Ectopic Parathyroid Adenoma in the Framework of an MEN1

Meriem Medjaher; Ali Khenniche; Feteh Allah Isnasni

doi:doi:10.11648/j.ajcem.20231101.11

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Ectopic Parathyroid Adenoma in the Framework of an MEN1

Meriem Medjaher, Ali Khenniche, Feteh Allah Isnasni

Published in American Journal of Clinical and Experimental Medicine (Volume 11, Issue 1)

Received: 2 August 2022 Accepted: 23 August 2022 Published: 9 January 2023

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Abstract

Multiple endocrine neoplasia type 1 (MEN1 or Wermer syndrome) is a rare hereditary disease, and especially its association with ectopic parathyroid adenomas is even more. Defined As a tumor developing in at least two endocrine glands including the anterior pituitary gland, the parathyroid glands and the duodeno-pancreatic endocrine tissue. This autosomal dominant hereditary pathology is caused by the mutation of the NEM1 gene encoding the tumor suppressor menin and located on chromosome 11q13. There is, however, sporadic cases account for 8 to 14%. Primary hyperparathyroidism is a frequent pathology secondary to autonomous overproduction of PTH (parathyroid hormone); it is mostly due to parathyroid adenomas (solitary or multiple). Diagnosis is purely biochemical. Cervical ultrasound and MIBI parathyroid scintigraphy is most often performed in the first line with good diagnostic performance, surgery is the only curative treatment for primary hyperparathyroidism, the reason why a preoperative localization and at best per-operative detection in the case of an ectopic adenoma to ensure proper resection and avoid subsequent recurrences.

Published in	American Journal of Clinical and Experimental Medicine (Volume 11, Issue 1)
DOI	10.11648/j.ajcem.20231101.11
Page(s)	1-4
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

MEN1, Primary Hyperparathyroidism, Parathyroid Scintigraphy, MIBI, Surgery, Per Operative Isotopic Detection, SPECT/CT, Ectopy

References

[1]	Adami S, Marco Cocci C, Gatti D, «Epidemiology of primary hyperparathyroidism in Europe» [archive] J Bone Miner Res. 2002; 17 (suppl 2): N18-23.
[2]	Calender A, Gadiot, Mignon M. Multiple endocrine neoplasia type 1: genetic and clinical aspects. Gastroenterol Clin biol. 2001 AD; 25.
[3]	Walker MD, Silverberg SJ. Primary hyperparathyroidism. Nat Rev Endocrinol. Feb 2018; 14 (2): 115-25.
[4]	Schappacher-Tilp G, Cherif A, Fuertinger DH, Bushinsky D, Kotanko P, A mathematical model of parathyroid gland biology. Physiological reports. 2019 Apr; [PubMed PMID: 30927339].
[5]	Taterra D, Wong L M, Vikse J, Sanna B, Pękala P, Walocha J, Cirocchi R, Tomaszewski K, Henry BM, The prevalence and anatomy of parathyroid glands: a meta-analysis with implications for parathyroid surgery. Langenbeck's archives of surgery. 2019 Feb; [PubMed PMID: 30762091].
[6]	CHAPUIS Y., FULLA Y., BONNICHON P., TALA E., ABDOU B., PITRE J., RICHARD B.—Values of ultrasonography, sestamibi scintigraphy, and intra operative measurement of 1 ¢ 84 PTH for unilateral neck exploration of primary hyperparathyroïdism. World J. Surg. 1996, 20, 835-840.
[7]	GIORDANO A., RUBELLO D., CASARA D. — New trends in parathyroid scintigraphy Eur. J. Nucl. Med. 2001, 28, 1409-1420.
[8]	Pata G, Casella C, Besuzio S, Mittempergher F, Salerni B. Clinical appraisal of 99m technetium-sestamibi SPECT/CT compared to conventional SPECT in patients with primary hyperparathyroidism and concomitant nodular goiter. Thyroid. 2010; 20: 1121–7.
[9]	Krausz Y, Bettman L, Guralnik L, Yoselevsky G, Keidar Z, Bar-Shalom R, et al. Technetium-99m-MIBI SPECT/CT in primary hyperparathyroidism. World J Surg. 2006; 30: 76–83.
[10]	Patrinos A, Zarokosta M, PiperosT, Chrysikos D, Kakaviatos D, Theodoropoulos P, Kalles V, Tsiaousis J, Noussios G, Mariolis-Sapsago T, An anatomic aberration and a surgical challenge: Mediastinal parathyroid adenoma anterior the pericardium. A case report. International journal of surgery case reports. 2019 Mar 21; [PubMed PMID: 30943449].

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APA Style

Meriem Medjaher, Ali Khenniche, Feteh Allah Isnasni. (2023). Ectopic Parathyroid Adenoma in the Framework of an MEN1. American Journal of Clinical and Experimental Medicine, 11(1), 1-4. https://doi.org/10.11648/j.ajcem.20231101.11

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ACS Style

Meriem Medjaher; Ali Khenniche; Feteh Allah Isnasni. Ectopic Parathyroid Adenoma in the Framework of an MEN1. Am. J. Clin. Exp. Med. 2023, 11(1), 1-4. doi: 10.11648/j.ajcem.20231101.11

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AMA Style

Meriem Medjaher, Ali Khenniche, Feteh Allah Isnasni. Ectopic Parathyroid Adenoma in the Framework of an MEN1. Am J Clin Exp Med. 2023;11(1):1-4. doi: 10.11648/j.ajcem.20231101.11

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@article{10.11648/j.ajcem.20231101.11,
  author = {Meriem Medjaher and Ali Khenniche and Feteh Allah Isnasni},
  title = {Ectopic Parathyroid Adenoma in the Framework of an MEN1},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {11},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.ajcem.20231101.11},
  url = {https://doi.org/10.11648/j.ajcem.20231101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20231101.11},
  abstract = {Multiple endocrine neoplasia type 1 (MEN1 or Wermer syndrome) is a rare hereditary disease, and especially its association with ectopic parathyroid adenomas is even more. Defined As a tumor developing in at least two endocrine glands including the anterior pituitary gland, the parathyroid glands and the duodeno-pancreatic endocrine tissue. This autosomal dominant hereditary pathology is caused by the mutation of the NEM1 gene encoding the tumor suppressor menin and located on chromosome 11q13. There is, however, sporadic cases account for 8 to 14%. Primary hyperparathyroidism is a frequent pathology secondary to autonomous overproduction of PTH (parathyroid hormone); it is mostly due to parathyroid adenomas (solitary or multiple). Diagnosis is purely biochemical. Cervical ultrasound and MIBI parathyroid scintigraphy is most often performed in the first line with good diagnostic performance, surgery is the only curative treatment for primary hyperparathyroidism, the reason why a preoperative localization and at best per-operative detection in the case of an ectopic adenoma to ensure proper resection and avoid subsequent recurrences.},
 year = {2023}
}

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TY  - JOUR
T1  - Ectopic Parathyroid Adenoma in the Framework of an MEN1
AU  - Meriem Medjaher
AU  - Ali Khenniche
AU  - Feteh Allah Isnasni
Y1  - 2023/01/09
PY  - 2023
N1  - https://doi.org/10.11648/j.ajcem.20231101.11
DO  - 10.11648/j.ajcem.20231101.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20231101.11
AB  - Multiple endocrine neoplasia type 1 (MEN1 or Wermer syndrome) is a rare hereditary disease, and especially its association with ectopic parathyroid adenomas is even more. Defined As a tumor developing in at least two endocrine glands including the anterior pituitary gland, the parathyroid glands and the duodeno-pancreatic endocrine tissue. This autosomal dominant hereditary pathology is caused by the mutation of the NEM1 gene encoding the tumor suppressor menin and located on chromosome 11q13. There is, however, sporadic cases account for 8 to 14%. Primary hyperparathyroidism is a frequent pathology secondary to autonomous overproduction of PTH (parathyroid hormone); it is mostly due to parathyroid adenomas (solitary or multiple). Diagnosis is purely biochemical. Cervical ultrasound and MIBI parathyroid scintigraphy is most often performed in the first line with good diagnostic performance, surgery is the only curative treatment for primary hyperparathyroidism, the reason why a preoperative localization and at best per-operative detection in the case of an ectopic adenoma to ensure proper resection and avoid subsequent recurrences.
VL  - 11
IS  - 1
ER  -

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Author Information

Meriem Medjaher

Nuclear Medicine Department, Mohamed Seghir Nekkache Central Hospital, Algiers, Algeria
Ali Khenniche

Nuclear Medicine Department, Mohamed Seghir Nekkache Central Hospital, Algiers, Algeria
Feteh Allah Isnasni

Nuclear Medicine Department, Mohamed Seghir Nekkache Central Hospital, Algiers, Algeria

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Plain Text BibTeX RIS

APA Style

Meriem Medjaher, Ali Khenniche, Feteh Allah Isnasni. (2023). Ectopic Parathyroid Adenoma in the Framework of an MEN1. American Journal of Clinical and Experimental Medicine, 11(1), 1-4. https://doi.org/10.11648/j.ajcem.20231101.11

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ACS Style

Meriem Medjaher; Ali Khenniche; Feteh Allah Isnasni. Ectopic Parathyroid Adenoma in the Framework of an MEN1. Am. J. Clin. Exp. Med. 2023, 11(1), 1-4. doi: 10.11648/j.ajcem.20231101.11

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AMA Style

Meriem Medjaher, Ali Khenniche, Feteh Allah Isnasni. Ectopic Parathyroid Adenoma in the Framework of an MEN1. Am J Clin Exp Med. 2023;11(1):1-4. doi: 10.11648/j.ajcem.20231101.11

Copy | Download

@article{10.11648/j.ajcem.20231101.11,
  author = {Meriem Medjaher and Ali Khenniche and Feteh Allah Isnasni},
  title = {Ectopic Parathyroid Adenoma in the Framework of an MEN1},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {11},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.ajcem.20231101.11},
  url = {https://doi.org/10.11648/j.ajcem.20231101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20231101.11},
  abstract = {Multiple endocrine neoplasia type 1 (MEN1 or Wermer syndrome) is a rare hereditary disease, and especially its association with ectopic parathyroid adenomas is even more. Defined As a tumor developing in at least two endocrine glands including the anterior pituitary gland, the parathyroid glands and the duodeno-pancreatic endocrine tissue. This autosomal dominant hereditary pathology is caused by the mutation of the NEM1 gene encoding the tumor suppressor menin and located on chromosome 11q13. There is, however, sporadic cases account for 8 to 14%. Primary hyperparathyroidism is a frequent pathology secondary to autonomous overproduction of PTH (parathyroid hormone); it is mostly due to parathyroid adenomas (solitary or multiple). Diagnosis is purely biochemical. Cervical ultrasound and MIBI parathyroid scintigraphy is most often performed in the first line with good diagnostic performance, surgery is the only curative treatment for primary hyperparathyroidism, the reason why a preoperative localization and at best per-operative detection in the case of an ectopic adenoma to ensure proper resection and avoid subsequent recurrences.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Ectopic Parathyroid Adenoma in the Framework of an MEN1
AU  - Meriem Medjaher
AU  - Ali Khenniche
AU  - Feteh Allah Isnasni
Y1  - 2023/01/09
PY  - 2023
N1  - https://doi.org/10.11648/j.ajcem.20231101.11
DO  - 10.11648/j.ajcem.20231101.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20231101.11
AB  - Multiple endocrine neoplasia type 1 (MEN1 or Wermer syndrome) is a rare hereditary disease, and especially its association with ectopic parathyroid adenomas is even more. Defined As a tumor developing in at least two endocrine glands including the anterior pituitary gland, the parathyroid glands and the duodeno-pancreatic endocrine tissue. This autosomal dominant hereditary pathology is caused by the mutation of the NEM1 gene encoding the tumor suppressor menin and located on chromosome 11q13. There is, however, sporadic cases account for 8 to 14%. Primary hyperparathyroidism is a frequent pathology secondary to autonomous overproduction of PTH (parathyroid hormone); it is mostly due to parathyroid adenomas (solitary or multiple). Diagnosis is purely biochemical. Cervical ultrasound and MIBI parathyroid scintigraphy is most often performed in the first line with good diagnostic performance, surgery is the only curative treatment for primary hyperparathyroidism, the reason why a preoperative localization and at best per-operative detection in the case of an ectopic adenoma to ensure proper resection and avoid subsequent recurrences.
VL  - 11
IS  - 1
ER  -

Copy | Download