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Mechanism and Therapeutic Value of Exosomes in Gastric Cancer

Received: 18 April 2023    Accepted: 10 May 2023    Published: 17 May 2023
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Abstract

Background Gastric cancer is a common gastrointestinal tumor with a high incidence and mortality rate, which is a serious threat to life and health; therefore, early diagnosis and interventions are particularly important. Currently, emerging gastric cancer-related targets Exosomes (EXOs) are being explored, (EXOs) are various bioactive substances, such as proteins, nucleic acids and lipids, actively secreted by various cells. It has been shown that exosomes are extensively involved in substance exchange and signal transduction between gastric cancer cells, affecting tumor proliferation and metastasis. Exosomes are biomarkers for the diagnosis and prognosis of gastric cancer, and are one of the hot spots in cancer research. Objective This paper mainly summarizes the research progress of related exosome detection methods and condenses a large amount of research evidence to systematically describe the characteristics of exosomes, related mechanisms and their diagnostic and therapeutic values in gastric cancer, hoping to provide new ideas and methods for the diagnosis and treatment of gastric cancer and new opportunities for better treatment of gastric cancer patients. Method Through extensive reading of relevant literature, we highly summarize relevant research mechanisms and diagnostic and therapeutic values, and explore and summarize the latest hot spots. Result and Conclusion EXOs as an emerging research hotspot, have extensive clinical value in gastric cancer progression. Using EXOs as key targets can provide new ideas and directions for the precise diagnosis and treatment of related GI tract tumors. It is also beneficial to the early diagnosis and of gastric cancer, and provides certain research prospects for the study of related inhibitory drugs.

Published in International Journal of Gastroenterology (Volume 7, Issue 1)
DOI 10.11648/j.ijg.20230701.14
Page(s) 25-31
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Exosomes, Gastric Cancer, Biomarker, Diagnosis and Treatment Value

References
[1] Harada T, Yamamoto H, Kishida S, et al. Wnt5b-associated exosomes promote cancer cell migration and proliferation [J]. Cancer Science, 2017, 108 (1): 42-52. doi: 10.1111/cas.13109.
[2] Cordonnier M, Chanteloup G, Isambert N, et al. Exosomes in cancer theranostic: Diamonds in the rough [J]. Cell Adhes Commun, 2017, 11 (2): 151-163. doi: 10.1080/19336918.2016.1250999.
[3] Tkach M, Thery C. Communication by Extracellular Vesicles: Where We Are and Where We Need to Go [J]. Cell, 2016, 164 (6): 1226-1232. doi: 10.1016/j.cell.2016.01.043.
[4] Zhang X, Zhou C. The function of tumor -derived exosomes [J]. J Buon, 2019, 24 (3): 897-904. doi: 10.1186/s13045-020-00991-2.
[5] Pegtel DM, Gould SJ. Exosomes [J]. Annu Rev Biochem, 2019, 88: 487-514. doi: 10.1146/annurev-biochem-013118-111902.
[6] Jeppesen DK, Fenix AM, Franklin JL, et al. Reassessment of exosome composition [J]. Cell, 2019, 177 (2): 428-445. doi: 10.1016/j.cell.2019.02.029.
[7] Meldolesi J. Exosomes and ectosomes in intercellular communication [J]. Curr Biol, 2018, 28 (8): R435-R444. doi: 10.1016/j.cub.2018.01.059.
[8] JOHNSTONE R M, A D A M M, HAMMOND JR, et al. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes) [J]. J Biol Chem, 1987, 262 (19): 9412-9420. PMID: 3597417.
[9] MATHIEU M, 9MARTIN-JAULAR L, LAVIEU G, et al. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication [J]. Nat Cell Biol, 2019, 21 (1): 9-17. doi: 10.1038/s41556-018-0250-9.
[10] Ragusa M, Barbagallo C, Cirnigliaro M, et al. Asymmetric RNA distribution among cells and their secreted exosomes: biomedical meaning and considerations on diagnostic applications [J]. Front Mol Biosci, 2017, 4: 66. doi: 10.3389/fmolb.2017.00066.
[11] Ludwig N, Whiteside TL. Potential roles of tumor-derived exosomes in angiogenesis [J]. Expert Opin Ther Targets, 2018, 22 (5): 409-417. doi: 10.1080/14728222.2018.1464141.
[12] Huang T, Song C, Zheng L, et al. The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapy [J]. Mol Cancer, 2019, 18 (1): 62. doi: 10.1186/s12943-019-0967-5.
[13] SEO N, AKIYOSHI K, SHIKU H. Exosome-mediated regulation of tumor immunology [J]. Cancer Sci, 2018, 109 (10): 2998-3004. doi: 10.1111/cas.13735.
[14] Ha D, Yang N, Nadithe V. Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges [J]. Acta Pharm Sin B, 2016, 6 (4): 287-296. doi: 10.1016/j.apsb.2016.02.001.
[15] Li P, Kaslan M, Lee SH, et al. Progress in Exosome Isolation Techniques [J]. Theranostics, 2017, 7 (3): 789-804. doi: 10.7150/thno.18133.
[16] STECM, SZATANEKR, BAJ -KRZYWORZEKA M, et al. Interactions of tumour-derived micro(nano)vesicles with human gastric cancer cells [J]. J Transl Med, 2015, 13: 376. doi: 10.1186/s12967-015-0737-0.
[17] SHENG J, XU Z. Three decades of research on angiogenin: a review and perspective [J]. Acta Biochim Biophys Sin (Shanghai), 2016, 48 (5): 399-410. doi: 10.1093/abbs/gmv131.
[18] OLEJARZ W, KUBIAK-TOMASZEWSKA G, CHRAZNOWSKA A, et al. Exosomes in angiogenesis and anti-angiogenic therapy in cancers [J]. Int J Mol Sci, 2020, 21 (16): 5840. doi: 10.3390/ijms21165840.
[19] WANG F, LI B, WEI Y, et al. Tumorderived exosomes induce PD1+ macrophage population in human gastric cancer that promotes disease progression [J]. Oncogenesis, 2018, 7 (5): 41. doi: 10.1038/s41389-022-00381-y.
[20] WU L, ZHANG X, ZHANG B, et al. Exosomes derived from gastric cancer cells activate NF-κB pathway in macrophages to promote cancer progression [J]. Tumour Biol, 2016, 37 (9): 12169-12180. doi: 10.1007/s13277-016-5071-5.
[21] LIU J, WU S X, ZHENG X, et al. Immune suppressed tumor microenvironment by exosomes derived from gastric cancer cells via modulating immune functions [J]. Sci Rep, 2020, 10 (1): 14749. doi: 10.1038/s41598-020-71573-y.
[22] ZHANG X, SHI H, YUAN X, et al. Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration [J]. Mol Cancer, 2018, 17 (1): 146. doi: 10.1186/s12943-018-0898-6.
[23] ZHAO R, ZHANG Y, ZHANG X, et al. Exosomal long noncoding RNA HOTTIP as potential novel diagnostic and prognostic biomarker test for gastric cancer [J]. Mol cancer, 2018, 17 (1): 68. doi: 10.1186/s12943-018-0817-x.
[24] PAN L, LIANG W, FU M, et al. Exosomes-mediated transfer of long noncoding RNA ZFAS1 promotes gastric cancer progression [J]. J Cancer Res Clin Oncol, 2017, 143 (6): 991-1004. doi: 10.1007/s00432-017-2361-2.
[25] Xie Y, Dang W, Zhang S, et al. The role of exosomal noncoding RNAs in cancer [J]. Mol Cancer, 2019, 18 (1): 37. doi: 10.1186/s12943-019-0984-4.
[26] PAN L, LIANG W, GU J, et al. Long noncoding RNA DANCR is activated by SALL4 and promotes the proliferation and invasion of gastric cancer cells [J]. Oncotarget, 2017, 9 (2): 1915-1930. doi: 10.18632/oncotarget.23019.
[27] Becker A, Thakur BK, Weiss JM, et al. Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis [J]. Cancer Cell, 2016, 30 (6): 836-848. doi: 10.1016/j.ccell.2016.10.009.
[28] Lebleu VS, Kalluri R. Exosomes as a Multicomponent Biomarker Platform in Cancer [J]. Trends Cancer, 2020, 6 (9): 767-774. doi: 10.1016/j.trecan.2020.03.007.
[29] YEN EY, MIAW SC, YU JS, et al. Exosomal TGF-β1 is correlated with lymphatic metastasis of gastric cancers [J]. Am J Cancer Res, 2017, 7 (11): 2199-2208.
[30] YOON JH, HAM IH, KIM O, et al. Gastrokine 1 protein is a potential theragnostic target for gastric cancer [J]. Gastric Cancer, 2018, 21 (6): 956-967.
[31] ZHENG P, LUO Q, WANG W, et al. Tumor-associated macrophagesderived exosomes promote the migration of gastric cancer cells by transfer of functional apolipoprotein E [J]. Cell Death Dis, 2018, 9 (4): 434.
[32] Liu D, Trojanowicz B, Radestock Y, et al. Role of CD97 isoforms in gastric carcinoma [J]. Int J Oncol, 2010, 36 (6): 1401-1408.
[33] Liu D, Li C, Trojanowicz B, et al. CD97 promotion of gastric carcinoma lymphatic metastasis is exosome dependent [J]. Gastric Cancer, 2016, 19 (3): 754-766.
[34] Shimoda A, Ueda K, Nishiumi S, et al. Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA [J]. Sci Reports, 2016, 6: 18346.
[35] Hoshino A, Costa-Silva B, Shen TL, et al. Tumour exosome integrins determine organotropic metastasis [J]. Nature, 2015, 527 (7578): 329-335.
[36] Chen WX, Lv XM, Lv MM, et al. Exosomes from drug -resistant breast cancer cells transmit chemoresistance by a horizontal transfer of microRNAs [J]. PLoS One, 2014, 9 (4): e95240.
[37] Sousa D, Lima RT, Vasconcelos MH. Intercellular transfer of cancer drug resistance traits by extracellular vesicles [J]. Trends Mol Med, 2015, 21 (10): 595-608.
[38] Ji R, Zhang B, Zhang X, et al. Exosomes derived from human mesenchymal stem cells confer drug resistance in gastric cancer [J]. Cell Cycle, 2015, 14 (15): 2473-2483.
[39] Zheng P, Chen L, Yuan X, et al. Exosomal transfer of tumor - associated macrophage-derived miR -21 confers cisplatin resistance in gastric cancer cells [J]. J Exp Clin Cancer Res, 2017, 36 (1): 53-87.
[40] Soda N, Rehm BHA, Sonar P, et al. Advanced liquid biopsy technologies for circulating biomarker detection [J]. J Mater Chem B, 2019, 7 (43): 6670-6704.
[41] Yang H, Fu H, Wang B, et al. Exosomal miR-423-5p targets SUFU to promote cancer growth and metastasis and serves as a novel marker for gastric cancer [J]. Mol Carcinog, 2018, 57 (9): 1223-1236.
[42] Loei H, Tan HT, Lim TK, et al. Mining the gastric cancer secretome: identification of GRN as a potential diagnostic marker for early gastric cancer [J]. J Proteome Res, 2012, 11 (3): 1759-1772.
[43] SUN ZP, LI AQ, JIA WH, et al. MicroRNA expression profiling in exosomes derived from gastric cancer stemlike cells [J]. Oncotarget, 2017, 8 (55): 93839-93855.
[44] ZHANG X, LIANG W, LIU J, et al. Long non-coding RNA UFC1 promotes gastric cancer progression by regulating miR-498/Lin28b [J]. J Exp Clin Cancer Res, 2018, 37 (1): 134.
[45] ZHONG H, YANG Y, MA S, et al. Induction of a tumour-specific CTL response by exosomes isolated from heat-treated malignant ascites of gastric cancer patients [J]. Int J Hyperthermia, 2011, 27 (6): 604-611.
[46] Poggio M, Hu T, Pai CC, et al. Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory. Cell. 2019 Apr 4; 177 (2): 414-427. e13.
[47] Liu X, Lu Y, Xu Y, et al. Exosomal transfer of miR-501 confers doxorubicin resistance and tumorigenesis via targeting of BUD in gastric cancer [J]. Cancer Lett, 2019, 459: 122-134.
[48] Zhang H, Deng T, Liu R, et al. CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer [J]. Mol Cancer, 2020, 19 (1): 43.
[49] Guan XW, Zhao F, Wang JY, et al. Tumor microenvironment interruption: a novel anti-cancer mechanism of Proton-pump inhibitor in gastric cancer by suppressing the release of microRNA-carrying exosomes [J]. Am J Cancer Res, 2017, 7 (9): 1913-1925.
[50] BAROK M, PUHKA M, VEREB G, et al. Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation [J]. BMC Cancer, 2018, 18 (1): 504.
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    Zaibo Zhang. (2023). Mechanism and Therapeutic Value of Exosomes in Gastric Cancer. International Journal of Gastroenterology, 7(1), 25-31. https://doi.org/10.11648/j.ijg.20230701.14

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    ACS Style

    Zaibo Zhang. Mechanism and Therapeutic Value of Exosomes in Gastric Cancer. Int. J. Gastroenterol. 2023, 7(1), 25-31. doi: 10.11648/j.ijg.20230701.14

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    AMA Style

    Zaibo Zhang. Mechanism and Therapeutic Value of Exosomes in Gastric Cancer. Int J Gastroenterol. 2023;7(1):25-31. doi: 10.11648/j.ijg.20230701.14

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  • @article{10.11648/j.ijg.20230701.14,
      author = {Zaibo Zhang},
      title = {Mechanism and Therapeutic Value of Exosomes in Gastric Cancer},
      journal = {International Journal of Gastroenterology},
      volume = {7},
      number = {1},
      pages = {25-31},
      doi = {10.11648/j.ijg.20230701.14},
      url = {https://doi.org/10.11648/j.ijg.20230701.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijg.20230701.14},
      abstract = {Background Gastric cancer is a common gastrointestinal tumor with a high incidence and mortality rate, which is a serious threat to life and health; therefore, early diagnosis and interventions are particularly important. Currently, emerging gastric cancer-related targets Exosomes (EXOs) are being explored, (EXOs) are various bioactive substances, such as proteins, nucleic acids and lipids, actively secreted by various cells. It has been shown that exosomes are extensively involved in substance exchange and signal transduction between gastric cancer cells, affecting tumor proliferation and metastasis. Exosomes are biomarkers for the diagnosis and prognosis of gastric cancer, and are one of the hot spots in cancer research. Objective This paper mainly summarizes the research progress of related exosome detection methods and condenses a large amount of research evidence to systematically describe the characteristics of exosomes, related mechanisms and their diagnostic and therapeutic values in gastric cancer, hoping to provide new ideas and methods for the diagnosis and treatment of gastric cancer and new opportunities for better treatment of gastric cancer patients. Method Through extensive reading of relevant literature, we highly summarize relevant research mechanisms and diagnostic and therapeutic values, and explore and summarize the latest hot spots. Result and Conclusion EXOs as an emerging research hotspot, have extensive clinical value in gastric cancer progression. Using EXOs as key targets can provide new ideas and directions for the precise diagnosis and treatment of related GI tract tumors. It is also beneficial to the early diagnosis and of gastric cancer, and provides certain research prospects for the study of related inhibitory drugs.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Mechanism and Therapeutic Value of Exosomes in Gastric Cancer
    AU  - Zaibo Zhang
    Y1  - 2023/05/17
    PY  - 2023
    N1  - https://doi.org/10.11648/j.ijg.20230701.14
    DO  - 10.11648/j.ijg.20230701.14
    T2  - International Journal of Gastroenterology
    JF  - International Journal of Gastroenterology
    JO  - International Journal of Gastroenterology
    SP  - 25
    EP  - 31
    PB  - Science Publishing Group
    SN  - 2640-169X
    UR  - https://doi.org/10.11648/j.ijg.20230701.14
    AB  - Background Gastric cancer is a common gastrointestinal tumor with a high incidence and mortality rate, which is a serious threat to life and health; therefore, early diagnosis and interventions are particularly important. Currently, emerging gastric cancer-related targets Exosomes (EXOs) are being explored, (EXOs) are various bioactive substances, such as proteins, nucleic acids and lipids, actively secreted by various cells. It has been shown that exosomes are extensively involved in substance exchange and signal transduction between gastric cancer cells, affecting tumor proliferation and metastasis. Exosomes are biomarkers for the diagnosis and prognosis of gastric cancer, and are one of the hot spots in cancer research. Objective This paper mainly summarizes the research progress of related exosome detection methods and condenses a large amount of research evidence to systematically describe the characteristics of exosomes, related mechanisms and their diagnostic and therapeutic values in gastric cancer, hoping to provide new ideas and methods for the diagnosis and treatment of gastric cancer and new opportunities for better treatment of gastric cancer patients. Method Through extensive reading of relevant literature, we highly summarize relevant research mechanisms and diagnostic and therapeutic values, and explore and summarize the latest hot spots. Result and Conclusion EXOs as an emerging research hotspot, have extensive clinical value in gastric cancer progression. Using EXOs as key targets can provide new ideas and directions for the precise diagnosis and treatment of related GI tract tumors. It is also beneficial to the early diagnosis and of gastric cancer, and provides certain research prospects for the study of related inhibitory drugs.
    VL  - 7
    IS  - 1
    ER  - 

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Author Information
  • The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China

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