Biochemistry and Molecular Biology

Special Issue

Stress and Alzheimer's Disease

  • Submission Deadline: Jan. 01, 2024
  • Status: Submission Closed
  • Lead Guest Editor: Fang Du
About This Special Issue
Stress damages the brain and is a risk factor for Alzheimer’s disease. Alzheimer’s disease is a progressive neurodegenerative diseases that is associated with the abnormal upregulation of oxidative stress, and its pathology is characterized by deposition of extracellular β-amyloid (Aβ) plaques and intracellular neurofibrillary tangles. Mitochondrial dysfunction and synaptic dysfunctions are early pathological features of Alzheimer’s disease-affected brains. Mitochondria are a major source of reactive oxygen species (ROS), and mitochondria-mediated oxidative stress contributes to Aβ and tau oligomer formation and accumulation. Therefore, inhibiting mitochondrial oxidative stress and dysfunctions could be a promising therapeutic target to prevent and treat Alzheimer’s disease.
Specific aims of the issue of Stress and Alzheimer's disease are to explore:
The proposed journal will encompass a wide range of articles, including original research, review papers, case studies, and expert commentaries, all focused on various aspects of laboratory medical education. The journal may include topics related to:
(1) Regulation of stress to Aβ formation and tau phosphorylation and oligomerization;
(2) Relationship between stress and mitochondrial defects during Alzheimer’s disease;
(3) Contribution of stress to synaptic function and neurodegeneration induced memory deficiency during Alzheimer’s disease;
(4) Effect of stress-targeted compounds or drugs on the progression and neurodegeneration of Alzheimer’s disease.
We invite researchers, educators and practitioners to contribute their insights, experiences and research findings to this special issue.

Keywords:

  1. Stress
  2. Alzheimer's Disease
  3. Tau
  4. β-Amyloid
  5. Reactive Oxygen Species
  6. Neurodegeneration
  7. Mitochondria
Lead Guest Editor
  • Fang Du

    Department of Pathology and Cell Biology,Taub Institute for Research on Alzheimer's Disease and the Aging Brain, at Columbia University Medical Center, New York., New York, United States

Guest Editors
  • Qing Yu

    Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, at Columbia University Medical Center, New York., New York, United States

  • Alessia Pascale

    Department of Drug Sciences, Section of Pharmacology, University of Pavia, Pavia, Italy

  • Eva-Maria Hanschmann

    Department of Otolaryngology, Heinrich Heine University of Düsseldorf, Essen, Germany

  • Claudia Balducci

    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy

  • Nektarios Tavernarakis

    Department of Basic Sciences, Institute of Molecular Biology and Biotechnology (IMBB) Medical School of the University of Crete, Greece, Greece

  • Annalisa Marcuzzi

    Department of Translational Medicine, University of Ferrara, Ferrara, Italy