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Study of Blood Groups and Rhesus Factor in Beta Thalassemia Patients Undergoing Blood Transfusions

Received: 19 September 2021    Accepted: 11 October 2021    Published: 5 February 2022
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Abstract

Beta thalassemia is the most common genetic blood disease, affecting millions of people in both developing and developed countries including Iraq. Patients with thalassemia require frequent blood transfusions, which can cause a variety of complications. Several researches have looked into the link between ABO blood groups and diseases. The associations of ABO blood group with thalassemia have not been extensively studied. In order to know the prevalence of thalassemia according to age, gender and blood group frequency, a study was conducted on 200 individuals, 100 of them were a control sample, which was considered a standard sample, while the rest 100 individuals were infected with beta thalassemia. The study aims to find out any relationship between the frequency of blood group phenotypes and susceptibility to thalassemia compared to the control sample. Our findings indicate that the prevalence of thalassemia was higher in female patients than in male patients. Found in the lowest age group 15-19 years. There was a significant difference (P 0.05) in the frequency of ABO blood groups that was O>B>A>AB. A significant difference of Rh factor (P<0.01) was found in the patients compared with the control group. The current study indicated the importance of the studied blood groups, as they are sources for detecting the risks of inheriting beta thalassemia or the variability in the likelihood of its appearance, and they can be used with other laboratory tests in genetic counseling.

Published in Biomedical Sciences (Volume 8, Issue 1)
DOI 10.11648/j.bs.20220801.11
Page(s) 1-5
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Beta-Thalassemia, Blood Groups, Rhesus Factor, Blood Transfusions

References
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[2] Hood, A. M., King, A. A., Fields, M. E., Ford, A. L., Guilliams, K. P., Hulbert, M. L., and White, D. A. (2019). Higher executive abilities following a blood transfusion in children and young adults with sickle cell disease. Pediatric blood & cancer, 66 (10), e27899.
[3] Rai, J. J., and Bisu, S. (2017).‏ Distribution of ABO blood groups and Rhesus factor percentage frequencies amongst the populations of Sikkim, India. National Science Academy 83 (1).
[4] Mohssin, M. Y., Mahmood, A. E., Kamal, S. B., and Batah, E. H. Frequency distribution of hemoglobin variant and ABO blood groups among thalassemia patients from Ibn-Al-Baladi pediatric hospital in Baghdad/Iraq. W J Pharma Pharmaceut Sci. 2015; 4 (11): 31-9.
[5] Galanello, R. and R. Origa. (2010). Beta-thalassemia Orphanet journal of rare diseases5 (1): 11.
[6] Purohit, P., (2014). Prevalence of deletional alpha thalassemia and sickle gene in a tribal dominated malaria endemic area of eastern India. ISRN hematology.
[7] Ahmed Kiani, R., (2016). Epidemiology of transfusion transmitted infection among patients with β thalassemia major in Pakistan. Journal of blood transfusion.
[8] Kondam, A. and Chandrasekhar, M. (2012). A study of “incidence of hypertension in abo and rhesus blood group system. Int J. Boil Med Res. 3 (1): 1426-1429.2.
[9] Nishi, K., Gupta, N. K. and Sharma, S. C. (2012). Study on the Incidence of Hypertension and Migraine in ABO Blood Groups. ISCA Journal of Biological Sciences 1 (2): 12-16.3.
[10] Pramanik, T. and Pramanik, S. (2000). Distribution of ABO and Rh blood groups in Nepalese medical students: A report. Eastern Mediterr Health. J. 6 (1): 156-158 Abdollahi A, Qorbani M, Salehi A and Mansourian M. ABO blood groups distribution and cardiovascular major risk factors in healthy population. Iranian Journal of Public Health 2009; 38 (3): 123 126.
[11] Abdollahi, A., Qorbani, M., Salehi, A., and Mansourian, M. (2009). ABO blood groups distribution and cardiovascular major risk factors in healthy population. Iranian Journal of Public Health. 38 (3): 123-126.
[12] Pennap, G., Envoh E., and Igbawua, I. (2011). Frequency distribution of Hemoglobin Variants, ABO and Rhesus Blood Groups among Students of African Descent. British Microbial, Res. J. 1: 33-40. 5.
[13] Mondal, B., Maiti, S., Biswas, BK., Ghosh, D., and Paul, S. (2012). Prevalence of hemoglobinopathy, ABO and rhesus blood groups in rural areas of West Bengal, India. J Res Med Sci. 17: 772-76. 6.
[14] Wu, O., Bayoumi,. N, Vickers, M., and Clark, P. (2008). ABO blood groups and vascular disease: A systematic review and meta-analysis. J. Thromb Haemost. 6: 62-9. 7.
[15] Anstee, D. J. The relationship between blood groups and disease. Blood. (2010) 115: 4635-4.
[16] Watkins, W. M. (2001). The ABO blood group system: historical background. Transfusion medicine, 11 (4), 243-265.‏
[17] Marbut, S. M. M., Hamdi, M. A., Jumaa, A. M., and Salman, B. A. (2018). Distribution of ABO blood groups in beta thalassemia patients dependent on blood transfusion In Bagdad city. Journal of Madenat Alelem University College, 10 (2), 1-11.‏
[18] Laghari, Z. A., Baig, N. M., Charan, T. R., Lashari, K. H., and Suhag, R. (2018). Distribution of ABO blood groups and Rhesus factor in ß-thalassemia patients at Thalassemia Care Center Nawabshah, Pakistan. Sindh University Research Journal-SURJ (Science Series), 50 (01), 123-128.‏
[19] Sinha, P. A., Mulkutkar, S. H., & Bhavani, J. B. (2017). Study of distribution of ABO blood groups in ß-thalassemia patients. International Journal of Research in Medical Sciences, 5 (8), 3479-3483.‏
[20] AL-Assadi., A. Z. M. (2007). Genetic biodiversity of some mutation association with beta thalassemia in Iraq. Phd. Thesis, Inst Genet. Eng. Biotchnol. post Grad. stud., Univ. Baghdad: 124 pp.
[21] Canatan, D., Oguz, N., Balta, N., Cosan, R., Karadogan, C., Ozancak, A., Dircan, H., Cengiz, O. and Alanglu, G. (2003) red cell antibodies in patients with b-thalasseia major.b.b.transfus. Med., 1 (1): 31-34.
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  • APA Style

    Maha Tareq Hussein. (2022). Study of Blood Groups and Rhesus Factor in Beta Thalassemia Patients Undergoing Blood Transfusions. Biomedical Sciences, 8(1), 1-5. https://doi.org/10.11648/j.bs.20220801.11

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    ACS Style

    Maha Tareq Hussein. Study of Blood Groups and Rhesus Factor in Beta Thalassemia Patients Undergoing Blood Transfusions. Biomed. Sci. 2022, 8(1), 1-5. doi: 10.11648/j.bs.20220801.11

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    AMA Style

    Maha Tareq Hussein. Study of Blood Groups and Rhesus Factor in Beta Thalassemia Patients Undergoing Blood Transfusions. Biomed Sci. 2022;8(1):1-5. doi: 10.11648/j.bs.20220801.11

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  • @article{10.11648/j.bs.20220801.11,
      author = {Maha Tareq Hussein},
      title = {Study of Blood Groups and Rhesus Factor in Beta Thalassemia Patients Undergoing Blood Transfusions},
      journal = {Biomedical Sciences},
      volume = {8},
      number = {1},
      pages = {1-5},
      doi = {10.11648/j.bs.20220801.11},
      url = {https://doi.org/10.11648/j.bs.20220801.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20220801.11},
      abstract = {Beta thalassemia is the most common genetic blood disease, affecting millions of people in both developing and developed countries including Iraq. Patients with thalassemia require frequent blood transfusions, which can cause a variety of complications. Several researches have looked into the link between ABO blood groups and diseases. The associations of ABO blood group with thalassemia have not been extensively studied. In order to know the prevalence of thalassemia according to age, gender and blood group frequency, a study was conducted on 200 individuals, 100 of them were a control sample, which was considered a standard sample, while the rest 100 individuals were infected with beta thalassemia. The study aims to find out any relationship between the frequency of blood group phenotypes and susceptibility to thalassemia compared to the control sample. Our findings indicate that the prevalence of thalassemia was higher in female patients than in male patients. Found in the lowest age group 15-19 years. There was a significant difference (P 0.05) in the frequency of ABO blood groups that was O>B>A>AB. A significant difference of Rh factor (P<0.01) was found in the patients compared with the control group. The current study indicated the importance of the studied blood groups, as they are sources for detecting the risks of inheriting beta thalassemia or the variability in the likelihood of its appearance, and they can be used with other laboratory tests in genetic counseling.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Study of Blood Groups and Rhesus Factor in Beta Thalassemia Patients Undergoing Blood Transfusions
    AU  - Maha Tareq Hussein
    Y1  - 2022/02/05
    PY  - 2022
    N1  - https://doi.org/10.11648/j.bs.20220801.11
    DO  - 10.11648/j.bs.20220801.11
    T2  - Biomedical Sciences
    JF  - Biomedical Sciences
    JO  - Biomedical Sciences
    SP  - 1
    EP  - 5
    PB  - Science Publishing Group
    SN  - 2575-3932
    UR  - https://doi.org/10.11648/j.bs.20220801.11
    AB  - Beta thalassemia is the most common genetic blood disease, affecting millions of people in both developing and developed countries including Iraq. Patients with thalassemia require frequent blood transfusions, which can cause a variety of complications. Several researches have looked into the link between ABO blood groups and diseases. The associations of ABO blood group with thalassemia have not been extensively studied. In order to know the prevalence of thalassemia according to age, gender and blood group frequency, a study was conducted on 200 individuals, 100 of them were a control sample, which was considered a standard sample, while the rest 100 individuals were infected with beta thalassemia. The study aims to find out any relationship between the frequency of blood group phenotypes and susceptibility to thalassemia compared to the control sample. Our findings indicate that the prevalence of thalassemia was higher in female patients than in male patients. Found in the lowest age group 15-19 years. There was a significant difference (P 0.05) in the frequency of ABO blood groups that was O>B>A>AB. A significant difference of Rh factor (P<0.01) was found in the patients compared with the control group. The current study indicated the importance of the studied blood groups, as they are sources for detecting the risks of inheriting beta thalassemia or the variability in the likelihood of its appearance, and they can be used with other laboratory tests in genetic counseling.
    VL  - 8
    IS  - 1
    ER  - 

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Author Information
  • Ministry of Education, Directorate of Institutional Development and Government Coordination, Baghdad, Iraq

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