Profound Sensorineural Hearing Loss Following Adjuvant Steroid Delay in Pediatric Bacterial Meningitis

Nayri Topalian; Amani Mansour; Saraa Wehbe; Sarah El Yaman

doi:doi:10.11648/j.ajp.20220802.26

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Profound Sensorineural Hearing Loss Following Adjuvant Steroid Delay in Pediatric Bacterial Meningitis

Nayri Topalian, Amani Mansour, Saraa Wehbe, Sarah El Yaman

Published in American Journal of Pediatrics (Volume 8, Issue 2)

Received: 23 May 2022 Accepted: 14 June 2022 Published: 27 June 2022

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Abstract

Streptococcus pneumonia is a gram positive, polysaccharide-encapsulated diplococcus associated with various pulmonary and extra-pulmonary clinical presentations including invasive diseases such as acute meningitis. It can be associated with high rates of morbidity and mortality in both the pediatric and the adult populations. The introduction of the pneumococcal conjugate vaccine which expanded to cover 13 strains allowed remarkable protection against these invasive infections. In addition, the use of adjuvant corticosteroid therapy in the last few years; in particular dexamethasone, for the management of acute bacterial meningitis reduced the incidence of severe hearing loss in both Hib and other bacterial meningitis. The IDS guidelines recommend administering the first dose of steroids just before or with the start of antibiotics due to its decreased effectiveness with the late presentations of meningitis. We present the case of a 14-year-old female adolescent refugee, with incomplete vaccination status prior to relocating to Lebanon presenting with pneumococcal meningitis. Her hospitalization was complicated by bilateral profound sensorineural hearing loss (SNHL) following a delay in steroid administration. The aim of this article is to highlight the role of vaccines in decreasing morbidity of vaccine-preventable illnesses, and the importance of early administration of steroids as adjuvant to therapy for prevention of neurologic sequeleae.

Published in	American Journal of Pediatrics (Volume 8, Issue 2)
DOI	10.11648/j.ajp.20220802.26
Page(s)	141-145
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Bacterial Meningitis, Streptococcus Pneumonia, Hearing Loss, Dexamethasone, Vaccines

References

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APA Style

Nayri Topalian, Amani Mansour, Saraa Wehbe, Sarah El Yaman. (2022). Profound Sensorineural Hearing Loss Following Adjuvant Steroid Delay in Pediatric Bacterial Meningitis. American Journal of Pediatrics, 8(2), 141-145. https://doi.org/10.11648/j.ajp.20220802.26

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ACS Style

Nayri Topalian; Amani Mansour; Saraa Wehbe; Sarah El Yaman. Profound Sensorineural Hearing Loss Following Adjuvant Steroid Delay in Pediatric Bacterial Meningitis. Am. J. Pediatr. 2022, 8(2), 141-145. doi: 10.11648/j.ajp.20220802.26

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AMA Style

Nayri Topalian, Amani Mansour, Saraa Wehbe, Sarah El Yaman. Profound Sensorineural Hearing Loss Following Adjuvant Steroid Delay in Pediatric Bacterial Meningitis. Am J Pediatr. 2022;8(2):141-145. doi: 10.11648/j.ajp.20220802.26

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@article{10.11648/j.ajp.20220802.26,
  author = {Nayri Topalian and Amani Mansour and Saraa Wehbe and Sarah El Yaman},
  title = {Profound Sensorineural Hearing Loss Following Adjuvant Steroid Delay in Pediatric Bacterial Meningitis},
  journal = {American Journal of Pediatrics},
  volume = {8},
  number = {2},
  pages = {141-145},
  doi = {10.11648/j.ajp.20220802.26},
  url = {https://doi.org/10.11648/j.ajp.20220802.26},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220802.26},
  abstract = {Streptococcus pneumonia is a gram positive, polysaccharide-encapsulated diplococcus associated with various pulmonary and extra-pulmonary clinical presentations including invasive diseases such as acute meningitis. It can be associated with high rates of morbidity and mortality in both the pediatric and the adult populations. The introduction of the pneumococcal conjugate vaccine which expanded to cover 13 strains allowed remarkable protection against these invasive infections. In addition, the use of adjuvant corticosteroid therapy in the last few years; in particular dexamethasone, for the management of acute bacterial meningitis reduced the incidence of severe hearing loss in both Hib and other bacterial meningitis. The IDS guidelines recommend administering the first dose of steroids just before or with the start of antibiotics due to its decreased effectiveness with the late presentations of meningitis. We present the case of a 14-year-old female adolescent refugee, with incomplete vaccination status prior to relocating to Lebanon presenting with pneumococcal meningitis. Her hospitalization was complicated by bilateral profound sensorineural hearing loss (SNHL) following a delay in steroid administration. The aim of this article is to highlight the role of vaccines in decreasing morbidity of vaccine-preventable illnesses, and the importance of early administration of steroids as adjuvant to therapy for prevention of neurologic sequeleae.},
 year = {2022}
}

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TY  - JOUR
T1  - Profound Sensorineural Hearing Loss Following Adjuvant Steroid Delay in Pediatric Bacterial Meningitis
AU  - Nayri Topalian
AU  - Amani Mansour
AU  - Saraa Wehbe
AU  - Sarah El Yaman
Y1  - 2022/06/27
PY  - 2022
N1  - https://doi.org/10.11648/j.ajp.20220802.26
DO  - 10.11648/j.ajp.20220802.26
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 141
EP  - 145
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20220802.26
AB  - Streptococcus pneumonia is a gram positive, polysaccharide-encapsulated diplococcus associated with various pulmonary and extra-pulmonary clinical presentations including invasive diseases such as acute meningitis. It can be associated with high rates of morbidity and mortality in both the pediatric and the adult populations. The introduction of the pneumococcal conjugate vaccine which expanded to cover 13 strains allowed remarkable protection against these invasive infections. In addition, the use of adjuvant corticosteroid therapy in the last few years; in particular dexamethasone, for the management of acute bacterial meningitis reduced the incidence of severe hearing loss in both Hib and other bacterial meningitis. The IDS guidelines recommend administering the first dose of steroids just before or with the start of antibiotics due to its decreased effectiveness with the late presentations of meningitis. We present the case of a 14-year-old female adolescent refugee, with incomplete vaccination status prior to relocating to Lebanon presenting with pneumococcal meningitis. Her hospitalization was complicated by bilateral profound sensorineural hearing loss (SNHL) following a delay in steroid administration. The aim of this article is to highlight the role of vaccines in decreasing morbidity of vaccine-preventable illnesses, and the importance of early administration of steroids as adjuvant to therapy for prevention of neurologic sequeleae.
VL  - 8
IS  - 2
ER  -

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Author Information

Nayri Topalian

Department of General Pediatrics, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon
Amani Mansour

Department of General Pediatrics, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon
Saraa Wehbe

Department of General Pediatrics, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon
Sarah El Yaman

Department of General Pediatrics, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon

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Plain Text BibTeX RIS

APA Style

Nayri Topalian, Amani Mansour, Saraa Wehbe, Sarah El Yaman. (2022). Profound Sensorineural Hearing Loss Following Adjuvant Steroid Delay in Pediatric Bacterial Meningitis. American Journal of Pediatrics, 8(2), 141-145. https://doi.org/10.11648/j.ajp.20220802.26

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ACS Style

Nayri Topalian; Amani Mansour; Saraa Wehbe; Sarah El Yaman. Profound Sensorineural Hearing Loss Following Adjuvant Steroid Delay in Pediatric Bacterial Meningitis. Am. J. Pediatr. 2022, 8(2), 141-145. doi: 10.11648/j.ajp.20220802.26

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AMA Style

Nayri Topalian, Amani Mansour, Saraa Wehbe, Sarah El Yaman. Profound Sensorineural Hearing Loss Following Adjuvant Steroid Delay in Pediatric Bacterial Meningitis. Am J Pediatr. 2022;8(2):141-145. doi: 10.11648/j.ajp.20220802.26

Copy | Download

@article{10.11648/j.ajp.20220802.26,
  author = {Nayri Topalian and Amani Mansour and Saraa Wehbe and Sarah El Yaman},
  title = {Profound Sensorineural Hearing Loss Following Adjuvant Steroid Delay in Pediatric Bacterial Meningitis},
  journal = {American Journal of Pediatrics},
  volume = {8},
  number = {2},
  pages = {141-145},
  doi = {10.11648/j.ajp.20220802.26},
  url = {https://doi.org/10.11648/j.ajp.20220802.26},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220802.26},
  abstract = {Streptococcus pneumonia is a gram positive, polysaccharide-encapsulated diplococcus associated with various pulmonary and extra-pulmonary clinical presentations including invasive diseases such as acute meningitis. It can be associated with high rates of morbidity and mortality in both the pediatric and the adult populations. The introduction of the pneumococcal conjugate vaccine which expanded to cover 13 strains allowed remarkable protection against these invasive infections. In addition, the use of adjuvant corticosteroid therapy in the last few years; in particular dexamethasone, for the management of acute bacterial meningitis reduced the incidence of severe hearing loss in both Hib and other bacterial meningitis. The IDS guidelines recommend administering the first dose of steroids just before or with the start of antibiotics due to its decreased effectiveness with the late presentations of meningitis. We present the case of a 14-year-old female adolescent refugee, with incomplete vaccination status prior to relocating to Lebanon presenting with pneumococcal meningitis. Her hospitalization was complicated by bilateral profound sensorineural hearing loss (SNHL) following a delay in steroid administration. The aim of this article is to highlight the role of vaccines in decreasing morbidity of vaccine-preventable illnesses, and the importance of early administration of steroids as adjuvant to therapy for prevention of neurologic sequeleae.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Profound Sensorineural Hearing Loss Following Adjuvant Steroid Delay in Pediatric Bacterial Meningitis
AU  - Nayri Topalian
AU  - Amani Mansour
AU  - Saraa Wehbe
AU  - Sarah El Yaman
Y1  - 2022/06/27
PY  - 2022
N1  - https://doi.org/10.11648/j.ajp.20220802.26
DO  - 10.11648/j.ajp.20220802.26
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 141
EP  - 145
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20220802.26
AB  - Streptococcus pneumonia is a gram positive, polysaccharide-encapsulated diplococcus associated with various pulmonary and extra-pulmonary clinical presentations including invasive diseases such as acute meningitis. It can be associated with high rates of morbidity and mortality in both the pediatric and the adult populations. The introduction of the pneumococcal conjugate vaccine which expanded to cover 13 strains allowed remarkable protection against these invasive infections. In addition, the use of adjuvant corticosteroid therapy in the last few years; in particular dexamethasone, for the management of acute bacterial meningitis reduced the incidence of severe hearing loss in both Hib and other bacterial meningitis. The IDS guidelines recommend administering the first dose of steroids just before or with the start of antibiotics due to its decreased effectiveness with the late presentations of meningitis. We present the case of a 14-year-old female adolescent refugee, with incomplete vaccination status prior to relocating to Lebanon presenting with pneumococcal meningitis. Her hospitalization was complicated by bilateral profound sensorineural hearing loss (SNHL) following a delay in steroid administration. The aim of this article is to highlight the role of vaccines in decreasing morbidity of vaccine-preventable illnesses, and the importance of early administration of steroids as adjuvant to therapy for prevention of neurologic sequeleae.
VL  - 8
IS  - 2
ER  -

Copy | Download