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Home / Journals / International Journal of Clinical and Experimental Medical Sciences / Non-coding RNAs: Master Players in Several Pathological Conditions
Non-coding RNAs: Master Players in Several Pathological Conditions

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Lead Guest Editor:
Rana Ahmed Youness Mohamed
Department of Pharmaceutical Biology, Faculty of Pharmacy and Biotechnology, Cairo, Egypt
Introduction
Vast numbers of unique noncoding RNA (ncRNA) molecules have been identified within different cellular compartments. Previous work has shifted the perception of ncRNAs from 'junk' transcriptional products to functional regulatory molecules. ncRNAs could potentially modulate different cellular processes including chromatin re-modeling, transcription, post-transcriptional modifications and most importantly signal transduction through having hundreds of targets that could simultaneously affect, thus nominating ncRNAs to play a key role in the process of carcinogenesis. In terms of oncology, the most abundant and well studied ncRNAs are the small ncRNA molecules known as microRNAs (miRNAs/miRs) and the long ncRNA (lncRNA) molecules. Such ncRNAs have been identified as either oncogenic drivers or tumor suppressors in different malignancies. Of note, ncRNAs have been recently involved in a bi-directional crosstalk between several oncogenic signaling cascades. Thus, a deeper understanding of the complex networks of interactions that ncRNAs could coordinate and are involved in would provide a unique opportunity to design better therapeutic interventions.

Aims and Scope:

  1. Role of microRNAs in Solid Malignancies
  2. Role of microRNAs in Hematological Malignancies
  3. Role of long non-coding RNAs in Solid Malignancies
  4. Role of long non-coding RNAs in Hematological Malignancies
  5. Role of piwi-RNAs in Health and disease
  6. Role of microRNAs in immunology
  7. Role of long non-coding RNAs in immunology
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