Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named ‘coronavirus disease 2019’ (COVID-19), which threatens human health and public safety.

It appears that all ages of the population are susceptible to SARS-CoV-2 infection, and the median age of infection is around 50 years. However, clinical manifestations differ with age. In general, older men (>60 years old) with co-morbidities are more likely to develop severe respiratory disease that requires hospitalization or even die, whereas most young people and children have only mild diseases (non-pneumonia or mild pneumonia) or are asymptomatic.

During the previous months, we have seen the rapid pandemic spread of SARS-CoV-2. Despite being considered a respiratory virus, it has become clear that other clinical presentations are possible and some of these are quite frequent. Atypical symptoms can lead to misdiagnosis and subsequently further facilitate the spread of the virus.

Focus of our proposed special issue is to identify possible atypical presentations of SARS-CoV-2 at the department of emergency, in order to promptly treat them.

Aims and Scope: