Biochemistry and Molecular Biology

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Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity

Received: 22 June 2022    Accepted: 09 July 2022    Published: 18 July 2022
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Abstract

Obesity has become a global epidemic and is a known risk factor for several adverse health outcomes. Single Nucleotide Polymorphism (SNP) in leptin receptor genes become interesting candidates as susceptibility genes for obesity and glucose homeostasis. The present study intended to explore the genetic analysis of LEPR gene K109, Q223R, and K656N polymorphisms and their relation to obesity and fasting plasma glucose (FPG) concentration in the Myanmar population. One hundred and fifty diagnosed obese subjects and 150 healthy non-obese controls were included. Fasting plasma glucose (FPG) was measured and LEPR gene K109R, Q223R, and K656N polymorphisms were detected by DNA analysis. Data were analyzed by chi-square and one-way ANOVA tests. Each genotype frequency distribution of LEPR gene (K109R, Q223R, and K656N) polymorphisms was not associated with obesity (p > 0.05), as well as each allele frequency distribution also similar outcome (p > 0.05). FPG levels of the study population showed no significant differences between each genotype of LEPR gene polymorphisms (p > 0.05). The K109R, Q223R, and K656N polymorphisms of the LEPR gene were not linked to obesity or FPG levels in the population of Myanmar, according to our findings. Therefore, it does not seem that these polymorphisms have an equivalently significant role for the people of Myanmar. To completely understand the unique genetic variables that predispose to obesity in humans, an ongoing study of diverse obesity phenotypes and related gene mutations is necessary as our understanding of the genes causing obesity increases as a result of new findings.

DOI 10.11648/j.bmb.20220703.11
Published in Biochemistry and Molecular Biology (Volume 7, Issue 3, September 2022)
Page(s) 54-60
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Obesity, Fasting Plasma Glucose, LEPR Gene K109R SNP, LEPR Gene Q223R SNP, LEPR Gene K656N SNP

References
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Author Information
  • Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar

  • Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar

  • Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar

  • Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar

  • Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar

  • Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar

  • Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar

  • Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar

  • Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar

  • Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar

  • Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar

Cite This Article
  • APA Style

    Mo Mo Than, Yan Naing Soe, Zaw Myo Lwin, Ye Wint Kyaw, Kyaw Thet Paing, et al. (2022). Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity. Biochemistry and Molecular Biology, 7(3), 54-60. https://doi.org/10.11648/j.bmb.20220703.11

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    ACS Style

    Mo Mo Than; Yan Naing Soe; Zaw Myo Lwin; Ye Wint Kyaw; Kyaw Thet Paing, et al. Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity. Biochem. Mol. Biol. 2022, 7(3), 54-60. doi: 10.11648/j.bmb.20220703.11

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    AMA Style

    Mo Mo Than, Yan Naing Soe, Zaw Myo Lwin, Ye Wint Kyaw, Kyaw Thet Paing, et al. Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity. Biochem Mol Biol. 2022;7(3):54-60. doi: 10.11648/j.bmb.20220703.11

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  • @article{10.11648/j.bmb.20220703.11,
      author = {Mo Mo Than and Yan Naing Soe and Zaw Myo Lwin and Ye Wint Kyaw and Kyaw Thet Paing and Khine Kyaw Oo and Phyo Thaw Htun and Aung Lin Oo and Min Thein and Ye Myat Kyaw and Zaw Min Htut},
      title = {Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity},
      journal = {Biochemistry and Molecular Biology},
      volume = {7},
      number = {3},
      pages = {54-60},
      doi = {10.11648/j.bmb.20220703.11},
      url = {https://doi.org/10.11648/j.bmb.20220703.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.bmb.20220703.11},
      abstract = {Obesity has become a global epidemic and is a known risk factor for several adverse health outcomes. Single Nucleotide Polymorphism (SNP) in leptin receptor genes become interesting candidates as susceptibility genes for obesity and glucose homeostasis. The present study intended to explore the genetic analysis of LEPR gene K109, Q223R, and K656N polymorphisms and their relation to obesity and fasting plasma glucose (FPG) concentration in the Myanmar population. One hundred and fifty diagnosed obese subjects and 150 healthy non-obese controls were included. Fasting plasma glucose (FPG) was measured and LEPR gene K109R, Q223R, and K656N polymorphisms were detected by DNA analysis. Data were analyzed by chi-square and one-way ANOVA tests. Each genotype frequency distribution of LEPR gene (K109R, Q223R, and K656N) polymorphisms was not associated with obesity (p > 0.05), as well as each allele frequency distribution also similar outcome (p > 0.05). FPG levels of the study population showed no significant differences between each genotype of LEPR gene polymorphisms (p > 0.05). The K109R, Q223R, and K656N polymorphisms of the LEPR gene were not linked to obesity or FPG levels in the population of Myanmar, according to our findings. Therefore, it does not seem that these polymorphisms have an equivalently significant role for the people of Myanmar. To completely understand the unique genetic variables that predispose to obesity in humans, an ongoing study of diverse obesity phenotypes and related gene mutations is necessary as our understanding of the genes causing obesity increases as a result of new findings.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity
    AU  - Mo Mo Than
    AU  - Yan Naing Soe
    AU  - Zaw Myo Lwin
    AU  - Ye Wint Kyaw
    AU  - Kyaw Thet Paing
    AU  - Khine Kyaw Oo
    AU  - Phyo Thaw Htun
    AU  - Aung Lin Oo
    AU  - Min Thein
    AU  - Ye Myat Kyaw
    AU  - Zaw Min Htut
    Y1  - 2022/07/18
    PY  - 2022
    N1  - https://doi.org/10.11648/j.bmb.20220703.11
    DO  - 10.11648/j.bmb.20220703.11
    T2  - Biochemistry and Molecular Biology
    JF  - Biochemistry and Molecular Biology
    JO  - Biochemistry and Molecular Biology
    SP  - 54
    EP  - 60
    PB  - Science Publishing Group
    SN  - 2575-5048
    UR  - https://doi.org/10.11648/j.bmb.20220703.11
    AB  - Obesity has become a global epidemic and is a known risk factor for several adverse health outcomes. Single Nucleotide Polymorphism (SNP) in leptin receptor genes become interesting candidates as susceptibility genes for obesity and glucose homeostasis. The present study intended to explore the genetic analysis of LEPR gene K109, Q223R, and K656N polymorphisms and their relation to obesity and fasting plasma glucose (FPG) concentration in the Myanmar population. One hundred and fifty diagnosed obese subjects and 150 healthy non-obese controls were included. Fasting plasma glucose (FPG) was measured and LEPR gene K109R, Q223R, and K656N polymorphisms were detected by DNA analysis. Data were analyzed by chi-square and one-way ANOVA tests. Each genotype frequency distribution of LEPR gene (K109R, Q223R, and K656N) polymorphisms was not associated with obesity (p > 0.05), as well as each allele frequency distribution also similar outcome (p > 0.05). FPG levels of the study population showed no significant differences between each genotype of LEPR gene polymorphisms (p > 0.05). The K109R, Q223R, and K656N polymorphisms of the LEPR gene were not linked to obesity or FPG levels in the population of Myanmar, according to our findings. Therefore, it does not seem that these polymorphisms have an equivalently significant role for the people of Myanmar. To completely understand the unique genetic variables that predispose to obesity in humans, an ongoing study of diverse obesity phenotypes and related gene mutations is necessary as our understanding of the genes causing obesity increases as a result of new findings.
    VL  - 7
    IS  - 3
    ER  - 

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