Green chemistry is emerged as popular topic in 21st century. Under green chemistry concepts, researchers develop new technology to replace toxic materials and production. In addition, researchers try their best to reduce environmental impact over the entire product lifecycle. We hope that, green chemistry seeks to protect human health as well and be most cost effective in future. That is the reason, we have to launch special issue on “green chemistry: synthesis and its uses”. We provide a platform to all researchers to share their latest research findings to readers. We welcome researchers from chemistry, engineering, and environmental science areas fully support special issues.