Alterations in Lipid Profile and Oxidative Stress Markers Following Heat Stress on Wistar Rats: Ameliorating Role of Vitamin C

Bruno Chukwuemeka Chinko; Onyinye Ukamaka Umeh

doi:doi:10.11648/j.bs.20230901.13

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Alterations in Lipid Profile and Oxidative Stress Markers Following Heat Stress on Wistar Rats: Ameliorating Role of Vitamin C

Bruno Chukwuemeka Chinko, Onyinye Ukamaka Umeh

Published in Biomedical Sciences (Volume 9, Issue 1)

Received: 6 February 2023 Accepted: 23 February 2023 Published: 9 March 2023

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Abstract

Global warming and the increased frequency of heat waves have generated more interest in the effect of heat stress on human physiology. The present study evaluated the effect of 30 days of controlled heat exposure (38.1±1°C) on the lipid profile and oxidative stress markers of male Wistar rats. Twenty-five (25) male Wistar rats (3 - 4 months old, 200-250g) were used for the study and grouped into five (5) groups of five (5) rats per group. Group 1 served as the control, while groups 2 – 4 were allowed exposed to controlled heat for two (2), four (4) and eight (8) hours respectively while group 5 were allowed an 8-hour heat exposure plus oral administration of vitamin C. The result of the study indicates that heat stress caused a significant increase in serum low-density lipoprotein (LDL), total cholesterol (TC), malondialdehyde (MDA) and catalase (CAT) among the heat-exposed group compared to the control (p<0.05) while the serum levels of superoxide dismutase (SOD), glutathione (GPH) and glutathione peroxidase (GPx) significantly reduced compared to the non-exposed control (P<0.05). The result also indicates that supplementation with vitamin C positively modulated the effects of heat stress on lipid profile and oxidative stress markers. The current evidence suggests that heat stress can cause an increase in oxidative stress leading to increased lipid peroxidation and cellular damage with a possible ameliorative role by vitamin C supplementation.

Published in	Biomedical Sciences (Volume 9, Issue 1)
DOI	10.11648/j.bs.20230901.13
Page(s)	12-17
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Heat Stress, Lipid Peroxidative, Lipid Profile, Oxidative Stress, Vitamin C

References

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APA Style

Bruno Chukwuemeka Chinko, Onyinye Ukamaka Umeh. (2023). Alterations in Lipid Profile and Oxidative Stress Markers Following Heat Stress on Wistar Rats: Ameliorating Role of Vitamin C. Biomedical Sciences, 9(1), 12-17. https://doi.org/10.11648/j.bs.20230901.13

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ACS Style

Bruno Chukwuemeka Chinko; Onyinye Ukamaka Umeh. Alterations in Lipid Profile and Oxidative Stress Markers Following Heat Stress on Wistar Rats: Ameliorating Role of Vitamin C. Biomed. Sci. 2023, 9(1), 12-17. doi: 10.11648/j.bs.20230901.13

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AMA Style

Bruno Chukwuemeka Chinko, Onyinye Ukamaka Umeh. Alterations in Lipid Profile and Oxidative Stress Markers Following Heat Stress on Wistar Rats: Ameliorating Role of Vitamin C. Biomed Sci. 2023;9(1):12-17. doi: 10.11648/j.bs.20230901.13

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@article{10.11648/j.bs.20230901.13,
  author = {Bruno Chukwuemeka Chinko and Onyinye Ukamaka Umeh},
  title = {Alterations in Lipid Profile and Oxidative Stress Markers Following Heat Stress on Wistar Rats: Ameliorating Role of Vitamin C},
  journal = {Biomedical Sciences},
  volume = {9},
  number = {1},
  pages = {12-17},
  doi = {10.11648/j.bs.20230901.13},
  url = {https://doi.org/10.11648/j.bs.20230901.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20230901.13},
  abstract = {Global warming and the increased frequency of heat waves have generated more interest in the effect of heat stress on human physiology. The present study evaluated the effect of 30 days of controlled heat exposure (38.1±1°C) on the lipid profile and oxidative stress markers of male Wistar rats. Twenty-five (25) male Wistar rats (3 - 4 months old, 200-250g) were used for the study and grouped into five (5) groups of five (5) rats per group. Group 1 served as the control, while groups 2 – 4 were allowed exposed to controlled heat for two (2), four (4) and eight (8) hours respectively while group 5 were allowed an 8-hour heat exposure plus oral administration of vitamin C. The result of the study indicates that heat stress caused a significant increase in serum low-density lipoprotein (LDL), total cholesterol (TC), malondialdehyde (MDA) and catalase (CAT) among the heat-exposed group compared to the control (p<0.05) while the serum levels of superoxide dismutase (SOD), glutathione (GPH) and glutathione peroxidase (GPx) significantly reduced compared to the non-exposed control (P<0.05). The result also indicates that supplementation with vitamin C positively modulated the effects of heat stress on lipid profile and oxidative stress markers. The current evidence suggests that heat stress can cause an increase in oxidative stress leading to increased lipid peroxidation and cellular damage with a possible ameliorative role by vitamin C supplementation.},
 year = {2023}
}

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TY  - JOUR
T1  - Alterations in Lipid Profile and Oxidative Stress Markers Following Heat Stress on Wistar Rats: Ameliorating Role of Vitamin C
AU  - Bruno Chukwuemeka Chinko
AU  - Onyinye Ukamaka Umeh
Y1  - 2023/03/09
PY  - 2023
N1  - https://doi.org/10.11648/j.bs.20230901.13
DO  - 10.11648/j.bs.20230901.13
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 12
EP  - 17
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20230901.13
AB  - Global warming and the increased frequency of heat waves have generated more interest in the effect of heat stress on human physiology. The present study evaluated the effect of 30 days of controlled heat exposure (38.1±1°C) on the lipid profile and oxidative stress markers of male Wistar rats. Twenty-five (25) male Wistar rats (3 - 4 months old, 200-250g) were used for the study and grouped into five (5) groups of five (5) rats per group. Group 1 served as the control, while groups 2 – 4 were allowed exposed to controlled heat for two (2), four (4) and eight (8) hours respectively while group 5 were allowed an 8-hour heat exposure plus oral administration of vitamin C. The result of the study indicates that heat stress caused a significant increase in serum low-density lipoprotein (LDL), total cholesterol (TC), malondialdehyde (MDA) and catalase (CAT) among the heat-exposed group compared to the control (p<0.05) while the serum levels of superoxide dismutase (SOD), glutathione (GPH) and glutathione peroxidase (GPx) significantly reduced compared to the non-exposed control (P<0.05). The result also indicates that supplementation with vitamin C positively modulated the effects of heat stress on lipid profile and oxidative stress markers. The current evidence suggests that heat stress can cause an increase in oxidative stress leading to increased lipid peroxidation and cellular damage with a possible ameliorative role by vitamin C supplementation.
VL  - 9
IS  - 1
ER  -

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Author Information

Bruno Chukwuemeka Chinko

Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Port Harcourt, Nigeria
Onyinye Ukamaka Umeh

Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Port Harcourt, Nigeria

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Bruno Chukwuemeka Chinko, Onyinye Ukamaka Umeh. (2023). Alterations in Lipid Profile and Oxidative Stress Markers Following Heat Stress on Wistar Rats: Ameliorating Role of Vitamin C. Biomedical Sciences, 9(1), 12-17. https://doi.org/10.11648/j.bs.20230901.13

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ACS Style

Bruno Chukwuemeka Chinko; Onyinye Ukamaka Umeh. Alterations in Lipid Profile and Oxidative Stress Markers Following Heat Stress on Wistar Rats: Ameliorating Role of Vitamin C. Biomed. Sci. 2023, 9(1), 12-17. doi: 10.11648/j.bs.20230901.13

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AMA Style

Bruno Chukwuemeka Chinko, Onyinye Ukamaka Umeh. Alterations in Lipid Profile and Oxidative Stress Markers Following Heat Stress on Wistar Rats: Ameliorating Role of Vitamin C. Biomed Sci. 2023;9(1):12-17. doi: 10.11648/j.bs.20230901.13

Copy | Download

@article{10.11648/j.bs.20230901.13,
  author = {Bruno Chukwuemeka Chinko and Onyinye Ukamaka Umeh},
  title = {Alterations in Lipid Profile and Oxidative Stress Markers Following Heat Stress on Wistar Rats: Ameliorating Role of Vitamin C},
  journal = {Biomedical Sciences},
  volume = {9},
  number = {1},
  pages = {12-17},
  doi = {10.11648/j.bs.20230901.13},
  url = {https://doi.org/10.11648/j.bs.20230901.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20230901.13},
  abstract = {Global warming and the increased frequency of heat waves have generated more interest in the effect of heat stress on human physiology. The present study evaluated the effect of 30 days of controlled heat exposure (38.1±1°C) on the lipid profile and oxidative stress markers of male Wistar rats. Twenty-five (25) male Wistar rats (3 - 4 months old, 200-250g) were used for the study and grouped into five (5) groups of five (5) rats per group. Group 1 served as the control, while groups 2 – 4 were allowed exposed to controlled heat for two (2), four (4) and eight (8) hours respectively while group 5 were allowed an 8-hour heat exposure plus oral administration of vitamin C. The result of the study indicates that heat stress caused a significant increase in serum low-density lipoprotein (LDL), total cholesterol (TC), malondialdehyde (MDA) and catalase (CAT) among the heat-exposed group compared to the control (p<0.05) while the serum levels of superoxide dismutase (SOD), glutathione (GPH) and glutathione peroxidase (GPx) significantly reduced compared to the non-exposed control (P<0.05). The result also indicates that supplementation with vitamin C positively modulated the effects of heat stress on lipid profile and oxidative stress markers. The current evidence suggests that heat stress can cause an increase in oxidative stress leading to increased lipid peroxidation and cellular damage with a possible ameliorative role by vitamin C supplementation.},
 year = {2023}
}

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TY  - JOUR
T1  - Alterations in Lipid Profile and Oxidative Stress Markers Following Heat Stress on Wistar Rats: Ameliorating Role of Vitamin C
AU  - Bruno Chukwuemeka Chinko
AU  - Onyinye Ukamaka Umeh
Y1  - 2023/03/09
PY  - 2023
N1  - https://doi.org/10.11648/j.bs.20230901.13
DO  - 10.11648/j.bs.20230901.13
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 12
EP  - 17
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20230901.13
AB  - Global warming and the increased frequency of heat waves have generated more interest in the effect of heat stress on human physiology. The present study evaluated the effect of 30 days of controlled heat exposure (38.1±1°C) on the lipid profile and oxidative stress markers of male Wistar rats. Twenty-five (25) male Wistar rats (3 - 4 months old, 200-250g) were used for the study and grouped into five (5) groups of five (5) rats per group. Group 1 served as the control, while groups 2 – 4 were allowed exposed to controlled heat for two (2), four (4) and eight (8) hours respectively while group 5 were allowed an 8-hour heat exposure plus oral administration of vitamin C. The result of the study indicates that heat stress caused a significant increase in serum low-density lipoprotein (LDL), total cholesterol (TC), malondialdehyde (MDA) and catalase (CAT) among the heat-exposed group compared to the control (p<0.05) while the serum levels of superoxide dismutase (SOD), glutathione (GPH) and glutathione peroxidase (GPx) significantly reduced compared to the non-exposed control (P<0.05). The result also indicates that supplementation with vitamin C positively modulated the effects of heat stress on lipid profile and oxidative stress markers. The current evidence suggests that heat stress can cause an increase in oxidative stress leading to increased lipid peroxidation and cellular damage with a possible ameliorative role by vitamin C supplementation.
VL  - 9
IS  - 1
ER  -

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