Department of Pharmacology,Faculty of Pharmacy,University of Erciyes,
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The link between inflammation and cancer has been suggested by epidemiological and experimental data and confirmed by anti-inflammatory therapies that show efficacy in cancer prevention and treatment. The fact that continuous irritation over long periods of time can lead to cancer had already been described in the traditional Ayurvedic (meaning “the science of long life”) medical system, written as far back as 5000 years ago. Whether this irritation is the same as what Rudolf Virchow referred to as inflammation in the 19th century is uncertain. Virchow first noted that inflammatory cells are present within tumors and that tumors arise at sites of chronic inflammation. This inflammation is now regarded as a “secret killer” for diseases such as cancer. For example, inflammatory bowel diseases such as Crohn disease and ulcerative colitis are associated with increased risk of colon adenocarcinoma, and chronic pancreatitis is related to an increased rate of pancreatic cancer. Taking into account the high relationship between cancer and inflammation it seems to be a necessity to gather this knowledge in a special issue, namely Cancer and Inflammation.