Serological Status of Viral Hepatitis B and Associated Factors Among Sex Workers in Douala (Littoral-Cameroon)

Dikosso Claire Astrid; Voundi-Voundi Esther; Well a Well a Koul Pascal Blaise; Moubitang Matomba Christine; Ntchimou Tochie Juliana Vinciane; Mbiandjeu Tchoumke Marius; Romaric De Manfouo Tuono; Fotsing Kwetche Pierre Rene

doi:doi:10.11648/j.bs.20230902.13

Serological Status of Viral Hepatitis B and Associated Factors Among Sex Workers in Douala (Littoral-Cameroon)

Dikosso Claire Astrid, Voundi-Voundi Esther, Well a Well a Koul Pascal Blaise, Moubitang Matomba Christine, Ntchimou Tochie Juliana Vinciane, Mbiandjeu Tchoumke Marius, Romaric De Manfouo Tuono, Fotsing Kwetche Pierre Rene

Published in Biomedical Sciences (Volume 9, Issue 2)

Received: 17 April 2023 Accepted: 28 April 2023 Published: 17 May 2023

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Abstract

Introduction: Viral Hepatitis B (VHB) is a real concern for international organisations in general and the Cameroonian authorities in particular; our work aimed to determine the serological status of VHB as well as the associated factors among female sex workers (FSWs) in the city of Douala. Method: We conducted a descriptive cross-sectional study over a period of two months from 01 August to 02 October 2022. For the detection of serological markers, we used immuno-chromatographic tests [HBV 5-in-1 Hepatitis B Virus markers Rapid Test Panel (batch number; China, 2022)] and enzyme-linked immunosorbent assays [Hepatitis B Virus surface Antigen (HBsAg) ELISA Test Kit, batch number: HBSG37310B, China, 2022], both of HIGHTOP brand. The markers investigated by the immuno-chromatographic tests were HBsAg, HBsAb, HBeAg, HBeAb, and cHbAb. Logistic regression analysis was performed to determine the degree of association with HBsAg carriage at the 5% significance level. Results: A total of 87 participants were included in the present work, with a mean age of 29.66 ± 6.24 years, ranging from 18 to 43 years; furthermore, the serological profiles obtained in these TS were distributed as follows: 1% (1/87) of the participants were infected with the presence of viral activity; 7% (6/87) were infected with the absence of viral activity; 19% (17/87) had received a vaccine; 13% (11/87) had been in contact with the virus; 7% (6/87) had been in contact with the virus in the past and were cured; and 53% (46/87) were not infected; However, univariate regression analyses showed that primary education (OR= 0.042; 95% CI = 0.002-0.973; P=0.048); secondary education (OR= 0.034; 95% CI = 0.003-0.459; P=0.011); barmaid activity (OR= 0.030; 95% CI = 0.002-0.495; P=0.014) and shopkeeper activity (OR= 0.056; 95% CI = 0.003-0.923; P=0.044) were significantly associated with HBsAg carriage Conclusion: The present study shows that a variety of serological profiles of HBV were found among SWs in the city of Douala; however, the implementation of large-scale sensitization campaigns (via the media, social networks, and within schools) and expanded vaccination programmes against HBV throughout the country would help reduce its prevalence.

Published in	Biomedical Sciences (Volume 9, Issue 2)
DOI	10.11648/j.bs.20230902.13
Page(s)	47-52
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Hepatitis B, Sex Workers, Cameroon

References

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[2]	Zoumana Doumbia. Seroprevalence of hepatitis b markers among female sex workers in the mining area of kenieba [Thesis]. Bamako: Faculty of Pharmacy; 2021. 96P.
[3]	Fournier C, Zoulim F. Antivirals in hepatitis B: mode of action and resistance. 2006; 9 (4): 1-6.
[4]	Bagnaka S, Luma H, Kapsang N, Bekolo W, Malongue A and Noah N. Chronic hepatitis B virus catchment strategy according to the World Health Organization: case of Douala general hospital. 2017.
[5]	WHO., Hepatitis B, Fac sheet N°204, Update July 2015 [Internet]. 2015 [cited 2015 Sep 16]. Available from: http://www.who.int/mediacentre/factsheets/fs204/en/
[6]	World Health Organization. Sexually Transmitted Infections. 2019.
[7]	Sandrine Marie-Odile Soudré, Madia Sandrine Mvodo, Zanga Damien Ouattara, Steve Léonce Zoungrana Mali Koura, Aboubacar Coulibaly, Sosthène Somda, Alain Bougouma, Arsène Roger Sombié. Knowledge of Sex Workers in the City of Ouagadougou on Viral Hepatitis B and Human Immunodeficiency Virus/AIDS: A Cross-Sectional Study. Health Sci. Dis. November 2021; 22 (11): 108-112.
[8]	Ouedraogo HG, Nikiema AR, Cisse K, Ky-Zerbo O, Samadoulougou BC, Ouedraogo AM, Traore Y, Ouedraogo/Traore R, Barro N, Kouanda S. Hepatitis B virus carriage among female sex workers in three secondary cities of Burkina Faso: Koudougou, Ouahigouya and Tenkodogo. Rev Mali Infect Microbiol. 2019; 14 (1): 32-42.
[9]	Katilé D, Konaté I, Goita D. Prevalence of Hbs antigen and serological profile of hepatitis B virus in general medicine consultation at the regional hospital of Kayes in Mali. HealthSci. Dis. 2018; 19 (4): 16-19.
[10]	Del Canho R, Grosheide PM, Mazel JA, Heijtink RA, Hop WC, Gerards LJ, et al. Ten-year neonatal hepatitis B vaccination program. The Netherlands, 1982-1992: protective efﬁcacy and long-term immunogenicity. Vaccine 1997; 15 (15): 1624-30.
[11]	Ngui SL, Andrews NJ, Underhill GS, Heptonstall J, Teo CG. Failed postnatal immunoprophylaxis for hepatitis B: characteristics of maternal hepatitis B virus as risk factors. Clin Infect Dis 1998; 27 (1): 100-6.
[12]	Raimondo G, Meucci G, Sardo MA, Rodinò G, Campo S, Vecchi M, et al. Persistence of ''wild-type'' and ''e-minus'' hepatitis B virus infection in chronic healthy HBsAg/anti-HBe positive carriers. J Hepatol 1994; 20 (1): 148-51.
[13]	Jardi R, Rodriguez F, Buti M, Costa X, Cotrina M, Valdes A, et al. Quantitative detection of hepatitis B virus DNA in serum by a new rapid real-time ﬂuorescence PCR assay. J Viral Hepat 2001; 8 (6): 465-71.
[14]	Zayet S, Osman M, Besghaier H, BenMoussadM, Belhadj A, Bellaaj R. Prevalence of hepatitis B markers and vaccination status of health personnel. Experience of the main military training hospital of Tunis. J. Epidemiology Community Health. 2019; 67 (4): 261-6.

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Dikosso Claire Astrid, Voundi-Voundi Esther, Well a Well a Koul Pascal Blaise, Moubitang Matomba Christine, Ntchimou Tochie Juliana Vinciane, et al. (2023). Serological Status of Viral Hepatitis B and Associated Factors Among Sex Workers in Douala (Littoral-Cameroon). Biomedical Sciences, 9(2), 47-52. https://doi.org/10.11648/j.bs.20230902.13

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Dikosso Claire Astrid; Voundi-Voundi Esther; Well a Well a Koul Pascal Blaise; Moubitang Matomba Christine; Ntchimou Tochie Juliana Vinciane, et al. Serological Status of Viral Hepatitis B and Associated Factors Among Sex Workers in Douala (Littoral-Cameroon). Biomed. Sci. 2023, 9(2), 47-52. doi: 10.11648/j.bs.20230902.13

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Dikosso Claire Astrid, Voundi-Voundi Esther, Well a Well a Koul Pascal Blaise, Moubitang Matomba Christine, Ntchimou Tochie Juliana Vinciane, et al. Serological Status of Viral Hepatitis B and Associated Factors Among Sex Workers in Douala (Littoral-Cameroon). Biomed Sci. 2023;9(2):47-52. doi: 10.11648/j.bs.20230902.13

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@article{10.11648/j.bs.20230902.13,
  author = {Dikosso Claire Astrid and Voundi-Voundi Esther and Well a Well a Koul Pascal Blaise and Moubitang Matomba Christine and Ntchimou Tochie Juliana Vinciane and Mbiandjeu Tchoumke Marius and Romaric De Manfouo Tuono and Fotsing Kwetche Pierre Rene},
  title = {Serological Status of Viral Hepatitis B and Associated Factors Among Sex Workers in Douala (Littoral-Cameroon)},
  journal = {Biomedical Sciences},
  volume = {9},
  number = {2},
  pages = {47-52},
  doi = {10.11648/j.bs.20230902.13},
  url = {https://doi.org/10.11648/j.bs.20230902.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20230902.13},
  abstract = {Introduction: Viral Hepatitis B (VHB) is a real concern for international organisations in general and the Cameroonian authorities in particular; our work aimed to determine the serological status of VHB as well as the associated factors among female sex workers (FSWs) in the city of Douala. Method: We conducted a descriptive cross-sectional study over a period of two months from 01 August to 02 October 2022. For the detection of serological markers, we used immuno-chromatographic tests [HBV 5-in-1 Hepatitis B Virus markers Rapid Test Panel (batch number; China, 2022)] and enzyme-linked immunosorbent assays [Hepatitis B Virus surface Antigen (HBsAg) ELISA Test Kit, batch number: HBSG37310B, China, 2022], both of HIGHTOP brand. The markers investigated by the immuno-chromatographic tests were HBsAg, HBsAb, HBeAg, HBeAb, and cHbAb. Logistic regression analysis was performed to determine the degree of association with HBsAg carriage at the 5% significance level. Results: A total of 87 participants were included in the present work, with a mean age of 29.66 ± 6.24 years, ranging from 18 to 43 years; furthermore, the serological profiles obtained in these TS were distributed as follows: 1% (1/87) of the participants were infected with the presence of viral activity; 7% (6/87) were infected with the absence of viral activity; 19% (17/87) had received a vaccine; 13% (11/87) had been in contact with the virus; 7% (6/87) had been in contact with the virus in the past and were cured; and 53% (46/87) were not infected; However, univariate regression analyses showed that primary education (OR= 0.042; 95% CI = 0.002-0.973; P=0.048); secondary education (OR= 0.034; 95% CI = 0.003-0.459; P=0.011); barmaid activity (OR= 0.030; 95% CI = 0.002-0.495; P=0.014) and shopkeeper activity (OR= 0.056; 95% CI = 0.003-0.923; P=0.044) were significantly associated with HBsAg carriage Conclusion: The present study shows that a variety of serological profiles of HBV were found among SWs in the city of Douala; however, the implementation of large-scale sensitization campaigns (via the media, social networks, and within schools) and expanded vaccination programmes against HBV throughout the country would help reduce its prevalence.},
 year = {2023}
}

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TY  - JOUR
T1  - Serological Status of Viral Hepatitis B and Associated Factors Among Sex Workers in Douala (Littoral-Cameroon)
AU  - Dikosso Claire Astrid
AU  - Voundi-Voundi Esther
AU  - Well a Well a Koul Pascal Blaise
AU  - Moubitang Matomba Christine
AU  - Ntchimou Tochie Juliana Vinciane
AU  - Mbiandjeu Tchoumke Marius
AU  - Romaric De Manfouo Tuono
AU  - Fotsing Kwetche Pierre Rene
Y1  - 2023/05/17
PY  - 2023
N1  - https://doi.org/10.11648/j.bs.20230902.13
DO  - 10.11648/j.bs.20230902.13
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 47
EP  - 52
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20230902.13
AB  - Introduction: Viral Hepatitis B (VHB) is a real concern for international organisations in general and the Cameroonian authorities in particular; our work aimed to determine the serological status of VHB as well as the associated factors among female sex workers (FSWs) in the city of Douala. Method: We conducted a descriptive cross-sectional study over a period of two months from 01 August to 02 October 2022. For the detection of serological markers, we used immuno-chromatographic tests [HBV 5-in-1 Hepatitis B Virus markers Rapid Test Panel (batch number; China, 2022)] and enzyme-linked immunosorbent assays [Hepatitis B Virus surface Antigen (HBsAg) ELISA Test Kit, batch number: HBSG37310B, China, 2022], both of HIGHTOP brand. The markers investigated by the immuno-chromatographic tests were HBsAg, HBsAb, HBeAg, HBeAb, and cHbAb. Logistic regression analysis was performed to determine the degree of association with HBsAg carriage at the 5% significance level. Results: A total of 87 participants were included in the present work, with a mean age of 29.66 ± 6.24 years, ranging from 18 to 43 years; furthermore, the serological profiles obtained in these TS were distributed as follows: 1% (1/87) of the participants were infected with the presence of viral activity; 7% (6/87) were infected with the absence of viral activity; 19% (17/87) had received a vaccine; 13% (11/87) had been in contact with the virus; 7% (6/87) had been in contact with the virus in the past and were cured; and 53% (46/87) were not infected; However, univariate regression analyses showed that primary education (OR= 0.042; 95% CI = 0.002-0.973; P=0.048); secondary education (OR= 0.034; 95% CI = 0.003-0.459; P=0.011); barmaid activity (OR= 0.030; 95% CI = 0.002-0.495; P=0.014) and shopkeeper activity (OR= 0.056; 95% CI = 0.003-0.923; P=0.044) were significantly associated with HBsAg carriage Conclusion: The present study shows that a variety of serological profiles of HBV were found among SWs in the city of Douala; however, the implementation of large-scale sensitization campaigns (via the media, social networks, and within schools) and expanded vaccination programmes against HBV throughout the country would help reduce its prevalence.
VL  - 9
IS  - 2
ER  -

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Author Information

Dikosso Claire Astrid

Higher Institute of Health Sciences, Université des Montagnes, Bangangte, Cameroon
Voundi-Voundi Esther

Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon
Well a Well a Koul Pascal Blaise

Higher Institute of Health Sciences, Université des Montagnes, Bangangte, Cameroon
Moubitang Matomba Christine

Higher Institute of Health Sciences, Université des Montagnes, Bangangte, Cameroon
Ntchimou Tochie Juliana Vinciane

Higher Institute of Health Sciences, Université des Montagnes, Bangangte, Cameroon
Mbiandjeu Tchoumke Marius

Higher Institute of Health Sciences, Université des Montagnes, Bangangte, Cameroon
Romaric De Manfouo Tuono

Higher Institute of Health Sciences, Université des Montagnes, Bangangte, Cameroon
Fotsing Kwetche Pierre Rene

Higher Institute of Health Sciences, Université des Montagnes, Bangangte, Cameroon

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Dikosso Claire Astrid, Voundi-Voundi Esther, Well a Well a Koul Pascal Blaise, Moubitang Matomba Christine, Ntchimou Tochie Juliana Vinciane, et al. (2023). Serological Status of Viral Hepatitis B and Associated Factors Among Sex Workers in Douala (Littoral-Cameroon). Biomedical Sciences, 9(2), 47-52. https://doi.org/10.11648/j.bs.20230902.13

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ACS Style

Dikosso Claire Astrid; Voundi-Voundi Esther; Well a Well a Koul Pascal Blaise; Moubitang Matomba Christine; Ntchimou Tochie Juliana Vinciane, et al. Serological Status of Viral Hepatitis B and Associated Factors Among Sex Workers in Douala (Littoral-Cameroon). Biomed. Sci. 2023, 9(2), 47-52. doi: 10.11648/j.bs.20230902.13

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AMA Style

Dikosso Claire Astrid, Voundi-Voundi Esther, Well a Well a Koul Pascal Blaise, Moubitang Matomba Christine, Ntchimou Tochie Juliana Vinciane, et al. Serological Status of Viral Hepatitis B and Associated Factors Among Sex Workers in Douala (Littoral-Cameroon). Biomed Sci. 2023;9(2):47-52. doi: 10.11648/j.bs.20230902.13

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@article{10.11648/j.bs.20230902.13,
  author = {Dikosso Claire Astrid and Voundi-Voundi Esther and Well a Well a Koul Pascal Blaise and Moubitang Matomba Christine and Ntchimou Tochie Juliana Vinciane and Mbiandjeu Tchoumke Marius and Romaric De Manfouo Tuono and Fotsing Kwetche Pierre Rene},
  title = {Serological Status of Viral Hepatitis B and Associated Factors Among Sex Workers in Douala (Littoral-Cameroon)},
  journal = {Biomedical Sciences},
  volume = {9},
  number = {2},
  pages = {47-52},
  doi = {10.11648/j.bs.20230902.13},
  url = {https://doi.org/10.11648/j.bs.20230902.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20230902.13},
  abstract = {Introduction: Viral Hepatitis B (VHB) is a real concern for international organisations in general and the Cameroonian authorities in particular; our work aimed to determine the serological status of VHB as well as the associated factors among female sex workers (FSWs) in the city of Douala. Method: We conducted a descriptive cross-sectional study over a period of two months from 01 August to 02 October 2022. For the detection of serological markers, we used immuno-chromatographic tests [HBV 5-in-1 Hepatitis B Virus markers Rapid Test Panel (batch number; China, 2022)] and enzyme-linked immunosorbent assays [Hepatitis B Virus surface Antigen (HBsAg) ELISA Test Kit, batch number: HBSG37310B, China, 2022], both of HIGHTOP brand. The markers investigated by the immuno-chromatographic tests were HBsAg, HBsAb, HBeAg, HBeAb, and cHbAb. Logistic regression analysis was performed to determine the degree of association with HBsAg carriage at the 5% significance level. Results: A total of 87 participants were included in the present work, with a mean age of 29.66 ± 6.24 years, ranging from 18 to 43 years; furthermore, the serological profiles obtained in these TS were distributed as follows: 1% (1/87) of the participants were infected with the presence of viral activity; 7% (6/87) were infected with the absence of viral activity; 19% (17/87) had received a vaccine; 13% (11/87) had been in contact with the virus; 7% (6/87) had been in contact with the virus in the past and were cured; and 53% (46/87) were not infected; However, univariate regression analyses showed that primary education (OR= 0.042; 95% CI = 0.002-0.973; P=0.048); secondary education (OR= 0.034; 95% CI = 0.003-0.459; P=0.011); barmaid activity (OR= 0.030; 95% CI = 0.002-0.495; P=0.014) and shopkeeper activity (OR= 0.056; 95% CI = 0.003-0.923; P=0.044) were significantly associated with HBsAg carriage Conclusion: The present study shows that a variety of serological profiles of HBV were found among SWs in the city of Douala; however, the implementation of large-scale sensitization campaigns (via the media, social networks, and within schools) and expanded vaccination programmes against HBV throughout the country would help reduce its prevalence.},
 year = {2023}
}

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TY  - JOUR
T1  - Serological Status of Viral Hepatitis B and Associated Factors Among Sex Workers in Douala (Littoral-Cameroon)
AU  - Dikosso Claire Astrid
AU  - Voundi-Voundi Esther
AU  - Well a Well a Koul Pascal Blaise
AU  - Moubitang Matomba Christine
AU  - Ntchimou Tochie Juliana Vinciane
AU  - Mbiandjeu Tchoumke Marius
AU  - Romaric De Manfouo Tuono
AU  - Fotsing Kwetche Pierre Rene
Y1  - 2023/05/17
PY  - 2023
N1  - https://doi.org/10.11648/j.bs.20230902.13
DO  - 10.11648/j.bs.20230902.13
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 47
EP  - 52
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20230902.13
AB  - Introduction: Viral Hepatitis B (VHB) is a real concern for international organisations in general and the Cameroonian authorities in particular; our work aimed to determine the serological status of VHB as well as the associated factors among female sex workers (FSWs) in the city of Douala. Method: We conducted a descriptive cross-sectional study over a period of two months from 01 August to 02 October 2022. For the detection of serological markers, we used immuno-chromatographic tests [HBV 5-in-1 Hepatitis B Virus markers Rapid Test Panel (batch number; China, 2022)] and enzyme-linked immunosorbent assays [Hepatitis B Virus surface Antigen (HBsAg) ELISA Test Kit, batch number: HBSG37310B, China, 2022], both of HIGHTOP brand. The markers investigated by the immuno-chromatographic tests were HBsAg, HBsAb, HBeAg, HBeAb, and cHbAb. Logistic regression analysis was performed to determine the degree of association with HBsAg carriage at the 5% significance level. Results: A total of 87 participants were included in the present work, with a mean age of 29.66 ± 6.24 years, ranging from 18 to 43 years; furthermore, the serological profiles obtained in these TS were distributed as follows: 1% (1/87) of the participants were infected with the presence of viral activity; 7% (6/87) were infected with the absence of viral activity; 19% (17/87) had received a vaccine; 13% (11/87) had been in contact with the virus; 7% (6/87) had been in contact with the virus in the past and were cured; and 53% (46/87) were not infected; However, univariate regression analyses showed that primary education (OR= 0.042; 95% CI = 0.002-0.973; P=0.048); secondary education (OR= 0.034; 95% CI = 0.003-0.459; P=0.011); barmaid activity (OR= 0.030; 95% CI = 0.002-0.495; P=0.014) and shopkeeper activity (OR= 0.056; 95% CI = 0.003-0.923; P=0.044) were significantly associated with HBsAg carriage Conclusion: The present study shows that a variety of serological profiles of HBV were found among SWs in the city of Douala; however, the implementation of large-scale sensitization campaigns (via the media, social networks, and within schools) and expanded vaccination programmes against HBV throughout the country would help reduce its prevalence.
VL  - 9
IS  - 2
ER  -

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