Evaluation of MAG3 Renal Scan for Detection of Differential Renal Function and Renal Scar in Comparison to DMSA Scan in Pediatric Population

Ferdous Ara Begum; Jasmine Ara Haque; Pupree Mutsuddy; Muhammad Zahangir Alam

doi:doi:10.11648/j.ajp.20220803.17

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Evaluation of MAG3 Renal Scan for Detection of Differential Renal Function and Renal Scar in Comparison to DMSA Scan in Pediatric Population

Ferdous Ara Begum, Jasmine Ara Haque, Pupree Mutsuddy, Muhammad Zahangir Alam

Published in American Journal of Pediatrics (Volume 8, Issue 3)

Received: 19 December 2021 Accepted: 16 May 2022 Published: 29 August 2022

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Abstract

Chronic kidney disease (CKD) in children is a devastating illness with long-term effects. Globally the prevalence of CKD in childhood has been variously reported at 15 to 74.7 per million children with an increased burden in developing countries like Bangladesh. The aim of the study was to evaluate the efficacy of Tc-99m MAG3 renal scintigraphy for accurate measurement of DRF and detection of renal cortical scar in comparison to Tc-99m DMSA scan in the pediatric population. This cross-sectional observational study was carried out at the National Institute of Nuclear Medicine & Allied Sciences (NINMAS), BSMMU campus, Dhaka from July 2017 to June 2018. The study was conducted with ethical approval from Medical Research Ethics Committee (MREC). A total of 54 pediatric patients of different renal disorders were enrolled according to selection criteria and all patients underwent both Tc-99m MAG3 renal scintigraphy and Tc-99m DMSA scan by following the practiced protocol in NINMAS. A total of 54 pediatric patients (39 male and 15 female) with a mean age of 4.57 ± 4.40 years, ranging from 0.08 to 18 years had a mean height of 96.70 ± 31.70 cm and mean weight16.97±11.95 kg. The mean of DRF measured by DMSA and MAG3 was 54.22 ±20.38% and S1.47 ± 23.88% in left kidneys and 45.78 ± 20.38% and 48.51 ± 23.88% in right kidneys respectively. The Independent t-test showed the mean difference of DRF measured by two radiotracers was not statistically significant in both kidneys. There was a positive significant correlation between the two methods (Pearson correlation test, r-0.948, p-0.001 in the left kidney and r-0.958, p-0.001 in the right kidney). Our findings support the notion of promoting Tc-99m MAG3 dynamic scintigraphy as an initial nuclear medicine technique in the diagnosis of the majority of kidney illnesses by giving information on differential renal function, cortical anomalies, and drainage at the same time.

Published in	American Journal of Pediatrics (Volume 8, Issue 3)
DOI	10.11648/j.ajp.20220803.17
Page(s)	185-190
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Renal Function, Renal Cortical Scar, Pediatric Population

References

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[8]	Miyazaki, C., Harada, H., Shuke, N., Okizaki, A., Miura. M. & Hirano, T. (2010) 99m Tc-DTPA dynamic SPECT and CT volumetry for measuring split renal function in live kidney donors. Annals of nuclear medicine. 24 (3), 189-195. Available from: doi: 10.1007/s12149-010-0349-y.
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[12]	Ritchie, G., Wilkinson, A. G. & Prescott, R. J. (2008) Comparison of differential renal function technetium-99m mercaptoacetyltriglycine (MAG3) and using dimercaptosuccinic acid (DMSA) renography in a paediatric population. Pediatric radiology. 38 (8), 857-862. Available from: https://doi.org/10.1007/s00247-008-0908-8
[13]	Smokvina, A., Grbac-Ivankovic, S., Girotto, N., Dezulovic, M. S., Saina, G. & Barkovic, M. M. (2006) The renal parenchyma evaluation: MAG3 vs. DMSA. Collegium antropologicum. 29 (2). 649-54.
[14]	Othman S, Al-Hawas, A. & Al-Maqtari, R (2012) Renal cortical imaging in children: 99mic MAG3 versus 99mTe DMSA. Clinical nuclear medicine. 37, 351-355. doi: 10.1097/RLU.Ob013e3182443f68.
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APA Style

Ferdous Ara Begum, Jasmine Ara Haque, Pupree Mutsuddy, Muhammad Zahangir Alam. (2022). Evaluation of MAG3 Renal Scan for Detection of Differential Renal Function and Renal Scar in Comparison to DMSA Scan in Pediatric Population. American Journal of Pediatrics, 8(3), 185-190. https://doi.org/10.11648/j.ajp.20220803.17

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ACS Style

Ferdous Ara Begum; Jasmine Ara Haque; Pupree Mutsuddy; Muhammad Zahangir Alam. Evaluation of MAG3 Renal Scan for Detection of Differential Renal Function and Renal Scar in Comparison to DMSA Scan in Pediatric Population. Am. J. Pediatr. 2022, 8(3), 185-190. doi: 10.11648/j.ajp.20220803.17

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AMA Style

Ferdous Ara Begum, Jasmine Ara Haque, Pupree Mutsuddy, Muhammad Zahangir Alam. Evaluation of MAG3 Renal Scan for Detection of Differential Renal Function and Renal Scar in Comparison to DMSA Scan in Pediatric Population. Am J Pediatr. 2022;8(3):185-190. doi: 10.11648/j.ajp.20220803.17

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@article{10.11648/j.ajp.20220803.17,
  author = {Ferdous Ara Begum and Jasmine Ara Haque and Pupree Mutsuddy and Muhammad Zahangir Alam},
  title = {Evaluation of MAG3 Renal Scan for Detection of Differential Renal Function and Renal Scar in Comparison to DMSA Scan in Pediatric Population},
  journal = {American Journal of Pediatrics},
  volume = {8},
  number = {3},
  pages = {185-190},
  doi = {10.11648/j.ajp.20220803.17},
  url = {https://doi.org/10.11648/j.ajp.20220803.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220803.17},
  abstract = {Chronic kidney disease (CKD) in children is a devastating illness with long-term effects. Globally the prevalence of CKD in childhood has been variously reported at 15 to 74.7 per million children with an increased burden in developing countries like Bangladesh. The aim of the study was to evaluate the efficacy of Tc-99m MAG3 renal scintigraphy for accurate measurement of DRF and detection of renal cortical scar in comparison to Tc-99m DMSA scan in the pediatric population. This cross-sectional observational study was carried out at the National Institute of Nuclear Medicine & Allied Sciences (NINMAS), BSMMU campus, Dhaka from July 2017 to June 2018. The study was conducted with ethical approval from Medical Research Ethics Committee (MREC). A total of 54 pediatric patients of different renal disorders were enrolled according to selection criteria and all patients underwent both Tc-99m MAG3 renal scintigraphy and Tc-99m DMSA scan by following the practiced protocol in NINMAS. A total of 54 pediatric patients (39 male and 15 female) with a mean age of 4.57 ± 4.40 years, ranging from 0.08 to 18 years had a mean height of 96.70 ± 31.70 cm and mean weight16.97±11.95 kg. The mean of DRF measured by DMSA and MAG3 was 54.22 ±20.38% and S1.47 ± 23.88% in left kidneys and 45.78 ± 20.38% and 48.51 ± 23.88% in right kidneys respectively. The Independent t-test showed the mean difference of DRF measured by two radiotracers was not statistically significant in both kidneys. There was a positive significant correlation between the two methods (Pearson correlation test, r-0.948, p-0.001 in the left kidney and r-0.958, p-0.001 in the right kidney). Our findings support the notion of promoting Tc-99m MAG3 dynamic scintigraphy as an initial nuclear medicine technique in the diagnosis of the majority of kidney illnesses by giving information on differential renal function, cortical anomalies, and drainage at the same time.},
 year = {2022}
}

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TY  - JOUR
T1  - Evaluation of MAG3 Renal Scan for Detection of Differential Renal Function and Renal Scar in Comparison to DMSA Scan in Pediatric Population
AU  - Ferdous Ara Begum
AU  - Jasmine Ara Haque
AU  - Pupree Mutsuddy
AU  - Muhammad Zahangir Alam
Y1  - 2022/08/29
PY  - 2022
N1  - https://doi.org/10.11648/j.ajp.20220803.17
DO  - 10.11648/j.ajp.20220803.17
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 185
EP  - 190
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20220803.17
AB  - Chronic kidney disease (CKD) in children is a devastating illness with long-term effects. Globally the prevalence of CKD in childhood has been variously reported at 15 to 74.7 per million children with an increased burden in developing countries like Bangladesh. The aim of the study was to evaluate the efficacy of Tc-99m MAG3 renal scintigraphy for accurate measurement of DRF and detection of renal cortical scar in comparison to Tc-99m DMSA scan in the pediatric population. This cross-sectional observational study was carried out at the National Institute of Nuclear Medicine & Allied Sciences (NINMAS), BSMMU campus, Dhaka from July 2017 to June 2018. The study was conducted with ethical approval from Medical Research Ethics Committee (MREC). A total of 54 pediatric patients of different renal disorders were enrolled according to selection criteria and all patients underwent both Tc-99m MAG3 renal scintigraphy and Tc-99m DMSA scan by following the practiced protocol in NINMAS. A total of 54 pediatric patients (39 male and 15 female) with a mean age of 4.57 ± 4.40 years, ranging from 0.08 to 18 years had a mean height of 96.70 ± 31.70 cm and mean weight16.97±11.95 kg. The mean of DRF measured by DMSA and MAG3 was 54.22 ±20.38% and S1.47 ± 23.88% in left kidneys and 45.78 ± 20.38% and 48.51 ± 23.88% in right kidneys respectively. The Independent t-test showed the mean difference of DRF measured by two radiotracers was not statistically significant in both kidneys. There was a positive significant correlation between the two methods (Pearson correlation test, r-0.948, p-0.001 in the left kidney and r-0.958, p-0.001 in the right kidney). Our findings support the notion of promoting Tc-99m MAG3 dynamic scintigraphy as an initial nuclear medicine technique in the diagnosis of the majority of kidney illnesses by giving information on differential renal function, cortical anomalies, and drainage at the same time.
VL  - 8
IS  - 3
ER  -

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Author Information

Ferdous Ara Begum

Department of Nuclear Medicine, 250 Bed District Sadar Hospital, Feni, Bangladesh
Jasmine Ara Haque

Department of Nuclear Medicine, Institute of Nuclear Medicine and Allied Sciences, Dhaka Medical College and Hospital Campus, Dhaka, Bangladesh
Pupree Mutsuddy

Department of Nuclear Medicine, National Institute of Nuclear Medicine and Allied Sciences, Bangabandhu Sheikh Mujib Medical University Campus, Dhaka, Bangladesh
Muhammad Zahangir Alam

Department of Pediatrics, Abdul Malek Ukil Medical College, Noakhali, Bangladesh

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APA Style

Ferdous Ara Begum, Jasmine Ara Haque, Pupree Mutsuddy, Muhammad Zahangir Alam. (2022). Evaluation of MAG3 Renal Scan for Detection of Differential Renal Function and Renal Scar in Comparison to DMSA Scan in Pediatric Population. American Journal of Pediatrics, 8(3), 185-190. https://doi.org/10.11648/j.ajp.20220803.17

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ACS Style

Ferdous Ara Begum; Jasmine Ara Haque; Pupree Mutsuddy; Muhammad Zahangir Alam. Evaluation of MAG3 Renal Scan for Detection of Differential Renal Function and Renal Scar in Comparison to DMSA Scan in Pediatric Population. Am. J. Pediatr. 2022, 8(3), 185-190. doi: 10.11648/j.ajp.20220803.17

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AMA Style

Ferdous Ara Begum, Jasmine Ara Haque, Pupree Mutsuddy, Muhammad Zahangir Alam. Evaluation of MAG3 Renal Scan for Detection of Differential Renal Function and Renal Scar in Comparison to DMSA Scan in Pediatric Population. Am J Pediatr. 2022;8(3):185-190. doi: 10.11648/j.ajp.20220803.17

Copy | Download

@article{10.11648/j.ajp.20220803.17,
  author = {Ferdous Ara Begum and Jasmine Ara Haque and Pupree Mutsuddy and Muhammad Zahangir Alam},
  title = {Evaluation of MAG3 Renal Scan for Detection of Differential Renal Function and Renal Scar in Comparison to DMSA Scan in Pediatric Population},
  journal = {American Journal of Pediatrics},
  volume = {8},
  number = {3},
  pages = {185-190},
  doi = {10.11648/j.ajp.20220803.17},
  url = {https://doi.org/10.11648/j.ajp.20220803.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220803.17},
  abstract = {Chronic kidney disease (CKD) in children is a devastating illness with long-term effects. Globally the prevalence of CKD in childhood has been variously reported at 15 to 74.7 per million children with an increased burden in developing countries like Bangladesh. The aim of the study was to evaluate the efficacy of Tc-99m MAG3 renal scintigraphy for accurate measurement of DRF and detection of renal cortical scar in comparison to Tc-99m DMSA scan in the pediatric population. This cross-sectional observational study was carried out at the National Institute of Nuclear Medicine & Allied Sciences (NINMAS), BSMMU campus, Dhaka from July 2017 to June 2018. The study was conducted with ethical approval from Medical Research Ethics Committee (MREC). A total of 54 pediatric patients of different renal disorders were enrolled according to selection criteria and all patients underwent both Tc-99m MAG3 renal scintigraphy and Tc-99m DMSA scan by following the practiced protocol in NINMAS. A total of 54 pediatric patients (39 male and 15 female) with a mean age of 4.57 ± 4.40 years, ranging from 0.08 to 18 years had a mean height of 96.70 ± 31.70 cm and mean weight16.97±11.95 kg. The mean of DRF measured by DMSA and MAG3 was 54.22 ±20.38% and S1.47 ± 23.88% in left kidneys and 45.78 ± 20.38% and 48.51 ± 23.88% in right kidneys respectively. The Independent t-test showed the mean difference of DRF measured by two radiotracers was not statistically significant in both kidneys. There was a positive significant correlation between the two methods (Pearson correlation test, r-0.948, p-0.001 in the left kidney and r-0.958, p-0.001 in the right kidney). Our findings support the notion of promoting Tc-99m MAG3 dynamic scintigraphy as an initial nuclear medicine technique in the diagnosis of the majority of kidney illnesses by giving information on differential renal function, cortical anomalies, and drainage at the same time.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Evaluation of MAG3 Renal Scan for Detection of Differential Renal Function and Renal Scar in Comparison to DMSA Scan in Pediatric Population
AU  - Ferdous Ara Begum
AU  - Jasmine Ara Haque
AU  - Pupree Mutsuddy
AU  - Muhammad Zahangir Alam
Y1  - 2022/08/29
PY  - 2022
N1  - https://doi.org/10.11648/j.ajp.20220803.17
DO  - 10.11648/j.ajp.20220803.17
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 185
EP  - 190
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20220803.17
AB  - Chronic kidney disease (CKD) in children is a devastating illness with long-term effects. Globally the prevalence of CKD in childhood has been variously reported at 15 to 74.7 per million children with an increased burden in developing countries like Bangladesh. The aim of the study was to evaluate the efficacy of Tc-99m MAG3 renal scintigraphy for accurate measurement of DRF and detection of renal cortical scar in comparison to Tc-99m DMSA scan in the pediatric population. This cross-sectional observational study was carried out at the National Institute of Nuclear Medicine & Allied Sciences (NINMAS), BSMMU campus, Dhaka from July 2017 to June 2018. The study was conducted with ethical approval from Medical Research Ethics Committee (MREC). A total of 54 pediatric patients of different renal disorders were enrolled according to selection criteria and all patients underwent both Tc-99m MAG3 renal scintigraphy and Tc-99m DMSA scan by following the practiced protocol in NINMAS. A total of 54 pediatric patients (39 male and 15 female) with a mean age of 4.57 ± 4.40 years, ranging from 0.08 to 18 years had a mean height of 96.70 ± 31.70 cm and mean weight16.97±11.95 kg. The mean of DRF measured by DMSA and MAG3 was 54.22 ±20.38% and S1.47 ± 23.88% in left kidneys and 45.78 ± 20.38% and 48.51 ± 23.88% in right kidneys respectively. The Independent t-test showed the mean difference of DRF measured by two radiotracers was not statistically significant in both kidneys. There was a positive significant correlation between the two methods (Pearson correlation test, r-0.948, p-0.001 in the left kidney and r-0.958, p-0.001 in the right kidney). Our findings support the notion of promoting Tc-99m MAG3 dynamic scintigraphy as an initial nuclear medicine technique in the diagnosis of the majority of kidney illnesses by giving information on differential renal function, cortical anomalies, and drainage at the same time.
VL  - 8
IS  - 3
ER  -

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