The human gut microbiota is known as the "second brain". Intestinal flora is a large number of microorganisms in the human gut, which is a highly diverse bacterial homeostasis system. If this homeostasis is out of balance, the intestinal flora will be disturbed, which will affect the physical health. A growing body of research has shown that intestinal flora participates in two-way communication between gut and brain through gut-brain axis (GBA) and is strongly associated with Alzheimer's disease (AD). At present, there is still a lack of effective treatment for AD. Recent studies have shown that polyphenols play a neuroprotective role by exerting their anti-inflammatory and antioxidant effects. This topic refers to a large number of recent literatures in the same field and makes a comprehensive review of them. It was found that polyphenols with complex structure could not be directly digested and absorbed by human organism, and their bioavailability was low, which affected the effective play of their health effects. The secretory enzymes in the intestinal flora convert them into small molecular metabolites that are biologically active and easy for the body to absorb. At the same time, polyphenols can the composition and function of intestinal flora by acting on its growth or metabolism, and further act on immune, endocrine and intestinal neural pathways in GBA, forming a complex network of relationships. By exerting its neuroprotective effect, it is expected to achieve the purpose of preventing and treating AD.
| Published in | World Journal of Public Health (Volume 8, Issue 2) |
| DOI | 10.11648/j.wjph.20230802.11 |
| Page(s) | 43-49 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Alzheimer's Disease, Intestinal Flora, Gut-Brain Axis, Polyphenols
| [1] | Blum HE1. The human microbiome [J]. Advances in medical sciences, 2017, 62 (2): 414-420. |
| [2] | Sochocka M, Donskow-Łysoniewska K, Diniz BS, Kurpas D, Brzozowska E, Leszek J. The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer's Disease-a Critical Review [J]. Molecular Neurobiology, 2019, 56 (3): 1841-1851. |
| [3] | Quigley EMM1. Microbiota-Brain-Gut Axis and Neurodegenerative Diseases [J]. Current neurology and neuroscience reports, 2017, 17 (12): 94. |
| [4] | Fried S, Wemelle E, Cani PD, Knauf C. Interactions between the microbiota and enteric nervous system during gut-brain disorders [J]. Neuropharmacology, 2021, 197: 108721. |
| [5] | Rao M, Gershon MD. The bowel and beyond: the enteric nervous system in neurological disorders [J]. Nature reviews. Gastroenterology & hepatology, 2016, 13 (9): 517-528. |
| [6] | Brglez Mojzer E, Knez Hrnčič M, Škerget M, Knez Ž, Bren U. Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects [J]. Molecules, 2016, 21 (7): E901. |
| [7] | Cardona F, Andrés-Lacueva C, Tulipani S, Tinahones FJ, Queipo-Ortuño MI. Benefits of polyphenols on gut microbiota and implications in human health [J]. The Journal of nutritional biochemistry, 2013, 24 (8): 1415-1422. |
| [8] | Figueira I, Garcia G, R. C. Pimpão, et al. Polyphenols journey through blood-brain barrier towards neuronal protection [J]. Scientific Reports, 2017, 7 (1): 11456. |
| [9] | Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system [J]. Science, 2012, 336 (6086): 1268-1273. |
| [10] | Lu D, He L, Xiang W, Ai WM, Cao Y, Wang XS, Pan A, Luo XG, Li Z, Yan XX. Somal and dendritic development of human CA3 pyramidal neurons from midgestation to middle childhood: a quantitative Golgi study [J]. The anatomical record, 2013, 296 (1): 123-132. |
| [11] | Smith PD, Smythies LE, Shen R, Greenwell-Wild T, Gliozzi M, Wahl SM. Intestinal macrophages and response to microbial encroachment [J]. Mucosal Immunol, 2011, 4 (1): 31–42. |
| [12] | Dinan TG, Cryan JF. Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration [J]. The Journal of physiology, 2017, 595 (2): 489-503. |
| [13] | Vaure C, Liu Y. A comparative review of toll-like receptor 4 expression and functionality in different animal species [J]. Frontiers in immunology, 2014, 5: 316. |
| [14] | Ciesielska A, Matyjek M, Kwiatkowska K. TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling [J]. Cell Mol Life Sci, 2021, 78 (4): 1233-1261. |
| [15] | Gąsiorowski K, Brokos B, Echeverria V, Barreto GE, Leszek J. RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration [J]. Molecular neurobiology, 2018, 55 (2): 1463-1476. |
| [16] | Zhang R, Miller RG, Gascon R, Champion S, Katz J, Lancero M, Narvaez A, Honrada R, Ruvalcaba D, McGrath MS. Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS) [J]. Journal of neuroimmunology, 2009, 206 (1-2): 121-124. |
| [17] | Miron J, Picard C, Frappier J, Dea D, Théroux L, Poirier J. TLR4 Gene Expression and Pro-Inflammatory Cytokines in Alzheimer's Disease and in Response to Hippocampal Deafferentation in Rodents [J]. Journal of Alzheimer's disease, 2018, 63 (4): 1547-1556. |
| [18] | Dodiya HB, Lutz HL, Weigle IQ, et al. Gut microbiota-driven brain Aβ amyloidosis in mice requires microglia [J]. J Exp Med, 2022, 219 (1): e20200895. |
| [19] | Liu JB, Zhou L, Wang YZ, Wang X, Zhou Y, Ho WZ, Li JL. Neuroprotective Activity of (-)-Epigallocatechin Gallate against Lipopolysaccharide-Mediated Cytotoxicity [J]. Journal of immunology research, 2016, 2016 (7): 1-10. |
| [20] | Bird JK, Raederstorff D, Weber P, Steinert RE. Cardiovascular and Antiobesity Effects of Resveratrol Mediated through the Gut Microbiota [J]. Advances in nutrition, 2017, 8 (6): 839-849. |
| [21] | Palomera-Ávalos V, Griñán-Ferré C, Izquierdo V, Camins A, Sanfeliu C, Canudas AM, Pallàs M. Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain [J]. Experimental gerontology, 2018, 102: 3-11. |
| [22] | Wang G, Hu Z, Fu Q, et al. Resveratrol mitigates lipopolysaccharide-mediated acute inflammation in rats by inhibiting the TLR4/NF-κBp65/MAPKs signaling cascade [J]. Sci Rep, 2017, 7: 45006. |
| [23] | Kim SY, Hassan AHE, Chung KS, et al. Mosloflavone-Resveratrol Hybrid TMS-HDMF-5z Exhibits Potent In Vitro and In Vivo Anti-Inflammatory Effects Through NF-κB, AP-1, and JAK/STAT Inactivation [J]. Front Pharmacol, 2022, 13: 857789. |
| [24] | Bigagli E, Cinci L, Paccosi S, Parenti A, D'Ambrosio M, Luceri C. Nutritionally relevant concentrations of resveratrol and hydroxytyrosol mitigate oxidative burst of human granulocytes and monocytes and the production of pro-inflammatory mediators in LPS-stimulated RAW 264.7 macrophages [J]. Int Immunopharmacol, 2017, 43: 147-155. |
| [25] | Frozza RL, Bernardi A, Hoppe JB, et al. Lipid-core nanocapsules improve the effects of resveratrol against Abeta-induced neuroinflammation [J]. J Biomed Nanotechnol, 2013, 9 (12): 2086-2104. |
| [26] | Wang J, Ghosh SS, Ghosh S. Curcumin improves intestinal barrier function: modulation of intracellular signaling, and organization of tight junctions [J]. American journal of physiology. Cell physiology, 2017, 312 (4): C438-C445. |
| [27] | de Weerth C1. Do bacteria shape our development? Crosstalk between intestinal microbiota and HPA axis [J]. Neuroscience and biobehavioral reviews, 2017, 83: 458-471. |
| [28] | Huo R, Zeng B, Zeng L, Cheng K, Li B, Luo Y, Wang H, Zhou C, Fang L, Li W, Niu R, Wei H, Xie P. Microbiota Modulate Anxiety-Like Behavior and Endocrine Abnormalities in Hypothalamic-Pituitary- Adrenal Axis [J]. Frontiers in cellular and infection microbiology, 2017, 7: 489. |
| [29] | Lund ML, Egerod KL, Engelstoft MS, Dmytriyeva O, Theodorsson E, Patel BA, Schwartz TW. Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites [J]. Molecular metabolism, 2018, 11: 70-83. |
| [30] | Cirrito JR, Disabato BM, Restivo JL, Verges DK, Goebel WD, Sathyan A, Hayreh D, D'Angelo G, Benzinger T, Yoon H, Kim J, Morris JC, Mintun MA, Sheline YI. Serotonin signaling is associated with lower amyloid-beta levels and plaques in Uansgenic mice and humans [J]. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (36): 14968-14973. |
| [31] | Villarroya-Pastor M T. [Profile of Alzheimer's disease in women] [J]. Revista de neurologia, 2001, 32 (12): 1178-1181. |
| [32] | Flores R1, Shi J, Fuhrman B, Xu X, Veenstra TD, Gail MH, Gajer P, Ravel J, Goedert JJ. Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study [J]. Journal of translational medicine, 2012, 10: 253. |
| [33] | Park S, Kim DS, Kang ES, Kim DB, Kang S. Low-dose brain estrogen prevents menopausal syndrome while maintaining the diversity of the gut microbiomes in estrogen-deficient rats [J]. American Journal of Physiology-Endocrinology and Metabolism, 2018, 315 (1): E99–E109. |
| [34] | Ali SH, Madhana RM, K V A, Kasala ER, Bodduluru LN, Pitta S, Mahareddy JR, Lahkar M. Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice [J]. Steroids, 2015, 101: 37-42. |
| [35] | Sarubbo F, Ramis MR, Aparicio S, Ruiz L, Esteban S, Miralles A, Moranta D. Improving effect of chronic resveratrol treatment on central monoamine synthesis and cognition in aged rats [J]. Age, 2015, 37 (3): 9777. |
| [36] | Rinwa P, Kumar A. Quercetin suppress microglial neuroinflammatory response and induce antidepressent-like effect in olfactory bulbectomized rats [J]. Neuroscience, 2013, 255: 86-98. |
| [37] | Sherwin BB. estrogen and cognitive aging in women [J]. Trends in pharmacological sciences, 2002, 23 (11): 527-534. |
| [38] | An J, Tzagarakis-Foster C, Scharschmidt TC, Lomri N, Leitman DC. Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens [J]. The Journal of biological chemistry, 2001, 276 (21): 17808-17814. |
| [39] | Vitale DC, Piazza C, Melilli B, Drago F, Salomone S. Isoflavones: estrogenic activity, biological effect and bioavailability [J]. European journal of drug metabolism and pharmacokinetics, 2013, 38 (1): 15-25. |
| [40] | Mirahmadi SM, Shahmohammadi A, Rousta AM, Azadi MR, Fahanik-Babaei J, Baluchnejadmojarad T, Roghani M. Soy isoflavone genistein attenuates lipopolysaccharide-induced cognitive impairments in the rat via exerting anti-oxidative and anti-inflammatory effects [J]. Cytokine, 2018, 104: 151-159. |
| [41] | Burgueño JF, Barba A, Eyre E, Romero C, Neunlist M, Fernández E. TLR2 and TLR9 modulate enteric nervous system inflammatory responses to lipopolysaccharide [J]. Journal of neuroinflammation, 2016, 13 (1): 187. |
| [42] | Mallappa Anitha, Matam Vijay–Kumar, Shanthi V. Sitaraman, Andrew T. Gewirtz, Shanthi Srinivasan. Gut Microbial Products Regulate Murine Gastrointestinal Motility via Toll-Like Receptor 4 Signaling [J], Gastroenterology, 2012, 143 (4): 1006-1016. |
| [43] | Schliebs R. Basal forebrain cholinergic dysfunction in Alzheimer's disease--interrelationship with beta-amyloid, inflammation and neurotrophin signaling [J]. Neurochemical research, 2005, 30 (6-7): 895-908. |
| [44] | Puig KL, Swigost AJ, Zhou X, Sens MA, Combs CK. Amyloid precursor protein expression modulates intestine immune phenotype [J]. Journal of neuroimmune pharmacology, 2012, 7 (1): 215-230. |
| [45] | Puig KL, Lutz BM, Urquhart SA, Rebel AA, Zhou X, Manocha GD, Sens M, Tuteja AK, Foster NL, Combs CK. Overexpression of mutant amyloid-β protein precursor and presenilin 1 modulates enteric nervous system [J]. Journal of Alzheimer's disease, 2015, 44 (4): 1263-1278. |
| [46] | Joachim CL, Mori H, Selkoe DJ. Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease [J]. Nature, 1989, 341 (6239): 226-230. |
| [47] | Shankle WR, Landing BH, Ang SM, Chui H, Villarreal-Engelhardt G, Zarow C. Studies of the enteric nervous system in Alzheimer disease and other dementias of the elderly: enteric neurons in Alzheimer disease [J]. Modern pathology, 1993: 6 (1): 10-14. |
| [48] | Remely M, Ferk F, Sterneder S, Setayesh T, Roth S, Kepcija T, Noorizadeh R, Rebhan I, Greunz M, Beckmann J, Wagner KH, Knasmüller S, Haslberger AG. EGCG Prevents High Fat Diet-Induced Changes in Gut Microbiota, Decreases of DNA Strand Breaks, and Changes in Expression and DNA Methylation of Dnmt1 and MLH1 in C57BL/6J Male Mice [J]. Oxidative medicine and cellular longevity, 2017, 2017: 3079148. |
| [49] | Katayama Y1, Homma T, Hara Y, Hirai K. Tea catechin, (-)-epigallocatechin gallate, facilitates cholinergic ganglion transmission in the myenteric plexus of the guinea-pig small intestine [J]. Neuroscience letters, 2002, 319 (2): 63-66. |
| [50] | Cano A, Ettcheto M, Chang JH, Barroso E, Espina M, Kühne BA, Barenys M, Auladell C, Folch J, Souto EB, Camins A, Turowski P, García ML. Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe/PS1dE9 Alzheimer's disease mice model [J]. Journal of controlled release, 2019, 301: 62-75. |
APA Style
Song Chenmeng, Wu Ming, Li Chune, Zhang Jingjing, Li Xiping. (2023). Research Progress of Polyphenols in the Prevention and Treatment of AD by Regulating Intestinal Flora. World Journal of Public Health, 8(2), 43-49. https://doi.org/10.11648/j.wjph.20230802.11
ACS Style
Song Chenmeng; Wu Ming; Li Chune; Zhang Jingjing; Li Xiping. Research Progress of Polyphenols in the Prevention and Treatment of AD by Regulating Intestinal Flora. World J. Public Health 2023, 8(2), 43-49. doi: 10.11648/j.wjph.20230802.11
AMA Style
Song Chenmeng, Wu Ming, Li Chune, Zhang Jingjing, Li Xiping. Research Progress of Polyphenols in the Prevention and Treatment of AD by Regulating Intestinal Flora. World J Public Health. 2023;8(2):43-49. doi: 10.11648/j.wjph.20230802.11
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Download@article{10.11648/j.wjph.20230802.11,
author = {Song Chenmeng and Wu Ming and Li Chune and Zhang Jingjing and Li Xiping},
title = {Research Progress of Polyphenols in the Prevention and Treatment of AD by Regulating Intestinal Flora},
journal = {World Journal of Public Health},
volume = {8},
number = {2},
pages = {43-49},
doi = {10.11648/j.wjph.20230802.11},
url = {https://doi.org/10.11648/j.wjph.20230802.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjph.20230802.11},
abstract = {The human gut microbiota is known as the "second brain". Intestinal flora is a large number of microorganisms in the human gut, which is a highly diverse bacterial homeostasis system. If this homeostasis is out of balance, the intestinal flora will be disturbed, which will affect the physical health. A growing body of research has shown that intestinal flora participates in two-way communication between gut and brain through gut-brain axis (GBA) and is strongly associated with Alzheimer's disease (AD). At present, there is still a lack of effective treatment for AD. Recent studies have shown that polyphenols play a neuroprotective role by exerting their anti-inflammatory and antioxidant effects. This topic refers to a large number of recent literatures in the same field and makes a comprehensive review of them. It was found that polyphenols with complex structure could not be directly digested and absorbed by human organism, and their bioavailability was low, which affected the effective play of their health effects. The secretory enzymes in the intestinal flora convert them into small molecular metabolites that are biologically active and easy for the body to absorb. At the same time, polyphenols can the composition and function of intestinal flora by acting on its growth or metabolism, and further act on immune, endocrine and intestinal neural pathways in GBA, forming a complex network of relationships. By exerting its neuroprotective effect, it is expected to achieve the purpose of preventing and treating AD.},
year = {2023}
}
TY - JOUR T1 - Research Progress of Polyphenols in the Prevention and Treatment of AD by Regulating Intestinal Flora AU - Song Chenmeng AU - Wu Ming AU - Li Chune AU - Zhang Jingjing AU - Li Xiping Y1 - 2023/04/11 PY - 2023 N1 - https://doi.org/10.11648/j.wjph.20230802.11 DO - 10.11648/j.wjph.20230802.11 T2 - World Journal of Public Health JF - World Journal of Public Health JO - World Journal of Public Health SP - 43 EP - 49 PB - Science Publishing Group SN - 2637-6059 UR - https://doi.org/10.11648/j.wjph.20230802.11 AB - The human gut microbiota is known as the "second brain". Intestinal flora is a large number of microorganisms in the human gut, which is a highly diverse bacterial homeostasis system. If this homeostasis is out of balance, the intestinal flora will be disturbed, which will affect the physical health. A growing body of research has shown that intestinal flora participates in two-way communication between gut and brain through gut-brain axis (GBA) and is strongly associated with Alzheimer's disease (AD). At present, there is still a lack of effective treatment for AD. Recent studies have shown that polyphenols play a neuroprotective role by exerting their anti-inflammatory and antioxidant effects. This topic refers to a large number of recent literatures in the same field and makes a comprehensive review of them. It was found that polyphenols with complex structure could not be directly digested and absorbed by human organism, and their bioavailability was low, which affected the effective play of their health effects. The secretory enzymes in the intestinal flora convert them into small molecular metabolites that are biologically active and easy for the body to absorb. At the same time, polyphenols can the composition and function of intestinal flora by acting on its growth or metabolism, and further act on immune, endocrine and intestinal neural pathways in GBA, forming a complex network of relationships. By exerting its neuroprotective effect, it is expected to achieve the purpose of preventing and treating AD. VL - 8 IS - 2 ER -
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