Takayasu's Arteritis: Monitoring of Clinical and Laboratory Activity in a Kyrgyz Cohort of Patients

Koilubaeva Gulazyk Malikovna; Bolotbekova Altynai Maratovna; Egorova Olga Nikolaevna; Tarasova Galina Michailovna; Sarybaev Akbai Shogaipovich; Chukubaev Marat Abdyganovich; Turdukulov Zamir Ergeshevich; Usupbaeva Dinara Abulmeizovna; Turusbekova Aijan Kemelovna

doi:doi:10.11648/j.sjcm.20221101.13

Takayasu's Arteritis: Monitoring of Clinical and Laboratory Activity in a Kyrgyz Cohort of Patients

Koilubaeva Gulazyk Malikovna, Bolotbekova Altynai Maratovna, Egorova Olga Nikolaevna, Tarasova Galina Michailovna, Sarybaev Akbai Shogaipovich, Chukubaev Marat Abdyganovich, Turdukulov Zamir Ergeshevich, Usupbaeva Dinara Abulmeizovna, Turusbekova Aijan Kemelovna

Published in Science Journal of Clinical Medicine (Volume 11, Issue 1)

Received: 4 January 2022 Accepted: 4 February 2022 Published: 16 February 2022

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Abstract

Monitoring of clinical and laboratory Takayasu's arteritis (TAK) activity was carried out in 40 patients. Most of them were female patients (92.5%), of Kyrgyz nationality (97.5%), of young age (median - 32 years [24; 44]), with a disease duration of 7.5 years (median – (3.5; 12.5)), with the onset of the disease at 24 years (median –(19; 30)), with V anatomical type - (72.5%), which had vascular stage (77.5%), III grade (≥2) of vascular complications (37.5%), severe exacerbation (65%), with pronounced activity (92.5%) according to the EULAR criteria, high laboratory activity (accelerated ESR in 75% and increased hsCRP - in 65.71% of patients). The lesion of the common carotid (85%) and subclavian arteries (85%) prevailed, the renal arteries were the second most frequently (62.5%) affected vessels, with a predominance of bilateral stenosis (96.1%). During the 5.5 year- follow-up course, a statistically significant partial remission (according to the BVAS index) was achieved in only 12.5% of patients, while frequency of mild and severe exacerbations of the disease remained at the same level (p> 0.05). However, according to the EULAR criteria, there was a statistically significant decrease in the disease activity (from 92.5% to 65% cases) and an increase in the frequency of remission (from 2.5% to 27.5% cases), with the exception of episodes of relapses: major (12.5%) and minor ones (45%).

Published in	Science Journal of Clinical Medicine (Volume 11, Issue 1)
DOI	10.11648/j.sjcm.20221101.13
Page(s)	14-24
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Takayasu's Arteritis, Disease Activity, Angiography, Doppler Ultrasound, Tomography, Monitoring

References

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Koilubaeva Gulazyk Malikovna, Bolotbekova Altynai Maratovna, Egorova Olga Nikolaevna, Tarasova Galina Michailovna, Sarybaev Akbai Shogaipovich, et al. (2022). Takayasu's Arteritis: Monitoring of Clinical and Laboratory Activity in a Kyrgyz Cohort of Patients. Science Journal of Clinical Medicine, 11(1), 14-24. https://doi.org/10.11648/j.sjcm.20221101.13

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ACS Style

Koilubaeva Gulazyk Malikovna; Bolotbekova Altynai Maratovna; Egorova Olga Nikolaevna; Tarasova Galina Michailovna; Sarybaev Akbai Shogaipovich, et al. Takayasu's Arteritis: Monitoring of Clinical and Laboratory Activity in a Kyrgyz Cohort of Patients. Sci. J. Clin. Med. 2022, 11(1), 14-24. doi: 10.11648/j.sjcm.20221101.13

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AMA Style

Koilubaeva Gulazyk Malikovna, Bolotbekova Altynai Maratovna, Egorova Olga Nikolaevna, Tarasova Galina Michailovna, Sarybaev Akbai Shogaipovich, et al. Takayasu's Arteritis: Monitoring of Clinical and Laboratory Activity in a Kyrgyz Cohort of Patients. Sci J Clin Med. 2022;11(1):14-24. doi: 10.11648/j.sjcm.20221101.13

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@article{10.11648/j.sjcm.20221101.13,
  author = {Koilubaeva Gulazyk Malikovna and Bolotbekova Altynai Maratovna and Egorova Olga Nikolaevna and Tarasova Galina Michailovna and Sarybaev Akbai Shogaipovich and Chukubaev Marat Abdyganovich and Turdukulov Zamir Ergeshevich and Usupbaeva Dinara Abulmeizovna and Turusbekova Aijan Kemelovna},
  title = {Takayasu's Arteritis: Monitoring of Clinical and Laboratory Activity in a Kyrgyz Cohort of Patients},
  journal = {Science Journal of Clinical Medicine},
  volume = {11},
  number = {1},
  pages = {14-24},
  doi = {10.11648/j.sjcm.20221101.13},
  url = {https://doi.org/10.11648/j.sjcm.20221101.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20221101.13},
  abstract = {Monitoring of clinical and laboratory Takayasu's arteritis (TAK) activity was carried out in 40 patients. Most of them were female patients (92.5%), of Kyrgyz nationality (97.5%), of young age (median - 32 years [24; 44]), with a disease duration of 7.5 years (median – (3.5; 12.5)), with the onset of the disease at 24 years (median –(19; 30)), with V anatomical type - (72.5%), which had vascular stage (77.5%), III grade (≥2) of vascular complications (37.5%), severe exacerbation (65%), with pronounced activity (92.5%) according to the EULAR criteria, high laboratory activity (accelerated ESR in 75% and increased hsCRP - in 65.71% of patients). The lesion of the common carotid (85%) and subclavian arteries (85%) prevailed, the renal arteries were the second most frequently (62.5%) affected vessels, with a predominance of bilateral stenosis (96.1%). During the 5.5 year- follow-up course, a statistically significant partial remission (according to the BVAS index) was achieved in only 12.5% of patients, while frequency of mild and severe exacerbations of the disease remained at the same level (p> 0.05). However, according to the EULAR criteria, there was a statistically significant decrease in the disease activity (from 92.5% to 65% cases) and an increase in the frequency of remission (from 2.5% to 27.5% cases), with the exception of episodes of relapses: major (12.5%) and minor ones (45%).},
 year = {2022}
}

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TY  - JOUR
T1  - Takayasu's Arteritis: Monitoring of Clinical and Laboratory Activity in a Kyrgyz Cohort of Patients
AU  - Koilubaeva Gulazyk Malikovna
AU  - Bolotbekova Altynai Maratovna
AU  - Egorova Olga Nikolaevna
AU  - Tarasova Galina Michailovna
AU  - Sarybaev Akbai Shogaipovich
AU  - Chukubaev Marat Abdyganovich
AU  - Turdukulov Zamir Ergeshevich
AU  - Usupbaeva Dinara Abulmeizovna
AU  - Turusbekova Aijan Kemelovna
Y1  - 2022/02/16
PY  - 2022
N1  - https://doi.org/10.11648/j.sjcm.20221101.13
DO  - 10.11648/j.sjcm.20221101.13
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 14
EP  - 24
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20221101.13
AB  - Monitoring of clinical and laboratory Takayasu's arteritis (TAK) activity was carried out in 40 patients. Most of them were female patients (92.5%), of Kyrgyz nationality (97.5%), of young age (median - 32 years [24; 44]), with a disease duration of 7.5 years (median – (3.5; 12.5)), with the onset of the disease at 24 years (median –(19; 30)), with V anatomical type - (72.5%), which had vascular stage (77.5%), III grade (≥2) of vascular complications (37.5%), severe exacerbation (65%), with pronounced activity (92.5%) according to the EULAR criteria, high laboratory activity (accelerated ESR in 75% and increased hsCRP - in 65.71% of patients). The lesion of the common carotid (85%) and subclavian arteries (85%) prevailed, the renal arteries were the second most frequently (62.5%) affected vessels, with a predominance of bilateral stenosis (96.1%). During the 5.5 year- follow-up course, a statistically significant partial remission (according to the BVAS index) was achieved in only 12.5% of patients, while frequency of mild and severe exacerbations of the disease remained at the same level (p> 0.05). However, according to the EULAR criteria, there was a statistically significant decrease in the disease activity (from 92.5% to 65% cases) and an increase in the frequency of remission (from 2.5% to 27.5% cases), with the exception of episodes of relapses: major (12.5%) and minor ones (45%).
VL  - 11
IS  - 1
ER  -

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Author Information

Koilubaeva Gulazyk Malikovna

National Centre of Cardiology and Internal Medicine (NCIIM), Bishkek, the Kyrgyz Republic
Bolotbekova Altynai Maratovna

National Centre of Cardiology and Internal Medicine (NCIIM), Bishkek, the Kyrgyz Republic
Egorova Olga Nikolaevna

Research Institute of Rheumatology Named After V. A. Nasonova Federal State Budgetary Institution, Moscow, the Russian Federation
Tarasova Galina Michailovna

Research Institute of Rheumatology Named After V. A. Nasonova Federal State Budgetary Institution, Moscow, the Russian Federation
Sarybaev Akbai Shogaipovich

National Centre of Cardiology and Internal Medicine (NCIIM), Bishkek, the Kyrgyz Republic
Chukubaev Marat Abdyganovich

National Centre of Cardiology and Internal Medicine (NCIIM), Bishkek, the Kyrgyz Republic
Turdukulov Zamir Ergeshevich

National Centre of Cardiology and Internal Medicine (NCIIM), Bishkek, the Kyrgyz Republic
Usupbaeva Dinara Abulmeizovna

National Centre of Cardiology and Internal Medicine (NCIIM), Bishkek, the Kyrgyz Republic
Turusbekova Aijan Kemelovna

National Centre of Cardiology and Internal Medicine (NCIIM), Bishkek, the Kyrgyz Republic

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APA Style

Koilubaeva Gulazyk Malikovna, Bolotbekova Altynai Maratovna, Egorova Olga Nikolaevna, Tarasova Galina Michailovna, Sarybaev Akbai Shogaipovich, et al. (2022). Takayasu's Arteritis: Monitoring of Clinical and Laboratory Activity in a Kyrgyz Cohort of Patients. Science Journal of Clinical Medicine, 11(1), 14-24. https://doi.org/10.11648/j.sjcm.20221101.13

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ACS Style

Koilubaeva Gulazyk Malikovna; Bolotbekova Altynai Maratovna; Egorova Olga Nikolaevna; Tarasova Galina Michailovna; Sarybaev Akbai Shogaipovich, et al. Takayasu's Arteritis: Monitoring of Clinical and Laboratory Activity in a Kyrgyz Cohort of Patients. Sci. J. Clin. Med. 2022, 11(1), 14-24. doi: 10.11648/j.sjcm.20221101.13

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AMA Style

Koilubaeva Gulazyk Malikovna, Bolotbekova Altynai Maratovna, Egorova Olga Nikolaevna, Tarasova Galina Michailovna, Sarybaev Akbai Shogaipovich, et al. Takayasu's Arteritis: Monitoring of Clinical and Laboratory Activity in a Kyrgyz Cohort of Patients. Sci J Clin Med. 2022;11(1):14-24. doi: 10.11648/j.sjcm.20221101.13

Copy | Download

@article{10.11648/j.sjcm.20221101.13,
  author = {Koilubaeva Gulazyk Malikovna and Bolotbekova Altynai Maratovna and Egorova Olga Nikolaevna and Tarasova Galina Michailovna and Sarybaev Akbai Shogaipovich and Chukubaev Marat Abdyganovich and Turdukulov Zamir Ergeshevich and Usupbaeva Dinara Abulmeizovna and Turusbekova Aijan Kemelovna},
  title = {Takayasu's Arteritis: Monitoring of Clinical and Laboratory Activity in a Kyrgyz Cohort of Patients},
  journal = {Science Journal of Clinical Medicine},
  volume = {11},
  number = {1},
  pages = {14-24},
  doi = {10.11648/j.sjcm.20221101.13},
  url = {https://doi.org/10.11648/j.sjcm.20221101.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20221101.13},
  abstract = {Monitoring of clinical and laboratory Takayasu's arteritis (TAK) activity was carried out in 40 patients. Most of them were female patients (92.5%), of Kyrgyz nationality (97.5%), of young age (median - 32 years [24; 44]), with a disease duration of 7.5 years (median – (3.5; 12.5)), with the onset of the disease at 24 years (median –(19; 30)), with V anatomical type - (72.5%), which had vascular stage (77.5%), III grade (≥2) of vascular complications (37.5%), severe exacerbation (65%), with pronounced activity (92.5%) according to the EULAR criteria, high laboratory activity (accelerated ESR in 75% and increased hsCRP - in 65.71% of patients). The lesion of the common carotid (85%) and subclavian arteries (85%) prevailed, the renal arteries were the second most frequently (62.5%) affected vessels, with a predominance of bilateral stenosis (96.1%). During the 5.5 year- follow-up course, a statistically significant partial remission (according to the BVAS index) was achieved in only 12.5% of patients, while frequency of mild and severe exacerbations of the disease remained at the same level (p> 0.05). However, according to the EULAR criteria, there was a statistically significant decrease in the disease activity (from 92.5% to 65% cases) and an increase in the frequency of remission (from 2.5% to 27.5% cases), with the exception of episodes of relapses: major (12.5%) and minor ones (45%).},
 year = {2022}
}

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TY  - JOUR
T1  - Takayasu's Arteritis: Monitoring of Clinical and Laboratory Activity in a Kyrgyz Cohort of Patients
AU  - Koilubaeva Gulazyk Malikovna
AU  - Bolotbekova Altynai Maratovna
AU  - Egorova Olga Nikolaevna
AU  - Tarasova Galina Michailovna
AU  - Sarybaev Akbai Shogaipovich
AU  - Chukubaev Marat Abdyganovich
AU  - Turdukulov Zamir Ergeshevich
AU  - Usupbaeva Dinara Abulmeizovna
AU  - Turusbekova Aijan Kemelovna
Y1  - 2022/02/16
PY  - 2022
N1  - https://doi.org/10.11648/j.sjcm.20221101.13
DO  - 10.11648/j.sjcm.20221101.13
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 14
EP  - 24
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20221101.13
AB  - Monitoring of clinical and laboratory Takayasu's arteritis (TAK) activity was carried out in 40 patients. Most of them were female patients (92.5%), of Kyrgyz nationality (97.5%), of young age (median - 32 years [24; 44]), with a disease duration of 7.5 years (median – (3.5; 12.5)), with the onset of the disease at 24 years (median –(19; 30)), with V anatomical type - (72.5%), which had vascular stage (77.5%), III grade (≥2) of vascular complications (37.5%), severe exacerbation (65%), with pronounced activity (92.5%) according to the EULAR criteria, high laboratory activity (accelerated ESR in 75% and increased hsCRP - in 65.71% of patients). The lesion of the common carotid (85%) and subclavian arteries (85%) prevailed, the renal arteries were the second most frequently (62.5%) affected vessels, with a predominance of bilateral stenosis (96.1%). During the 5.5 year- follow-up course, a statistically significant partial remission (according to the BVAS index) was achieved in only 12.5% of patients, while frequency of mild and severe exacerbations of the disease remained at the same level (p> 0.05). However, according to the EULAR criteria, there was a statistically significant decrease in the disease activity (from 92.5% to 65% cases) and an increase in the frequency of remission (from 2.5% to 27.5% cases), with the exception of episodes of relapses: major (12.5%) and minor ones (45%).
VL  - 11
IS  - 1
ER  -

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