Background: Pneumonia is the leading cause of death in children. An easy and inexpensive diagnostic tool is needed in managing the disease effectively. Neutrophil lymphocytes ratio (NLR), monocyte lymphocytes (MLR), and platelet lymphocytes (PLR) have role in predicting outcome of adult community acquired pneumonia but data in pediatric population is still limited. Objective: To prove that peripheral blood examination could be use as predictor of outcome in pediatric patients with community-acquired pneumonia. Methods: This is an observational analytic study with a retrospective case control design, to know value of neutrophil lymphocytes ratio (NLR), monocyte lymphocytes (MLR), and platelet lymphocytes (PLR) as predictor of outcome in pediatric community-acquired pneumonia. The study was conducted using medical record data of hospitalized patient in the Pediatric Ward Prof. Dr. I.G.N.G Ngoerah Hospital from November 2020 to December 2021 with the consecutive sampling method. Data analysis was carried out using receiver operator characteristic curve to find the optimal cut-off value then continued with chi-square analysis. The significance level (α) of this study was set at a probability value (p) of less than 0.05. Results: This study involved 104 subjects, divided equally into survive and deceased groups. After adjustment of age, gender, nutritional status, and result of microbiology examination, increase in NLR value ≥ 2.47 had 67.98 times risk of death (95% CI 17.18-268.95; p < 0.001) with 86.5% sensitivity and 90.4% specificity, an increase in MLR value ≥ 0.32 had 11.96 times risk of death (95% CI 4.5-31.72; p < 0.001) with 75% sensitivity and 80.8% specificity, and an increase in PLR value ≥ 121.07 had 8.41 times risk of death (95% CI 3.15-22.49; p < 0.001) with 65.4% sensitivity and 82.7% specificity. Conclusion: The increase in neutrophil lymphocytes, monocyte lymphocytes, and platelet lymphocytes ratio were predictor of mortality in pediatric community-acquired pneumonia.
| Published in | American Journal of Pediatrics (Volume 8, Issue 3) |
| DOI | 10.11648/j.ajp.20220803.18 |
| Page(s) | 191-195 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, Monocyte to Lymphocyte Ratio, Pneumonia
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APA Style
Handoyo, Ni Putu Siadi Purniti, I Gusti Ngurah Sanjaya Putra, I Gusti Ngurah Made Suwarba, I Putu Gede Karyana, et al. (2022). Neutrophil to Lymphocyte Ratio, Monocyte to Lymphocyte Ratio, Platelet to Lymphocyte Ratio as Predictor of Outcome in Children with Community Acquired Pneumonia. American Journal of Pediatrics, 8(3), 191-195. https://doi.org/10.11648/j.ajp.20220803.18
ACS Style
Handoyo; Ni Putu Siadi Purniti; I Gusti Ngurah Sanjaya Putra; I Gusti Ngurah Made Suwarba; I Putu Gede Karyana, et al. Neutrophil to Lymphocyte Ratio, Monocyte to Lymphocyte Ratio, Platelet to Lymphocyte Ratio as Predictor of Outcome in Children with Community Acquired Pneumonia. Am. J. Pediatr. 2022, 8(3), 191-195. doi: 10.11648/j.ajp.20220803.18
AMA Style
Handoyo, Ni Putu Siadi Purniti, I Gusti Ngurah Sanjaya Putra, I Gusti Ngurah Made Suwarba, I Putu Gede Karyana, et al. Neutrophil to Lymphocyte Ratio, Monocyte to Lymphocyte Ratio, Platelet to Lymphocyte Ratio as Predictor of Outcome in Children with Community Acquired Pneumonia. Am J Pediatr. 2022;8(3):191-195. doi: 10.11648/j.ajp.20220803.18
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author = {Handoyo and Ni Putu Siadi Purniti and I Gusti Ngurah Sanjaya Putra and I Gusti Ngurah Made Suwarba and I Putu Gede Karyana and I Gusti Ayu Eka Pratiwi},
title = {Neutrophil to Lymphocyte Ratio, Monocyte to Lymphocyte Ratio, Platelet to Lymphocyte Ratio as Predictor of Outcome in Children with Community Acquired Pneumonia},
journal = {American Journal of Pediatrics},
volume = {8},
number = {3},
pages = {191-195},
doi = {10.11648/j.ajp.20220803.18},
url = {https://doi.org/10.11648/j.ajp.20220803.18},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220803.18},
abstract = {Background: Pneumonia is the leading cause of death in children. An easy and inexpensive diagnostic tool is needed in managing the disease effectively. Neutrophil lymphocytes ratio (NLR), monocyte lymphocytes (MLR), and platelet lymphocytes (PLR) have role in predicting outcome of adult community acquired pneumonia but data in pediatric population is still limited. Objective: To prove that peripheral blood examination could be use as predictor of outcome in pediatric patients with community-acquired pneumonia. Methods: This is an observational analytic study with a retrospective case control design, to know value of neutrophil lymphocytes ratio (NLR), monocyte lymphocytes (MLR), and platelet lymphocytes (PLR) as predictor of outcome in pediatric community-acquired pneumonia. The study was conducted using medical record data of hospitalized patient in the Pediatric Ward Prof. Dr. I.G.N.G Ngoerah Hospital from November 2020 to December 2021 with the consecutive sampling method. Data analysis was carried out using receiver operator characteristic curve to find the optimal cut-off value then continued with chi-square analysis. The significance level (α) of this study was set at a probability value (p) of less than 0.05. Results: This study involved 104 subjects, divided equally into survive and deceased groups. After adjustment of age, gender, nutritional status, and result of microbiology examination, increase in NLR value ≥ 2.47 had 67.98 times risk of death (95% CI 17.18-268.95; p Conclusion: The increase in neutrophil lymphocytes, monocyte lymphocytes, and platelet lymphocytes ratio were predictor of mortality in pediatric community-acquired pneumonia.},
year = {2022}
}
TY - JOUR T1 - Neutrophil to Lymphocyte Ratio, Monocyte to Lymphocyte Ratio, Platelet to Lymphocyte Ratio as Predictor of Outcome in Children with Community Acquired Pneumonia AU - Handoyo AU - Ni Putu Siadi Purniti AU - I Gusti Ngurah Sanjaya Putra AU - I Gusti Ngurah Made Suwarba AU - I Putu Gede Karyana AU - I Gusti Ayu Eka Pratiwi Y1 - 2022/09/27 PY - 2022 N1 - https://doi.org/10.11648/j.ajp.20220803.18 DO - 10.11648/j.ajp.20220803.18 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 191 EP - 195 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20220803.18 AB - Background: Pneumonia is the leading cause of death in children. An easy and inexpensive diagnostic tool is needed in managing the disease effectively. Neutrophil lymphocytes ratio (NLR), monocyte lymphocytes (MLR), and platelet lymphocytes (PLR) have role in predicting outcome of adult community acquired pneumonia but data in pediatric population is still limited. Objective: To prove that peripheral blood examination could be use as predictor of outcome in pediatric patients with community-acquired pneumonia. Methods: This is an observational analytic study with a retrospective case control design, to know value of neutrophil lymphocytes ratio (NLR), monocyte lymphocytes (MLR), and platelet lymphocytes (PLR) as predictor of outcome in pediatric community-acquired pneumonia. The study was conducted using medical record data of hospitalized patient in the Pediatric Ward Prof. Dr. I.G.N.G Ngoerah Hospital from November 2020 to December 2021 with the consecutive sampling method. Data analysis was carried out using receiver operator characteristic curve to find the optimal cut-off value then continued with chi-square analysis. The significance level (α) of this study was set at a probability value (p) of less than 0.05. Results: This study involved 104 subjects, divided equally into survive and deceased groups. After adjustment of age, gender, nutritional status, and result of microbiology examination, increase in NLR value ≥ 2.47 had 67.98 times risk of death (95% CI 17.18-268.95; p Conclusion: The increase in neutrophil lymphocytes, monocyte lymphocytes, and platelet lymphocytes ratio were predictor of mortality in pediatric community-acquired pneumonia. VL - 8 IS - 3 ER -
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