Ectopic Parathyroid Adenoma in the Framework of an MEN1
Meriem Medjaher,
Ali Khenniche,
Feteh Allah Isnasni
Issue:
Volume 11, Issue 1, January 2023
Pages:
1-4
Received:
2 August 2022
Accepted:
23 August 2022
Published:
9 January 2023
Abstract: Multiple endocrine neoplasia type 1 (MEN1 or Wermer syndrome) is a rare hereditary disease, and especially its association with ectopic parathyroid adenomas is even more. Defined As a tumor developing in at least two endocrine glands including the anterior pituitary gland, the parathyroid glands and the duodeno-pancreatic endocrine tissue. This autosomal dominant hereditary pathology is caused by the mutation of the NEM1 gene encoding the tumor suppressor menin and located on chromosome 11q13. There is, however, sporadic cases account for 8 to 14%. Primary hyperparathyroidism is a frequent pathology secondary to autonomous overproduction of PTH (parathyroid hormone); it is mostly due to parathyroid adenomas (solitary or multiple). Diagnosis is purely biochemical. Cervical ultrasound and MIBI parathyroid scintigraphy is most often performed in the first line with good diagnostic performance, surgery is the only curative treatment for primary hyperparathyroidism, the reason why a preoperative localization and at best per-operative detection in the case of an ectopic adenoma to ensure proper resection and avoid subsequent recurrences.
Abstract: Multiple endocrine neoplasia type 1 (MEN1 or Wermer syndrome) is a rare hereditary disease, and especially its association with ectopic parathyroid adenomas is even more. Defined As a tumor developing in at least two endocrine glands including the anterior pituitary gland, the parathyroid glands and the duodeno-pancreatic endocrine tissue. This aut...
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The Features of the Course of Traumatic Brain Disease in Persons with Combat Traumatic Brain Injury
Issue:
Volume 11, Issue 1, January 2023
Pages:
5-8
Received:
29 August 2022
Accepted:
20 September 2022
Published:
9 January 2023
Abstract: This article is devoted to the problem of survival and prognosis of treatment outcomes of patients with traumatic brain injury who have sustained craniocerebral trauma according to changes in neurospecific protein (S100β) levels during the acute period of trauma. The material includes data from the examination of 250 combatants and invalids who sustained craniocerebral trauma in the ATO-JFO zone at the neurological department of the Regional Hospital for War Veterans. An analysis of the course and results of treatment of patients who had sustained severe craniocerebral trauma was carried out. Patients underwent routine biochemical examinations, neuroimaging studies and neurospecific protein (S100β) levels examination in the acute period of trauma. On the basis of the data obtained, it was found that the level of neurospecific protein S100β in the blood serum takes a great role in predicting the course and outcome of the disease.
Abstract: This article is devoted to the problem of survival and prognosis of treatment outcomes of patients with traumatic brain injury who have sustained craniocerebral trauma according to changes in neurospecific protein (S100β) levels during the acute period of trauma. The material includes data from the examination of 250 combatants and invalids who sus...
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Coagulation Parameters Among Sudanese Individuals Vaccinated with Johnson and Johnson Vaccine at Khartoum State, 2022
Nihad Elsadig Babiker,
Bashir Ahmed Albashir Ahmed,
Faihaa Alhady Alhussien Mohammed,
Aamir Yassir Bashir Mohammed,
Amna Ibrahim Hroon Abdelrhman,
Duaa Adel Abdalrehim,
Maye Mohammed Merghani,
Tyseer Alabid
Issue:
Volume 11, Issue 1, January 2023
Pages:
9-16
Received:
15 November 2022
Accepted:
4 January 2023
Published:
13 January 2023
Abstract: Background: A COVID 19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome corona virus 2. Ad26.COV2.S (Johnson & Johnson) vaccine is adenovirus vector-based vaccine that targets the spike protein of the SARS-CoV-2 virus, when it enters the body it stimulates the immune response. Materials and methods: This was a cross sectional study, health facility base, Conducted in Vaccine centre at Omer ben Alkhatab, Khartoum, Sudan during the period July to August, 2022 to estimate changes of coagulation parameters among Sudanese vaccinated with Johnson & Johnson vaccine. Sixty samples were collected from the Participants that took the first dose of Johnson & Johnson vaccine; thirty samples before the vaccination, and thirty after vaccination. The coagulation parameters were performing by different methods. Results: The means of parameters before the vaccination were; APTT was (36.2 ±3), PT was (15.8±2.4), INR (1.2 ±0.2), platelets (285.9 ±7.2), fibrinogen (243.4 ±4.6) and D-dimer (0.17±0.03). The means of parameters after the vaccination for the APTT, PT, INR, platelets count, fibrinogen and the D-dimer were; (35.2 ±2.9), (13.9±2.1), (1.21±0.3), (272.8±57.9), (284.2 ±53.3) and (0.37±0.8) respectively. When compared between the results of parameters per and post vaccination the results revealed that; there was significant decrease in the time for the APTT and PTT (p value ≤0.05), in significant differences with the INR and platelets count (p value ≥0.05), significant increase for the fibrinogen and D- dimer level (p value ≤0.05). While when compared the mean of the parameters with the age, genders, and symptoms there was insignificant differences (p value ≥0.05), except the D – dimer had a significant differences with the age and symptoms (p value ≤0.05). Conclusion: In the conclusion of this study there was significant decrease of the activated partial thromboplastin time (APTT), Prothrombin time (PT), and significant increase in fibrinogen and D-dimer level in the Sudanese individuals after the first dose of Johnson and Johnson Vaccine.
Abstract: Background: A COVID 19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome corona virus 2. Ad26.COV2.S (Johnson & Johnson) vaccine is adenovirus vector-based vaccine that targets the spike protein of the SARS-CoV-2 virus, when it enters the body it stimulates the immune response. Materials and method...
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Oblique Lateral Lumbar Interbody Fusion and Transforaminal Lumbar Interbody Fusion for Lumbar Degenerative Disease: A Meta-Analysis
Weibin Liang,
Yukun Jia,
Kaishuai Zhao,
Guangye Wang
Issue:
Volume 11, Issue 1, January 2023
Pages:
17-28
Received:
11 January 2023
Accepted:
8 February 2023
Published:
21 February 2023
Abstract: Introduction: Oblique lateral lumbar interbody fusion (OLIF) and transforaminal lumbar interbody fusion (TLIF) are two commonly used procedures for the treatment of lumbar degenerative diseases, but the efficacy of the two procedures is not clear. Materials and Methods: PubMed, Embase, and Cochrane Library databases were searched for controlled studies of OLIF and TLIF in the treatment of lumbar degenerative diseases. Include all articles published before Oct 2022. Two researchers conducted quality evaluation and data extraction on the research respectively. Results: This meta-analysis finally included 27 studies. The VAS and ODI scores of the two groups decreased significantly after the operation. The decrease of the visual Analogue Score (VAS) and The Oswestry Disability Index (ODI) scores in the OLIF group was greater than that in the TLIF group within 6 months after the operation, but no difference was found in the follow-up for more than 6 months. The OLIF group was better than TLIF in restoring the lumbar lordosis angle and intervertebral height. The operation time, blood loss and hospital stay of the OLIF group were less than those of the TLIF group, and there was no significant difference between the two in terms of surgical complications and fusion rate. Conclusions: Although there was no significant difference between the OLIF and TLIF groups in terms of long-term pain relief and functional improvement, the OLIF group experienced greater short-term efficacy than the TLIF group and the surgical safety of OLIF was better than that of TLIF.
Abstract: Introduction: Oblique lateral lumbar interbody fusion (OLIF) and transforaminal lumbar interbody fusion (TLIF) are two commonly used procedures for the treatment of lumbar degenerative diseases, but the efficacy of the two procedures is not clear. Materials and Methods: PubMed, Embase, and Cochrane Library databases were searched for controlled stu...
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