Serological Status of Hepatitis B Virus Among Pregnant Women in the Mifi District (West Cameroon)

Juliana Vinciane Ntchimou Tochie; Pascal Blaise Well a Well a Koul; Esther Voundi-Voundi; Claire Astrid Dikosso; Christine Moubitang Matomba; Marius Mbiandjeu Tchoumke; Romaric de Manfouo Tuono; Pierre Rene Fotsing Kwetche

doi:doi:10.11648/j.bs.20230902.12

Serological Status of Hepatitis B Virus Among Pregnant Women in the Mifi District (West Cameroon)

Juliana Vinciane Ntchimou Tochie, Pascal Blaise Well a Well a Koul, Esther Voundi-Voundi, Claire Astrid Dikosso, Christine Moubitang Matomba, Marius Mbiandjeu Tchoumke, Romaric de Manfouo Tuono, Pierre Rene Fotsing Kwetche

Published in Biomedical Sciences (Volume 9, Issue 2)

Received: 8 March 2023 Accepted: 28 March 2023 Published: 11 April 2023

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Abstract

Introduction: Mother-to-child transmission is a major route of hepatitis B virus (HBV) transmission, particularly in highly endemic areas. The aim of our work was to determine the extent of HBV serological markers in pregnant women in the Mifi district (West Cameroon). Method: We conducted a descriptive cross-sectional study over a period of two months from 01 August to 02 October 2022. For the search for serological markers, we used immuno-chromatographic tests [HBV 5-in-1 Hepatitis B Virus markers Rapid Test Panel (serum/plasma), China, 2022] and enzyme-linked immunosorbent assays [Hepatitis B Virus surface Antigen (HBsAg) ELISA Test Kit, lot: HBSG37310B, China, 2022], both of which are from HIGHTOP. The markers investigated by the immuno-chromatographic tests were HBsAg, HBsAb, HBeAg, HBeAb, and HBcAb. Logistic regression analysis was performed to determine the degree of association with HBsAg carriage at the 5% significance level. Results: A total of 109 pregnant women were enrolled in the present study, the mean age was 26.89 ± 6 years with a range of 16 to 42 years. The following serological profiles were obtained in 27 (24.77%) participants and distributed as follows 19% (5/27) of the pregnant women were surface antigen positive (AgHbs +; AcHbc +); 37% (10/27) had been in contact with the virus in the past and were cured (AcHbs +; AcHbc +), 7% (2/27) had been vaccinated against hepatitis B virus (AgHBs -; Ac Hbs +; Ac anti Hbc -) and 37% (10/27) were in contact with the virus (AcHbc +). Logistic regression analyses revealed no association between socio-demographic variables and HBsAg carriage. Conclusion: In sum, the present work resulted in a prevalence of HBsAg of 4.59% (5/50); with an estimated marker positivity of 11% (12/50); 22.94% (25/50); 7.34% (8/50) and 0% for HBsAg, cAbAg, HBeAg and HBeAg respectively. Furthermore, no socio-demographic variables showed an association with HBsAg carriage.

Published in	Biomedical Sciences (Volume 9, Issue 2)
DOI	10.11648/j.bs.20230902.12
Page(s)	42-46
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Serological Markers, Viral Hepatitis B, Cameroon

References

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[2]	Hannachi N, Bahri O, Mhalla S, Marzouk M, Sadraoui A, Belguith A, Triki H, Boukadida J. Viral hepatitis B in Tunisian pregnant women: risk factors and interest of the study of viral replication in case of negative HBe antigen. Pathol. Biol. 2009; 57 (3): 43-7.
[3]	Njigou Mawouma AR, Hapsatou Djoulatou A, Komnang EO, Kimessoukie EO. Factors associated with hepatitis B infection among pregnant women in the health facilities of Mokolo District/Far North Region Cameroon. PAMJ. 2022; 41 (61): 1-16.
[4]	Njigou Mawouma AR, Hapsatou Djoulatou A, Ornella Komnang E, Omolomo Kimessoukie E. Factors associated with hepatitis B infection among pregnant women in the health facilities of Mokolo District/Far North Region of Cameroon. PAMJ. 2022; 41 (61): 1-16.
[5]	Brouard C, Gautier A, Saboni L, Jestin C, Semaille C, Beltzer N. Knowledge, perceptions and practices regarding hepatitis B and C in metropolitan France in 2010. Bull Epidemiol Hebd. 2012; 29 (30): 331-53.
[6]	Besong AA, Julius A, Peter N, Peter M. Prevalence of HBsAg and knowledge about hepatitis B in pregnancy in the Buea Health District, Cameroon: a cross-sectional study. BMC Research Notes. 2014; 7 (1): 394.
[7]	Noubiap N JJ, Nansseu N JR, Tchokfe Ndoula S, Bigna R JJ, M Jingi A, Fokom-Domgue J. Prevalence, infectivity and correlates of hepatitis B virus infection among pregnant women in a rural district of the Far North Region of Cameroon. BMC Public Health. 2015; 15 (1): 454.
[8]	8-Zayet S, Osman M, Besghaier H, BenMoussadM, Belhadj A, Bellaaj R. Prevalence of hepatitis B markers and vaccination status of health personnel. Experience of the main military training hospital of Tunis. J. Epidemiology Community Health. 2019; 67 (4): 261-6.
[9]	Katilé D, Konaté I, Goita D. Prevalence of Hbs antigen and serological profile of hepatitis B virus in general medicine consultation at the regional hospital of Kayes in Mali. HealthSci. Dis. 2018; 19 (4): 16-19.
[10]	Kengne M, Onomo Medja YF, Mbekem Nwobegahay TJ. Residual risk of transfusion transmission of hepatitis B virus infection due to donors with occult hepatitis B virus infection in Yaounde, Cameroon. Pan african medical journal. 2021; 39 (175): 1-8.
[11]	Ducancelle A, Abgueguen P, Birguel J, Mansour W, Pivert A, Le Guillou-Guillemette H et al. High endemicity and low molecular diversity of Hepatitis B virus infections in pregnant women in a Rural District of North Cameroon. Plos One. 2013; 8 (11): 1-9.
[12]	Del Canho R, Grosheide PM, Mazel JA, Heijtink RA, Hop WC, Gerards LJ, et al. Ten-year neonatal hepatitis B vaccination program. The Netherlands, 1982-1992: protective efﬁcacy and long-term immunogenicity. Vaccine 1997; 15 (15): 1624-30.
[13]	Ngui SL, Andrews NJ, Underhill GS, Heptonstall J, Teo CG. Failed postnatal immunoprophylaxis for hepatitis B: characteristics of maternal hepatitis B virus as risk factors. Clin Infect Dis 1998; 27 (1): 100-6.
[14]	Raimondo G, Meucci G, Sardo MA, Rodinò G, Campo S, Vecchi M, et al. Persistence of ''wild-type'' and ''e-minus'' hepatitis B virus infection in chronic healthy HBsAg/anti-HBe positive carriers. J Hepatol 1994; 20 (1): 148-51.
[15]	Jardi R, Rodriguez F, Buti M, Costa X, Cotrina M, Valdes A, et al. Quantitative detection of hepatitis B virus DNA in serum by a new rapid real-time ﬂuorescence PCR assay. J Viral Hepat 2001; 8 (6): 465-71.
[16]	Noubiap JJ, Ndoula ST. Prevention of mother-to-child transmission of hepatitis B: birth-dose vaccination is not enough. Lancet Glob Health. 2022; 10 (4): 455-6.

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Juliana Vinciane Ntchimou Tochie, Pascal Blaise Well a Well a Koul, Esther Voundi-Voundi, Claire Astrid Dikosso, Christine Moubitang Matomba, et al. (2023). Serological Status of Hepatitis B Virus Among Pregnant Women in the Mifi District (West Cameroon). Biomedical Sciences, 9(2), 42-46. https://doi.org/10.11648/j.bs.20230902.12

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Juliana Vinciane Ntchimou Tochie; Pascal Blaise Well a Well a Koul; Esther Voundi-Voundi; Claire Astrid Dikosso; Christine Moubitang Matomba, et al. Serological Status of Hepatitis B Virus Among Pregnant Women in the Mifi District (West Cameroon). Biomed. Sci. 2023, 9(2), 42-46. doi: 10.11648/j.bs.20230902.12

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AMA Style

Juliana Vinciane Ntchimou Tochie, Pascal Blaise Well a Well a Koul, Esther Voundi-Voundi, Claire Astrid Dikosso, Christine Moubitang Matomba, et al. Serological Status of Hepatitis B Virus Among Pregnant Women in the Mifi District (West Cameroon). Biomed Sci. 2023;9(2):42-46. doi: 10.11648/j.bs.20230902.12

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@article{10.11648/j.bs.20230902.12,
  author = {Juliana Vinciane Ntchimou Tochie and Pascal Blaise Well a Well a Koul and Esther Voundi-Voundi and Claire Astrid Dikosso and Christine Moubitang Matomba and Marius Mbiandjeu Tchoumke and Romaric de Manfouo Tuono and Pierre Rene Fotsing Kwetche},
  title = {Serological Status of Hepatitis B Virus Among Pregnant Women in the Mifi District (West Cameroon)},
  journal = {Biomedical Sciences},
  volume = {9},
  number = {2},
  pages = {42-46},
  doi = {10.11648/j.bs.20230902.12},
  url = {https://doi.org/10.11648/j.bs.20230902.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20230902.12},
  abstract = {Introduction: Mother-to-child transmission is a major route of hepatitis B virus (HBV) transmission, particularly in highly endemic areas. The aim of our work was to determine the extent of HBV serological markers in pregnant women in the Mifi district (West Cameroon). Method: We conducted a descriptive cross-sectional study over a period of two months from 01 August to 02 October 2022. For the search for serological markers, we used immuno-chromatographic tests [HBV 5-in-1 Hepatitis B Virus markers Rapid Test Panel (serum/plasma), China, 2022] and enzyme-linked immunosorbent assays [Hepatitis B Virus surface Antigen (HBsAg) ELISA Test Kit, lot: HBSG37310B, China, 2022], both of which are from HIGHTOP. The markers investigated by the immuno-chromatographic tests were HBsAg, HBsAb, HBeAg, HBeAb, and HBcAb. Logistic regression analysis was performed to determine the degree of association with HBsAg carriage at the 5% significance level. Results: A total of 109 pregnant women were enrolled in the present study, the mean age was 26.89 ± 6 years with a range of 16 to 42 years. The following serological profiles were obtained in 27 (24.77%) participants and distributed as follows 19% (5/27) of the pregnant women were surface antigen positive (AgHbs +; AcHbc +); 37% (10/27) had been in contact with the virus in the past and were cured (AcHbs +; AcHbc +), 7% (2/27) had been vaccinated against hepatitis B virus (AgHBs -; Ac Hbs +; Ac anti Hbc -) and 37% (10/27) were in contact with the virus (AcHbc +). Logistic regression analyses revealed no association between socio-demographic variables and HBsAg carriage. Conclusion: In sum, the present work resulted in a prevalence of HBsAg of 4.59% (5/50); with an estimated marker positivity of 11% (12/50); 22.94% (25/50); 7.34% (8/50) and 0% for HBsAg, cAbAg, HBeAg and HBeAg respectively. Furthermore, no socio-demographic variables showed an association with HBsAg carriage.},
 year = {2023}
}

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TY  - JOUR
T1  - Serological Status of Hepatitis B Virus Among Pregnant Women in the Mifi District (West Cameroon)
AU  - Juliana Vinciane Ntchimou Tochie
AU  - Pascal Blaise Well a Well a Koul
AU  - Esther Voundi-Voundi
AU  - Claire Astrid Dikosso
AU  - Christine Moubitang Matomba
AU  - Marius Mbiandjeu Tchoumke
AU  - Romaric de Manfouo Tuono
AU  - Pierre Rene Fotsing Kwetche
Y1  - 2023/04/11
PY  - 2023
N1  - https://doi.org/10.11648/j.bs.20230902.12
DO  - 10.11648/j.bs.20230902.12
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 42
EP  - 46
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20230902.12
AB  - Introduction: Mother-to-child transmission is a major route of hepatitis B virus (HBV) transmission, particularly in highly endemic areas. The aim of our work was to determine the extent of HBV serological markers in pregnant women in the Mifi district (West Cameroon). Method: We conducted a descriptive cross-sectional study over a period of two months from 01 August to 02 October 2022. For the search for serological markers, we used immuno-chromatographic tests [HBV 5-in-1 Hepatitis B Virus markers Rapid Test Panel (serum/plasma), China, 2022] and enzyme-linked immunosorbent assays [Hepatitis B Virus surface Antigen (HBsAg) ELISA Test Kit, lot: HBSG37310B, China, 2022], both of which are from HIGHTOP. The markers investigated by the immuno-chromatographic tests were HBsAg, HBsAb, HBeAg, HBeAb, and HBcAb. Logistic regression analysis was performed to determine the degree of association with HBsAg carriage at the 5% significance level. Results: A total of 109 pregnant women were enrolled in the present study, the mean age was 26.89 ± 6 years with a range of 16 to 42 years. The following serological profiles were obtained in 27 (24.77%) participants and distributed as follows 19% (5/27) of the pregnant women were surface antigen positive (AgHbs +; AcHbc +); 37% (10/27) had been in contact with the virus in the past and were cured (AcHbs +; AcHbc +), 7% (2/27) had been vaccinated against hepatitis B virus (AgHBs -; Ac Hbs +; Ac anti Hbc -) and 37% (10/27) were in contact with the virus (AcHbc +). Logistic regression analyses revealed no association between socio-demographic variables and HBsAg carriage. Conclusion: In sum, the present work resulted in a prevalence of HBsAg of 4.59% (5/50); with an estimated marker positivity of 11% (12/50); 22.94% (25/50); 7.34% (8/50) and 0% for HBsAg, cAbAg, HBeAg and HBeAg respectively. Furthermore, no socio-demographic variables showed an association with HBsAg carriage.
VL  - 9
IS  - 2
ER  -

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Author Information

Juliana Vinciane Ntchimou Tochie

Higher Institute of Health Sciences, Université des Montagnes, Bangangté, Cameroon
Pascal Blaise Well a Well a Koul

Higher Institute of Health Sciences, Université des Montagnes, Bangangté, Cameroon
Esther Voundi-Voundi

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Claire Astrid Dikosso

Higher Institute of Health Sciences, Université des Montagnes, Bangangté, Cameroon
Christine Moubitang Matomba

Higher Institute of Health Sciences, Université des Montagnes, Bangangté, Cameroon
Marius Mbiandjeu Tchoumke

Higher Institute of Health Sciences, Université des Montagnes, Bangangté, Cameroon
Romaric de Manfouo Tuono

Higher Institute of Health Sciences, Université des Montagnes, Bangangté, Cameroon
Pierre Rene Fotsing Kwetche

Higher Institute of Health Sciences, Université des Montagnes, Bangangté, Cameroon

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APA Style

Juliana Vinciane Ntchimou Tochie, Pascal Blaise Well a Well a Koul, Esther Voundi-Voundi, Claire Astrid Dikosso, Christine Moubitang Matomba, et al. (2023). Serological Status of Hepatitis B Virus Among Pregnant Women in the Mifi District (West Cameroon). Biomedical Sciences, 9(2), 42-46. https://doi.org/10.11648/j.bs.20230902.12

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ACS Style

Juliana Vinciane Ntchimou Tochie; Pascal Blaise Well a Well a Koul; Esther Voundi-Voundi; Claire Astrid Dikosso; Christine Moubitang Matomba, et al. Serological Status of Hepatitis B Virus Among Pregnant Women in the Mifi District (West Cameroon). Biomed. Sci. 2023, 9(2), 42-46. doi: 10.11648/j.bs.20230902.12

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AMA Style

Juliana Vinciane Ntchimou Tochie, Pascal Blaise Well a Well a Koul, Esther Voundi-Voundi, Claire Astrid Dikosso, Christine Moubitang Matomba, et al. Serological Status of Hepatitis B Virus Among Pregnant Women in the Mifi District (West Cameroon). Biomed Sci. 2023;9(2):42-46. doi: 10.11648/j.bs.20230902.12

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@article{10.11648/j.bs.20230902.12,
  author = {Juliana Vinciane Ntchimou Tochie and Pascal Blaise Well a Well a Koul and Esther Voundi-Voundi and Claire Astrid Dikosso and Christine Moubitang Matomba and Marius Mbiandjeu Tchoumke and Romaric de Manfouo Tuono and Pierre Rene Fotsing Kwetche},
  title = {Serological Status of Hepatitis B Virus Among Pregnant Women in the Mifi District (West Cameroon)},
  journal = {Biomedical Sciences},
  volume = {9},
  number = {2},
  pages = {42-46},
  doi = {10.11648/j.bs.20230902.12},
  url = {https://doi.org/10.11648/j.bs.20230902.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20230902.12},
  abstract = {Introduction: Mother-to-child transmission is a major route of hepatitis B virus (HBV) transmission, particularly in highly endemic areas. The aim of our work was to determine the extent of HBV serological markers in pregnant women in the Mifi district (West Cameroon). Method: We conducted a descriptive cross-sectional study over a period of two months from 01 August to 02 October 2022. For the search for serological markers, we used immuno-chromatographic tests [HBV 5-in-1 Hepatitis B Virus markers Rapid Test Panel (serum/plasma), China, 2022] and enzyme-linked immunosorbent assays [Hepatitis B Virus surface Antigen (HBsAg) ELISA Test Kit, lot: HBSG37310B, China, 2022], both of which are from HIGHTOP. The markers investigated by the immuno-chromatographic tests were HBsAg, HBsAb, HBeAg, HBeAb, and HBcAb. Logistic regression analysis was performed to determine the degree of association with HBsAg carriage at the 5% significance level. Results: A total of 109 pregnant women were enrolled in the present study, the mean age was 26.89 ± 6 years with a range of 16 to 42 years. The following serological profiles were obtained in 27 (24.77%) participants and distributed as follows 19% (5/27) of the pregnant women were surface antigen positive (AgHbs +; AcHbc +); 37% (10/27) had been in contact with the virus in the past and were cured (AcHbs +; AcHbc +), 7% (2/27) had been vaccinated against hepatitis B virus (AgHBs -; Ac Hbs +; Ac anti Hbc -) and 37% (10/27) were in contact with the virus (AcHbc +). Logistic regression analyses revealed no association between socio-demographic variables and HBsAg carriage. Conclusion: In sum, the present work resulted in a prevalence of HBsAg of 4.59% (5/50); with an estimated marker positivity of 11% (12/50); 22.94% (25/50); 7.34% (8/50) and 0% for HBsAg, cAbAg, HBeAg and HBeAg respectively. Furthermore, no socio-demographic variables showed an association with HBsAg carriage.},
 year = {2023}
}

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TY  - JOUR
T1  - Serological Status of Hepatitis B Virus Among Pregnant Women in the Mifi District (West Cameroon)
AU  - Juliana Vinciane Ntchimou Tochie
AU  - Pascal Blaise Well a Well a Koul
AU  - Esther Voundi-Voundi
AU  - Claire Astrid Dikosso
AU  - Christine Moubitang Matomba
AU  - Marius Mbiandjeu Tchoumke
AU  - Romaric de Manfouo Tuono
AU  - Pierre Rene Fotsing Kwetche
Y1  - 2023/04/11
PY  - 2023
N1  - https://doi.org/10.11648/j.bs.20230902.12
DO  - 10.11648/j.bs.20230902.12
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 42
EP  - 46
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20230902.12
AB  - Introduction: Mother-to-child transmission is a major route of hepatitis B virus (HBV) transmission, particularly in highly endemic areas. The aim of our work was to determine the extent of HBV serological markers in pregnant women in the Mifi district (West Cameroon). Method: We conducted a descriptive cross-sectional study over a period of two months from 01 August to 02 October 2022. For the search for serological markers, we used immuno-chromatographic tests [HBV 5-in-1 Hepatitis B Virus markers Rapid Test Panel (serum/plasma), China, 2022] and enzyme-linked immunosorbent assays [Hepatitis B Virus surface Antigen (HBsAg) ELISA Test Kit, lot: HBSG37310B, China, 2022], both of which are from HIGHTOP. The markers investigated by the immuno-chromatographic tests were HBsAg, HBsAb, HBeAg, HBeAb, and HBcAb. Logistic regression analysis was performed to determine the degree of association with HBsAg carriage at the 5% significance level. Results: A total of 109 pregnant women were enrolled in the present study, the mean age was 26.89 ± 6 years with a range of 16 to 42 years. The following serological profiles were obtained in 27 (24.77%) participants and distributed as follows 19% (5/27) of the pregnant women were surface antigen positive (AgHbs +; AcHbc +); 37% (10/27) had been in contact with the virus in the past and were cured (AcHbs +; AcHbc +), 7% (2/27) had been vaccinated against hepatitis B virus (AgHBs -; Ac Hbs +; Ac anti Hbc -) and 37% (10/27) were in contact with the virus (AcHbc +). Logistic regression analyses revealed no association between socio-demographic variables and HBsAg carriage. Conclusion: In sum, the present work resulted in a prevalence of HBsAg of 4.59% (5/50); with an estimated marker positivity of 11% (12/50); 22.94% (25/50); 7.34% (8/50) and 0% for HBsAg, cAbAg, HBeAg and HBeAg respectively. Furthermore, no socio-demographic variables showed an association with HBsAg carriage.
VL  - 9
IS  - 2
ER  -

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