Objective: The objective of this paper is to present, from a case, clinical parameters, imaging and anatomopathological assessments of the pulmonary squamous carcinomatous process in a non-smoking woman with a survival of more than 5 years. Case presentation: A 52-year-old patient who has had a pulmonary squamous carcinomatous process since 2014, revealed from a dry cough associated with mild dyspnoea without hemoptysis or chest pain. The imaging showed a left lung seat of two large masses, one of which extended towards the diaphragmatic dome, penetrating extensively into the abdomen, with a large abdominal contingent. Anatomopathological examination and the Immuno study -history -chemical evidence of a moderately differentiated squamous carcinoma infiltrating the lung. According to the TNM and AJCC 2016 classification, the patient was classified as T4N0M0 and she benefited from a navelbine cisplatin type chemotherapy with a minimal response of approximately 10% according to the RECIST criteria then two other lines of chemotherapy with initiation therapeutic pose. In 2019, she had a histologically confirmed metastatic relapse to the liver, treated with paclitaxel-carboplatin-type chemotherapy with clinical and radiological stability at assessment. Discussion: Squamous cell carcinoma is present in both smokers and non-smokers. Non-smoking females are two to three times more likely to develop lung cancer than non-smoking males, but female gender is a favourable risk factor. Conclusion: lung cancer in non-smoker females is becoming more and more frequent with genetic susceptibility as one of the etiological factors. The search for molecular alterations allows an increase in survival with the use of targeted therapies. Molecular biology is becoming an essential tool in the management of lung cancer with the presence of metastases.
| Published in | World Journal of Medical Case Reports (Volume 2, Issue 3) |
| DOI | 10.11648/j.wjmcr.20210203.15 |
| Page(s) | 51-54 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Squamous Cell, Lung, Non-smoking, Woman
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APA Style
Zongo Esdras, Khoaya Ayoub, Sidki Sanaa, Kaddouri Hajar, Talib Hatim, et al. (2021). Squamous Cell Lung Cancer in a Non-smoking Woman: A Case Report with Review of the Literature. World Journal of Medical Case Reports, 2(3), 51-54. https://doi.org/10.11648/j.wjmcr.20210203.15
ACS Style
Zongo Esdras; Khoaya Ayoub; Sidki Sanaa; Kaddouri Hajar; Talib Hatim, et al. Squamous Cell Lung Cancer in a Non-smoking Woman: A Case Report with Review of the Literature. World J. Med. Case Rep. 2021, 2(3), 51-54. doi: 10.11648/j.wjmcr.20210203.15
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Download@article{10.11648/j.wjmcr.20210203.15,
author = {Zongo Esdras and Khoaya Ayoub and Sidki Sanaa and Kaddouri Hajar and Talib Hatim and Chekrine Tarek and Bourhafour Mouna and Bouchbika Zineb and Benchakroun Nadia and Jouhadi Hassan and Sahraoui Souha and Karkouri Mehdi and Tawfik Nezha and Benider Abdellatif},
title = {Squamous Cell Lung Cancer in a Non-smoking Woman: A Case Report with Review of the Literature},
journal = {World Journal of Medical Case Reports},
volume = {2},
number = {3},
pages = {51-54},
doi = {10.11648/j.wjmcr.20210203.15},
url = {https://doi.org/10.11648/j.wjmcr.20210203.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjmcr.20210203.15},
abstract = {Objective: The objective of this paper is to present, from a case, clinical parameters, imaging and anatomopathological assessments of the pulmonary squamous carcinomatous process in a non-smoking woman with a survival of more than 5 years. Case presentation: A 52-year-old patient who has had a pulmonary squamous carcinomatous process since 2014, revealed from a dry cough associated with mild dyspnoea without hemoptysis or chest pain. The imaging showed a left lung seat of two large masses, one of which extended towards the diaphragmatic dome, penetrating extensively into the abdomen, with a large abdominal contingent. Anatomopathological examination and the Immuno study -history -chemical evidence of a moderately differentiated squamous carcinoma infiltrating the lung. According to the TNM and AJCC 2016 classification, the patient was classified as T4N0M0 and she benefited from a navelbine cisplatin type chemotherapy with a minimal response of approximately 10% according to the RECIST criteria then two other lines of chemotherapy with initiation therapeutic pose. In 2019, she had a histologically confirmed metastatic relapse to the liver, treated with paclitaxel-carboplatin-type chemotherapy with clinical and radiological stability at assessment. Discussion: Squamous cell carcinoma is present in both smokers and non-smokers. Non-smoking females are two to three times more likely to develop lung cancer than non-smoking males, but female gender is a favourable risk factor. Conclusion: lung cancer in non-smoker females is becoming more and more frequent with genetic susceptibility as one of the etiological factors. The search for molecular alterations allows an increase in survival with the use of targeted therapies. Molecular biology is becoming an essential tool in the management of lung cancer with the presence of metastases.},
year = {2021}
}
TY - JOUR T1 - Squamous Cell Lung Cancer in a Non-smoking Woman: A Case Report with Review of the Literature AU - Zongo Esdras AU - Khoaya Ayoub AU - Sidki Sanaa AU - Kaddouri Hajar AU - Talib Hatim AU - Chekrine Tarek AU - Bourhafour Mouna AU - Bouchbika Zineb AU - Benchakroun Nadia AU - Jouhadi Hassan AU - Sahraoui Souha AU - Karkouri Mehdi AU - Tawfik Nezha AU - Benider Abdellatif Y1 - 2021/08/27 PY - 2021 N1 - https://doi.org/10.11648/j.wjmcr.20210203.15 DO - 10.11648/j.wjmcr.20210203.15 T2 - World Journal of Medical Case Reports JF - World Journal of Medical Case Reports JO - World Journal of Medical Case Reports SP - 51 EP - 54 PB - Science Publishing Group SN - 2994-726X UR - https://doi.org/10.11648/j.wjmcr.20210203.15 AB - Objective: The objective of this paper is to present, from a case, clinical parameters, imaging and anatomopathological assessments of the pulmonary squamous carcinomatous process in a non-smoking woman with a survival of more than 5 years. Case presentation: A 52-year-old patient who has had a pulmonary squamous carcinomatous process since 2014, revealed from a dry cough associated with mild dyspnoea without hemoptysis or chest pain. The imaging showed a left lung seat of two large masses, one of which extended towards the diaphragmatic dome, penetrating extensively into the abdomen, with a large abdominal contingent. Anatomopathological examination and the Immuno study -history -chemical evidence of a moderately differentiated squamous carcinoma infiltrating the lung. According to the TNM and AJCC 2016 classification, the patient was classified as T4N0M0 and she benefited from a navelbine cisplatin type chemotherapy with a minimal response of approximately 10% according to the RECIST criteria then two other lines of chemotherapy with initiation therapeutic pose. In 2019, she had a histologically confirmed metastatic relapse to the liver, treated with paclitaxel-carboplatin-type chemotherapy with clinical and radiological stability at assessment. Discussion: Squamous cell carcinoma is present in both smokers and non-smokers. Non-smoking females are two to three times more likely to develop lung cancer than non-smoking males, but female gender is a favourable risk factor. Conclusion: lung cancer in non-smoker females is becoming more and more frequent with genetic susceptibility as one of the etiological factors. The search for molecular alterations allows an increase in survival with the use of targeted therapies. Molecular biology is becoming an essential tool in the management of lung cancer with the presence of metastases. VL - 2 IS - 3 ER -
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