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Volume 4, Issue 2-1
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Feb. 28, 2016
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Home / Journals / Science Journal of Public Health / Obstructive Sleep Apnea: A Systemic Disease
Obstructive Sleep Apnea: A Systemic Disease
Lead Guest Editor:
Professor Aliae AR Mohamed-Hussein
Chest Department, Assiut University Hospitals, Assiut, Egypt
Guest Editors
Klaus Dulhoff
Pulmonology Department, Medical University of Lubeck
Lubeck, Germany
Tenor Henning Koth
Pulmonology Department, Medical University of Lubeck
Lubeck, Germany
Andreas Rembert Koczulla
Pulmonology Department, Marburg University
Marburg, Germany
Roland Buhl
Pulmonary Department, Mainz University Hospital
Mainz, Germany
Ayman Khairy
Cardiology Department, Assiut University Hospitals
Assiut, Egypt
Professor Sherifa Hamed
Department of Neurology and Psychiatry, Assiut University Hospital
Assiut, Egypt
Hossam Gendi
Essex Cardiac Center, Princess Alexandra Hospital
London, UK
John Moxham
Physiology Department, Kings College London
London, UK
Micheal Polkey
Physiology Department, Imperial College London
London, UK
Yoshino Ichiro
Pulmonology Department, Chiba University
Chiba, Japan
Jafar Al-Sharab
Northwestern State University
Las Vegas, Nevada, USA
Mohammed Obeidat
Jordan University of Science and Technology
Amman, Jordan
Obair Siddiqui
LG Electronics Inc.
Detroit, Michigan, USA
Paper List
1
Authors: Aliae AR Mohamed-Hussein, Mohamed-Eltaher AA Ibrahim
Pages: 1-5 Published Online: Sep. 8, 2015
Views 3492 Downloads 68
2
Authors: Sherifa Ahmed Hamed
Pages: 6-16 Published Online: Sep. 8, 2015
Views 6952 Downloads 126
Introduction
Obstructive sleep apnea syndrome (OSAS) is a highly prevalent sleep disorder, characterized by repeated disruptions of breathing during sleep. This disease has many potential consequences including excessive daytime sleepiness, neurocognitive deterioration, endocrinologic and metabolic effects, and decreased quality of life. Metabolic syndrome is another highly prevalence emerging public health problem that represents a constellation of cardiovascular risk factors. Each single component of the cluster increases the cardiovascular risk, but the combination of factors is much more significant. It has been suggested that the presence of OSAS may increase the risk of developing some metabolic syndrome features. Moreover, OSAS patients are at an increased risk for vascular events, which represent the greatest morbidity and mortality of all associated complications.

Although the etiology of OSAS is uncertain, intense local and systemic inflammation is present. A variety of phenomena are implicated in this disease such as modifications in the autonomic nervous system, hypoxemia–reoxygenation cycles, inflammation, and coagulation–fibrinolysis imbalance. OSAS patients also present increased levels of certain biomarkers linked to endocrine-metabolic and cardiovascular alterations among other systemic consequences.

The Aim of this Special issue is to clarify that OSAS is more than a local abnormality, and it should be considered a systemic disease.
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