Evaluation of the Nephroprotective Effect of Omega-3 Polyunsaturated Fatty Acids on Gentamicin-Induced Renal Toxicity in Albino Wistar Rats

Ahon Gnamien Marcel; Ouattara Sitapha; Djyh Bernard Nazaire; Lago Gnonseka Constantin Mederic; Yapi Houphouet Felix; Djaman Allico Joseph

doi:doi:10.11648/j.ajbio.20221006.17

Evaluation of the Nephroprotective Effect of Omega-3 Polyunsaturated Fatty Acids on Gentamicin-Induced Renal Toxicity in Albino Wistar Rats

Ahon Gnamien Marcel, Ouattara Sitapha, Djyh Bernard Nazaire, Lago Gnonseka Constantin Mederic, Yapi Houphouet Felix, Djaman Allico Joseph

Published in American Journal of BioScience (Volume 10, Issue 6)

Received: 16 November 2022 Accepted: 5 December 2022 Published: 30 December 2022

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Abstract

The kidney performs several important functions in the body. Its failure leads to a dysfunction that deserves a solution. Thus, this study was initiated to investigate the protective effects of omega-3 fatty acids on nephrotoxicity. For this purpose, 48 Albino Wistar rats (male and female) were divided into 8 groups of 6 rats. The first group, serving as a control, received 1 mL/g body weight of distilled water daily by gavage and a 0.9% NaCl solution intraperitoneally one hour later. The second, received gentamicin at a dose of 80 mg/Kg/day by intraperitoneal injection for 7 days, the third, treated with the combination of omega 3 by gavage at a dose of 200 mg/Kg of body weight plus gentamicin by intraperitoneal injection at a dose of 80 mg/Kg for the same period. The fourth, treated with the combination of omega 3 by gavage at a dose of 600 mg/Kg body weight plus gentamycin by intraperitoneal injection at a dose of 80 mg/Kg for 7 days, the fifth, treated with the combination of vitamin E at a dose of 250 mg/kg/day body weight by gavage plus gentamicin by intraperitoneal injection at a dose of 80 mg/Kg for 7 days. The sixth and seventh received 200 mg/kg and 600 mg/kg body weight by gavage of omega-3 for 7 days, respectively. The last group received vitamin E at a dose of 250 mg/kg/day of body weight by gavage. Omega-3 at a dose of 600 mg/kg body weight exerts a protective effect against induced nephrotoxicity in rats (especially females), with a decrease in urea and creatinine levels. The consumption of food rich in omega 3 in the protection of the kidneys advised. Further studies could be envisaged to compare the protective effects of omega-3 with other polyunsaturated fatty acids (omega-6 and 9) on nephrotoxicity.

Published in	American Journal of BioScience (Volume 10, Issue 6)
DOI	10.11648/j.ajbio.20221006.17
Page(s)	230-237
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Gentamicin, Nephrotoxicity, Kidney, Omega-3

References

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[15]	Ali B H., Bachir A. A. & Tanira M., 1995 - The effect of thyroxine or carbimazole treatment on gentamicin nephrotoxicity in rats. Human Exposition Toxicology, 14: 13-17.
[16]	Gilbert D. N., Wood C. A., Kohlepp P. W., Houghton D. C., Finkbeiner H. C. & Lindsley J., 1989. Polyaspartic acid prevents experimental nephrotoxicity of aminoglycosides. Journal of Infection Disease, 159: 945-953.
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[18]	Khan M. W., Priyamvada S., Khan S. A., Khan S., Naqshbandi A. and Yusufi A. N., 2012. Protective effect of omega-3 polyunsaturated fatty acids (PUFAs) on sodium nitroprusside-induced nephrotoxicity and oxidative damage in rat kidney. Human Exposition Toxicology, 10: 1035-49.
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APA Style

Ahon Gnamien Marcel, Ouattara Sitapha, Djyh Bernard Nazaire, Lago Gnonseka Constantin Mederic, Yapi Houphouet Felix, et al. (2022). Evaluation of the Nephroprotective Effect of Omega-3 Polyunsaturated Fatty Acids on Gentamicin-Induced Renal Toxicity in Albino Wistar Rats. American Journal of BioScience, 10(6), 230-237. https://doi.org/10.11648/j.ajbio.20221006.17

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ACS Style

Ahon Gnamien Marcel; Ouattara Sitapha; Djyh Bernard Nazaire; Lago Gnonseka Constantin Mederic; Yapi Houphouet Felix, et al. Evaluation of the Nephroprotective Effect of Omega-3 Polyunsaturated Fatty Acids on Gentamicin-Induced Renal Toxicity in Albino Wistar Rats. Am. J. BioScience 2022, 10(6), 230-237. doi: 10.11648/j.ajbio.20221006.17

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AMA Style

Ahon Gnamien Marcel, Ouattara Sitapha, Djyh Bernard Nazaire, Lago Gnonseka Constantin Mederic, Yapi Houphouet Felix, et al. Evaluation of the Nephroprotective Effect of Omega-3 Polyunsaturated Fatty Acids on Gentamicin-Induced Renal Toxicity in Albino Wistar Rats. Am J BioScience. 2022;10(6):230-237. doi: 10.11648/j.ajbio.20221006.17

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@article{10.11648/j.ajbio.20221006.17,
  author = {Ahon Gnamien Marcel and Ouattara Sitapha and Djyh Bernard Nazaire and Lago Gnonseka Constantin Mederic and Yapi Houphouet Felix and Djaman Allico Joseph},
  title = {Evaluation of the Nephroprotective Effect of Omega-3 Polyunsaturated Fatty Acids on Gentamicin-Induced Renal Toxicity in Albino Wistar Rats},
  journal = {American Journal of BioScience},
  volume = {10},
  number = {6},
  pages = {230-237},
  doi = {10.11648/j.ajbio.20221006.17},
  url = {https://doi.org/10.11648/j.ajbio.20221006.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20221006.17},
  abstract = {The kidney performs several important functions in the body. Its failure leads to a dysfunction that deserves a solution. Thus, this study was initiated to investigate the protective effects of omega-3 fatty acids on nephrotoxicity. For this purpose, 48 Albino Wistar rats (male and female) were divided into 8 groups of 6 rats. The first group, serving as a control, received 1 mL/g body weight of distilled water daily by gavage and a 0.9% NaCl solution intraperitoneally one hour later. The second, received gentamicin at a dose of 80 mg/Kg/day by intraperitoneal injection for 7 days, the third, treated with the combination of omega 3 by gavage at a dose of 200 mg/Kg of body weight plus gentamicin by intraperitoneal injection at a dose of 80 mg/Kg for the same period. The fourth, treated with the combination of omega 3 by gavage at a dose of 600 mg/Kg body weight plus gentamycin by intraperitoneal injection at a dose of 80 mg/Kg for 7 days, the fifth, treated with the combination of vitamin E at a dose of 250 mg/kg/day body weight by gavage plus gentamicin by intraperitoneal injection at a dose of 80 mg/Kg for 7 days. The sixth and seventh received 200 mg/kg and 600 mg/kg body weight by gavage of omega-3 for 7 days, respectively. The last group received vitamin E at a dose of 250 mg/kg/day of body weight by gavage. Omega-3 at a dose of 600 mg/kg body weight exerts a protective effect against induced nephrotoxicity in rats (especially females), with a decrease in urea and creatinine levels. The consumption of food rich in omega 3 in the protection of the kidneys advised. Further studies could be envisaged to compare the protective effects of omega-3 with other polyunsaturated fatty acids (omega-6 and 9) on nephrotoxicity.},
 year = {2022}
}

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TY  - JOUR
T1  - Evaluation of the Nephroprotective Effect of Omega-3 Polyunsaturated Fatty Acids on Gentamicin-Induced Renal Toxicity in Albino Wistar Rats
AU  - Ahon Gnamien Marcel
AU  - Ouattara Sitapha
AU  - Djyh Bernard Nazaire
AU  - Lago Gnonseka Constantin Mederic
AU  - Yapi Houphouet Felix
AU  - Djaman Allico Joseph
Y1  - 2022/12/30
PY  - 2022
N1  - https://doi.org/10.11648/j.ajbio.20221006.17
DO  - 10.11648/j.ajbio.20221006.17
T2  - American Journal of BioScience
JF  - American Journal of BioScience
JO  - American Journal of BioScience
SP  - 230
EP  - 237
PB  - Science Publishing Group
SN  - 2330-0167
UR  - https://doi.org/10.11648/j.ajbio.20221006.17
AB  - The kidney performs several important functions in the body. Its failure leads to a dysfunction that deserves a solution. Thus, this study was initiated to investigate the protective effects of omega-3 fatty acids on nephrotoxicity. For this purpose, 48 Albino Wistar rats (male and female) were divided into 8 groups of 6 rats. The first group, serving as a control, received 1 mL/g body weight of distilled water daily by gavage and a 0.9% NaCl solution intraperitoneally one hour later. The second, received gentamicin at a dose of 80 mg/Kg/day by intraperitoneal injection for 7 days, the third, treated with the combination of omega 3 by gavage at a dose of 200 mg/Kg of body weight plus gentamicin by intraperitoneal injection at a dose of 80 mg/Kg for the same period. The fourth, treated with the combination of omega 3 by gavage at a dose of 600 mg/Kg body weight plus gentamycin by intraperitoneal injection at a dose of 80 mg/Kg for 7 days, the fifth, treated with the combination of vitamin E at a dose of 250 mg/kg/day body weight by gavage plus gentamicin by intraperitoneal injection at a dose of 80 mg/Kg for 7 days. The sixth and seventh received 200 mg/kg and 600 mg/kg body weight by gavage of omega-3 for 7 days, respectively. The last group received vitamin E at a dose of 250 mg/kg/day of body weight by gavage. Omega-3 at a dose of 600 mg/kg body weight exerts a protective effect against induced nephrotoxicity in rats (especially females), with a decrease in urea and creatinine levels. The consumption of food rich in omega 3 in the protection of the kidneys advised. Further studies could be envisaged to compare the protective effects of omega-3 with other polyunsaturated fatty acids (omega-6 and 9) on nephrotoxicity.
VL  - 10
IS  - 6
ER  -

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Author Information

Ahon Gnamien Marcel

National Pedagogical Institute of Technical and Vocational Education (NPITVE), Abidjan, Ivory Coast; Biosciences Department, Laboratory of Biology and Health, Felix Houphouetboigny University, Abidjan, Ivory Coast
Ouattara Sitapha

Biosciences Department, Laboratory of Biology and Health, Felix Houphouetboigny University, Abidjan, Ivory Coast
Djyh Bernard Nazaire

Biosciences Department, Laboratory of Biology and Health, Felix Houphouetboigny University, Abidjan, Ivory Coast
Lago Gnonseka Constantin Mederic

Biosciences Department, Laboratory of Biology and Health, Felix Houphouetboigny University, Abidjan, Ivory Coast
Yapi Houphouet Felix

Biosciences Department, Laboratory of Biology and Health, Felix Houphouetboigny University, Abidjan, Ivory Coast
Djaman Allico Joseph

Biosciences Department, Laboratory of Biology and Health, Felix Houphouetboigny University, Abidjan, Ivory Coast

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APA Style

Ahon Gnamien Marcel, Ouattara Sitapha, Djyh Bernard Nazaire, Lago Gnonseka Constantin Mederic, Yapi Houphouet Felix, et al. (2022). Evaluation of the Nephroprotective Effect of Omega-3 Polyunsaturated Fatty Acids on Gentamicin-Induced Renal Toxicity in Albino Wistar Rats. American Journal of BioScience, 10(6), 230-237. https://doi.org/10.11648/j.ajbio.20221006.17

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ACS Style

Ahon Gnamien Marcel; Ouattara Sitapha; Djyh Bernard Nazaire; Lago Gnonseka Constantin Mederic; Yapi Houphouet Felix, et al. Evaluation of the Nephroprotective Effect of Omega-3 Polyunsaturated Fatty Acids on Gentamicin-Induced Renal Toxicity in Albino Wistar Rats. Am. J. BioScience 2022, 10(6), 230-237. doi: 10.11648/j.ajbio.20221006.17

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AMA Style

Ahon Gnamien Marcel, Ouattara Sitapha, Djyh Bernard Nazaire, Lago Gnonseka Constantin Mederic, Yapi Houphouet Felix, et al. Evaluation of the Nephroprotective Effect of Omega-3 Polyunsaturated Fatty Acids on Gentamicin-Induced Renal Toxicity in Albino Wistar Rats. Am J BioScience. 2022;10(6):230-237. doi: 10.11648/j.ajbio.20221006.17

Copy | Download

@article{10.11648/j.ajbio.20221006.17,
  author = {Ahon Gnamien Marcel and Ouattara Sitapha and Djyh Bernard Nazaire and Lago Gnonseka Constantin Mederic and Yapi Houphouet Felix and Djaman Allico Joseph},
  title = {Evaluation of the Nephroprotective Effect of Omega-3 Polyunsaturated Fatty Acids on Gentamicin-Induced Renal Toxicity in Albino Wistar Rats},
  journal = {American Journal of BioScience},
  volume = {10},
  number = {6},
  pages = {230-237},
  doi = {10.11648/j.ajbio.20221006.17},
  url = {https://doi.org/10.11648/j.ajbio.20221006.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20221006.17},
  abstract = {The kidney performs several important functions in the body. Its failure leads to a dysfunction that deserves a solution. Thus, this study was initiated to investigate the protective effects of omega-3 fatty acids on nephrotoxicity. For this purpose, 48 Albino Wistar rats (male and female) were divided into 8 groups of 6 rats. The first group, serving as a control, received 1 mL/g body weight of distilled water daily by gavage and a 0.9% NaCl solution intraperitoneally one hour later. The second, received gentamicin at a dose of 80 mg/Kg/day by intraperitoneal injection for 7 days, the third, treated with the combination of omega 3 by gavage at a dose of 200 mg/Kg of body weight plus gentamicin by intraperitoneal injection at a dose of 80 mg/Kg for the same period. The fourth, treated with the combination of omega 3 by gavage at a dose of 600 mg/Kg body weight plus gentamycin by intraperitoneal injection at a dose of 80 mg/Kg for 7 days, the fifth, treated with the combination of vitamin E at a dose of 250 mg/kg/day body weight by gavage plus gentamicin by intraperitoneal injection at a dose of 80 mg/Kg for 7 days. The sixth and seventh received 200 mg/kg and 600 mg/kg body weight by gavage of omega-3 for 7 days, respectively. The last group received vitamin E at a dose of 250 mg/kg/day of body weight by gavage. Omega-3 at a dose of 600 mg/kg body weight exerts a protective effect against induced nephrotoxicity in rats (especially females), with a decrease in urea and creatinine levels. The consumption of food rich in omega 3 in the protection of the kidneys advised. Further studies could be envisaged to compare the protective effects of omega-3 with other polyunsaturated fatty acids (omega-6 and 9) on nephrotoxicity.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Evaluation of the Nephroprotective Effect of Omega-3 Polyunsaturated Fatty Acids on Gentamicin-Induced Renal Toxicity in Albino Wistar Rats
AU  - Ahon Gnamien Marcel
AU  - Ouattara Sitapha
AU  - Djyh Bernard Nazaire
AU  - Lago Gnonseka Constantin Mederic
AU  - Yapi Houphouet Felix
AU  - Djaman Allico Joseph
Y1  - 2022/12/30
PY  - 2022
N1  - https://doi.org/10.11648/j.ajbio.20221006.17
DO  - 10.11648/j.ajbio.20221006.17
T2  - American Journal of BioScience
JF  - American Journal of BioScience
JO  - American Journal of BioScience
SP  - 230
EP  - 237
PB  - Science Publishing Group
SN  - 2330-0167
UR  - https://doi.org/10.11648/j.ajbio.20221006.17
AB  - The kidney performs several important functions in the body. Its failure leads to a dysfunction that deserves a solution. Thus, this study was initiated to investigate the protective effects of omega-3 fatty acids on nephrotoxicity. For this purpose, 48 Albino Wistar rats (male and female) were divided into 8 groups of 6 rats. The first group, serving as a control, received 1 mL/g body weight of distilled water daily by gavage and a 0.9% NaCl solution intraperitoneally one hour later. The second, received gentamicin at a dose of 80 mg/Kg/day by intraperitoneal injection for 7 days, the third, treated with the combination of omega 3 by gavage at a dose of 200 mg/Kg of body weight plus gentamicin by intraperitoneal injection at a dose of 80 mg/Kg for the same period. The fourth, treated with the combination of omega 3 by gavage at a dose of 600 mg/Kg body weight plus gentamycin by intraperitoneal injection at a dose of 80 mg/Kg for 7 days, the fifth, treated with the combination of vitamin E at a dose of 250 mg/kg/day body weight by gavage plus gentamicin by intraperitoneal injection at a dose of 80 mg/Kg for 7 days. The sixth and seventh received 200 mg/kg and 600 mg/kg body weight by gavage of omega-3 for 7 days, respectively. The last group received vitamin E at a dose of 250 mg/kg/day of body weight by gavage. Omega-3 at a dose of 600 mg/kg body weight exerts a protective effect against induced nephrotoxicity in rats (especially females), with a decrease in urea and creatinine levels. The consumption of food rich in omega 3 in the protection of the kidneys advised. Further studies could be envisaged to compare the protective effects of omega-3 with other polyunsaturated fatty acids (omega-6 and 9) on nephrotoxicity.
VL  - 10
IS  - 6
ER  -

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