Effective intervention strategy to contain Ebola disease and epidemic remains daunting. Ebola which is ranks as one of the deadliest contemporary scourge has killed more than 5000 people in just a couple of months. Ebola Virus Disease (EVD) formerly known as Ebola hemorrhagic fever closely resembles Marburg hemorrhagic fever in its clinical manifestations is a severe, often fatal illness in humans. EVD has a fatality rate of above 90%. Ebola is introduced into the human population through close contact with the blood, secretions, organs or other bodily fluids of infected animals. In Africa, infection has been documented through the handling of infected chimpanzees, gorillas, fruit bats, monkeys, forest antelope and porcupines found ill or dead or in the rain forest. Ebola then spreads in the community through human-to-human transmission, with infection resulting from direct contact (through broken skin or mucous membranes) with the blood, secretions, organs or other bodily fluids of infected people, and indirect contact with environments contaminated with such fluids. Burial ceremonies in which mourners have direct contact with the body of the deceased person can also play a role in the transmission of Ebola. Men who have recovered from the disease can still transmit the virus through their semen for up to 7 weeks after recovery from illness. Health-care workers have frequently been infected while treating patients with suspected or confirmed EVD. This has occurred through close contact with patients when infection control precautions are not strictly practiced. Among workers in contact with monkeys or pigs infected with Reston ebolavirus, several infections have been documented in people who were clinically asymptomatic. The current global approach to the tackle Ebola still inadequate to contain this scourge. There are, ultimately, a lot of clinical, scientific and epidemiological and social gaps required to be able to effectively address the global ebola threats. For this purpose, Kenneth Yongabi of the Catholic University of Cameroon organized and convened a conference in September 2014 that looked at several scientific, clinical, and anthropological and possibly control strategies for EVD in Africa.The articles discussed during that session are being published in this special edition of this journal. The aim of this special edition is to provide an opportunity for all medical, health care personnel, the entire global scientific community to publish scientific updates on EVD. It would also provide an opportunity for scientists to share and to network and share new ideas on how to prevent, manage and contain the EVD.