Optical Coherence Tomography as an Alternative for Diagnosing Polypoidal Choroidal Vasculopathy in Developing Countries

Armando Bautista-Barba; Erick Andres Quiroz-Gonzalez; Miguel Angel Quiroz-Reyes; Mario Leon-Meza; Alan Chew-Bonilla; Danna Alexandra Alvirde-Ayala; Federico Graue-Wiechers

doi:doi:10.11648/j.ijovs.20210604.17

Optical Coherence Tomography as an Alternative for Diagnosing Polypoidal Choroidal Vasculopathy in Developing Countries

Armando Bautista-Barba, Erick Andres Quiroz-Gonzalez, Miguel Angel Quiroz-Reyes, Mario Leon-Meza, Alan Chew-Bonilla, Danna Alexandra Alvirde-Ayala, Federico Graue-Wiechers

Published in International Journal of Ophthalmology & Visual Science (Volume 6, Issue 4)

Received: 25 October 2021 Accepted: 11 November 2021 Published: 19 November 2021

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Introduction: Polypoidal choroidal vasculopathy (PCV) is a variant of neovascular age-related macular degeneration (nAMD). In clinical practice, PCV is frequently differentiated from nAMD or other retinal diseases using imaging modalities like optical coherence tomography, especially in ophthalmology clinics and hospitals which do not have access to indocyanine green angiography (ICGA), the gold standard in diagnosing PCV. As such, definite diagnosis of PCV is not possible in some cases and the actual prevalence of PCV remains unknown. Case series presentation: We have described a report of four patients without significant past medical history who presented with acute central or paracentral scotoma caused by PCV. Our approach to diagnosing PCV relied on the clinical manifestations of fundus fluorescein angiography (FFA) and spectral domain optical coherence tomography imaging (SS-OCT). Conclusion: In the absence of ICGA and OCT angiography in developing countries, it is essential to distinguish PCV from other retinal diseases, especially neovascular age-related macular degeneration as the treatment and prognosis of PCV differs from that of other retinal diseases. We believe that the key features observed in FFA and SS-OCT can potentially be equivalent to the findings on ICGA in accurate diagnosis of PCV, which is essential in tailoring patient treatment plans, set expectations, and find more effective and precise solutions.

Published in	International Journal of Ophthalmology & Visual Science (Volume 6, Issue 4)
DOI	10.11648/j.ijovs.20210604.17
Page(s)	219-224
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Occult Peripapillary Choroidal Neovascular Membrane, Polypoidal Choroidal Vasculopathy, Anti-VEGF, Age-Related Macular Degeneration, Type 1 Neovascularization

References

[1]	Sahu Y, Chaudhary N, Joshi M, Gandhi A. Idiopathic polypoidal choroidal vasculopathy: a review of literature with clinical update on current management practices. Int Ophthalmol. 2021; 41 (2): 753-65. doi: 10.1007/s10792-020-01620-0.
[2]	Cheung CMG, Lai TYY, Ruamviboonsuk P, et al. Polypoidal Choroidal Vasculopathy: Definition, Pathogenesis, Diagnosis, and Management. Ophthalmology. 2018; 125 (5): 708-24. doi: 10.1016/j.ophtha.2017.11.019.
[3]	Cheung CMG, Lai TYY, Teo K, et al. Polypoidal Choroidal Vasculopathy: Consensus Nomenclature and Non-Indocyanine Green Angiography Diagnostic Criteria from the Asia-Pacific Ocular Imaging Society PCV Workgroup. Ophthalmology. 2021; 128 (3): 443-52. doi: 10.1016/j.ophtha.2020.08.006.
[4]	Lee WK, Iida T, Ogura Y, et al. Efficacy and Safety of Intravitreal Aflibercept for Polypoidal Choroidal Vasculopathy in the PLANET Study: A Randomized Clinical Trial. JAMA Ophthalmol. 2018; 136 (7): 786-93. doi: 10.1001/jamaophthalmol.2018.1804.
[5]	Chaikitmongkol V, Cheung CMG, Koizumi H, Govindahar V, Chhablani J, Lai TYY. Latest Developments in Polypoidal Choroidal Vasculopathy: Epidemiology, Etiology, Diagnosis, and Treatment. Asia-Pac J Ophthalmol. 2020; 9 (3): 260-8. doi: 10.1097/01.APO.0000656992.00746.48.
[6]	Lorentzen TD, Subhi Y, Sørensen TL. PREVALENCE OF POLYPOIDAL CHOROIDAL VASCULOPATHY IN WHITE PATIENTS WITH EXUDATIVE AGE-RELATED MACULAR DEGENERATION: Systematic Review and Meta-Analysis. Retina Phila Pa. 2018 Dec; 38 (12): 2363–71.
[7]	Liu Z-Y, Li B, Xia S, Chen Y-X. Analysis of choroidal morphology and comparison of imaging findings of subtypes of polypoidal choroidal vasculopathy: a new classification system. Int J Ophthalmol. 2020; 13 (5): 731–6.
[8]	Eraydin B, Koçak N, Birinci H. The comparison of spectral domain optical coherence tomography and indocyanine green angiography in the diagnosis of polypoidal choroidal vasculopathy. Int Ophthalmol. 2021 Feb; 41 (2): 659–65.9.
[9]	De Salvo G, Vaz-Pereira S, Keane PA, Tufail A, Liew G. Sensitivity and specificity of spectral-domain optical coherence tomography in detecting idiopathic polypoidal choroidal vasculopathy. Am J Ophthalmol. 2014 Dec; 158 (6): 1228-1238.e1.
[10]	Inoue M, Balaratnasingam C, Freund KB. Optical coherence tomography angiography of polypoidal choroidal vasculopathy and polypoidal choroidal neovascularization. Retina. 2015 Nov; 35 (11): 2265-74.
[11]	Tomiyasu T, Nozaki M, Yoshida M, Ogura Y. Characteristics of polypoidal choroidal vasculopathy evaluated by optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2016 Jul 1; 57 (9): 324-30.
[12]	Wang M, Zhou Y, Gao SS, Liu W, Huang Y, Huang D, Jia Y. Evaluating polypoidal choroidal vasculopathy with optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2016 Jul 1; 57 (9): 526-32.
[13]	Cheung CMG, Lai TYY, Teo K, Ruamviboonsuk P, Chen SJ, Kim JE, Gomi F, et al. Polypoidal choroidal vasculopathy: Consensus Nomenclature and Non-Indocianine green angiography diagnostic criteria from the Asia-Pacific Ocular Imaging Society. PCV Workroup. Ophthalmology. 2021. Mar; 128 (3): 443-452. doi 10.1016/j.ophtha.2020.08.006. Epub 2020 Aug 11. PMID: 32795496.
[14]	Ogura Y, Iida T, Lee WK, Cheung CMG, Mitchell P, Leal S, Schmelter T, Ishibashi T. Efficacy and safety of intravitreal aflibercept for polypoidal choroidal vasculopathy: 96-week outcomes in the Japanese subgroup of the PLANET study. Jpn J Ophthalmol 2021; 65: 344-53. [PMID: 33474611 DOI: 10.1007/s10384-020-00805-5.
[15]	Cho JH, Park YJ, Cho SC, Ryoo NK, Cho KH, Park SJ, Park KH, Woo SJ. POSTTREATMENT POLYP REGRESSION AND RISK OF MASSIVE SUBMACULAR HEMORRHAGE IN EYES WITH POLYPOIDAL CHOROIDAL VASCULOPATHY. Retina 2020; 40: 468-76. [PMID: 30422938 DOI: 10.1097/IAE.0000000000002384] [Cited by in Crossref: 13] [Cited by in F6Publishing: 2] [Article Influence: 13.0].

Cite This Article

Plain Text BibTeX RIS

APA Style

Armando Bautista-Barba, Erick Andres Quiroz-Gonzalez, Miguel Angel Quiroz-Reyes, Mario Leon-Meza, Alan Chew-Bonilla, et al. (2021). Optical Coherence Tomography as an Alternative for Diagnosing Polypoidal Choroidal Vasculopathy in Developing Countries. International Journal of Ophthalmology & Visual Science, 6(4), 219-224. https://doi.org/10.11648/j.ijovs.20210604.17

Copy | Download

ACS Style

Armando Bautista-Barba; Erick Andres Quiroz-Gonzalez; Miguel Angel Quiroz-Reyes; Mario Leon-Meza; Alan Chew-Bonilla, et al. Optical Coherence Tomography as an Alternative for Diagnosing Polypoidal Choroidal Vasculopathy in Developing Countries. Int. J. Ophthalmol. Vis. Sci. 2021, 6(4), 219-224. doi: 10.11648/j.ijovs.20210604.17

Copy | Download

AMA Style

Armando Bautista-Barba, Erick Andres Quiroz-Gonzalez, Miguel Angel Quiroz-Reyes, Mario Leon-Meza, Alan Chew-Bonilla, et al. Optical Coherence Tomography as an Alternative for Diagnosing Polypoidal Choroidal Vasculopathy in Developing Countries. Int J Ophthalmol Vis Sci. 2021;6(4):219-224. doi: 10.11648/j.ijovs.20210604.17

Copy | Download

@article{10.11648/j.ijovs.20210604.17,
  author = {Armando Bautista-Barba and Erick Andres Quiroz-Gonzalez and Miguel Angel Quiroz-Reyes and Mario Leon-Meza and Alan Chew-Bonilla and Danna Alexandra Alvirde-Ayala and Federico Graue-Wiechers},
  title = {Optical Coherence Tomography as an Alternative for Diagnosing Polypoidal Choroidal Vasculopathy in Developing Countries},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {6},
  number = {4},
  pages = {219-224},
  doi = {10.11648/j.ijovs.20210604.17},
  url = {https://doi.org/10.11648/j.ijovs.20210604.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20210604.17},
  abstract = {Introduction: Polypoidal choroidal vasculopathy (PCV) is a variant of neovascular age-related macular degeneration (nAMD). In clinical practice, PCV is frequently differentiated from nAMD or other retinal diseases using imaging modalities like optical coherence tomography, especially in ophthalmology clinics and hospitals which do not have access to indocyanine green angiography (ICGA), the gold standard in diagnosing PCV. As such, definite diagnosis of PCV is not possible in some cases and the actual prevalence of PCV remains unknown. Case series presentation: We have described a report of four patients without significant past medical history who presented with acute central or paracentral scotoma caused by PCV. Our approach to diagnosing PCV relied on the clinical manifestations of fundus fluorescein angiography (FFA) and spectral domain optical coherence tomography imaging (SS-OCT). Conclusion: In the absence of ICGA and OCT angiography in developing countries, it is essential to distinguish PCV from other retinal diseases, especially neovascular age-related macular degeneration as the treatment and prognosis of PCV differs from that of other retinal diseases. We believe that the key features observed in FFA and SS-OCT can potentially be equivalent to the findings on ICGA in accurate diagnosis of PCV, which is essential in tailoring patient treatment plans, set expectations, and find more effective and precise solutions.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Optical Coherence Tomography as an Alternative for Diagnosing Polypoidal Choroidal Vasculopathy in Developing Countries
AU  - Armando Bautista-Barba
AU  - Erick Andres Quiroz-Gonzalez
AU  - Miguel Angel Quiroz-Reyes
AU  - Mario Leon-Meza
AU  - Alan Chew-Bonilla
AU  - Danna Alexandra Alvirde-Ayala
AU  - Federico Graue-Wiechers
Y1  - 2021/11/19
PY  - 2021
N1  - https://doi.org/10.11648/j.ijovs.20210604.17
DO  - 10.11648/j.ijovs.20210604.17
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 219
EP  - 224
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20210604.17
AB  - Introduction: Polypoidal choroidal vasculopathy (PCV) is a variant of neovascular age-related macular degeneration (nAMD). In clinical practice, PCV is frequently differentiated from nAMD or other retinal diseases using imaging modalities like optical coherence tomography, especially in ophthalmology clinics and hospitals which do not have access to indocyanine green angiography (ICGA), the gold standard in diagnosing PCV. As such, definite diagnosis of PCV is not possible in some cases and the actual prevalence of PCV remains unknown. Case series presentation: We have described a report of four patients without significant past medical history who presented with acute central or paracentral scotoma caused by PCV. Our approach to diagnosing PCV relied on the clinical manifestations of fundus fluorescein angiography (FFA) and spectral domain optical coherence tomography imaging (SS-OCT). Conclusion: In the absence of ICGA and OCT angiography in developing countries, it is essential to distinguish PCV from other retinal diseases, especially neovascular age-related macular degeneration as the treatment and prognosis of PCV differs from that of other retinal diseases. We believe that the key features observed in FFA and SS-OCT can potentially be equivalent to the findings on ICGA in accurate diagnosis of PCV, which is essential in tailoring patient treatment plans, set expectations, and find more effective and precise solutions.
VL  - 6
IS  - 4
ER  -

Copy | Download

Author Information

Armando Bautista-Barba

Department of Ophthalmology, Institute of Ophthalmology, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
Erick Andres Quiroz-Gonzalez

Department of Ophthalmology, Institute of Ophthalmology, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
Miguel Angel Quiroz-Reyes

Retina Department, Institute of Ophthalmology, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
Mario Leon-Meza

Department of Ophthalmology, Institute of Ophthalmology, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
Alan Chew-Bonilla

Department of Ophthalmology, Institute of Ophthalmology, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
Danna Alexandra Alvirde-Ayala

Department of Ophthalmology, Institute of Ophthalmology, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
Federico Graue-Wiechers

Retina Department, Institute of Ophthalmology, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Armando Bautista-Barba, Erick Andres Quiroz-Gonzalez, Miguel Angel Quiroz-Reyes, Mario Leon-Meza, Alan Chew-Bonilla, et al. (2021). Optical Coherence Tomography as an Alternative for Diagnosing Polypoidal Choroidal Vasculopathy in Developing Countries. International Journal of Ophthalmology & Visual Science, 6(4), 219-224. https://doi.org/10.11648/j.ijovs.20210604.17

Copy | Download

ACS Style

Armando Bautista-Barba; Erick Andres Quiroz-Gonzalez; Miguel Angel Quiroz-Reyes; Mario Leon-Meza; Alan Chew-Bonilla, et al. Optical Coherence Tomography as an Alternative for Diagnosing Polypoidal Choroidal Vasculopathy in Developing Countries. Int. J. Ophthalmol. Vis. Sci. 2021, 6(4), 219-224. doi: 10.11648/j.ijovs.20210604.17

Copy | Download

AMA Style

Armando Bautista-Barba, Erick Andres Quiroz-Gonzalez, Miguel Angel Quiroz-Reyes, Mario Leon-Meza, Alan Chew-Bonilla, et al. Optical Coherence Tomography as an Alternative for Diagnosing Polypoidal Choroidal Vasculopathy in Developing Countries. Int J Ophthalmol Vis Sci. 2021;6(4):219-224. doi: 10.11648/j.ijovs.20210604.17

Copy | Download

@article{10.11648/j.ijovs.20210604.17,
  author = {Armando Bautista-Barba and Erick Andres Quiroz-Gonzalez and Miguel Angel Quiroz-Reyes and Mario Leon-Meza and Alan Chew-Bonilla and Danna Alexandra Alvirde-Ayala and Federico Graue-Wiechers},
  title = {Optical Coherence Tomography as an Alternative for Diagnosing Polypoidal Choroidal Vasculopathy in Developing Countries},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {6},
  number = {4},
  pages = {219-224},
  doi = {10.11648/j.ijovs.20210604.17},
  url = {https://doi.org/10.11648/j.ijovs.20210604.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20210604.17},
  abstract = {Introduction: Polypoidal choroidal vasculopathy (PCV) is a variant of neovascular age-related macular degeneration (nAMD). In clinical practice, PCV is frequently differentiated from nAMD or other retinal diseases using imaging modalities like optical coherence tomography, especially in ophthalmology clinics and hospitals which do not have access to indocyanine green angiography (ICGA), the gold standard in diagnosing PCV. As such, definite diagnosis of PCV is not possible in some cases and the actual prevalence of PCV remains unknown. Case series presentation: We have described a report of four patients without significant past medical history who presented with acute central or paracentral scotoma caused by PCV. Our approach to diagnosing PCV relied on the clinical manifestations of fundus fluorescein angiography (FFA) and spectral domain optical coherence tomography imaging (SS-OCT). Conclusion: In the absence of ICGA and OCT angiography in developing countries, it is essential to distinguish PCV from other retinal diseases, especially neovascular age-related macular degeneration as the treatment and prognosis of PCV differs from that of other retinal diseases. We believe that the key features observed in FFA and SS-OCT can potentially be equivalent to the findings on ICGA in accurate diagnosis of PCV, which is essential in tailoring patient treatment plans, set expectations, and find more effective and precise solutions.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Optical Coherence Tomography as an Alternative for Diagnosing Polypoidal Choroidal Vasculopathy in Developing Countries
AU  - Armando Bautista-Barba
AU  - Erick Andres Quiroz-Gonzalez
AU  - Miguel Angel Quiroz-Reyes
AU  - Mario Leon-Meza
AU  - Alan Chew-Bonilla
AU  - Danna Alexandra Alvirde-Ayala
AU  - Federico Graue-Wiechers
Y1  - 2021/11/19
PY  - 2021
N1  - https://doi.org/10.11648/j.ijovs.20210604.17
DO  - 10.11648/j.ijovs.20210604.17
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 219
EP  - 224
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20210604.17
AB  - Introduction: Polypoidal choroidal vasculopathy (PCV) is a variant of neovascular age-related macular degeneration (nAMD). In clinical practice, PCV is frequently differentiated from nAMD or other retinal diseases using imaging modalities like optical coherence tomography, especially in ophthalmology clinics and hospitals which do not have access to indocyanine green angiography (ICGA), the gold standard in diagnosing PCV. As such, definite diagnosis of PCV is not possible in some cases and the actual prevalence of PCV remains unknown. Case series presentation: We have described a report of four patients without significant past medical history who presented with acute central or paracentral scotoma caused by PCV. Our approach to diagnosing PCV relied on the clinical manifestations of fundus fluorescein angiography (FFA) and spectral domain optical coherence tomography imaging (SS-OCT). Conclusion: In the absence of ICGA and OCT angiography in developing countries, it is essential to distinguish PCV from other retinal diseases, especially neovascular age-related macular degeneration as the treatment and prognosis of PCV differs from that of other retinal diseases. We believe that the key features observed in FFA and SS-OCT can potentially be equivalent to the findings on ICGA in accurate diagnosis of PCV, which is essential in tailoring patient treatment plans, set expectations, and find more effective and precise solutions.
VL  - 6
IS  - 4
ER  -

Copy | Download