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Gene Mutations and Hereditary Hearing Loss
Submission Deadline: Feb. 20, 2020

This special issue currently is open for paper submission and guest editor application.

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Lead Guest Editor
Mahbobeh Koohiyan
Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
Guest Editors
  • Amirhossein Ahmadi
    Department of Pharmacy, School of Medicine, Tehran University of Medical Sciences
    Tehran, Iran
  • Farideh Koohian
    Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences
    Isfahan, Iran
  • Mohammadsaied Jami
    Department of Biotechnology, University of Leon
    Leon, Spain
  • Morteza Hashemzadeh
    Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences
    Shahrekord, Iran
  • Mansour Salehi
    Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences
    Isfahan, Iran
  • Mohamma Amin Tabatabaiefar
    Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences
    Isfahan, Iran
Guidelines for Submission
Manuscripts can be submitted until the expiry of the deadline. Submissions must be previously unpublished and may not be under consideration elsewhere.
Papers should be formatted according to the guidelines for authors (see: http://www.sciencepublishinggroup.com/journal/guideforauthors?journalid=373). By submitting your manuscripts to the special issue, you are acknowledging that you accept the rules established for publication of manuscripts, including agreement to pay the Article Processing Charges for the manuscripts. Manuscripts should be submitted electronically through the online manuscript submission system at http://www.sciencepublishinggroup.com/login. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal and will be listed together on the special issue website.
Published Papers
The special issue currently is open for paper submission. Potential authors are humbly requested to submit an electronic copy of their complete manuscript by clicking here.

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Special Issue

Hearing loss (HL) is the most frequent sensory impairment. The incidence is 1–2 in 1000 neonates (http://hearing. screening.nhs.uk/nationalprog), with approximately 50–70% of cases being related to genetic causes. Autosomal recessive mode of inheritance is highly heterogeneous, for which over 100 mapped loci are known to be involved (http://hereditaryhearingloss.org). This extreme heterogeneity, as well as the assortative mating of deaf individuals, has hindered the search for HL-related genes by medical geneticists. For many years, traditional methods of genetic identification have depended on Sanger sequencing of genes in candidate regions identified through linkage. However, this approach is costly, time consuming, and unsuitable for families with inadequate numbers of available affected individuals combined with locus heterogeneity. Fortunately, a high-throughput, powerful technology known as next-generation sequencing (NGS) has been developed over the past 15 years. This revolutionary sequencing technique is capable of sequencing millions of small fragments covering the whole genome or large regions of interest, such as the entire coding portion of the genome (i.e. exome), at a reasonable cost and reduced runtime compared to Sanger sequencing.
Aims and Scope:
  1. Hereditary hearing loss
  2. Audiology
  3. Gene mutations
  4. Next generation sequencing
  5. Cochlear implantation
  6. Pre-implantation genetic diagnosis
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