Procalcitonin (PCT) is a biomarker for bacterial infections. The aim of this study was to evaluate diagnostic performance of cerebrospinal fluid procalcitonin (CSF PCT) as tools for detecting bacterial meningitis. This was a prospective and descriptive study conducted at Sourô Sanou University Hospital from May to August 2022. Random sampling was carried out, including patients with suspected bacterial meningitis. Quantitative procalcitonin was determined on CSF supernatants by electrochemiluminescence. Direct real-time PCR (rt-PCR) was applied from the specimen, for species diagnosis of Neisseria meningitidis, Streptococcus pneumoniae and Haemophilus influenzae. Fisher's exact test was used to assess associations with a significance level of 0.05%. Receiver Operating Characteristic (ROC) analysis was used to assess diagnostic performance. A total of 52 patients with a median age of 18.00 years (minimum-maximum: 0.030-87 years) were included. PCR analysis was positive in 13.46% CSF samples (7/52). A new CSF PCT cut-off value equal to 0.106 ng/mL was determined, with a diagnostic sensitivity and specificity of 100.0% [IC95%=59.0-100.0] and 40.0% [IC95%= 25.7-55.7]. The area under the curve (AUC) for CSF PCT obtained was equal to 0.597 [CI95%=0.439-0.754]. So, we can assume CSF PCT to be a fairly good tool for detecting bacterial meningitis in suspected meningitis. Further research is needed to better determine CSF PCT's diagnostic contribution in patients with tropical diseases.
| Published in | Advances in Biochemistry (Volume 11, Issue 3) |
| DOI | 10.11648/j.ab.20231103.13 |
| Page(s) | 41-46 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Bacterial Meningitis, Procalcitonin, Cerebrospinal Fluid
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APA Style
Ollo Da, Constantin Dabiré, Arnaud Kouraogo, Adama Kabore, Emmanuel Zongo, et al. (2023). Diagnostic Performance Evaluation of Cerebrospinal Fluid Procalcitonin in Patients with Bacterial Meningitis from Sourô Sanou University Hospital, Burkina Faso. Advances in Biochemistry, 11(3), 41-46. https://doi.org/10.11648/j.ab.20231103.13
ACS Style
Ollo Da; Constantin Dabiré; Arnaud Kouraogo; Adama Kabore; Emmanuel Zongo, et al. Diagnostic Performance Evaluation of Cerebrospinal Fluid Procalcitonin in Patients with Bacterial Meningitis from Sourô Sanou University Hospital, Burkina Faso. Adv. Biochem. 2023, 11(3), 41-46. doi: 10.11648/j.ab.20231103.13
AMA Style
Ollo Da, Constantin Dabiré, Arnaud Kouraogo, Adama Kabore, Emmanuel Zongo, et al. Diagnostic Performance Evaluation of Cerebrospinal Fluid Procalcitonin in Patients with Bacterial Meningitis from Sourô Sanou University Hospital, Burkina Faso. Adv Biochem. 2023;11(3):41-46. doi: 10.11648/j.ab.20231103.13
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Download@article{10.11648/j.ab.20231103.13,
author = {Ollo Da and Constantin Dabiré and Arnaud Kouraogo and Adama Kabore and Emmanuel Zongo and Fatou Gueye Tal and Nelly Maurine Yaméogo and Abdoul Salam Ouédraogo and Bamba Sanata and Georges Anicet Ouédraogo},
title = {Diagnostic Performance Evaluation of Cerebrospinal Fluid Procalcitonin in Patients with Bacterial Meningitis from Sourô Sanou University Hospital, Burkina Faso},
journal = {Advances in Biochemistry},
volume = {11},
number = {3},
pages = {41-46},
doi = {10.11648/j.ab.20231103.13},
url = {https://doi.org/10.11648/j.ab.20231103.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20231103.13},
abstract = {Procalcitonin (PCT) is a biomarker for bacterial infections. The aim of this study was to evaluate diagnostic performance of cerebrospinal fluid procalcitonin (CSF PCT) as tools for detecting bacterial meningitis. This was a prospective and descriptive study conducted at Sourô Sanou University Hospital from May to August 2022. Random sampling was carried out, including patients with suspected bacterial meningitis. Quantitative procalcitonin was determined on CSF supernatants by electrochemiluminescence. Direct real-time PCR (rt-PCR) was applied from the specimen, for species diagnosis of Neisseria meningitidis, Streptococcus pneumoniae and Haemophilus influenzae. Fisher's exact test was used to assess associations with a significance level of 0.05%. Receiver Operating Characteristic (ROC) analysis was used to assess diagnostic performance. A total of 52 patients with a median age of 18.00 years (minimum-maximum: 0.030-87 years) were included. PCR analysis was positive in 13.46% CSF samples (7/52). A new CSF PCT cut-off value equal to 0.106 ng/mL was determined, with a diagnostic sensitivity and specificity of 100.0% [IC95%=59.0-100.0] and 40.0% [IC95%= 25.7-55.7]. The area under the curve (AUC) for CSF PCT obtained was equal to 0.597 [CI95%=0.439-0.754]. So, we can assume CSF PCT to be a fairly good tool for detecting bacterial meningitis in suspected meningitis. Further research is needed to better determine CSF PCT's diagnostic contribution in patients with tropical diseases.},
year = {2023}
}
TY - JOUR T1 - Diagnostic Performance Evaluation of Cerebrospinal Fluid Procalcitonin in Patients with Bacterial Meningitis from Sourô Sanou University Hospital, Burkina Faso AU - Ollo Da AU - Constantin Dabiré AU - Arnaud Kouraogo AU - Adama Kabore AU - Emmanuel Zongo AU - Fatou Gueye Tal AU - Nelly Maurine Yaméogo AU - Abdoul Salam Ouédraogo AU - Bamba Sanata AU - Georges Anicet Ouédraogo Y1 - 2023/09/20 PY - 2023 N1 - https://doi.org/10.11648/j.ab.20231103.13 DO - 10.11648/j.ab.20231103.13 T2 - Advances in Biochemistry JF - Advances in Biochemistry JO - Advances in Biochemistry SP - 41 EP - 46 PB - Science Publishing Group SN - 2329-0862 UR - https://doi.org/10.11648/j.ab.20231103.13 AB - Procalcitonin (PCT) is a biomarker for bacterial infections. The aim of this study was to evaluate diagnostic performance of cerebrospinal fluid procalcitonin (CSF PCT) as tools for detecting bacterial meningitis. This was a prospective and descriptive study conducted at Sourô Sanou University Hospital from May to August 2022. Random sampling was carried out, including patients with suspected bacterial meningitis. Quantitative procalcitonin was determined on CSF supernatants by electrochemiluminescence. Direct real-time PCR (rt-PCR) was applied from the specimen, for species diagnosis of Neisseria meningitidis, Streptococcus pneumoniae and Haemophilus influenzae. Fisher's exact test was used to assess associations with a significance level of 0.05%. Receiver Operating Characteristic (ROC) analysis was used to assess diagnostic performance. A total of 52 patients with a median age of 18.00 years (minimum-maximum: 0.030-87 years) were included. PCR analysis was positive in 13.46% CSF samples (7/52). A new CSF PCT cut-off value equal to 0.106 ng/mL was determined, with a diagnostic sensitivity and specificity of 100.0% [IC95%=59.0-100.0] and 40.0% [IC95%= 25.7-55.7]. The area under the curve (AUC) for CSF PCT obtained was equal to 0.597 [CI95%=0.439-0.754]. So, we can assume CSF PCT to be a fairly good tool for detecting bacterial meningitis in suspected meningitis. Further research is needed to better determine CSF PCT's diagnostic contribution in patients with tropical diseases. VL - 11 IS - 3 ER -
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