The discovery and development of antibiotics are among the most powerful and successful achievements of modern science and technology for the control of infectious diseases. However, the increasing microbial resistance to antibiotics in use nowadays necessitates the search for new compounds with potential effects against pathogenic bacteria. The most spectacular advances in medicinal chemistry have been made when nitrogen and sulphur containing compounds with heterocyclic, aromatic and heteroaromatic nucleus played an important role in regulating biological activities. When heterocyclic part like imidazole, nitromidazole etc. becomes attached to carbohydrate, their efficiency to inhibit fungus or bacteria sharply increased. Extensive investigations in the field of Schiff bases have been reported. Many Schiff bases are known to be medicinally important and are used to design medicinal compounds. Schiff bases appear to be an important intermediate in a number of enzymatic reactions involving interaction of an enzyme with an amino or a carbonyl group of the substrate. Schiff-base ligands with heterocyclic molecule and/or containing heteroatoms such as N, O, and S show a broad biological activity. Nitro and halo derivatives of Schiff bases are reported to have antimicrobial and antitumor activities. Schiff-base complexes are explored to DNA binding and cleavage and hence have been regarded as models for enzymes such as urease.
We invite investigators to contribute original research articles as well as review articles focused on new synthesis in coordination and organic compounds and their microbial studies.
Potential topics include the following: 1. Synthesis and characterization of coordination compounds 2. Synthesis and characterization of organic compounds 3. Isolation and characterization of natural products 4. Their application in antimicrobial, antitumor, anticancer, DNA cleavage studies etc.