Homocysteinemia Level Determination Among Retired People in Bobo Dioulasso, Burkina Faso
Ollo Da,
Souleymane Fofana,
Emmanuel Zongo,
Arnaud Kouraogo,
Dieudonne Sanon,
Adama Hermann Traore,
Fatou Gueye Tall,
Sanata Bamba,
Georges Anicet Ouedraogo
Issue:
Volume 11, Issue 3, September 2023
Pages:
29-33
Received:
30 May 2023
Accepted:
25 June 2023
Published:
11 July 2023
Abstract: Hyperhomocysteinemia, currently a public health problem, has been associated with the onset of critical diseases among elderly persons. Our aim in this study was to determine homocysteinemia levels in retired people. A cross sectional study was carried out among retired people in Bobo Dioulasso. Sociodemographic and clinico-biological variables were collected. Quantitative determination of total homocysteinemia in serum was carried out by a chemiluminescence microparticle immunoassay (CMIA). Three homocysteinemia levels were considered: moderate (16-30 µmol/L), intermediate (31-100 µmol/L), and severe (>100 µmol/L). Fisher's exact test was used to examine the significance of the association with a p-value of 0.05. We included a total of 71 retired people, with a median age of 64 years [minimum - maximum: 45 - 92 years], Hyperhomocysteinemia between [16-30 µmol/L [was observed in 16.90% (12/71) with a median homocysteinemia value equal to 18.71 µmol/L [minimum - maximum = 16.57 - 26.60 µmol/L]. Hyperhomocysteinemia was not significantly associated with increased blood pressure (p = 0.817), age group (p = 0.958), sex (p = 0.106), body mass index (0.053), estimated GFR (p = 0.590). A low frequency of moderate hyperhomocysteinemia was recorded in retired persons in Bobo-Dioulasso. An investigation of genetic polymorphisms associated with hyperhomocysteinemia could be considered.
Abstract: Hyperhomocysteinemia, currently a public health problem, has been associated with the onset of critical diseases among elderly persons. Our aim in this study was to determine homocysteinemia levels in retired people. A cross sectional study was carried out among retired people in Bobo Dioulasso. Sociodemographic and clinico-biological variables wer...
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Multivariate Analysis of Tea (Camellia sinensis (L.) O. Kuntze) Clones on Biochemical Characters in Southwestern Ethiopia
Lemi Beksisa,
Mohammedsani Zakir,
Melaku Addisu
Issue:
Volume 11, Issue 3, September 2023
Pages:
34-40
Received:
6 July 2023
Accepted:
21 July 2023
Published:
31 July 2023
Abstract: Information on genetic diversity with respect to biochemical characteristics is very important for improving tea quality. Thirteen introduced tea clones were characterized at Jimma agricultural research center (Melko and Gera research stations) with the aim of identifying the diversity of tea clones based on biochemical traits. The study was conducted in triplicate of RCBD during the 2017/18 crop season. Data on biochemical traits such as total polyphenols, total antioxidants, β-carotene, ascorbic acid, leaf water content, chlorophyll content, and photosynthetic efficiency were recorded. Cluster analysis showed that the tea clones were classified into four groups, indicating the presence of variability among the examined clones. The maximum distance was observed between clusters III and IV (1216) whereas, the minimum distance (373.39) was between clusters II and IV. The results of principal components analysis exhibited that the first three principal components contributed for 77.22% diversity among the tea clones. In general, the study showed existing of difference among tea clones on considered biochemical parameters. Nevertheless, high biochemical variation among clones does not only a assurance for a high genetic difference; hence, molecular research need to be complemented as corresponding to biochemical studies.
Abstract: Information on genetic diversity with respect to biochemical characteristics is very important for improving tea quality. Thirteen introduced tea clones were characterized at Jimma agricultural research center (Melko and Gera research stations) with the aim of identifying the diversity of tea clones based on biochemical traits. The study was conduc...
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Diagnostic Performance Evaluation of Cerebrospinal Fluid Procalcitonin in Patients with Bacterial Meningitis from Sourô Sanou University Hospital, Burkina Faso
Ollo Da,
Constantin Dabiré,
Arnaud Kouraogo,
Adama Kabore,
Emmanuel Zongo,
Fatou Gueye Tal,
Nelly Maurine Yaméogo,
Abdoul Salam Ouédraogo,
Bamba Sanata,
Georges Anicet Ouédraogo
Issue:
Volume 11, Issue 3, September 2023
Pages:
41-46
Received:
17 August 2023
Accepted:
11 September 2023
Published:
20 September 2023
Abstract: Procalcitonin (PCT) is a biomarker for bacterial infections. The aim of this study was to evaluate diagnostic performance of cerebrospinal fluid procalcitonin (CSF PCT) as tools for detecting bacterial meningitis. This was a prospective and descriptive study conducted at Sourô Sanou University Hospital from May to August 2022. Random sampling was carried out, including patients with suspected bacterial meningitis. Quantitative procalcitonin was determined on CSF supernatants by electrochemiluminescence. Direct real-time PCR (rt-PCR) was applied from the specimen, for species diagnosis of Neisseria meningitidis, Streptococcus pneumoniae and Haemophilus influenzae. Fisher's exact test was used to assess associations with a significance level of 0.05%. Receiver Operating Characteristic (ROC) analysis was used to assess diagnostic performance. A total of 52 patients with a median age of 18.00 years (minimum-maximum: 0.030-87 years) were included. PCR analysis was positive in 13.46% CSF samples (7/52). A new CSF PCT cut-off value equal to 0.106 ng/mL was determined, with a diagnostic sensitivity and specificity of 100.0% [IC95%=59.0-100.0] and 40.0% [IC95%= 25.7-55.7]. The area under the curve (AUC) for CSF PCT obtained was equal to 0.597 [CI95%=0.439-0.754]. So, we can assume CSF PCT to be a fairly good tool for detecting bacterial meningitis in suspected meningitis. Further research is needed to better determine CSF PCT's diagnostic contribution in patients with tropical diseases.
Abstract: Procalcitonin (PCT) is a biomarker for bacterial infections. The aim of this study was to evaluate diagnostic performance of cerebrospinal fluid procalcitonin (CSF PCT) as tools for detecting bacterial meningitis. This was a prospective and descriptive study conducted at Sourô Sanou University Hospital from May to August 2022. Random sampling was c...
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