Aim: The clinical, 3D volumetric, and histological evaluation for effectiveness of addition of melatonin to β-tri calcium phosphate (β-TCP) in socket preservation after tooth extraction. Patients and methods: 24 patients were treatment planned for extraction of isolated hopeless mandibular teeth followed by delayed implant placement. They were divided randomly into two equal groups as follows: Group (A) sockets were grafted with β-TCP mixed with 1% melatonin, Group (B) included sockets were grafted with β-TCP alone. Clinical evaluation and Cone beam computed tomography (CBCT) were done immediately and 6 months postoperatively. Microscopic evaluation was performed after 6 months before implant insertion. All readings were recorded and analyzed statistically. Results: After 6 months, all clinical and radiographic parameters showed significant difference between the tested groups where Group (A) produced the highest mean values of bone density, bone height, and width followed by Group (B). Histological study referred to more maturation of bone in group A than group B. Where complete bone maturation occurred later in group II than group I. Conclusion: The results clearly concluded that melatonin had promotion effect for bone formation. Therefore, addition of melatonin to β-TCP has high successful effect in decrease bone resorption with increased bone density of alveolar ridge leading to preserve on 3-D volume of alveolar ridge after tooth extraction.
| Published in | Biomedical Sciences (Volume 7, Issue 1) |
| DOI | 10.11648/j.bs.20210701.12 |
| Page(s) | 10-16 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Socket Preservation, Beta-tri-calcium Phosphate (β-TCP), Melatonin, Cone Beam Computed Tomography (CBCT)
| [1] | Abdel-Rasoul M, El-Domiaty S, and Kotry G. The effect of local application of 5-methoxy-n-acetyltryptamine (melatonin) in the management of periodontal intrabony defects E. D. J. 2019, 58,. 4: 1-9. |
| [2] | Chen S, Wilson T and Hammerle C. Immediate or early placement of implants following tooth extraction: review of biologic basis, clinical procedures and outcomes. Int J Oral Maxillofac implants. 2004; 19: 12-25. |
| [3] | Modhi Al Deeb. Role of Platelet-Rich Fibrin (PRF) and Platelet-Rich Plasma (PRP) in Oro-Facial Tissue Regeneration: A Narrative Review. J Adv Oral Res. 2020; 11 (1): 5-11. |
| [4] | Barry k and Barteee J. Extraction site reconstruction for alveolar ridge preservation. Part II: Membrane – assisted surgical technique. J Oral Implant. 2001; 27: 194. |
| [5] | Tehemer S philiphanes and Sharawy M. Enhancement of osseointegration of implants placed in extraction sockets of healthy and periodontal diseased teeth by using grafting material, an PTFE membrane. Clin implant Dent Rel Res. 2003; 5 (3): 193. |
| [6] | Ramachandran P and Jens s. Observation on healing of human tooth in extraction sockets implants with PLGA copolymer root replices. Oral Surg Oral Med Oral Pathol. 2004; 97: 559. |
| [7] | Callan D and Salkaled S. Histological analysis of implant sites after grafting with DBM putty and sheets, part I. Implant Dent. 2000; 9: 36. |
| [8] | Perelman-Karmon M., Kozlovsky A., Liloy R. and Artzi Z.: Socket site preservation using bovine bone mineral with and without a bioresorbable collagen membrane. Int J Perio Resto Dent. Aug2012; 22 (4): 416-23. |
| [9] | Tassos I and Moe T. Preserving the socket dimensions with bone grafting in single sites: An esthetic surgical approach when planning delayed implant placement. J Oral Implant. 2007; 33: 156. |
| [10] | Minsk L. Extraction-site ridge preservation. Compend Contin Educ Dent. 2005; 26 (4): 272, 274-6. |
| [11] | Artzi Z, Weinreb M, Givol N, Rohrer M, Nemcovsky C and Tal H. Biomaterial Resorption Rate and Healing Site Morphology of Inorganic Bovine Bone and β-Tricalcium Phosphate in the Canine: a 24-month Longitudinal Histologic Study and Morphometric Analysis. Int J Oral Maxillofac Implants2004; 19 (3): 357-368. |
| [12] | Brkovic B, Prasad H, Rohrer M, Konandreas G, Agrogiannis G, Antunovic D et al. Beta-tricalcium phosphate/type I collagen cones with or without a barrier membrane in human extraction socket healing: clinical, histologic, histomorphometric, and immunohistochemical evaluation. Clin Oral Investig. Apr 2012; 16 (2): 581-90. |
| [13] | Swati Das, Rajesh Jhingran, Vivek Kumar Bains, Rohit Madan, Ruchi Srivastava, and Iram Rizvi. Eur J Dent. Socket preservation by beta-tri-calcium phosphate with collagen compared to platelet-rich fibrin: A clinico-radiographic study. 2016; 10 (2): 264–76. |
| [14] | Cutando A, Aneiros-Fernandez J, Lopez-Valverde A, Arias- Santiago S, Aneiros-Cachaza J, Reiter RJ. A new perspective in Oral health: potential importance and actions of melatonin receptors MT1, MT2, MT3, and RZR/ROR in the oral cavity. Arch Oral Biol 2011; 56: 944-50. |
| [15] | Cutando A, Montero J, Gomez-de Diego R, Ferrera MJ, Lopez- Valverde A. Effect of topical application of melatonin on serum levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in patients with type 1 or type 2 diabetes and periodontal disease. J Clin Exp Dent 2015; 7: 628-33. |
| [16] | Kose O, Arabaci T, Kara A, Yemenoglu H, Kermen E, Kizildag A, et al. Effects of melatonin on oxidative stress index and alveolar bone loss in diabetic rats with periodontitis. J Periodontol 2016; 87: 82-90. |
| [17] | Reiter RJ, Rosales-Corral SA, Liu XY, Acuna-Castroviejo D, Escames G, Tan DX. Melatonin in the oral cavity: physiological and pathological implications. J Periodontal Res 2015; 50: 9-17. |
| [18] | Darby ST, Chen and Buser D. Ridge preservation techniques for implant therapy. Inter J Oral Maxillofac Implants 2009; 24: 260-27. |
| [19] | Dawood A, Patel S and Brown J. Cone beam CT in dental practice. Bri Dent J. 2009; 207 (1), 23-8. |
| [20] | Caplanis N, Lozada LJ, Kan JYK. Extraction Defect Assessment, Classification and Management. CDA Journal; 2005; 33: 853-9. |
| [21] | Brownfield LA, Weltman RL. Ridge preservation with or without an osteoinductive allograft: a clinical, radiographic, micro-computed tomography, and histologic study evaluating dimensional changes and new bone formation of the alveolar ridge. J Periodontol; 2012; 83: 581-3. |
| [22] | Orgeas GV, Clemintini M, Valeria DR, Sanctis MD. Surgical techniques for alveolar socket preservation: A systematic review. International Journal of oral and maxillofacial implant 2013; 28: 1049-61. |
| [23] | Horowitz R., Mazor Z., Miller R., Krauser J., Prasad H. and Rohrer M. Clinical evaluation alveolar ridge preservation with a beta-tricalcium phosphate socket graft. Compend Contin Educ Dent. 2009; 30 (9): 588-90. |
| [24] | Cutando A, Arana C, Gomez-Moreno G, Escames G, Lopez A, Ferrera MJ, et al. Local application of melatonin into alveolar sockets of beagle dogs reduces tooth removal-induced oxidative stress. J Periodontol 2007; 78: 576-83. |
| [25] | Moshfeghi M, Tavakoli MA, Hosseini ET, Hosseini AT and Hosseini I T. Analysis of linear measurement accuracy obtained by cone beam computed tomography (CBCT-NewTom VG). Dent Res J (Isfahan). 2012; 9 (1), 57-62. |
| [26] | Aimetti M, Romano F, Griga FB, & Godio L. Clinical and histologic healing of human extraction sockets filled with calcium sulfate. International Journal of Oral and Maxillofacial Implants. 2009; 24, 902–9. |
| [27] | Barone A, Ricci M, Tonelli P, Santini S, & Covani U. Tissue changes of extraction sockets in humans: A comparison of spontaneous healing vs. ridge preservation with secondary soft tissue healing. Clin Ora Impla Res. 2013; 24, 1231–7. |
| [28] | Barone A, Toti P, Menchini-Fabris GB, Derchi G, Marconcini S, & Covani U. Extra oral digital scanning and imaging superimposition for volume analysis of bone remodeling after tooth extraction with and without 2 types of particulate porcine mineral insertion: A randomized controlled trial. Clin Impla Dent and Relat Res. 2017; 19, 750–9. |
| [29] | Pang C, Ding Y, Zhou H, Qin R, Hou R, Zhang G et al. Alveolar ridge preservation with deproteinized bovine bone graft and collagen membrane and delayed implants. J Craniofac Surg. 2014; 25, 1698–1702. |
| [30] | Schneider D, Schmidlin PR, Philipp A, Annen B M, Ronay V, Hammerle C et al. Labial soft tissue volume evaluation of different techniques for ridge preservation after tooth extraction: A randomized controlled clinical trial. J Clin Periodontol. 2014; 41, 612–7. |
| [31] | Temmerman A, Vandessel J, Castro A, Jacobs R, Teughels W, Pinto N et al. The use of leucocyte and platelet-rich fibrin in socket management and ridge preservation: A split-mouth, randomized, controlled clinical trial. J Clin Periodontol. 2016, 43, 990–9. |
| [32] | Araujo MG, da Silva JC, de Mendonca AF, & Lindhe J. Ridge alterations following grafting of fresh extraction sockets in man. A randomized clinical trial. Clin Ora Impla Res. 2015; 26, 407–12. |
| [33] | Jung RE, Philipp A, Annen BM, Signorelli L, Thoma DS, Hammerle C et al. Radiographic evaluation of different techniques for ridge preservation after tooth extraction: A randomized controlled clinical trial. J Clin Periodontol. 2013, 40, 90–8. |
| [34] | Pandey A, Kaur G, Marwaha J, Biswas A, Kumari S, Singh O. Evaluation of Effects of Melatonin Application on Osseo Integration of Dental Implant. J Appl. Den. Med. Scien. 2019; 5 (4); 6-10. |
| [35] | Srinath R, Acharya AB, Thakur SL. Salivary and gingival crevicular fluid melatonin in periodontal health and disease. J Periodontol 2010; 8: 277-83. |
APA Style
Abdel Aziz Baiomy Abdullah, Mohamed Fouad Edrees, Ahmed Mohamed Bakry. (2021). Clinical, Radiographic, and Histological Assessment of Socket Preservation Using Melatonin with Beta-Tri-Calcium Phosphate for Receiving Dental Implant. Biomedical Sciences, 7(1), 10-16. https://doi.org/10.11648/j.bs.20210701.12
ACS Style
Abdel Aziz Baiomy Abdullah; Mohamed Fouad Edrees; Ahmed Mohamed Bakry. Clinical, Radiographic, and Histological Assessment of Socket Preservation Using Melatonin with Beta-Tri-Calcium Phosphate for Receiving Dental Implant. Biomed. Sci. 2021, 7(1), 10-16. doi: 10.11648/j.bs.20210701.12
AMA Style
Abdel Aziz Baiomy Abdullah, Mohamed Fouad Edrees, Ahmed Mohamed Bakry. Clinical, Radiographic, and Histological Assessment of Socket Preservation Using Melatonin with Beta-Tri-Calcium Phosphate for Receiving Dental Implant. Biomed Sci. 2021;7(1):10-16. doi: 10.11648/j.bs.20210701.12
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.bs.20210701.12,
author = {Abdel Aziz Baiomy Abdullah and Mohamed Fouad Edrees and Ahmed Mohamed Bakry},
title = {Clinical, Radiographic, and Histological Assessment of Socket Preservation Using Melatonin with Beta-Tri-Calcium Phosphate for Receiving Dental Implant},
journal = {Biomedical Sciences},
volume = {7},
number = {1},
pages = {10-16},
doi = {10.11648/j.bs.20210701.12},
url = {https://doi.org/10.11648/j.bs.20210701.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20210701.12},
abstract = {Aim: The clinical, 3D volumetric, and histological evaluation for effectiveness of addition of melatonin to β-tri calcium phosphate (β-TCP) in socket preservation after tooth extraction. Patients and methods: 24 patients were treatment planned for extraction of isolated hopeless mandibular teeth followed by delayed implant placement. They were divided randomly into two equal groups as follows: Group (A) sockets were grafted with β-TCP mixed with 1% melatonin, Group (B) included sockets were grafted with β-TCP alone. Clinical evaluation and Cone beam computed tomography (CBCT) were done immediately and 6 months postoperatively. Microscopic evaluation was performed after 6 months before implant insertion. All readings were recorded and analyzed statistically. Results: After 6 months, all clinical and radiographic parameters showed significant difference between the tested groups where Group (A) produced the highest mean values of bone density, bone height, and width followed by Group (B). Histological study referred to more maturation of bone in group A than group B. Where complete bone maturation occurred later in group II than group I. Conclusion: The results clearly concluded that melatonin had promotion effect for bone formation. Therefore, addition of melatonin to β-TCP has high successful effect in decrease bone resorption with increased bone density of alveolar ridge leading to preserve on 3-D volume of alveolar ridge after tooth extraction.},
year = {2021}
}
TY - JOUR T1 - Clinical, Radiographic, and Histological Assessment of Socket Preservation Using Melatonin with Beta-Tri-Calcium Phosphate for Receiving Dental Implant AU - Abdel Aziz Baiomy Abdullah AU - Mohamed Fouad Edrees AU - Ahmed Mohamed Bakry Y1 - 2021/01/12 PY - 2021 N1 - https://doi.org/10.11648/j.bs.20210701.12 DO - 10.11648/j.bs.20210701.12 T2 - Biomedical Sciences JF - Biomedical Sciences JO - Biomedical Sciences SP - 10 EP - 16 PB - Science Publishing Group SN - 2575-3932 UR - https://doi.org/10.11648/j.bs.20210701.12 AB - Aim: The clinical, 3D volumetric, and histological evaluation for effectiveness of addition of melatonin to β-tri calcium phosphate (β-TCP) in socket preservation after tooth extraction. Patients and methods: 24 patients were treatment planned for extraction of isolated hopeless mandibular teeth followed by delayed implant placement. They were divided randomly into two equal groups as follows: Group (A) sockets were grafted with β-TCP mixed with 1% melatonin, Group (B) included sockets were grafted with β-TCP alone. Clinical evaluation and Cone beam computed tomography (CBCT) were done immediately and 6 months postoperatively. Microscopic evaluation was performed after 6 months before implant insertion. All readings were recorded and analyzed statistically. Results: After 6 months, all clinical and radiographic parameters showed significant difference between the tested groups where Group (A) produced the highest mean values of bone density, bone height, and width followed by Group (B). Histological study referred to more maturation of bone in group A than group B. Where complete bone maturation occurred later in group II than group I. Conclusion: The results clearly concluded that melatonin had promotion effect for bone formation. Therefore, addition of melatonin to β-TCP has high successful effect in decrease bone resorption with increased bone density of alveolar ridge leading to preserve on 3-D volume of alveolar ridge after tooth extraction. VL - 7 IS - 1 ER -
Information
Email: