The Contribution of Obesity to Alterations in Atherogenic Lipids in Cameroon Children

Lifoter Kenneth Navti; Dufe Martha Yimbu; Loveline Lum Niba; Charlotte Mungho Tata; Mary Bi Suh Atanga

doi:doi:10.11648/j.jfns.20221004.16

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The Contribution of Obesity to Alterations in Atherogenic Lipids in Cameroon Children

Lifoter Kenneth Navti, Dufe Martha Yimbu, Loveline Lum Niba, Charlotte Mungho Tata, Mary Bi Suh Atanga

Published in Journal of Food and Nutrition Sciences (Volume 10, Issue 4)

Received: 22 June 2022 Accepted: 14 July 2022 Published: 22 July 2022

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Abstract

Background: Obesity among children is rising steadily in Cameroon and its association with dyslipidemia and consequently cardiovascular risk has become a concern for medical researchers. This study aims at determining the prevalence of dyslipidemia and also quantifying the effects of obesity assessed using BMI, waist circumference (WC) and waist-to-height ratio (WHtR) on changes in atherogenic lipid levels in children. Methods: A hospital-based analysis was carried out in children (270 males, 296 females) of ages 5 to 16 years at the outpatient unit of the Bamenda Regional Hospital in Cameroon. Body weight, height and waist circumference were measured and adjusted for age and gender. BMI and WHtR were calculated. A vacutainer was used to obtain fasting venous blood samples from the children. The total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) concentrations were determined by enzymatic method using an automated clinical chemistry analyzer - RX Monaco (RANDOX, UK). The relationships between obesity and altered serum lipid concentrations were assessed using multiple quantile regression analysis. Results: From this sample, 46.4% and 44.9% of females and males respectively had at least one lipid disorder and the most common lipid disorder was low HDL-C. After adjusting for age and gender, BMI-obesity was significantly associated with a 6.76mg/dl, 4.92mg/dl and 5.09mg/dl increase in TC (p = 0.016), TG (p = 0.021) and LDL-C (p = 0.001) respectively, and a decrease (-3.92mg/dl) in HDL-C (p = 0.030). Also, central obesity (WC) significantly increased TC (p = 0.001) and LDL-C (p = 0.020) by 6.01mg/dl and 4.32mg/dl respectively and decreased HDL-C by -4.01mg/dl (p = 0.003). WHtR was also associated with a 6.69mg/dl and 5.18mg/dl increase in TC (p < 0.001) and LDL-C (p < 0.001) respectively. Conclusion: This study reinforces the frequent occurrence of altered serum lipid levels in Cameroon children and the contribution of BMI-obesity to the condition. Future studies are required to evaluate the contribution of other modifiable drivers of dyslipidemia in childhood to aid interventions, as this condition can increase the risk of future cardiovascular disease.

Published in	Journal of Food and Nutrition Sciences (Volume 10, Issue 4)
DOI	10.11648/j.jfns.20221004.16
Page(s)	142-150
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Obesity, Dyslipidemia, Children, Quantile Regression, Cameroon

References

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Lifoter Kenneth Navti, Dufe Martha Yimbu, Loveline Lum Niba, Charlotte Mungho Tata, Mary Bi Suh Atanga. (2022). The Contribution of Obesity to Alterations in Atherogenic Lipids in Cameroon Children. Journal of Food and Nutrition Sciences, 10(4), 142-150. https://doi.org/10.11648/j.jfns.20221004.16

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ACS Style

Lifoter Kenneth Navti; Dufe Martha Yimbu; Loveline Lum Niba; Charlotte Mungho Tata; Mary Bi Suh Atanga. The Contribution of Obesity to Alterations in Atherogenic Lipids in Cameroon Children. J. Food Nutr. Sci. 2022, 10(4), 142-150. doi: 10.11648/j.jfns.20221004.16

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AMA Style

Lifoter Kenneth Navti, Dufe Martha Yimbu, Loveline Lum Niba, Charlotte Mungho Tata, Mary Bi Suh Atanga. The Contribution of Obesity to Alterations in Atherogenic Lipids in Cameroon Children. J Food Nutr Sci. 2022;10(4):142-150. doi: 10.11648/j.jfns.20221004.16

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@article{10.11648/j.jfns.20221004.16,
  author = {Lifoter Kenneth Navti and Dufe Martha Yimbu and Loveline Lum Niba and Charlotte Mungho Tata and Mary Bi Suh Atanga},
  title = {The Contribution of Obesity to Alterations in Atherogenic Lipids in Cameroon Children},
  journal = {Journal of Food and Nutrition Sciences},
  volume = {10},
  number = {4},
  pages = {142-150},
  doi = {10.11648/j.jfns.20221004.16},
  url = {https://doi.org/10.11648/j.jfns.20221004.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20221004.16},
  abstract = {Background: Obesity among children is rising steadily in Cameroon and its association with dyslipidemia and consequently cardiovascular risk has become a concern for medical researchers. This study aims at determining the prevalence of dyslipidemia and also quantifying the effects of obesity assessed using BMI, waist circumference (WC) and waist-to-height ratio (WHtR) on changes in atherogenic lipid levels in children. Methods: A hospital-based analysis was carried out in children (270 males, 296 females) of ages 5 to 16 years at the outpatient unit of the Bamenda Regional Hospital in Cameroon. Body weight, height and waist circumference were measured and adjusted for age and gender. BMI and WHtR were calculated. A vacutainer was used to obtain fasting venous blood samples from the children. The total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) concentrations were determined by enzymatic method using an automated clinical chemistry analyzer - RX Monaco (RANDOX, UK). The relationships between obesity and altered serum lipid concentrations were assessed using multiple quantile regression analysis. Results: From this sample, 46.4% and 44.9% of females and males respectively had at least one lipid disorder and the most common lipid disorder was low HDL-C. After adjusting for age and gender, BMI-obesity was significantly associated with a 6.76mg/dl, 4.92mg/dl and 5.09mg/dl increase in TC (p = 0.016), TG (p = 0.021) and LDL-C (p = 0.001) respectively, and a decrease (-3.92mg/dl) in HDL-C (p = 0.030). Also, central obesity (WC) significantly increased TC (p = 0.001) and LDL-C (p = 0.020) by 6.01mg/dl and 4.32mg/dl respectively and decreased HDL-C by -4.01mg/dl (p = 0.003). WHtR was also associated with a 6.69mg/dl and 5.18mg/dl increase in TC (p p Conclusion: This study reinforces the frequent occurrence of altered serum lipid levels in Cameroon children and the contribution of BMI-obesity to the condition. Future studies are required to evaluate the contribution of other modifiable drivers of dyslipidemia in childhood to aid interventions, as this condition can increase the risk of future cardiovascular disease.},
 year = {2022}
}

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TY  - JOUR
T1  - The Contribution of Obesity to Alterations in Atherogenic Lipids in Cameroon Children
AU  - Lifoter Kenneth Navti
AU  - Dufe Martha Yimbu
AU  - Loveline Lum Niba
AU  - Charlotte Mungho Tata
AU  - Mary Bi Suh Atanga
Y1  - 2022/07/22
PY  - 2022
N1  - https://doi.org/10.11648/j.jfns.20221004.16
DO  - 10.11648/j.jfns.20221004.16
T2  - Journal of Food and Nutrition Sciences
JF  - Journal of Food and Nutrition Sciences
JO  - Journal of Food and Nutrition Sciences
SP  - 142
EP  - 150
PB  - Science Publishing Group
SN  - 2330-7293
UR  - https://doi.org/10.11648/j.jfns.20221004.16
AB  - Background: Obesity among children is rising steadily in Cameroon and its association with dyslipidemia and consequently cardiovascular risk has become a concern for medical researchers. This study aims at determining the prevalence of dyslipidemia and also quantifying the effects of obesity assessed using BMI, waist circumference (WC) and waist-to-height ratio (WHtR) on changes in atherogenic lipid levels in children. Methods: A hospital-based analysis was carried out in children (270 males, 296 females) of ages 5 to 16 years at the outpatient unit of the Bamenda Regional Hospital in Cameroon. Body weight, height and waist circumference were measured and adjusted for age and gender. BMI and WHtR were calculated. A vacutainer was used to obtain fasting venous blood samples from the children. The total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) concentrations were determined by enzymatic method using an automated clinical chemistry analyzer - RX Monaco (RANDOX, UK). The relationships between obesity and altered serum lipid concentrations were assessed using multiple quantile regression analysis. Results: From this sample, 46.4% and 44.9% of females and males respectively had at least one lipid disorder and the most common lipid disorder was low HDL-C. After adjusting for age and gender, BMI-obesity was significantly associated with a 6.76mg/dl, 4.92mg/dl and 5.09mg/dl increase in TC (p = 0.016), TG (p = 0.021) and LDL-C (p = 0.001) respectively, and a decrease (-3.92mg/dl) in HDL-C (p = 0.030). Also, central obesity (WC) significantly increased TC (p = 0.001) and LDL-C (p = 0.020) by 6.01mg/dl and 4.32mg/dl respectively and decreased HDL-C by -4.01mg/dl (p = 0.003). WHtR was also associated with a 6.69mg/dl and 5.18mg/dl increase in TC (p p Conclusion: This study reinforces the frequent occurrence of altered serum lipid levels in Cameroon children and the contribution of BMI-obesity to the condition. Future studies are required to evaluate the contribution of other modifiable drivers of dyslipidemia in childhood to aid interventions, as this condition can increase the risk of future cardiovascular disease.
VL  - 10
IS  - 4
ER  -

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Author Information

Lifoter Kenneth Navti

Department of Biochemistry, Faculty of Science, The University of Bamenda, Bambili, Cameroon
Dufe Martha Yimbu

Department of Biochemistry, Faculty of Science, The University of Bamenda, Bambili, Cameroon
Loveline Lum Niba

Department of Public Health, Faculty of Health Sciences, The University of Bamenda, Bambili, Cameroon
Charlotte Mungho Tata

Department of Biochemistry, Faculty of Science, The University of Bamenda, Bambili, Cameroon
Mary Bi Suh Atanga

Department of Nursing and Midwifery, Faculty of Health Sciences, The University of Bamenda, Bambili, Cameroon

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Lifoter Kenneth Navti, Dufe Martha Yimbu, Loveline Lum Niba, Charlotte Mungho Tata, Mary Bi Suh Atanga. (2022). The Contribution of Obesity to Alterations in Atherogenic Lipids in Cameroon Children. Journal of Food and Nutrition Sciences, 10(4), 142-150. https://doi.org/10.11648/j.jfns.20221004.16

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ACS Style

Lifoter Kenneth Navti; Dufe Martha Yimbu; Loveline Lum Niba; Charlotte Mungho Tata; Mary Bi Suh Atanga. The Contribution of Obesity to Alterations in Atherogenic Lipids in Cameroon Children. J. Food Nutr. Sci. 2022, 10(4), 142-150. doi: 10.11648/j.jfns.20221004.16

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AMA Style

Lifoter Kenneth Navti, Dufe Martha Yimbu, Loveline Lum Niba, Charlotte Mungho Tata, Mary Bi Suh Atanga. The Contribution of Obesity to Alterations in Atherogenic Lipids in Cameroon Children. J Food Nutr Sci. 2022;10(4):142-150. doi: 10.11648/j.jfns.20221004.16

Copy | Download

@article{10.11648/j.jfns.20221004.16,
  author = {Lifoter Kenneth Navti and Dufe Martha Yimbu and Loveline Lum Niba and Charlotte Mungho Tata and Mary Bi Suh Atanga},
  title = {The Contribution of Obesity to Alterations in Atherogenic Lipids in Cameroon Children},
  journal = {Journal of Food and Nutrition Sciences},
  volume = {10},
  number = {4},
  pages = {142-150},
  doi = {10.11648/j.jfns.20221004.16},
  url = {https://doi.org/10.11648/j.jfns.20221004.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20221004.16},
  abstract = {Background: Obesity among children is rising steadily in Cameroon and its association with dyslipidemia and consequently cardiovascular risk has become a concern for medical researchers. This study aims at determining the prevalence of dyslipidemia and also quantifying the effects of obesity assessed using BMI, waist circumference (WC) and waist-to-height ratio (WHtR) on changes in atherogenic lipid levels in children. Methods: A hospital-based analysis was carried out in children (270 males, 296 females) of ages 5 to 16 years at the outpatient unit of the Bamenda Regional Hospital in Cameroon. Body weight, height and waist circumference were measured and adjusted for age and gender. BMI and WHtR were calculated. A vacutainer was used to obtain fasting venous blood samples from the children. The total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) concentrations were determined by enzymatic method using an automated clinical chemistry analyzer - RX Monaco (RANDOX, UK). The relationships between obesity and altered serum lipid concentrations were assessed using multiple quantile regression analysis. Results: From this sample, 46.4% and 44.9% of females and males respectively had at least one lipid disorder and the most common lipid disorder was low HDL-C. After adjusting for age and gender, BMI-obesity was significantly associated with a 6.76mg/dl, 4.92mg/dl and 5.09mg/dl increase in TC (p = 0.016), TG (p = 0.021) and LDL-C (p = 0.001) respectively, and a decrease (-3.92mg/dl) in HDL-C (p = 0.030). Also, central obesity (WC) significantly increased TC (p = 0.001) and LDL-C (p = 0.020) by 6.01mg/dl and 4.32mg/dl respectively and decreased HDL-C by -4.01mg/dl (p = 0.003). WHtR was also associated with a 6.69mg/dl and 5.18mg/dl increase in TC (p p Conclusion: This study reinforces the frequent occurrence of altered serum lipid levels in Cameroon children and the contribution of BMI-obesity to the condition. Future studies are required to evaluate the contribution of other modifiable drivers of dyslipidemia in childhood to aid interventions, as this condition can increase the risk of future cardiovascular disease.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - The Contribution of Obesity to Alterations in Atherogenic Lipids in Cameroon Children
AU  - Lifoter Kenneth Navti
AU  - Dufe Martha Yimbu
AU  - Loveline Lum Niba
AU  - Charlotte Mungho Tata
AU  - Mary Bi Suh Atanga
Y1  - 2022/07/22
PY  - 2022
N1  - https://doi.org/10.11648/j.jfns.20221004.16
DO  - 10.11648/j.jfns.20221004.16
T2  - Journal of Food and Nutrition Sciences
JF  - Journal of Food and Nutrition Sciences
JO  - Journal of Food and Nutrition Sciences
SP  - 142
EP  - 150
PB  - Science Publishing Group
SN  - 2330-7293
UR  - https://doi.org/10.11648/j.jfns.20221004.16
AB  - Background: Obesity among children is rising steadily in Cameroon and its association with dyslipidemia and consequently cardiovascular risk has become a concern for medical researchers. This study aims at determining the prevalence of dyslipidemia and also quantifying the effects of obesity assessed using BMI, waist circumference (WC) and waist-to-height ratio (WHtR) on changes in atherogenic lipid levels in children. Methods: A hospital-based analysis was carried out in children (270 males, 296 females) of ages 5 to 16 years at the outpatient unit of the Bamenda Regional Hospital in Cameroon. Body weight, height and waist circumference were measured and adjusted for age and gender. BMI and WHtR were calculated. A vacutainer was used to obtain fasting venous blood samples from the children. The total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) concentrations were determined by enzymatic method using an automated clinical chemistry analyzer - RX Monaco (RANDOX, UK). The relationships between obesity and altered serum lipid concentrations were assessed using multiple quantile regression analysis. Results: From this sample, 46.4% and 44.9% of females and males respectively had at least one lipid disorder and the most common lipid disorder was low HDL-C. After adjusting for age and gender, BMI-obesity was significantly associated with a 6.76mg/dl, 4.92mg/dl and 5.09mg/dl increase in TC (p = 0.016), TG (p = 0.021) and LDL-C (p = 0.001) respectively, and a decrease (-3.92mg/dl) in HDL-C (p = 0.030). Also, central obesity (WC) significantly increased TC (p = 0.001) and LDL-C (p = 0.020) by 6.01mg/dl and 4.32mg/dl respectively and decreased HDL-C by -4.01mg/dl (p = 0.003). WHtR was also associated with a 6.69mg/dl and 5.18mg/dl increase in TC (p p Conclusion: This study reinforces the frequent occurrence of altered serum lipid levels in Cameroon children and the contribution of BMI-obesity to the condition. Future studies are required to evaluate the contribution of other modifiable drivers of dyslipidemia in childhood to aid interventions, as this condition can increase the risk of future cardiovascular disease.
VL  - 10
IS  - 4
ER  -

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