Abstract: Paget's disease is a chronic disorder of the adult skeleton characterized by focal dys-regulation of bone remodelling. The aim of this study was to demonstrate the contribution of bone scintigraphy to the diagnosis of Paget's disease. The study was observational, cross-sectional and descriptive. It included patients who underwent bone scintigraphy in the nuclear medicine department of Dakar's Idrissa Pouye General Hospital from January 2020 to June 2023, and whose results suspected or confirmed Paget's disease of the bone. We collected a total of seven (07) patients during the study period, six (06) of whom were male with an average age of 67.42 years. Two (02) reasons justified the performance of scintigraphy in these patients. These were suspicion of Paget's disease and assessment of bone extension of prostate cancer with incidental discovery of Paget's disease. Two patients (28.57% of cases) had the monostotic form and five (71.43% of cases) had the polyostotic form. All lesions found on bone scans were hyper-fixating. Three (03) patients showed bone deformities, notably deformities of the long bones, and two (02) had typical osteocondensing (hyperfixation) images of the vertebrae, giving them a "Mickey Mouse" or clover appearance. Whole-body bone scintigraphy has made an important contribution to the diagnosis and assessment of the extent of Paget's disease, with a favourable dosimetric ratio.
Abstract: Paget's disease is a chronic disorder of the adult skeleton characterized by focal dys-regulation of bone remodelling. The aim of this study was to demonstrate the contribution of bone scintigraphy to the diagnosis of Paget's disease. The study was observational, cross-sectional and descriptive. It included patients who underwent bone scintigraphy ...Show More
Abstract: Hyperparathyroidism is a common endocrinopathy, and parathyroid scintigraphy is part of the preoperative work-up. A prerequisite for adenoma surgery is precise localization of the pathological gland(s) concerned. Our aim was to review the parathyroid scans performed for hyperparathyroidism in Senegal. We carried out a retrospective study over a period of 2.5 years, including patients with hyperparathyroidism who underwent parathyroid scintigraphy with 99mTc-MIBI, in the nuclear medicine department of the Idrissa Pouye General Hospital in Dakar. A total of 66 patients were included. The mean age was 52 years, with a sex ratio (M/F) of 0.34. The majority of patients were from the capital, Dakar (93%). Primary hyperparathyroidism was the predominant indication (70%). Most patients were symptomatic. Mean parathyroid hormone (PTH) and Calcemia were 464 pg/ml and 98 mg/l respectively. Ultrasound revealed a thyroid nodule in 35% of cases. The scintigraphy was in favour of parathyroid adenoma (30%) with a predominant right upper location (right P4) (35%) and poor concordance between cervical ultrasound and parathyroid scintigraphy was observed with a kappa coefficient k=0.04. Parathyroid scintigraphy with 99mTc-MIBI allows precise localization of hyper functioning glands, enabling unilateral or minimally invasive cervical surgery to be adopted and reducing the therapeutic failure rate.
Abstract: Hyperparathyroidism is a common endocrinopathy, and parathyroid scintigraphy is part of the preoperative work-up. A prerequisite for adenoma surgery is precise localization of the pathological gland(s) concerned. Our aim was to review the parathyroid scans performed for hyperparathyroidism in Senegal. We carried out a retrospective study over a per...Show More