Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review

Kenneth Chinedu Ugoeze; Inderbir Singh Bakshi; Bruno Chukwuemeka Chinko; Kennedy Emeka Oluigbo; Ngozi Augustine Okoronkwo; Christian Arerusuoghene Alalor

doi:doi:10.11648/j.bs.20230901.14

Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review

Kenneth Chinedu Ugoeze, Inderbir Singh Bakshi, Bruno Chukwuemeka Chinko, Kennedy Emeka Oluigbo, Ngozi Augustine Okoronkwo, Christian Arerusuoghene Alalor

Published in Biomedical Sciences (Volume 9, Issue 1)

Received: 11 February 2023 Accepted: 27 February 2023 Published: 9 March 2023

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Abstract

In the last few decades, natural products have enjoyed an extensive range of acceptability for the prevention, treatment and management of various health conditions. Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a common phytoalexin found in grapes, peanuts, cocoa, and berries of Vaccinium species, together with blueberries, bilberries, and cranberries. Research interest in resveratrol has been increasing due to growing evidence of its many health benefits. This review is aimed at highlighting the various benefits of resveratrol in health and diseases. The present study reviewed published advances in the health-promoting benefits of resveratrol in human clinical trials as well as in animal experimental models with a focus on postulated molecular mechanisms of action. We discussed the sources, biochemistry, bioavailability and biological effects such as antioxidant, anti-inflammatory, anti-cancer, anti-platelet, anti-diabetic, immunomodulatory and cardio-protective, anti-obesity and neuroprotective effects. The study observed that these varieties of biotic influences are initiated by multiple molecular targets and pathways involving cyclooxygenases/lipooxygenases, kinases, sirtuins, transcription factors, cytokines, DNA polymerase, adenylyl cyclase, ribonucleotide reductase and aromatase and thus, enhancing their potential to influence many physiological processes. The study concludes that resveratrol has demonstrated a potent effect against several disease conditions, however, its low bioavailability greatly limits its applications. This review recommends further research direction in the development of health maintenance and therapeutic agents from resveratrol.

Published in	Biomedical Sciences (Volume 9, Issue 1)
DOI	10.11648/j.bs.20230901.14
Page(s)	18-29
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Resveratrol, 3,4′,5-trihydroxy-trans-stilbene, Antioxidant, Phytopharmaceutical

References

[1]	Ariane P. Phytopharmaceuticals – Fighting Disease With Natural Substances Germany: BIOPRO Baden-Württemberg; 2017 [cited 2012 05/11/2002]. Available from: https://www.gesundheitsindustrie-bw.de/en/article/dossier/phytopharmaceuticals-fighting-disease-with-natural-substances.
[2]	Ugoeze KC. Phytopharmaceuticals for Treating Sexually Transmitted Diseases. In: Herbal Drugs for the Management of Infectious Diseases. 2022. In: Herbal Drugs for the Management of Infectious Disease [Internet]. USA: John Wiley & Sons.
[3]	Sukhikh S, Noskova S, Pungin A, Ivanova S, Skrypnik L, Chupakhin E, et al. Study of the biologically active properties of medicinal plant Cotinus coggygria. Plants. 2021; 10 (6): 1224.
[4]	WHO. WHO establishes the Global Centre for Traditional Medicine in India Geneve, Switzerland: World Health Organism; 2022 [cited 2022 05/11/2022]. Available from: https://www.who.int/news/item/25-03-2022-who-establishes-the-global-centre-for-traditional-medicine-in-india.
[5]	Ozioma E-OJ, Chinwe OAN. Herbal medicines in African traditional medicine. Herbal medicine. 2019; 10: 191-214.
[6]	Sandberg F, Corrigan D. Natural remedies: their origins and uses: CRC Press; 2003.
[7]	Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxidative medicine and cellular longevity. 2009; 2 (5): 270-8.
[8]	El Gharras H. Polyphenols: food sources, properties and applications–a review. International journal of food science & technology. 2009; 44 (12): 2512-8.
[9]	Grosso G, Godos J, Lamuela-Raventos R, Ray S, Micek A, Pajak A, et al. A comprehensive meta-analysis on dietary flavonoid and lignan intake and cancer risk: Level of evidence and limitations. Molecular nutrition & food research. 2017; 61 (4): 1600930.
[10]	He X, Sun L-m. Dietary intake of flavonoid subclasses and risk of colorectal cancer: Evidence from population studies. Oncotarget. 2016; 7 (18): 26617.
[11]	Singla RK, Dubey AK, Garg A, Sharma RK, Fiorino M, Ameen SM, et al. Natural polyphenols: Chemical classification, definition of classes, subcategories, and structures. Oxford University Press; 2019. p. 1397-400.
[12]	Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. Journal of nutritional science. 2016; 5.
[13]	Ugoeze KC, Oluigbo KE, Chinko BC. Phytomedicinal and Nutraceutical Benefits of the GC-FID Quantified Phytocomponents of the Aqueous Extract of Azadirachta indica leaves. Journal of Pharmacy and Pharmacology Research. 2020; 4 (4): 149-63.
[14]	Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L. Polyphenols: food sources and bioavailability. The American journal of clinical nutrition. 2004; 79 (5): 727-47.
[15]	Atanassova M, Bagdassarian V. Rutin content in plant products. Journal of the University of Chemical Technology and Metallurgy. 2009; 44 (2): 201-3.
[16]	Liu RH. Health-promoting components of fruits and vegetables in the diet. Advances in nutrition. 2013; 4 (3): 384S-92S.
[17]	Justesen U, Knuthsen P. Composition of flavonoids in fresh herbs and calculation of flavonoid intake by use of herbs in traditional Danish dishes. Food chemistry. 2001; 73 (2): 245-50.
[18]	Ross JA, Kasum CM. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annual review of Nutrition. 2002; 22: 19.
[19]	Khan MTH, Orhan I, Şenol F, Kartal M, Şener B, Dvorská M, et al. Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies. Chemico-Biological Interactions. 2009; 181 (3): 383-9.
[20]	Iwashina T. Flavonoid properties of five families newly incorporated into the order Caryophyllales. Bull Natl Mus Nat Sci. 2013; 39: 25-51.
[21]	Lattanzio V. Phenolic Compounds: Introduction. In: Ramawat KG, Mérillon J-M, editors. Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes. Berlin, Heidelberg: Springer Berlin Heidelberg; 2013. p. 1543-80.
[22]	Crozier A, Clifford MN, Ashihara H. Plant secondary metabolites: occurrence, structure and role in the human diet: John Wiley & Sons; 2008.
[23]	Vladimir-Knežević S, Blažeković B, Štefan MB, Babac M. Plant polyphenols as antioxidants influencing the human health. Phytochemicals as nutraceuticals-Global approaches to their role in nutrition and health: IntechOpen; 2012.
[24]	Gadkari PV, Balaraman M. Catechins: Sources, extraction and encapsulation: A review. Food and Bioproducts Processing. 2015; 93: 122-38.
[25]	Butelli E, Titta L, Giorgio M, Mock H-P, Matros A, Peterek S, et al. Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors. Nature biotechnology. 2008; 26 (11): 1301-8.
[26]	Han X, Shen T, Lou H. Dietary polyphenols and their biological significance. International journal of molecular sciences. 2007; 8 (9): 950-88.
[27]	Reinisalo M, Kårlund A, Koskela A, Kaarniranta K, Karjalainen RO. Polyphenol stilbenes: molecular mechanisms of defence against oxidative stress and aging-related diseases. Oxidative medicine and cellular longevity. 2015; 2015.
[28]	Gull A, Lone AA, Wani NUI. Biotic and Abiotic Stresses in Plants. 2019.
[29]	Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer research. 2004; 24 (5A): 2783-840.
[30]	Jeandet P. Phytoalexins: current progress and future prospects. Molecules. 2015; 20 (2): 2770-4.
[31]	Takaoka M. Resveratrol, a new phenolic compound, from Veratrum grandiflorum. Nippon Kagaku Kaishi. 1939; 60: 1090-100.
[32]	Pezzuto JM. Resveratrol: twenty years of growth, development and controversy. Biomolecules & therapeutics. 2019; 27 (1): 1.
[33]	Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nature reviews Drug discovery. 2006; 5 (6): 493-506.
[34]	Renaud Sd, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. The Lancet. 1992; 339 (8808): 1523-6.
[35]	Ugoeze KC, Amadi N, Okoronkwo NA, Abali SO, Oluigbo KE, Chinko BC. GC-FID guided Identification and Quantification of detectable Phytochemicals in selected Commercial Chamomile Herbal Tea. International Journal of Applied Biology and Pharmaceutical Technology. 2023; 14 (1): 1-11.
[36]	Bradamante S, Barenghi L, Villa A. Cardiovascular protective effects of resveratrol. Cardiovascular drug reviews. 2004; 22 (3): 169-88.
[37]	Wang Q, Xu J, Rottinghaus GE, Simonyi A, Lubahn D, Sun GY, et al. Resveratrol protects against global cerebral ischemic injury in gerbils. Brain research. 2002; 958 (2): 439-47.
[38]	Sinha K, Chaudhary G, Gupta YK. Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats. Life sciences. 2002; 71 (6): 655-65.
[39]	Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Current biology. 2006; 16 (3): 296-300.
[40]	Das S, Vasanthi HR, Das DK. Resveratrol: Biochemistry and Functions. Plant Phenolics and Human Health2009. p. 299-330.
[41]	Orallo F. Comparative studies of the antioxidant effects of cis-and trans-resveratrol. Current medicinal chemistry. 2006; 13 (1): 87-98.
[42]	Bernard E, Britz-McKibbin P, Gernigon N. Resveratrol photoisomerization: an integrative guided-inquiry experiment. Journal of chemical education. 2007; 84 (7): 1159.
[43]	Trela BC, Waterhouse AL. Resveratrol: isomeric molar absorptivities and stability. Journal of agricultural and food chemistry. 1996; 44 (5): 1253-7.
[44]	Pervaiz S. Resveratrol: from grapevines to mammalian biology. The FASEB journal. 2003; 17 (14): 1975-85.
[45]	Hu Y, Wang S, Wu X, Zhang J, Chen R, Chen M, et al. Chinese herbal medicine-derived compounds for cancer therapy: a focus on hepatocellular carcinoma. Journal of Ethnopharmacology. 2013; 149 (3): 601-12.
[46]	Burns J, Yokota T, Ashihara H, Lean ME, Crozier A. Plant foods and herbal sources of resveratrol. Journal of agricultural and food chemistry. 2002; 50 (11): 3337-40.
[47]	Rimando AM, Kalt W, Magee JB, Dewey J, Ballington JR. Resveratrol, pterostilbene, and piceatannol in vaccinium berries. Journal of agricultural and food chemistry. 2004; 52 (15): 4713-9.
[48]	Sanders TH, McMichael RW, Hendrix KW. Occurrence of resveratrol in edible peanuts. Journal of agricultural and food chemistry. 2000; 48 (4): 1243-6.
[49]	Kopp P. Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the'French paradox'? European journal of endocrinology. 1998; 138 (6): 619-20.
[50]	Siemann E, Creasy L. Concentration of the phytoalexin resveratrol in wine. American Journal of Enology and Viticulture. 1992; 43 (1): 49-52.
[51]	Gambini J, Inglés M, Olaso G, Lopez-Grueso R, Bonet-Costa V, Gimeno-Mallench L, et al. Properties of resveratrol: in vitro and in vivo studies about metabolism, bioavailability, and biological effects in animal models and humans. Oxidative medicine and cellular longevity. 2015; 2015.
[52]	King RE, Bomser JA, Min DB. Bioactivity of resveratrol. Comprehensive reviews in food science and food safety. 2006; 5 (3): 65-70.
[53]	Jannin B, Menzel M, Berlot J-P, Delmas D, Lançon A, Latruffe N. Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake. Biochemical pharmacology. 2004; 68 (6): 1113-8.
[54]	Vitrac X, Desmoulière A, Brouillaud B, Krisa S, Deffieux G, Barthe N, et al. Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration. Life Sciences. 2003; 72 (20): 2219-33.
[55]	Mukherjee S, Dudley JI, Das DK. Dose-dependency of resveratrol in providing health benefits. Dose-response. 2010; 8 (4): dose-response. 09-015. Mukherjee.
[56]	Gülçin İ. Antioxidant properties of resveratrol: A structure–activity insight. Innovative food science & emerging technologies. 2010; 11 (1): 210-8.
[57]	De La Lastra CA, Villegas I. Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications. Biochemical Society Transactions. 2007; 35 (5): 1156-60.
[58]	Hung L-M, Chen J-K, Huang S-S, Lee R-S, Su M-J. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovascular research. 2000; 47 (3): 549-55.
[59]	Kirk RI, Deitch JA, Wu JM, Lerea KM. Resveratrol decreases early signaling events in washed platelets but has little effect on platelet aggregation in whole blood. Blood Cells, Molecules, and Diseases. 2000; 26 (2): 144-50.
[60]	Das S, Das DK. Anti-inflammatory responses of resveratrol. Inflammation & Allergy-Drug Targets (Formerly Current Drug Targets-Inflammation & Allergy) (Discontinued). 2007; 6 (3): 168-73.
[61]	Szkudelski T, Szkudelska K. Anti-diabetic effects of resveratrol. Annals of the New York Academy of Sciences. 2011; 1215 (1): 34-9.
[62]	Aguirre L, Fernández-Quintela A, Arias N, Portillo MP. Resveratrol: anti-obesity mechanisms of action. Molecules. 2014; 19 (11): 18632-55.
[63]	Sun AY, Wang Q, Simonyi A, Sun GY. Resveratrol as a therapeutic agent for neurodegenerative diseases. Molecular neurobiology. 2010; 41 (2): 375-83.
[64]	Zini R, Morin C, Bertelli A, Bertelli Aa, Tillement J. Effects of resveratrol on the rat brain respiratory chain. Drugs under experimental and clinical research. 1999; 25 (2-3): 87-97.
[65]	Losa G. Resveratrol modulates apoptosis and oxidation in human blood mononuclear cells. European journal of clinical investigation. 2003; 33 (9): 818-23.
[66]	Yen G-C, Duh P-D, Lin C-W. Effects of resveratrol and 4-hexylresorcinol on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes. Free radical research. 2003; 37 (5): 509-14.
[67]	Hattori R, Otani H, Maulik N, Das DK. Pharmacological preconditioning with resveratrol: role of nitric oxide. American Journal of Physiology-Heart and Circulatory Physiology. 2002; 282 (6): H1988-H95.
[68]	Inglés M, Gambini J, Miguel MG, Bonet-Costa V, Abdelaziz KM, El Alami M, et al. PTEN mediates the antioxidant effect of resveratrol at nutritionally relevant concentrations. BioMed Research International. 2014; 2014.
[69]	Singh AK, Vinayak M. Resveratrol alleviates inflammatory hyperalgesia by modulation of reactive oxygen species (ROS), antioxidant enzymes and ERK activation. Inflammation Research. 2017; 66 (10): 911-21.
[70]	Markiewski MM, Lambris JD. The role of complement in inflammatory diseases from behind the scenes into the spotlight. The American journal of pathology. 2007; 171 (3): 715-27.
[71]	Arulselvan P, Fard MT, Tan WS, Gothai S, Fakurazi S, Norhaizan ME, et al. Role of antioxidants and natural products in inflammation. Oxidative medicine and cellular longevity. 2016; 2016.
[72]	Meng T, Xiao D, Muhammed A, Deng J, Chen L, He J. Anti-inflammatory action and mechanisms of resveratrol. Molecules. 2021; 26 (1): 229.
[73]	de Sá Coutinho D, Pacheco MT, Frozza RL, Bernardi A. Anti-inflammatory effects of resveratrol: Mechanistic insights. International journal of molecular sciences. 2018; 19 (6): 1812.
[74]	Xian Y, Gao Y, Lv W, Ma X, Hu J, Chi J, et al. Resveratrol prevents diabetic nephropathy by reducing chronic inflammation and improving the blood glucose memory effect in non-obese diabetic mice. Naunyn-Schmiedeberg's Archives of Pharmacology. 2020; 393 (10): 2009-17.
[75]	Zou M, Yang W, Niu L, Sun Y, Luo R, Wang Y, et al. Polydatin attenuates Mycoplasma gallisepticum (HS strain)-induced inflammation injury via inhibiting the TLR6/MyD88/NF-κB pathway. Microbial Pathogenesis. 2020; 149: 104552.
[76]	Simão F, Matté A, Pagnussat AS, Netto CA, Salbego CG. Resveratrol preconditioning modulates inflammatory response in the rat hippocampus following global cerebral ischemia. Neurochemistry international. 2012; 61 (5): 659-65.
[77]	Hou Y, Zhang Y, Mi Y, Wang J, Zhang H, Xu J, et al. A Novel Quinolyl-Substituted Analogue of Resveratrol Inhibits LPS-Induced Inflammatory Responses in Microglial Cells by Blocking the NF-κB/MAPK Signaling Pathways. Molecular nutrition & food research. 2019; 63 (20): 1801380.
[78]	Ahmad SF, Ansari MA, Nadeem A, Alzahrani MZ, Bakheet SA, Attia SM. Resveratrol improves neuroimmune dysregulation through the inhibition of neuronal toll-like receptors and COX-2 signaling in BTBR T+ Itpr3tf/J mice. Neuromolecular Medicine. 2018; 20 (1): 133-46.
[79]	Patel KR, Andreadi C, Britton RG, Horner-Glister E, Karmokar A, Sale S, et al. Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence. Science translational medicine. 2013; 5 (205): 205ra133-205ra133.
[80]	Elshaer M, Chen Y, Wang XJ, Tang X. Resveratrol: An overview of its anti-cancer mechanisms. Life sciences. 2018; 207: 340-9.
[81]	Tessitore L, Davit A, Sarotto I, Caderni G. Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21 CIP expression. Carcinogenesis. 2000; 21 (8): 1619-22.
[82]	Schneider Y, Duranton B, Goss F, Schleiffer R, Seiler N, Raul F. Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposis. Nutrition and cancer. 2001; 39 (1): 102-7.
[83]	Afaq F, Adhami VM, Ahmad N. Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless miceToxicology and Applied Pharmacology. 2003; 186 (1): 28-37.
[84]	Fabbrocini G, Kisslinger A, Iannelli P, Vitale N, Procaccini C, Sparaneo G, et al. Resveratrol regulates p66Shc activation in HaCaT cells. Experimental Dermatology. 2010; 19 (10): 895-903.
[85]	Meng X, Zhou J, Zhao C-N, Gan R-Y, Li H-B. Health benefits and molecular mechanisms of resveratrol: A narrative review. Foods. 2020; 9 (3): 340.
[86]	Awajiomowa J, Chinko BC, Green KI. Haematological Parameters and Oxidative Stress Changes in Apparently Healthy Pregnant Women in Bori, Nigeria. International Journal of Research and Reports in Hematology. 2022; 5 (4): 30-9.
[87]	Ememe AM, Edeh R, Abdullahi U, Sackey A, Ayo J. Changes in hematological parameters and erythrocyte osmotic fragility in lame and aged horses administered with resveratrol supplement. African Journal of Biomedical Research. 2016; 19 (1): 1-7.
[88]	Atmaca N, Yıldırım E, Güner B, Kabakçı R, Bilmen FS. Effect of resveratrol on hematological and biochemical alterations in rats exposed to fluoride. BioMed Research International. 2014; 2014.
[89]	Doubek J, Volný T, Lojek A, Knotkova Z, Kotrbáček V, Scheer P, et al. Effect of stilbene resveratrol on haematological indices of rats. Acta Veterinaria Brno. 2005; 74 (2): 205-8.
[90]	Stef G, Csiszar A, Lerea K, Ungvari Z, Veress G. Resveratrol inhibits aggregation of platelets from high-risk cardiac patients with aspirin resistance. Journal of Cardiovascular Pharmacology. 2006; 48 (2): 1-5.
[91]	Lannan KL, Refaai MA, Ture SK, Morrell CN, Blumberg N, Phipps RP, et al. Resveratrol preserves the function of human platelets stored for transfusion. British journal of haematology. 2016; 172 (5): 794-806.
[92]	Rimmelé P, Lofek-Czubek S, Ghaffari S. Resveratrol increases the bone marrow hematopoietic stem and progenitor cell capacity. American journal of hematology. 2014; 89 (12): E235-E8.
[93]	Falchetti R, Fuggetta MP, Lanzilli G, Tricarico M, Ravagnan G. Effects of resveratrol on human immune cell function. Life sciences. 2001; 70 (1): 81-96.
[94]	Zhang C, Tian Y, Yan F, Kang X, Han R, Sun G, et al. Modulation of growth and immunity by dietary supplementation with resveratrol in young chickens receiving conventional vaccinations. American journal of veterinary research. 2014; 75 (8): 752-9.
[95]	Feng Y-H, Zhou W-L, Wu Q-L, Li X-Y, Zhao W-M, Zou J-P. Low dose of resveratrol enhanced immune response of mice. Acta Pharmacologica Sinica. 2002; 23 (10): 893-7.
[96]	Cui Q, Fu Q, Zhao X, Song X, Yu J, Yang Y, et al. Protective effects and immunomodulation on piglets infected with rotavirus following resveratrol supplementation. PLoS One. 2018; 13 (2): e0192692.
[97]	Euba B, López-López N, Rodríguez-Arce I, Fernández-Calvet A, Barberán M, Caturla N, et al. Resveratrol therapeutics combines both antimicrobial and immunomodulatory properties against respiratory infection by nontypeable Haemophilus influenzae. Sci Rep. 2017; 7 (1): 12860.
[98]	Guo N-H, Fu X, Zi F-M, Song Y, Wang S, Cheng J. The potential therapeutic benefit of resveratrol on Th17/Treg imbalance in immune thrombocytopenic purpura. International Immunopharmacology. 2019; 73: 181-92.
[99]	Arguelles Arias A. Science against microbial pathogens: communicating current research and technological advances. 2011.
[100]	Weber K, Schulz B, Ruhnke M. Resveratrol and its antifungal activity against Candida species. Mycoses. 2011; 54 (1): 30-3.
[101]	Duarte A, Alves AC, Ferreira S, Silva F, Domingues FC. Resveratrol inclusion complexes: antibacterial and anti-biofilm activity against Campylobacter spp. and Arcobacter butzleri. Food Research International. 2015; 77: 244-50.
[102]	Abba Y, Hassim H, Hamzah H, Noordin MM. Antiviral activity of resveratrol against human and animal viruses. Advances in virology. 2015; 2015.
[103]	Paulo L, Ferreira S, Gallardo E, Queiroz JA, Domingues F. Antimicrobial activity and effects of resveratrol on human pathogenic bacteria. World Journal of Microbiology and Biotechnology. 2010; 26 (8): 1533-8.
[104]	Zhao X, Tong W, Song X, Jia R, Li L, Zou Y, et al. Antiviral effect of resveratrol in piglets infected with virulent pseudorabies virus. Viruses. 2018; 10 (9): 457.
[105]	Kalantari H, Das DK. Physiological effects of resveratrol. Biofactors. 2010; 36 (5): 401-6.
[106]	Bonnefont-Rousselot D. Resveratrol and cardiovascular diseases. Nutrients. 2016; 8 (5): 250.
[107]	Das D, Sato M, Ray P, Maulik G, Engelman R, Bertelli A, et al. Cardioprotection of red wine: role of polyphenolic antioxidants. Drugs under experimental and clinical research. 1999; 25 (2-3): 115-20.
[108]	Dolinsky VW, Chakrabarti S, Pereira TJ, Oka T, Levasseur J, Beker D, et al. Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2013; 1832 (10): 1723-33.
[109]	Liu Z, Song Y, Zhang X, Liu Z, Zhang W, Mao W, et al. Effects of trans-resveratrol on hypertension-induced cardiac hypertrophy using the partially nephrectomized rat model. Clinical and Experimental Pharmacology and Physiology. 2005; 32 (12): 1049-54.
[110]	Chan V, Fenning A, Iyer A, Hoey A, Brown L. Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats. Current Pharmaceutical Biotechnology. 2011; 12 (3): 429-36.
[111]	Aubin M-C, Lajoie C, Clement R, Gosselin H, Calderone A, Perrault LP. Female rats fed a high-fat diet were associated with vascular dysfunction and cardiac fibrosis in the absence of overt obesity and hyperlipidemia: therapeutic potential of resveratrol. Journal of Pharmacology and Experimental Therapeutics. 2008; 325 (3): 961-8.
[112]	Zordoky BN, Robertson IM, Dyck JR. Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2015; 1852 (6): 1155-77.
[113]	Xu Q, Hao X, Yang Q, Si L. Resveratrol prevents hyperglycemia-induced endothelial dysfunction via activation of adenosine monophosphate-activated protein kinase. Biochemical and biophysical research communications. 2009; 388 (2): 389-94.
[114]	Goh SSC, Woodman OL, Pepe S, Cao AH, Qin C, Ritchie RH. The red wine antioxidant resveratrol prevents cardiomyocyte injury following ischemia-reperfusion via multiple sites and mechanisms. Antioxidants & redox signaling. 2007; 9 (1): 101-13.
[115]	Wallerath T, Deckert G, Ternes T, Anderson H, Li H, Witte K, et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation. 2002; 106 (13): 1652-8.
[116]	Cao X, Luo T, Luo X, Tang Z. Resveratrol prevents AngII-induced hypertension via AMPK activation and RhoA/ROCK suppression in mice. Hypertension Research. 2014; 37 (9): 803-10.
[117]	Campos-Toimil M, Elíes J, Álvarez E, Verde I, Orallo F. Effects of trans-and cis-resveratrol on Ca2+ handling in A7r5 vascular myocytes. European journal of pharmacology. 2007; 577 (1-3): 91-9.
[118]	Shen M, Zhao L, Wu R-x, Yue S-q, Pei J-m. The vasorelaxing effect of resveratrol on abdominal aorta from rats and its underlying mechanisms. Vascular pharmacology. 2013; 58 (1-2): 64-70.
[119]	Wang LM, Wang YJ, Cui M, Luo WJ, Wang XJ, Barber PA, et al. A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT 1 signaling, thereby reducing energy requirements during ischemia. European Journal of Neuroscience. 2013; 37 (10): 1669-81.
[120]	Clark D, Tuor UI, Thompson R, Institoris A, Kulynych A, Zhang X, et al. Protection against recurrent stroke with resveratrol: endothelial protection. 2012.
[121]	Wightman EL, Reay JL, Haskell CF, Williamson G, Dew TP, Kennedy DO. Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation. British Journal of Nutrition. 2014; 112 (2): 203-13.
[122]	Couillard C, Mauriege P, Imbeault P, Prud'homme D, Nadeau A, Tremblay A, et al. Hyperleptinemia is more closely associated with adipose cell hypertrophy than with adipose tissue hyperplasia. International journal of obesity. 2000; 24 (6): 782-8.
[123]	Lim JP, Leung BP, Ding YY, Tay L, Ismail NH, Yeo A, et al. Monocyte chemoattractant protein-1: a proinflammatory cytokine elevated in sarcopenic obesity. Clinical interventions in aging. 2015; 10: 605.
[124]	Nishimura Y, Sasagawa S, Ariyoshi M, Ichikawa S, Shimada Y, Kawaguchi K, et al. Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity. Frontiers in pharmacology. 2015; 6: 199.
[125]	Chang C-C, Lin K-Y, Peng K-Y, Day Y-J, Hung L-M. Resveratrol exerts anti-obesity effects in high-fat diet obese mice and displays differential dosage effects on cytotoxicity, differentiation, and lipolysis in 3T3-L1 cells. Endocrine journal. 2016; 63 (2): 169-78.
[126]	Zou T, Chen D, Yang Q, Wang B, Zhu MJ, Nathanielsz PW, et al. Resveratrol supplementation of high-fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring. The Journal of physiology. 2017; 595 (5): 1547-62.
[127]	Huang Y, Zhu X, Chen K, Lang H, Zhang Y, Hou P, et al. Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway. Aging (Albany NY). 2019; 11 (8): 2217.
[128]	Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes care. 2004; 27 (5): 1047-53.
[129]	Zimmet P, Alberti KG, Magliano DJ, Bennett PH. Diabetes mellitus statistics on prevalence and mortality: facts and fallacies. Nature Reviews Endocrinology. 2016; 12 (10): 616-22.
[130]	Zhang H, Zhang J, Ungvari Z, Zhang C. Resveratrol improves endothelial function: role of TNFα and vascular oxidative stress. Arteriosclerosis, thrombosis, and vascular biology. 2009; 29 (8): 1164-71.
[131]	Palsamy P, Subramanian S. Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin–nicotinamide-induced diabetic rats. Chemico-biological interactions. 2009; 179 (2-3): 356-62.
[132]	Penumathsa SV, Thirunavukkarasu M, Zhan L, Maulik G, Menon V, Bagchi D, et al. Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium. Journal of cellular and molecular medicine. 2008; 12 (6a): 2350-61.
[133]	McCarty MF. Potential utility of natural polyphenols for reversing fat-induced insulin resistance. Medical Hypotheses. 2005; 64 (3): 628-35.
[134]	Su H-C, Hung L-M, Chen J-K. Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats. American Journal of Physiology-Endocrinology and Metabolism. 2006; 290 (6): E1339-E46.
[135]	Zhang G, Wang X, Ren B, Zhao Q, Zhang F. The effect of resveratrol on blood glucose and blood lipids in rats with gestational diabetes mellitus. Evidence-Based Complementary and Alternative Medicine. 2021; 2021.
[136]	Kuršvietienė L, Stanevičienė I, Mongirdienė A, Bernatonienė J. Multiplicity of effects and health benefits of resveratrol. Medicina. 2016; 52 (3): 148-55.
[137]	Savaskan E, Olivieri G, Meier F, Seifritz E, Wirz-Justice A, Müller-Spahn F. Red wine ingredient resveratrol protects from β-amyloid neurotoxicity. Gerontology. 2003; 49 (6): 380-3.
[138]	Jang J-H, Surh Y-J. Protective effect of resveratrol on β-amyloid-induced oxidative PC12 cell death. Free Radical Biology and Medicine. 2003; 34 (8): 1100-10.
[139]	Camandola S, Mattson MP. NF-κB as a therapeutic target in neurodegenerative diseases. Expert Opinion on Therapeutic Targets. 2007; 11 (2): 123-32.
[140]	Wang J, Ho L, Zhao Z, Seror I, Humala N, Dickstein DL, et al. Moderate consumption of Cabernet Sauvignon attenuates A neuropathology in a mouse model of Alzheimer's disease. The FASEB Journal. 2006; 20 (13): 2313-20.
[141]	Lee MK, Kang SJ, Poncz M, Song K-J, Park KS. Resveratrol protects SH-SY5Y neuroblastoma cells from apoptosis induced by dopamine. Experimental & molecular medicine. 2007; 39 (3): 376-84.
[142]	Bowers JL, Tyulmenkov VV, Jernigan SC, Klinge CM. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors α and β. Endocrinology. 2000; 141 (10): 3657-67.
[143]	Gehm BD, McAndrews JM, Chien P-Y, Jameson JL. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proceedings of the National Academy of Sciences. 1997; 94 (25): 14138-43.
[144]	Citrinovitz ACM, Langer L, Strowitzki T, Germeyer A. Resveratrol enhances decidualization of human endometrial stromal cells. Reproduction. 2020; 159 (4): 453-63.
[145]	Morita Y, Wada-Hiraike O, Yano T, Shirane A, Hirano M, Hiraike H, et al. Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary. Reproductive Biology and Endocrinology. 2012; 10 (1): 1-10.
[146]	Novakovic R, Rajkovic J, Gostimirovic M, Gojkovic-Bukarica L, Radunovic N. Resveratrol and Reproductive Health. Life. 2022; 12 (2): 294.
[147]	Sharpe RM. Do males rely on female hormones? Nature. 1997; 390 (6659): 447-8.
[148]	Nguyen C, Savouret J-F, Widerak M, Corvol M-T, Rannou F. Resveratrol, potential therapeutic interest in joint disorders: a critical narrative review. Nutrients. 2017; 9 (1): 45.
[149]	Chen H-Y, Lin P-H, Shih Y-H, Wang K-L, Hong Y-H, Shieh T-M, et al. Natural antioxidant resveratrol suppresses uterine fibroid cell growth and extracellular matrix formation in vitro and in vivo. Antioxidants. 2019; 8 (4): 99.
[150]	Poulsen MM, Jørgensen JOL, Jessen N, Richelsen B, Pedersen SB. Resveratrol in metabolic health: an overview of the current evidence and perspectives. Annals of the New York Academy of Sciences. 2013; 1290 (1): 74-82.
[151]	Nishikawa K, Iwaya K, Kinoshita M, Fujiwara Y, Akao M, Sonoda M, et al. Resveratrol increases CD68+ Kupffer cells colocalized with adipose differentiation-related protein and ameliorates high-fat-diet-induced fatty liver in mice. Molecular nutrition & food research. 2015; 59 (6): 1155-70.
[152]	Ma Z, Zhang Y, Li Q, Xu M, Bai J, Wu S. Resveratrol improves alcoholic fatty liver disease by downregulating HIF-1α expression and mitochondrial ROS production. PloS one. 2017; 12 (8): e0183426.

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Kenneth Chinedu Ugoeze, Inderbir Singh Bakshi, Bruno Chukwuemeka Chinko, Kennedy Emeka Oluigbo, Ngozi Augustine Okoronkwo, et al. (2023). Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review. Biomedical Sciences, 9(1), 18-29. https://doi.org/10.11648/j.bs.20230901.14

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Kenneth Chinedu Ugoeze; Inderbir Singh Bakshi; Bruno Chukwuemeka Chinko; Kennedy Emeka Oluigbo; Ngozi Augustine Okoronkwo, et al. Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review. Biomed. Sci. 2023, 9(1), 18-29. doi: 10.11648/j.bs.20230901.14

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Kenneth Chinedu Ugoeze, Inderbir Singh Bakshi, Bruno Chukwuemeka Chinko, Kennedy Emeka Oluigbo, Ngozi Augustine Okoronkwo, et al. Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review. Biomed Sci. 2023;9(1):18-29. doi: 10.11648/j.bs.20230901.14

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@article{10.11648/j.bs.20230901.14,
  author = {Kenneth Chinedu Ugoeze and Inderbir Singh Bakshi and Bruno Chukwuemeka Chinko and Kennedy Emeka Oluigbo and Ngozi Augustine Okoronkwo and Christian Arerusuoghene Alalor},
  title = {Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review},
  journal = {Biomedical Sciences},
  volume = {9},
  number = {1},
  pages = {18-29},
  doi = {10.11648/j.bs.20230901.14},
  url = {https://doi.org/10.11648/j.bs.20230901.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20230901.14},
  abstract = {In the last few decades, natural products have enjoyed an extensive range of acceptability for the prevention, treatment and management of various health conditions. Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a common phytoalexin found in grapes, peanuts, cocoa, and berries of Vaccinium species, together with blueberries, bilberries, and cranberries. Research interest in resveratrol has been increasing due to growing evidence of its many health benefits. This review is aimed at highlighting the various benefits of resveratrol in health and diseases. The present study reviewed published advances in the health-promoting benefits of resveratrol in human clinical trials as well as in animal experimental models with a focus on postulated molecular mechanisms of action. We discussed the sources, biochemistry, bioavailability and biological effects such as antioxidant, anti-inflammatory, anti-cancer, anti-platelet, anti-diabetic, immunomodulatory and cardio-protective, anti-obesity and neuroprotective effects. The study observed that these varieties of biotic influences are initiated by multiple molecular targets and pathways involving cyclooxygenases/lipooxygenases, kinases, sirtuins, transcription factors, cytokines, DNA polymerase, adenylyl cyclase, ribonucleotide reductase and aromatase and thus, enhancing their potential to influence many physiological processes. The study concludes that resveratrol has demonstrated a potent effect against several disease conditions, however, its low bioavailability greatly limits its applications. This review recommends further research direction in the development of health maintenance and therapeutic agents from resveratrol.},
 year = {2023}
}

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TY  - JOUR
T1  - Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review
AU  - Kenneth Chinedu Ugoeze
AU  - Inderbir Singh Bakshi
AU  - Bruno Chukwuemeka Chinko
AU  - Kennedy Emeka Oluigbo
AU  - Ngozi Augustine Okoronkwo
AU  - Christian Arerusuoghene Alalor
Y1  - 2023/03/09
PY  - 2023
N1  - https://doi.org/10.11648/j.bs.20230901.14
DO  - 10.11648/j.bs.20230901.14
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 18
EP  - 29
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20230901.14
AB  - In the last few decades, natural products have enjoyed an extensive range of acceptability for the prevention, treatment and management of various health conditions. Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a common phytoalexin found in grapes, peanuts, cocoa, and berries of Vaccinium species, together with blueberries, bilberries, and cranberries. Research interest in resveratrol has been increasing due to growing evidence of its many health benefits. This review is aimed at highlighting the various benefits of resveratrol in health and diseases. The present study reviewed published advances in the health-promoting benefits of resveratrol in human clinical trials as well as in animal experimental models with a focus on postulated molecular mechanisms of action. We discussed the sources, biochemistry, bioavailability and biological effects such as antioxidant, anti-inflammatory, anti-cancer, anti-platelet, anti-diabetic, immunomodulatory and cardio-protective, anti-obesity and neuroprotective effects. The study observed that these varieties of biotic influences are initiated by multiple molecular targets and pathways involving cyclooxygenases/lipooxygenases, kinases, sirtuins, transcription factors, cytokines, DNA polymerase, adenylyl cyclase, ribonucleotide reductase and aromatase and thus, enhancing their potential to influence many physiological processes. The study concludes that resveratrol has demonstrated a potent effect against several disease conditions, however, its low bioavailability greatly limits its applications. This review recommends further research direction in the development of health maintenance and therapeutic agents from resveratrol.
VL  - 9
IS  - 1
ER  -

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Author Information

Kenneth Chinedu Ugoeze

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Port Harcourt, Nigeria
Inderbir Singh Bakshi

Department of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Punjab, India
Bruno Chukwuemeka Chinko

Department of Human Physiology, Faculty of Basic Medical Sciences, University of Port Harcourt, Port Harcourt, Nigeria
Kennedy Emeka Oluigbo

Department of Clinical Pharmacy and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Agbani City, Nigeria
Ngozi Augustine Okoronkwo

Department of Zoology & Environmental Biology, Michael Okpara University of Agriculture, Umudike, Nigeria
Christian Arerusuoghene Alalor

Department of Pharmaceutics and Industrial Pharmacy, Delta State University, Abraka, Nigeria

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APA Style

Kenneth Chinedu Ugoeze, Inderbir Singh Bakshi, Bruno Chukwuemeka Chinko, Kennedy Emeka Oluigbo, Ngozi Augustine Okoronkwo, et al. (2023). Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review. Biomedical Sciences, 9(1), 18-29. https://doi.org/10.11648/j.bs.20230901.14

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ACS Style

Kenneth Chinedu Ugoeze; Inderbir Singh Bakshi; Bruno Chukwuemeka Chinko; Kennedy Emeka Oluigbo; Ngozi Augustine Okoronkwo, et al. Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review. Biomed. Sci. 2023, 9(1), 18-29. doi: 10.11648/j.bs.20230901.14

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AMA Style

Kenneth Chinedu Ugoeze, Inderbir Singh Bakshi, Bruno Chukwuemeka Chinko, Kennedy Emeka Oluigbo, Ngozi Augustine Okoronkwo, et al. Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review. Biomed Sci. 2023;9(1):18-29. doi: 10.11648/j.bs.20230901.14

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@article{10.11648/j.bs.20230901.14,
  author = {Kenneth Chinedu Ugoeze and Inderbir Singh Bakshi and Bruno Chukwuemeka Chinko and Kennedy Emeka Oluigbo and Ngozi Augustine Okoronkwo and Christian Arerusuoghene Alalor},
  title = {Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review},
  journal = {Biomedical Sciences},
  volume = {9},
  number = {1},
  pages = {18-29},
  doi = {10.11648/j.bs.20230901.14},
  url = {https://doi.org/10.11648/j.bs.20230901.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20230901.14},
  abstract = {In the last few decades, natural products have enjoyed an extensive range of acceptability for the prevention, treatment and management of various health conditions. Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a common phytoalexin found in grapes, peanuts, cocoa, and berries of Vaccinium species, together with blueberries, bilberries, and cranberries. Research interest in resveratrol has been increasing due to growing evidence of its many health benefits. This review is aimed at highlighting the various benefits of resveratrol in health and diseases. The present study reviewed published advances in the health-promoting benefits of resveratrol in human clinical trials as well as in animal experimental models with a focus on postulated molecular mechanisms of action. We discussed the sources, biochemistry, bioavailability and biological effects such as antioxidant, anti-inflammatory, anti-cancer, anti-platelet, anti-diabetic, immunomodulatory and cardio-protective, anti-obesity and neuroprotective effects. The study observed that these varieties of biotic influences are initiated by multiple molecular targets and pathways involving cyclooxygenases/lipooxygenases, kinases, sirtuins, transcription factors, cytokines, DNA polymerase, adenylyl cyclase, ribonucleotide reductase and aromatase and thus, enhancing their potential to influence many physiological processes. The study concludes that resveratrol has demonstrated a potent effect against several disease conditions, however, its low bioavailability greatly limits its applications. This review recommends further research direction in the development of health maintenance and therapeutic agents from resveratrol.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review
AU  - Kenneth Chinedu Ugoeze
AU  - Inderbir Singh Bakshi
AU  - Bruno Chukwuemeka Chinko
AU  - Kennedy Emeka Oluigbo
AU  - Ngozi Augustine Okoronkwo
AU  - Christian Arerusuoghene Alalor
Y1  - 2023/03/09
PY  - 2023
N1  - https://doi.org/10.11648/j.bs.20230901.14
DO  - 10.11648/j.bs.20230901.14
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 18
EP  - 29
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20230901.14
AB  - In the last few decades, natural products have enjoyed an extensive range of acceptability for the prevention, treatment and management of various health conditions. Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a common phytoalexin found in grapes, peanuts, cocoa, and berries of Vaccinium species, together with blueberries, bilberries, and cranberries. Research interest in resveratrol has been increasing due to growing evidence of its many health benefits. This review is aimed at highlighting the various benefits of resveratrol in health and diseases. The present study reviewed published advances in the health-promoting benefits of resveratrol in human clinical trials as well as in animal experimental models with a focus on postulated molecular mechanisms of action. We discussed the sources, biochemistry, bioavailability and biological effects such as antioxidant, anti-inflammatory, anti-cancer, anti-platelet, anti-diabetic, immunomodulatory and cardio-protective, anti-obesity and neuroprotective effects. The study observed that these varieties of biotic influences are initiated by multiple molecular targets and pathways involving cyclooxygenases/lipooxygenases, kinases, sirtuins, transcription factors, cytokines, DNA polymerase, adenylyl cyclase, ribonucleotide reductase and aromatase and thus, enhancing their potential to influence many physiological processes. The study concludes that resveratrol has demonstrated a potent effect against several disease conditions, however, its low bioavailability greatly limits its applications. This review recommends further research direction in the development of health maintenance and therapeutic agents from resveratrol.
VL  - 9
IS  - 1
ER  -

Copy | Download