar, Patna, Bihar, India
Guest Editors
Department of Molecular Biology and Genetics, Istanbul Arel University
Istanbul, Buyukcekmece, Turkey
Department of Biochemistry, All India Institute of Medical Sciences (AIIMS)
Bhopal, Madhya Pradesh, India
Centre for Biological Sciences (Biotechnology), Central University South Bihar
Patna, Bihar, India
Department of Pathology and Laboratory Medicine, AIIMS-Patna
Patna, Bihar, India
Department of Biodesign, Stanford University
Palo Alto, California, USA
Ashutosh Shrivastava
Division of Experimental Medicine, Beth Israel Deaconess Medical Center
Boston, Massachusetts, USA
Paper List
1
Authors: Rajeev Nema, Ashok Kumar
Pages: 1-7 Published Online: Feb. 10, 2015
Views 3338 Downloads 190
2
Authors: Lokendra Kumar Sharma, Meenakshi Tiwari, Santosh Kumar Mishra
Pages: 8-16 Published Online: Feb. 10, 2015
Views 2917 Downloads 203
3
Authors: Ashutosh Shrivastava
Pages: 17-21 Published Online: Mar. 12, 2015
Views 2703 Downloads 144
4
Authors: Meenakshi Tiwari, Lokendra Kumar Sharma, Ajit K. Saxena, Madan M. Godbole
Pages: 22-30 Published Online: Mar. 20, 2015
Views 2754 Downloads 145
5
Authors: Nadra Sadaf, Jawaid Ahsan, Saif Ahmad, Rizwanul Haque
Pages: 31-37 Published Online: Jun. 9, 2015
Views 5464 Downloads 195
Introduction
Mitochondria play a central role in energy metabolism. It is now well established that functional mitochondria are important in the regulation of several essential cellular metabolic pathways, apoptosis, signal transduction and cell growth. It is of particular importance in the high energy requiring tissues such as brain, heart and muscle. Mitochondrial defects have been implicated in a wide range of clinical conditions such as cancer, neuro-degeneration, obesity, diabetes, ageing and age associated disorders including Parkinson's, Alzheimer's and loss of muscle mass. Since mitochondrial DNA is maternally inherited, mutations in the mitochondrial DNA have also been linked to rare childhood diseases and metabolic syndromes. In recent years tremendous progress has been made in deciphering novel mechanisms of mitochondria in cellular signaling. Rerouting of metabolites in mitochondrial TCA cycle provides alternative ways to generate building blocks such as nucleotides and amino acids for cellular growth and proliferation. Damaged mitochondria are removed through autophagy or functional mitochondria are maintained through enhancing mitochondrial biogenesis. Mitochondrial fission and fusion mechanisms are providing new insights into mitochondrial quality control. In this special issue we will highlight functional aspects of mitochondria in maintaining cellular homeostasis and also the consequences of mitochondrial defects that contributes in disease progression.
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