Dept. of Pharmacology, SSM college of Pharmacy and research Centre Bldeas,
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Objectives: To evaluate the anti-diabetic effect of Cyperus rotundus rhizome extracts in streptozotocin induced diabetic rats. Methods: Petroleum ether, methanol and aqueous extract of Cyperus rotundus rhizome were tested orally at the dose of 500 mg/kg for hypoglycemic effect in streptozotocin induced diabetic rats for 14 d and on the last day serum was subjected for various biochemical parameters viz. glucose, cholesterol, triglyceride etc., Results: Methanol extract of Cyperus rotundus rhizome has shown a significant antidiabetic activity in streptozotocin induced diabetic rats. Further, this is confirmed by significantly restoring the levels of biochemical parameters and improvement in body weight. Conclusion: The significant antihyperglycemic effect of mehanolic extract in streptozotocin induced diabetic rats could be due to high phenolic constituents present in it. So it might be of value in the treatment of diabetes.