Early Clinical Efficacy of Prone Ventilation in Patients with Connective Tissue Disease-Related Interstitial Lung Disease with Concurrent Acute Respiratory Distress Syndrome

Ying Zhou; Ming Jin; Guohui Yu

doi:doi:10.11648/j.cmr.20221105.13

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Early Clinical Efficacy of Prone Ventilation in Patients with Connective Tissue Disease-Related Interstitial Lung Disease with Concurrent Acute Respiratory Distress Syndrome

Ying Zhou, Ming Jin, Guohui Yu

Published in Clinical Medicine Research (Volume 11, Issue 5)

Received: 18 August 2022 Accepted: 4 September 2022 Published: 16 September 2022

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Abstract

In this prospective study, we aimed to compare the early (4h) clinical responses of prone conventional ventilation (CV) in connective tissue disease-related interstitial lung disease (CTD-ILD) patients with concurrent acute respiratory distress syndrome (ARDS). 40 patients with CTD-ILD combined with early onset of ARDS were recruited from May 2021 to March 2022 in the First Hospital of Jinmen, China. They were separated into two groups (n=20 per group). Patients in the control group were given routine treatment, which included infection control, correcting electrolyte disorder, correcting the acid-base imbalance, and nutritional support, etc. For the intervention group, additional conventional ventilation in the prone position (prone-CV) was provided. The following indicators were monitored, including respiratory rate (RR), heart rate (HR), mean arterial pressure (MAP) and central venous pressure (CVP). The changes in sequential organ failure assessment score (SOFA), respiratory dynamic indexes (RR and PaO₂/FIO₂) and hemodynamics, including HR, CVP (mm Hg) and MAP (mmHg) were compared before and 4 hours after treatment. After 4 h of treatment, patients in the prone-CV group had significantly lowered SOFA scores (9.134 ± 1.12 vs. 10.03 ± 0.84, p = 0.007) and improved PaO₂/FIO₂ ratio (184.8 ± 35.59 vs. 104.2 ± 14.64, p < 0.001) compared to the control group. The hemodynamics, including HR, MAP and CVP were stable. In conclusion, early administration of Prone-CV could rapidly improve the SOFA score and oxygenation among CTD-ILD patients during acute exacerbations of ARDS.

Published in	Clinical Medicine Research (Volume 11, Issue 5)
DOI	10.11648/j.cmr.20221105.13
Page(s)	130-134
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

CTD, ILD, Prone-CV, Oxygenation

References

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[6]	Shi Y, Zhang Y, Liu R, et al. The "Hand as Foot" teaching method in the ultrasound characteristics of connective tissue diseases associated interstitial lung disease (CTD-ILD) [J]. Asian J Surg, 2022.
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APA Style

Ying Zhou, Ming Jin, Guohui Yu. (2022). Early Clinical Efficacy of Prone Ventilation in Patients with Connective Tissue Disease-Related Interstitial Lung Disease with Concurrent Acute Respiratory Distress Syndrome. Clinical Medicine Research, 11(5), 130-134. https://doi.org/10.11648/j.cmr.20221105.13

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ACS Style

Ying Zhou; Ming Jin; Guohui Yu. Early Clinical Efficacy of Prone Ventilation in Patients with Connective Tissue Disease-Related Interstitial Lung Disease with Concurrent Acute Respiratory Distress Syndrome. Clin. Med. Res. 2022, 11(5), 130-134. doi: 10.11648/j.cmr.20221105.13

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AMA Style

Ying Zhou, Ming Jin, Guohui Yu. Early Clinical Efficacy of Prone Ventilation in Patients with Connective Tissue Disease-Related Interstitial Lung Disease with Concurrent Acute Respiratory Distress Syndrome. Clin Med Res. 2022;11(5):130-134. doi: 10.11648/j.cmr.20221105.13

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@article{10.11648/j.cmr.20221105.13,
  author = {Ying Zhou and Ming Jin and Guohui Yu},
  title = {Early Clinical Efficacy of Prone Ventilation in Patients with Connective Tissue Disease-Related Interstitial Lung Disease with Concurrent Acute Respiratory Distress Syndrome},
  journal = {Clinical Medicine Research},
  volume = {11},
  number = {5},
  pages = {130-134},
  doi = {10.11648/j.cmr.20221105.13},
  url = {https://doi.org/10.11648/j.cmr.20221105.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20221105.13},
  abstract = {In this prospective study, we aimed to compare the early (4h) clinical responses of prone conventional ventilation (CV) in connective tissue disease-related interstitial lung disease (CTD-ILD) patients with concurrent acute respiratory distress syndrome (ARDS). 40 patients with CTD-ILD combined with early onset of ARDS were recruited from May 2021 to March 2022 in the First Hospital of Jinmen, China. They were separated into two groups (n=20 per group). Patients in the control group were given routine treatment, which included infection control, correcting electrolyte disorder, correcting the acid-base imbalance, and nutritional support, etc. For the intervention group, additional conventional ventilation in the prone position (prone-CV) was provided. The following indicators were monitored, including respiratory rate (RR), heart rate (HR), mean arterial pressure (MAP) and central venous pressure (CVP). The changes in sequential organ failure assessment score (SOFA), respiratory dynamic indexes (RR and PaO2/FIO2) and hemodynamics, including HR, CVP (mm Hg) and MAP (mmHg) were compared before and 4 hours after treatment. After 4 h of treatment, patients in the prone-CV group had significantly lowered SOFA scores (9.134 ± 1.12 vs. 10.03 ± 0.84, p = 0.007) and improved PaO2/FIO2 ratio (184.8 ± 35.59 vs. 104.2 ± 14.64, p < 0.001) compared to the control group. The hemodynamics, including HR, MAP and CVP were stable. In conclusion, early administration of Prone-CV could rapidly improve the SOFA score and oxygenation among CTD-ILD patients during acute exacerbations of ARDS.},
 year = {2022}
}

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TY  - JOUR
T1  - Early Clinical Efficacy of Prone Ventilation in Patients with Connective Tissue Disease-Related Interstitial Lung Disease with Concurrent Acute Respiratory Distress Syndrome
AU  - Ying Zhou
AU  - Ming Jin
AU  - Guohui Yu
Y1  - 2022/09/16
PY  - 2022
N1  - https://doi.org/10.11648/j.cmr.20221105.13
DO  - 10.11648/j.cmr.20221105.13
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 130
EP  - 134
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20221105.13
AB  - In this prospective study, we aimed to compare the early (4h) clinical responses of prone conventional ventilation (CV) in connective tissue disease-related interstitial lung disease (CTD-ILD) patients with concurrent acute respiratory distress syndrome (ARDS). 40 patients with CTD-ILD combined with early onset of ARDS were recruited from May 2021 to March 2022 in the First Hospital of Jinmen, China. They were separated into two groups (n=20 per group). Patients in the control group were given routine treatment, which included infection control, correcting electrolyte disorder, correcting the acid-base imbalance, and nutritional support, etc. For the intervention group, additional conventional ventilation in the prone position (prone-CV) was provided. The following indicators were monitored, including respiratory rate (RR), heart rate (HR), mean arterial pressure (MAP) and central venous pressure (CVP). The changes in sequential organ failure assessment score (SOFA), respiratory dynamic indexes (RR and PaO2/FIO2) and hemodynamics, including HR, CVP (mm Hg) and MAP (mmHg) were compared before and 4 hours after treatment. After 4 h of treatment, patients in the prone-CV group had significantly lowered SOFA scores (9.134 ± 1.12 vs. 10.03 ± 0.84, p = 0.007) and improved PaO2/FIO2 ratio (184.8 ± 35.59 vs. 104.2 ± 14.64, p < 0.001) compared to the control group. The hemodynamics, including HR, MAP and CVP were stable. In conclusion, early administration of Prone-CV could rapidly improve the SOFA score and oxygenation among CTD-ILD patients during acute exacerbations of ARDS.
VL  - 11
IS  - 5
ER  -

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Author Information

Ying Zhou

Pulmonary and Critical Care Medicine, Jingmen No. 1 People’s Hospital, Jingmen, China
Ming Jin

Pulmonary and Critical Care Medicine, Jingmen No. 1 People’s Hospital, Jingmen, China
Guohui Yu

Pulmonary and Critical Care Medicine, Jingmen No. 1 People’s Hospital, Jingmen, China

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APA Style

Ying Zhou, Ming Jin, Guohui Yu. (2022). Early Clinical Efficacy of Prone Ventilation in Patients with Connective Tissue Disease-Related Interstitial Lung Disease with Concurrent Acute Respiratory Distress Syndrome. Clinical Medicine Research, 11(5), 130-134. https://doi.org/10.11648/j.cmr.20221105.13

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ACS Style

Ying Zhou; Ming Jin; Guohui Yu. Early Clinical Efficacy of Prone Ventilation in Patients with Connective Tissue Disease-Related Interstitial Lung Disease with Concurrent Acute Respiratory Distress Syndrome. Clin. Med. Res. 2022, 11(5), 130-134. doi: 10.11648/j.cmr.20221105.13

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AMA Style

Ying Zhou, Ming Jin, Guohui Yu. Early Clinical Efficacy of Prone Ventilation in Patients with Connective Tissue Disease-Related Interstitial Lung Disease with Concurrent Acute Respiratory Distress Syndrome. Clin Med Res. 2022;11(5):130-134. doi: 10.11648/j.cmr.20221105.13

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@article{10.11648/j.cmr.20221105.13,
  author = {Ying Zhou and Ming Jin and Guohui Yu},
  title = {Early Clinical Efficacy of Prone Ventilation in Patients with Connective Tissue Disease-Related Interstitial Lung Disease with Concurrent Acute Respiratory Distress Syndrome},
  journal = {Clinical Medicine Research},
  volume = {11},
  number = {5},
  pages = {130-134},
  doi = {10.11648/j.cmr.20221105.13},
  url = {https://doi.org/10.11648/j.cmr.20221105.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20221105.13},
  abstract = {In this prospective study, we aimed to compare the early (4h) clinical responses of prone conventional ventilation (CV) in connective tissue disease-related interstitial lung disease (CTD-ILD) patients with concurrent acute respiratory distress syndrome (ARDS). 40 patients with CTD-ILD combined with early onset of ARDS were recruited from May 2021 to March 2022 in the First Hospital of Jinmen, China. They were separated into two groups (n=20 per group). Patients in the control group were given routine treatment, which included infection control, correcting electrolyte disorder, correcting the acid-base imbalance, and nutritional support, etc. For the intervention group, additional conventional ventilation in the prone position (prone-CV) was provided. The following indicators were monitored, including respiratory rate (RR), heart rate (HR), mean arterial pressure (MAP) and central venous pressure (CVP). The changes in sequential organ failure assessment score (SOFA), respiratory dynamic indexes (RR and PaO2/FIO2) and hemodynamics, including HR, CVP (mm Hg) and MAP (mmHg) were compared before and 4 hours after treatment. After 4 h of treatment, patients in the prone-CV group had significantly lowered SOFA scores (9.134 ± 1.12 vs. 10.03 ± 0.84, p = 0.007) and improved PaO2/FIO2 ratio (184.8 ± 35.59 vs. 104.2 ± 14.64, p < 0.001) compared to the control group. The hemodynamics, including HR, MAP and CVP were stable. In conclusion, early administration of Prone-CV could rapidly improve the SOFA score and oxygenation among CTD-ILD patients during acute exacerbations of ARDS.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Early Clinical Efficacy of Prone Ventilation in Patients with Connective Tissue Disease-Related Interstitial Lung Disease with Concurrent Acute Respiratory Distress Syndrome
AU  - Ying Zhou
AU  - Ming Jin
AU  - Guohui Yu
Y1  - 2022/09/16
PY  - 2022
N1  - https://doi.org/10.11648/j.cmr.20221105.13
DO  - 10.11648/j.cmr.20221105.13
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 130
EP  - 134
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20221105.13
AB  - In this prospective study, we aimed to compare the early (4h) clinical responses of prone conventional ventilation (CV) in connective tissue disease-related interstitial lung disease (CTD-ILD) patients with concurrent acute respiratory distress syndrome (ARDS). 40 patients with CTD-ILD combined with early onset of ARDS were recruited from May 2021 to March 2022 in the First Hospital of Jinmen, China. They were separated into two groups (n=20 per group). Patients in the control group were given routine treatment, which included infection control, correcting electrolyte disorder, correcting the acid-base imbalance, and nutritional support, etc. For the intervention group, additional conventional ventilation in the prone position (prone-CV) was provided. The following indicators were monitored, including respiratory rate (RR), heart rate (HR), mean arterial pressure (MAP) and central venous pressure (CVP). The changes in sequential organ failure assessment score (SOFA), respiratory dynamic indexes (RR and PaO2/FIO2) and hemodynamics, including HR, CVP (mm Hg) and MAP (mmHg) were compared before and 4 hours after treatment. After 4 h of treatment, patients in the prone-CV group had significantly lowered SOFA scores (9.134 ± 1.12 vs. 10.03 ± 0.84, p = 0.007) and improved PaO2/FIO2 ratio (184.8 ± 35.59 vs. 104.2 ± 14.64, p < 0.001) compared to the control group. The hemodynamics, including HR, MAP and CVP were stable. In conclusion, early administration of Prone-CV could rapidly improve the SOFA score and oxygenation among CTD-ILD patients during acute exacerbations of ARDS.
VL  - 11
IS  - 5
ER  -

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