Intraocular Pressure Changes After Intravitreal Bevacizumab Injection Alone or Combination of Bevacizumab and Triamcinolone Acetonide
Nour Yasser Barakat,
Yusuf Suleiman,
Kahtan Jalloul
Issue:
Volume 6, Issue 2, December 2020
Pages:
6-14
Received:
31 July 2020
Accepted:
12 August 2020
Published:
11 December 2020
Abstract: Aim: To evaluate intraocular pressure changes after intravitreal injection of Bevacizumab alone or in combination with Triamcinolone Acetonide. Method: Our study included 63 eyes from the ophthalmology department at Tishreen University Hospital who had vascular retinal diseases. The patients were divided into two groups according to the indication of injection. The first group was injected with bevacizumab (B) at a concentration of 2.5mg / 0.1 ml and the second group was injected with the combination treatment of Triamcinolone Acetonide at a concentration of 2mg / 0.05ml with bevacizumab (B+TA) at a concentration of 1.25mg/ 0.05ml. Intraocular pressure was monitored on the Goldman applanation tonometry and values were recorded as follows: before injection, the second injection day, a week after injection, a month after injection and after three months. Results: The mean values of the intraocular pressure mean increased from the second day of injection in the study groups (B) and (B+TA) and the mean of the IOP values before injection (13.34-13.31 mmHg) respectively, and the IOP values showed the maximum in both groups after a week of the injection (17.81-17.31 mmHg) then began to decrease after a month and three months later to (17.34-17.06mmHg) and (17.6-16.75mmHg) mercury respectively, but they remained higher than they were before the injection, and the number of injections had no effect on intraocular pressure. Conclusion: intravitreal injections with both bevacizumab alone or in combination with triamcinolone acetonide resulted in a rise in intraocular pressure, and differences in pressure values were statistically significant within the same group during the studied time periods but were not statistically significant between the two groups, and the number of injections had no effect on intraocular pressure.
Abstract: Aim: To evaluate intraocular pressure changes after intravitreal injection of Bevacizumab alone or in combination with Triamcinolone Acetonide. Method: Our study included 63 eyes from the ophthalmology department at Tishreen University Hospital who had vascular retinal diseases. The patients were divided into two groups according to the indication ...
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Inter-Simple Sequence Repeat (ISSR) Polymorphism of Tuberculosis Patients from Mile Four Hospital, Abakaliki, Nigeria
Egesimba Ifeyinwa Gladys,
Ogah Fidelis,
Nnamani Catherine,
Afiukwa Celestine,
Igwe David
Issue:
Volume 6, Issue 2, December 2020
Pages:
15-22
Received:
21 June 2020
Accepted:
15 July 2020
Published:
16 December 2020
Abstract: Tuberculosis (TB) is a serious health issue in Ebonyi State and Nigeria at large. The knowledge of genetic diversity and population structure of TB patients in Ebonyi State is still inadequate. Therefore, this work tends to assess the genetic diversity and population structure in association with tuberculosis population using Inter-simple sequence repeat (ISSR) markers. A total of 25 samples were collected, in which 21 were from TB patients and 4 from NTB patients as controls. DNA extraction was done using Cetyltrimethylammonium bromide (CTAB) method followed by Polymerase chain reaction (PCR) with ISSR primers. Analyses of dendrogram, principal component analysis, genetic diversity and population structure were computed with the scored matrix data. Six ISSR markers were polymorphic. The polymorphic information content (PIC) values ranged from 0.2635 to 0.8158 with a mean of 0.6156. The genetic diversity ranged from 0.1504 to 0.8352 with a mean of 0.6156, while the major allele frequency ranged from 0.2800 to 0.9200 with a mean of 0.5018. The allele count ranged from 1 to 23, while the frequency ranged from 0.0400 to 0.9200. The values of number of alleles (Na), effective number of alleles (Ne), Nei's gene diversity (H) and Shannon's information index (I) from the entire population were 2.000±0.000, 1.8562±0.1011, 0.4595±0.0330 and 0.6517±0.0350, respectively while that of the six ISSR markers ranges from 1.3200-2.0000, 1.1184-1.9091, 0.0456-0.4571 and 0.1388-0.6611, respectively. From the six ISSR marker data, the number of polymorphic loci (NPL) and percentage polymorphic loci (PPL) ranged from 2 to 25 and 32% to 100% respectively. A dendrogram of the 25 TB and non- NTB clustered them into nine major groups. This study revealed high diversity among TB patientsatgene loci also probed, but did not show any clear association between TB susceptibility and the gene loci.
Abstract: Tuberculosis (TB) is a serious health issue in Ebonyi State and Nigeria at large. The knowledge of genetic diversity and population structure of TB patients in Ebonyi State is still inadequate. Therefore, this work tends to assess the genetic diversity and population structure in association with tuberculosis population using Inter-simple sequence ...
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Review of Phytochemical Analysis of Selected Traditional Medicinal Plants in Ethiopia
Issue:
Volume 6, Issue 2, December 2020
Pages:
23-31
Received:
16 November 2020
Accepted:
30 November 2020
Published:
16 December 2020
Abstract: The aim of this review is to identify which types of selected medicinal plants for phytochemical characteristics were analyzed and which one is not analyzed as Ethiopian levels. In this review, the most traditional medicinal plant species found and used in Ethiopia are chosen. The state of the phytochemical characteristics of selected medicinal plants was stated under the literature. The qualitative phytochemical characteristics, some of which are the most important phytochemicals such as Tannins, Alkaloids, Saponins, Cardiac Glycosides, Steroids, Terpenoids, Flavonoids, Phlobatannins, Anthraquinones, and Reducing Sugars are studied by researcher. Most studies reviled that some phytochemical properties present in some medicinal plants while some of phytochemical properties are absent in some medicinal plants as well as the phytochemical properties of some species were studied like Opuntia ficusindica (L.) Miller (Yebereha Kulkual), Eucalyptus globules Labill (Nech Bahir Zaf), Cordia Africana Lam. (Wanza), Foeniculum vulgare. (Ensilal). However, some most important phytochemical properties of medicinal plants like Barleria eranthemoides R. Br. Ex C. B. Cl. (Yesetaf), Premna schimperi Engl. (Chocho), Capparis tomentosa L. (Gumero), Tragia pungens (Forssk.) Mull. Arg. (Ablalit) and Cymbopogonsp. (Serdo), Tribulus terrestris L. (Kurinchit) are not studied in Ethiopia. This review has shown that traditional medicinal plants those phytochemical properties are not studied have various medicinal purpose like treating mastitis, preventing boils, Haemorrhoids, congestion, headache, hepatitis, liver, vertigo, stomatitis, kidneys, liver, and vision for treating anemia, hemorrhoid coughs, fluxes, and stomatitis in most animals and human beings. So that identifying the plants based on the investigation and analysis of phytochemical properties of such plant species are more important as Ethiopian levels.
Abstract: The aim of this review is to identify which types of selected medicinal plants for phytochemical characteristics were analyzed and which one is not analyzed as Ethiopian levels. In this review, the most traditional medicinal plant species found and used in Ethiopia are chosen. The state of the phytochemical characteristics of selected medicinal pla...
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