Neuroprotective Effect of Xylopia Aethiopica Seed on Lead-Induced Injury on the Cerebral Cortex of Male Wistar Rat

Chinna Nneka Orish; Samuel Sotonye George; Eberechi Wogu; Anthoneth Ndidiamaka Ezejiofor

doi:doi:10.11648/j.ijpbs.20210601.12

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Neuroprotective Effect of Xylopia Aethiopica Seed on Lead-Induced Injury on the Cerebral Cortex of Male Wistar Rat

Chinna Nneka Orish, Samuel Sotonye George, Eberechi Wogu, Anthoneth Ndidiamaka Ezejiofor

Published in International Journal of Psychological and Brain Sciences (Volume 6, Issue 1)

Received: 27 December 2020 Accepted: 15 January 2021 Published: 10 March 2021

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Abstract

Background: Lead (Pb) is one of the most common environmental toxicants, exposure to which can cause significant neurotoxicity and an associated decline in brain function. Plant derived products with antioxidants activity are useful in reducing lead induced neurotoxicity. This study investigated neuroprotective and antioxidant properties of the aqueous Xylopia aethiopica against lead -induced neurotoxicity in male Wistar rats. Methods: Six groups of six weight-matched animals each, were used for the study. The group 1 (normal control) was treated with distilled water and group 2 (toxic control) with lead acetate at the doses of 50 mg/kg b.wt, whereas group 3 received only Xylopia aethiopica 40 mg/kg only, groups 4, 5, and 6 were simultaneously treated with lead (50 mg/kg b.w.), and 40mg/kg, 80mg/kg, and 160mg/kg of Xylopia aethiopica respectively The treatment was administered orally for 42 days. Their biochemical and histopathological investigations were carried out following animal sacrifice at the end of the study period. The neuroprotective effect of Xylopia aethiopica was assessed by measuring redox status (malondialdehyde), enzymatic antioxidant activities (Superoxide dismutase, Catalase, Glutathione peroxidase and glutathione reductase) and histopathology of the cerebral cortex. Results: The increase in the malondialdehyde, the decrease in the activity of antioxidant enzymes (Catalase, Glutathione peroxidase and reductase), and the altered histology of the brain induced neurotoxicity by lead acetate were mitigated in the brain of rats treated with Xylopia aethiopica. Conclusion: Aqueous Xylopia aethiopica has a neuroprotective role against lead - induced neurotoxicity probably mediated through its antioxidant properties.

Published in	International Journal of Psychological and Brain Sciences (Volume 6, Issue 1)
DOI	10.11648/j.ijpbs.20210601.12
Page(s)	7-12
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Neurotoxicity, Xylopia aethiopica, Antioxidant, Lead

References

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APA Style

Chinna Nneka Orish, Samuel Sotonye George, Eberechi Wogu, Anthoneth Ndidiamaka Ezejiofor. (2021). Neuroprotective Effect of Xylopia Aethiopica Seed on Lead-Induced Injury on the Cerebral Cortex of Male Wistar Rat. International Journal of Psychological and Brain Sciences, 6(1), 7-12. https://doi.org/10.11648/j.ijpbs.20210601.12

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ACS Style

Chinna Nneka Orish; Samuel Sotonye George; Eberechi Wogu; Anthoneth Ndidiamaka Ezejiofor. Neuroprotective Effect of Xylopia Aethiopica Seed on Lead-Induced Injury on the Cerebral Cortex of Male Wistar Rat. Int. J. Psychol. Brain Sci. 2021, 6(1), 7-12. doi: 10.11648/j.ijpbs.20210601.12

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AMA Style

Chinna Nneka Orish, Samuel Sotonye George, Eberechi Wogu, Anthoneth Ndidiamaka Ezejiofor. Neuroprotective Effect of Xylopia Aethiopica Seed on Lead-Induced Injury on the Cerebral Cortex of Male Wistar Rat. Int J Psychol Brain Sci. 2021;6(1):7-12. doi: 10.11648/j.ijpbs.20210601.12

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@article{10.11648/j.ijpbs.20210601.12,
  author = {Chinna Nneka Orish and Samuel Sotonye George and Eberechi Wogu and Anthoneth Ndidiamaka Ezejiofor},
  title = {Neuroprotective Effect of Xylopia Aethiopica Seed on Lead-Induced Injury on the Cerebral Cortex of Male Wistar Rat},
  journal = {International Journal of Psychological and Brain Sciences},
  volume = {6},
  number = {1},
  pages = {7-12},
  doi = {10.11648/j.ijpbs.20210601.12},
  url = {https://doi.org/10.11648/j.ijpbs.20210601.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpbs.20210601.12},
  abstract = {Background: Lead (Pb) is one of the most common environmental toxicants, exposure to which can cause significant neurotoxicity and an associated decline in brain function. Plant derived products with antioxidants activity are useful in reducing lead induced neurotoxicity. This study investigated neuroprotective and antioxidant properties of the aqueous Xylopia aethiopica against lead -induced neurotoxicity in male Wistar rats. Methods: Six groups of six weight-matched animals each, were used for the study. The group 1 (normal control) was treated with distilled water and group 2 (toxic control) with lead acetate at the doses of 50 mg/kg b.wt, whereas group 3 received only Xylopia aethiopica 40 mg/kg only, groups 4, 5, and 6 were simultaneously treated with lead (50 mg/kg b.w.), and 40mg/kg, 80mg/kg, and 160mg/kg of Xylopia aethiopica respectively The treatment was administered orally for 42 days. Their biochemical and histopathological investigations were carried out following animal sacrifice at the end of the study period. The neuroprotective effect of Xylopia aethiopica was assessed by measuring redox status (malondialdehyde), enzymatic antioxidant activities (Superoxide dismutase, Catalase, Glutathione peroxidase and glutathione reductase) and histopathology of the cerebral cortex. Results: The increase in the malondialdehyde, the decrease in the activity of antioxidant enzymes (Catalase, Glutathione peroxidase and reductase), and the altered histology of the brain induced neurotoxicity by lead acetate were mitigated in the brain of rats treated with Xylopia aethiopica. Conclusion: Aqueous Xylopia aethiopica has a neuroprotective role against lead - induced neurotoxicity probably mediated through its antioxidant properties.},
 year = {2021}
}

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TY  - JOUR
T1  - Neuroprotective Effect of Xylopia Aethiopica Seed on Lead-Induced Injury on the Cerebral Cortex of Male Wistar Rat
AU  - Chinna Nneka Orish
AU  - Samuel Sotonye George
AU  - Eberechi Wogu
AU  - Anthoneth Ndidiamaka Ezejiofor
Y1  - 2021/03/10
PY  - 2021
N1  - https://doi.org/10.11648/j.ijpbs.20210601.12
DO  - 10.11648/j.ijpbs.20210601.12
T2  - International Journal of Psychological and Brain Sciences
JF  - International Journal of Psychological and Brain Sciences
JO  - International Journal of Psychological and Brain Sciences
SP  - 7
EP  - 12
PB  - Science Publishing Group
SN  - 2575-1573
UR  - https://doi.org/10.11648/j.ijpbs.20210601.12
AB  - Background: Lead (Pb) is one of the most common environmental toxicants, exposure to which can cause significant neurotoxicity and an associated decline in brain function. Plant derived products with antioxidants activity are useful in reducing lead induced neurotoxicity. This study investigated neuroprotective and antioxidant properties of the aqueous Xylopia aethiopica against lead -induced neurotoxicity in male Wistar rats. Methods: Six groups of six weight-matched animals each, were used for the study. The group 1 (normal control) was treated with distilled water and group 2 (toxic control) with lead acetate at the doses of 50 mg/kg b.wt, whereas group 3 received only Xylopia aethiopica 40 mg/kg only, groups 4, 5, and 6 were simultaneously treated with lead (50 mg/kg b.w.), and 40mg/kg, 80mg/kg, and 160mg/kg of Xylopia aethiopica respectively The treatment was administered orally for 42 days. Their biochemical and histopathological investigations were carried out following animal sacrifice at the end of the study period. The neuroprotective effect of Xylopia aethiopica was assessed by measuring redox status (malondialdehyde), enzymatic antioxidant activities (Superoxide dismutase, Catalase, Glutathione peroxidase and glutathione reductase) and histopathology of the cerebral cortex. Results: The increase in the malondialdehyde, the decrease in the activity of antioxidant enzymes (Catalase, Glutathione peroxidase and reductase), and the altered histology of the brain induced neurotoxicity by lead acetate were mitigated in the brain of rats treated with Xylopia aethiopica. Conclusion: Aqueous Xylopia aethiopica has a neuroprotective role against lead - induced neurotoxicity probably mediated through its antioxidant properties.
VL  - 6
IS  - 1
ER  -

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Author Information

Chinna Nneka Orish

Department of Anatomy, Faculty of Basic Medical Science, University of Port-Harcourt, Port Harcourt, Nigeria
Samuel Sotonye George

Department of Anatomy, Faculty of Basic Medical Science, University of Port-Harcourt, Port Harcourt, Nigeria
Eberechi Wogu

Department of Anatomy, Faculty of Basic Medical Science, University of Port-Harcourt, Port Harcourt, Nigeria
Anthoneth Ndidiamaka Ezejiofor

African Centre of Excellence for Public Health and Toxicological Research, University of Port Harcourt, Port Harcourt, Nigeria

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APA Style

Chinna Nneka Orish, Samuel Sotonye George, Eberechi Wogu, Anthoneth Ndidiamaka Ezejiofor. (2021). Neuroprotective Effect of Xylopia Aethiopica Seed on Lead-Induced Injury on the Cerebral Cortex of Male Wistar Rat. International Journal of Psychological and Brain Sciences, 6(1), 7-12. https://doi.org/10.11648/j.ijpbs.20210601.12

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Chinna Nneka Orish; Samuel Sotonye George; Eberechi Wogu; Anthoneth Ndidiamaka Ezejiofor. Neuroprotective Effect of Xylopia Aethiopica Seed on Lead-Induced Injury on the Cerebral Cortex of Male Wistar Rat. Int. J. Psychol. Brain Sci. 2021, 6(1), 7-12. doi: 10.11648/j.ijpbs.20210601.12

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AMA Style

Chinna Nneka Orish, Samuel Sotonye George, Eberechi Wogu, Anthoneth Ndidiamaka Ezejiofor. Neuroprotective Effect of Xylopia Aethiopica Seed on Lead-Induced Injury on the Cerebral Cortex of Male Wistar Rat. Int J Psychol Brain Sci. 2021;6(1):7-12. doi: 10.11648/j.ijpbs.20210601.12

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@article{10.11648/j.ijpbs.20210601.12,
  author = {Chinna Nneka Orish and Samuel Sotonye George and Eberechi Wogu and Anthoneth Ndidiamaka Ezejiofor},
  title = {Neuroprotective Effect of Xylopia Aethiopica Seed on Lead-Induced Injury on the Cerebral Cortex of Male Wistar Rat},
  journal = {International Journal of Psychological and Brain Sciences},
  volume = {6},
  number = {1},
  pages = {7-12},
  doi = {10.11648/j.ijpbs.20210601.12},
  url = {https://doi.org/10.11648/j.ijpbs.20210601.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpbs.20210601.12},
  abstract = {Background: Lead (Pb) is one of the most common environmental toxicants, exposure to which can cause significant neurotoxicity and an associated decline in brain function. Plant derived products with antioxidants activity are useful in reducing lead induced neurotoxicity. This study investigated neuroprotective and antioxidant properties of the aqueous Xylopia aethiopica against lead -induced neurotoxicity in male Wistar rats. Methods: Six groups of six weight-matched animals each, were used for the study. The group 1 (normal control) was treated with distilled water and group 2 (toxic control) with lead acetate at the doses of 50 mg/kg b.wt, whereas group 3 received only Xylopia aethiopica 40 mg/kg only, groups 4, 5, and 6 were simultaneously treated with lead (50 mg/kg b.w.), and 40mg/kg, 80mg/kg, and 160mg/kg of Xylopia aethiopica respectively The treatment was administered orally for 42 days. Their biochemical and histopathological investigations were carried out following animal sacrifice at the end of the study period. The neuroprotective effect of Xylopia aethiopica was assessed by measuring redox status (malondialdehyde), enzymatic antioxidant activities (Superoxide dismutase, Catalase, Glutathione peroxidase and glutathione reductase) and histopathology of the cerebral cortex. Results: The increase in the malondialdehyde, the decrease in the activity of antioxidant enzymes (Catalase, Glutathione peroxidase and reductase), and the altered histology of the brain induced neurotoxicity by lead acetate were mitigated in the brain of rats treated with Xylopia aethiopica. Conclusion: Aqueous Xylopia aethiopica has a neuroprotective role against lead - induced neurotoxicity probably mediated through its antioxidant properties.},
 year = {2021}
}

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TY  - JOUR
T1  - Neuroprotective Effect of Xylopia Aethiopica Seed on Lead-Induced Injury on the Cerebral Cortex of Male Wistar Rat
AU  - Chinna Nneka Orish
AU  - Samuel Sotonye George
AU  - Eberechi Wogu
AU  - Anthoneth Ndidiamaka Ezejiofor
Y1  - 2021/03/10
PY  - 2021
N1  - https://doi.org/10.11648/j.ijpbs.20210601.12
DO  - 10.11648/j.ijpbs.20210601.12
T2  - International Journal of Psychological and Brain Sciences
JF  - International Journal of Psychological and Brain Sciences
JO  - International Journal of Psychological and Brain Sciences
SP  - 7
EP  - 12
PB  - Science Publishing Group
SN  - 2575-1573
UR  - https://doi.org/10.11648/j.ijpbs.20210601.12
AB  - Background: Lead (Pb) is one of the most common environmental toxicants, exposure to which can cause significant neurotoxicity and an associated decline in brain function. Plant derived products with antioxidants activity are useful in reducing lead induced neurotoxicity. This study investigated neuroprotective and antioxidant properties of the aqueous Xylopia aethiopica against lead -induced neurotoxicity in male Wistar rats. Methods: Six groups of six weight-matched animals each, were used for the study. The group 1 (normal control) was treated with distilled water and group 2 (toxic control) with lead acetate at the doses of 50 mg/kg b.wt, whereas group 3 received only Xylopia aethiopica 40 mg/kg only, groups 4, 5, and 6 were simultaneously treated with lead (50 mg/kg b.w.), and 40mg/kg, 80mg/kg, and 160mg/kg of Xylopia aethiopica respectively The treatment was administered orally for 42 days. Their biochemical and histopathological investigations were carried out following animal sacrifice at the end of the study period. The neuroprotective effect of Xylopia aethiopica was assessed by measuring redox status (malondialdehyde), enzymatic antioxidant activities (Superoxide dismutase, Catalase, Glutathione peroxidase and glutathione reductase) and histopathology of the cerebral cortex. Results: The increase in the malondialdehyde, the decrease in the activity of antioxidant enzymes (Catalase, Glutathione peroxidase and reductase), and the altered histology of the brain induced neurotoxicity by lead acetate were mitigated in the brain of rats treated with Xylopia aethiopica. Conclusion: Aqueous Xylopia aethiopica has a neuroprotective role against lead - induced neurotoxicity probably mediated through its antioxidant properties.
VL  - 6
IS  - 1
ER  -

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