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Expired Date:
May. 30, 2017
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Home / Journals / International Journal of Pharmacy and Chemistry / Analysis and Removal of Genotoxic Impurities in Pharmaceutical Compounds
Analysis and Removal of Genotoxic Impurities in Pharmaceutical Compounds
Lead Guest Editor:
Göksel Arli
Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey
Guest Editors
Murat Soyseven
Department of Medical Services and Techniques/Yunus Emre Vocational School, Anadolu University
Eskişehir, Turkey
Rüstem Keçili
Department of Medical Services and Techniques/Yunus Emre Vocational School, Anadolu University
Eskişehir, Turkey
Introduction
The presence of chemicals also called impurities in pharmaceutical compounds may effect the efficiency and reliability of the final product. Especially, trace amount of genotoxic impurities in the pharmaceutical compounds play a crucial role in human mutagenicity and carcinogenicity. Considering this matter, either pharma industry or regulatory authorities have carefully focused on this issue. In 2007, a genotoxic compound ethyl mesylate was determined in some batches of Viracept which is an antiviral drug used for the treatment of AIDS produced by Roche. Thereupon, EU has suspended the licence of the drug and drug has been recalled. After this incident, research on the determination and removal of genotoxic impurities has rapidly increased.
This special issue aims to provide a comprehensive collection of original research articles on the analysis and removal of genotoxic impurities in pharmaceutical compounds.

Aims and Scope:
Development of analytical methods for the analysis of genotoxic impurities
Design and preparation of new materials for the removal of genotoxic impurities
Purification of pharmaceutical compounds
Application of polymers in genotoxic impurity removal
Application of reactive scavengers in genotoxic impurity removal
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