Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance

Danny Mafuta-Munganga; Benjamin Longo-Mbenza; Reine Freudlendrich Eboka-Loumingou Sakou; Etienne Mokondjimobe; Gombet Thierry Raoul Alexis; Moise Mvitu; Mireille Nganga; Christian Kisoka Lusunsi

doi:doi:10.11648/j.ccr.20220602.12

Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance

Danny Mafuta-Munganga, Benjamin Longo-Mbenza, Reine Freudlendrich Eboka-Loumingou Sakou, Etienne Mokondjimobe, Gombet Thierry Raoul Alexis, Moise Mvitu, Mireille Nganga, Christian Kisoka Lusunsi

Published in Cardiology and Cardiovascular Research (Volume 6, Issue 2)

Received: 9 March 2022 Accepted: 24 March 2022 Published: 26 April 2022

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Back ground: Tumor necrosis factor-alpha (TNF-α), adiponectin (ADP) and C-reactive protein (CRP) are associated with the risk of cardiovascular or non communicable diseases. Aims: To evaluate the association between TNF-α, ADP, CRP and metabolic markers in Congelese Bantu from Brazzaville. Methods: A cross-sectional case-control study was conducted during the period from July 2018 to February 2021. A total of 233 participants were recruited then divided into 130 healthy participants (control group) and 103 insulin resistant patients (case group). The Spearman correlation coefficient was calculated in order to search for an association between TNFα, ADP and the metabolic markers. An exponential nonlinear regression was used for the analysis of the association between TNFα (dependent variable) and CRP. Results: Participants were aged of 45.5 ± 13.1 years with a median BMI of 25.4 kg/m², were included in this study. The median values of TNFα, CRP, ADP and HOMA-IR were 96.2 pg/mL, 12.3 mg/L, 8.6 ng/mL and 2.3, respectively. TNFα was positively correlated with anthropometric parameters, CRP and insulin resistance. In contrast, ADP was negatively correlated with anthropometric parameters, CRP and insulin resistance. In control group, the equation was written as TNF alpha = 187 * (1 - 0.96^CRP). The model shows that CRP explains 84.62% of the variability of TNFα in healthy participants. In case group, the equation was written as TNF alpha = 186.4 * (1 - 0.95^CRP). The model shows that CRP explains 93.65% of the variability of TNFα in insulin-resistant participants. Conclusion: TNF alpha and ADP are associated at NC, WC, WHR, WHtR, LDL, CRP and insulin resistance in Congolese Bantu from Brazzaville.

Published in	Cardiology and Cardiovascular Research (Volume 6, Issue 2)
DOI	10.11648/j.ccr.20220602.12
Page(s)	55-59
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

TNF Alpha, Adiponectin, Obesity, Insulin Resistance, Bantu, Brazzaville

References

[1]	Alzamil, H. (2020). Elevated Serum TNF-α Is Related to Obesity in Type 2 Diabetes Mellitus and Is Associated with Glycemic Control and Insulin Resistance. Journal of Obesity, 5 pages.
[2]	Asai, K., Hiki, N., Mimura, Y., Ogawa, T., Unou, K., & Kaminishi, M. (2001). Gender differences in cytokine secretion by human peripheral blood mononuclear cells: Role of estrogen in modulating LPS-induced cytokine secretion in an ex vivo septic model. Shock, 16, 340–343.
[3]	Bonora, E., Targher, G., Alberiche, M., Bonadonna, R., Saggiani, F., & Zenere, M. (2000). Homeostasis Model Assessment Closely Mirrors the Glucose Clamp Technique in the Assessment of Insulin Sensitivity. Diabetes Care, 23, 57-63.
[4]	Bouman, A., Schipper, M., Heineman, M., & Faas, M. (2004). Gender difference in the non-specific and specific immune response in humans. Am. J. Reprod. Immunol., 52, 19–26.
[5]	Calabró, P., Willerson, J., & Yeh, E. (2003). Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells. Circulation, 108 (16), 1930-2.
[6]	Hitoshi, N., Iichiro, S., Ken, K., Norikazu, M., Hiroshi, K., Hiroyuki, N., et al. (2002). Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein. Diabetes 51:, 51, 2734–2741.
[7]	Hotamisligil, G. S., & Spiegelman, B. M. (1994). Tumor Necrosis Factor a: A Key Component of the Obesity-Diabetes Link. Diabetes, 1271-1278.
[8]	Kamil, J., Wojciech, M., Piotr, P., & Grzegorz, K. (2019). Triglyceride-to-High-Density Lipoprotein Cholesterol Ratio and Systemic Inflammation in Patients with Idiopathic Pulmonary Arterial Hypertension. Med Sci Monit, 25, 746-753.
[9]	Mehaffey, E., & Majid, D. S. (2017). Tumor necrosis factor-alpha, kidney function, and hypertension. Am J Physiol Renal Physiol, F1005-F1008.
[10]	Plomgaard, P., Nielsen, A., Fischer, C., Mortensen, O., Broholm, C., & Penkowa, M. (2007). Associations between insulin resistance and TNF-α in plasma, skeletal muscle and adipose tissue in humans with and without type 2 diabetes. Diabetologia, 50, 2562–2571.
[11]	Sanchez-Garcıa, A., Rodrıguez-Gutierrez, R., Mancillas-Adame, L., Gonzalez-Nava, V., Gonzalez-Colmenero, A., & Cesar Solis, R. (2020). Diagnostic Accuracy of the Triglyceride and Glucose Index for Insulin Resistance: A Systematic Review. Hindawi International Journal of Endocrinology, 7 pages.
[12]	Sproston, N., & Ashworth, J. (2018). Role of C-Reactive Protein at Sites of Inflammation and Infection. Front. Immunol., 9.
[13]	Swaroop, J. J., Rajarajeswari, D., & Naidu, J. (2012). Association of TNF-α with insulin resistance in type 2 diabetes mellitus. Indian J Med Res, 135, 127-130.
[14]	Ter Horst, R., Jaeger, M., Smeekens, S., Oosting, M., Swertz, M., Li, Y., et al. (2016). Host and environmental factors influencing individual human cytokine responses. Cell, 167, 1111–1124.
[15]	Yeo, E.-S., Hwang, J.-Y., Park, J. E., Choi, Y. J., Huh, K. B., & Kim, W. Y. (2010). Tumor Necrosis Factor (TNF-α) and C-reactive Protein (CRP) are Positively Associated with the Risk of Chronic Kidney Disease in Patients with Type 2 Diabetes. Yonsei Med J, 51 (4), 519-525.
[16]	Yudkin, J., Stehouwer, C., Emeis, J., & Coppack, S. (1999). C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol, 19, 972-8.

Cite This Article

Plain Text BibTeX RIS

APA Style

Danny Mafuta-Munganga, Benjamin Longo-Mbenza, Reine Freudlendrich Eboka-Loumingou Sakou, Etienne Mokondjimobe, Gombet Thierry Raoul Alexis, et al. (2022). Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance. Cardiology and Cardiovascular Research, 6(2), 55-59. https://doi.org/10.11648/j.ccr.20220602.12

Copy | Download

ACS Style

Danny Mafuta-Munganga; Benjamin Longo-Mbenza; Reine Freudlendrich Eboka-Loumingou Sakou; Etienne Mokondjimobe; Gombet Thierry Raoul Alexis, et al. Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance. Cardiol. Cardiovasc. Res. 2022, 6(2), 55-59. doi: 10.11648/j.ccr.20220602.12

Copy | Download

AMA Style

Danny Mafuta-Munganga, Benjamin Longo-Mbenza, Reine Freudlendrich Eboka-Loumingou Sakou, Etienne Mokondjimobe, Gombet Thierry Raoul Alexis, et al. Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance. Cardiol Cardiovasc Res. 2022;6(2):55-59. doi: 10.11648/j.ccr.20220602.12

Copy | Download

@article{10.11648/j.ccr.20220602.12,
  author = {Danny Mafuta-Munganga and Benjamin Longo-Mbenza and Reine Freudlendrich Eboka-Loumingou Sakou and Etienne Mokondjimobe and Gombet Thierry Raoul Alexis and Moise Mvitu and Mireille Nganga and Christian Kisoka Lusunsi},
  title = {Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance},
  journal = {Cardiology and Cardiovascular Research},
  volume = {6},
  number = {2},
  pages = {55-59},
  doi = {10.11648/j.ccr.20220602.12},
  url = {https://doi.org/10.11648/j.ccr.20220602.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20220602.12},
  abstract = {Back ground: Tumor necrosis factor-alpha (TNF-α), adiponectin (ADP) and C-reactive protein (CRP) are associated with the risk of cardiovascular or non communicable diseases. Aims: To evaluate the association between TNF-α, ADP, CRP and metabolic markers in Congelese Bantu from Brazzaville. Methods: A cross-sectional case-control study was conducted during the period from July 2018 to February 2021. A total of 233 participants were recruited then divided into 130 healthy participants (control group) and 103 insulin resistant patients (case group). The Spearman correlation coefficient was calculated in order to search for an association between TNFα, ADP and the metabolic markers. An exponential nonlinear regression was used for the analysis of the association between TNFα (dependent variable) and CRP. Results: Participants were aged of 45.5 ± 13.1 years with a median BMI of 25.4 kg/m2, were included in this study. The median values of TNFα, CRP, ADP and HOMA-IR were 96.2 pg/mL, 12.3 mg/L, 8.6 ng/mL and 2.3, respectively. TNFα was positively correlated with anthropometric parameters, CRP and insulin resistance. In contrast, ADP was negatively correlated with anthropometric parameters, CRP and insulin resistance. In control group, the equation was written as TNF alpha = 187 * (1 - 0.96CRP). The model shows that CRP explains 84.62% of the variability of TNFα in healthy participants. In case group, the equation was written as TNF alpha = 186.4 * (1 - 0.95CRP). The model shows that CRP explains 93.65% of the variability of TNFα in insulin-resistant participants. Conclusion: TNF alpha and ADP are associated at NC, WC, WHR, WHtR, LDL, CRP and insulin resistance in Congolese Bantu from Brazzaville.},
 year = {2022}
}

Copy | Download

TY - JOUR
T1 - Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance
AU - Danny Mafuta-Munganga
AU - Benjamin Longo-Mbenza
AU - Reine Freudlendrich Eboka-Loumingou Sakou
AU - Etienne Mokondjimobe
AU - Gombet Thierry Raoul Alexis
AU - Moise Mvitu
AU - Mireille Nganga
AU - Christian Kisoka Lusunsi
Y1 - 2022/04/26
PY - 2022
N1 - https://doi.org/10.11648/j.ccr.20220602.12
DO - 10.11648/j.ccr.20220602.12
T2 - Cardiology and Cardiovascular Research
JF - Cardiology and Cardiovascular Research
JO - Cardiology and Cardiovascular Research
SP - 55
EP - 59
PB - Science Publishing Group
SN - 2578-8914
UR - https://doi.org/10.11648/j.ccr.20220602.12
AB - Back ground: Tumor necrosis factor-alpha (TNF-α), adiponectin (ADP) and C-reactive protein (CRP) are associated with the risk of cardiovascular or non communicable diseases. Aims: To evaluate the association between TNF-α, ADP, CRP and metabolic markers in Congelese Bantu from Brazzaville. Methods: A cross-sectional case-control study was conducted during the period from July 2018 to February 2021. A total of 233 participants were recruited then divided into 130 healthy participants (control group) and 103 insulin resistant patients (case group). The Spearman correlation coefficient was calculated in order to search for an association between TNFα, ADP and the metabolic markers. An exponential nonlinear regression was used for the analysis of the association between TNFα (dependent variable) and CRP. Results: Participants were aged of 45.5 ± 13.1 years with a median BMI of 25.4 kg/m2, were included in this study. The median values of TNFα, CRP, ADP and HOMA-IR were 96.2 pg/mL, 12.3 mg/L, 8.6 ng/mL and 2.3, respectively. TNFα was positively correlated with anthropometric parameters, CRP and insulin resistance. In contrast, ADP was negatively correlated with anthropometric parameters, CRP and insulin resistance. In control group, the equation was written as TNF alpha = 187 * (1 - 0.96CRP). The model shows that CRP explains 84.62% of the variability of TNFα in healthy participants. In case group, the equation was written as TNF alpha = 186.4 * (1 - 0.95CRP). The model shows that CRP explains 93.65% of the variability of TNFα in insulin-resistant participants. Conclusion: TNF alpha and ADP are associated at NC, WC, WHR, WHtR, LDL, CRP and insulin resistance in Congolese Bantu from Brazzaville.
VL - 6
IS - 2
ER -

Copy | Download

Author Information

Danny Mafuta-Munganga

Department of Internal Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo
Benjamin Longo-Mbenza

Department of Internal Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo
Reine Freudlendrich Eboka-Loumingou Sakou

Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo
Etienne Mokondjimobe

Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo
Gombet Thierry Raoul Alexis

Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo
Moise Mvitu

Faculty of Health Sciences, Kongo University, Kongo-Central, Democratic Republic of Congo
Mireille Nganga

Department of Clinical Biology, Faculty of Medicine, University of Kinshasa, Kinshasa, DR of Congo
Christian Kisoka Lusunsi

Department of Public Health, Lomo University of Research, Kinshasa, Democratic Republic of Congo

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Danny Mafuta-Munganga, Benjamin Longo-Mbenza, Reine Freudlendrich Eboka-Loumingou Sakou, Etienne Mokondjimobe, Gombet Thierry Raoul Alexis, et al. (2022). Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance. Cardiology and Cardiovascular Research, 6(2), 55-59. https://doi.org/10.11648/j.ccr.20220602.12

Copy | Download

ACS Style

Danny Mafuta-Munganga; Benjamin Longo-Mbenza; Reine Freudlendrich Eboka-Loumingou Sakou; Etienne Mokondjimobe; Gombet Thierry Raoul Alexis, et al. Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance. Cardiol. Cardiovasc. Res. 2022, 6(2), 55-59. doi: 10.11648/j.ccr.20220602.12

Copy | Download

AMA Style

Danny Mafuta-Munganga, Benjamin Longo-Mbenza, Reine Freudlendrich Eboka-Loumingou Sakou, Etienne Mokondjimobe, Gombet Thierry Raoul Alexis, et al. Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance. Cardiol Cardiovasc Res. 2022;6(2):55-59. doi: 10.11648/j.ccr.20220602.12

Copy | Download

@article{10.11648/j.ccr.20220602.12,
  author = {Danny Mafuta-Munganga and Benjamin Longo-Mbenza and Reine Freudlendrich Eboka-Loumingou Sakou and Etienne Mokondjimobe and Gombet Thierry Raoul Alexis and Moise Mvitu and Mireille Nganga and Christian Kisoka Lusunsi},
  title = {Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance},
  journal = {Cardiology and Cardiovascular Research},
  volume = {6},
  number = {2},
  pages = {55-59},
  doi = {10.11648/j.ccr.20220602.12},
  url = {https://doi.org/10.11648/j.ccr.20220602.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20220602.12},
  abstract = {Back ground: Tumor necrosis factor-alpha (TNF-α), adiponectin (ADP) and C-reactive protein (CRP) are associated with the risk of cardiovascular or non communicable diseases. Aims: To evaluate the association between TNF-α, ADP, CRP and metabolic markers in Congelese Bantu from Brazzaville. Methods: A cross-sectional case-control study was conducted during the period from July 2018 to February 2021. A total of 233 participants were recruited then divided into 130 healthy participants (control group) and 103 insulin resistant patients (case group). The Spearman correlation coefficient was calculated in order to search for an association between TNFα, ADP and the metabolic markers. An exponential nonlinear regression was used for the analysis of the association between TNFα (dependent variable) and CRP. Results: Participants were aged of 45.5 ± 13.1 years with a median BMI of 25.4 kg/m2, were included in this study. The median values of TNFα, CRP, ADP and HOMA-IR were 96.2 pg/mL, 12.3 mg/L, 8.6 ng/mL and 2.3, respectively. TNFα was positively correlated with anthropometric parameters, CRP and insulin resistance. In contrast, ADP was negatively correlated with anthropometric parameters, CRP and insulin resistance. In control group, the equation was written as TNF alpha = 187 * (1 - 0.96CRP). The model shows that CRP explains 84.62% of the variability of TNFα in healthy participants. In case group, the equation was written as TNF alpha = 186.4 * (1 - 0.95CRP). The model shows that CRP explains 93.65% of the variability of TNFα in insulin-resistant participants. Conclusion: TNF alpha and ADP are associated at NC, WC, WHR, WHtR, LDL, CRP and insulin resistance in Congolese Bantu from Brazzaville.},
 year = {2022}
}

Copy | Download