@article{10.11648/j.frontiers.20210104.18,
  author = {Hossam Mohamed and Houda Almansour and Dalal Alsaadoun and Mariam Almansour and Sulaiman Alnassera},
  title = {Hossam Zero Holes (HZH) Unravel Osteoporosis Roots and the coincidental Soft Tissue Calcification in the Elderly: Granted US Patent Review},
  journal = {Frontiers},
  volume = {1},
  number = {4},
  pages = {112-120},
  doi = {10.11648/j.frontiers.20210104.18},
  url = {https://doi.org/10.11648/j.frontiers.20210104.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.frontiers.20210104.18},
  abstract = {The mineralization of the bone is the most important step in its strengthening & preventing its fracture. Calcium is by far the most important and most predominant mineral inside the bone. There is a wrong concept that blood calcium always has access to the bone. This is the basis of calcium supplementation in the elderly or patients with low bone mineral density (BMD). There is an increasing evidence that low BMD is almost always associated with soft tissue calcification. This is why the precipitating factors predisposing to low BMD may have a role in soft tissue calcification. For the calcium to be fixed in the bone, it needs collaboration from all its components namely, the functional collagen, the apatite chips, and the bone cells. The most fundamental point is the zero holes and the zero channels of the collagen bundles. Other factors that could modulate bone mineralization are outside the bone. These extra-osseous parameters act as adjuvants or co-factors that can modify the process of bone mineralization. By the same token, these co-factors may lead to soft tissue calcification. These adjuvant co-factors include hormonal status, visceral fat, hyperinsulinemia, and some minerals in the serum other than calcium itself. If these co-factors are not in an optimal condition for the bone, they would induce low BMD. Therefore, calcium supplementation is not always the right choice in cases of low BMD. This is because it may exaggerate the consequential soft tissue calcification. The US patent (US9801905) suggests that calcium can be supplemented in low BMD only if the bone is prepared to accept the calcium. The molecular mechanics of the zero holes and the orientation of the apatite chips help in the better understanding of the mechanism of bone mineralization & the associated soft tissue calcification},
 year = {2021}
}

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TY  - JOUR
T1  - Hossam Zero Holes (HZH) Unravel Osteoporosis Roots and the coincidental Soft Tissue Calcification in the Elderly: Granted US Patent Review
AU  - Hossam Mohamed
AU  - Houda Almansour
AU  - Dalal Alsaadoun
AU  - Mariam Almansour
AU  - Sulaiman Alnassera
Y1  - 2021/12/29
PY  - 2021
N1  - https://doi.org/10.11648/j.frontiers.20210104.18
DO  - 10.11648/j.frontiers.20210104.18
T2  - Frontiers
JF  - Frontiers
JO  - Frontiers
SP  - 112
EP  - 120
PB  - Science Publishing Group
SN  - 2994-7197
UR  - https://doi.org/10.11648/j.frontiers.20210104.18
AB  - The mineralization of the bone is the most important step in its strengthening & preventing its fracture. Calcium is by far the most important and most predominant mineral inside the bone. There is a wrong concept that blood calcium always has access to the bone. This is the basis of calcium supplementation in the elderly or patients with low bone mineral density (BMD). There is an increasing evidence that low BMD is almost always associated with soft tissue calcification. This is why the precipitating factors predisposing to low BMD may have a role in soft tissue calcification. For the calcium to be fixed in the bone, it needs collaboration from all its components namely, the functional collagen, the apatite chips, and the bone cells. The most fundamental point is the zero holes and the zero channels of the collagen bundles. Other factors that could modulate bone mineralization are outside the bone. These extra-osseous parameters act as adjuvants or co-factors that can modify the process of bone mineralization. By the same token, these co-factors may lead to soft tissue calcification. These adjuvant co-factors include hormonal status, visceral fat, hyperinsulinemia, and some minerals in the serum other than calcium itself. If these co-factors are not in an optimal condition for the bone, they would induce low BMD. Therefore, calcium supplementation is not always the right choice in cases of low BMD. This is because it may exaggerate the consequential soft tissue calcification. The US patent (US9801905) suggests that calcium can be supplemented in low BMD only if the bone is prepared to accept the calcium. The molecular mechanics of the zero holes and the orientation of the apatite chips help in the better understanding of the mechanism of bone mineralization & the associated soft tissue calcification
VL  - 1
IS  - 4
ER  - 

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