The Research Status of Class II Histone Deace-tylases Physiological Function
Jianyu Wang,
Songpo Yao,
Xingzhou Li,
Xiaoxia Xu,
Ruidi Zhang,
Ye Lu,
Liangchen Liu,
Baosheng Guan,
Xianglin Yin
Issue:
Volume 3, Issue 1, March 2020
Pages:
1-4
Received:
29 November 2019
Accepted:
19 February 2020
Published:
6 March 2020
Abstract: Histone deace-tylases (HDACs) are proteases, The main function of HDACs are to modify the structure of chromosomes and regulate gene expression in organisms. HDACs can catalyze the deacetylation of histones, regulate histone acetylation process and deacetylation process in the nucleus, and maintain its dynamic balance state, which is closely related to the occurrence of cell apoptosis, oxidative stress and with it inflammatory response, metabolic disorders, senescence, tumor and other processes in living things. There are many members of the HDACs family, as many as 18 of which have been discovered so far, was divided into classesI, classesIIa, classesIIb, classesIII and classesIV, The structure, function, subcellular localization and expression patterns of each enzyme are not the same. In recent years, the physiological function of classII HDACs is more widespread attention by researchers, In this paper, we will review the physiological function of classII HDACs in the regulation of bone formation, skeletal muscle regulation, cardiovascular growth and formation, endothelial cells, cytoskeletal dynamics and so on, It also gives a brief description of possible research directions of HDACs, so that it can be widely used in clinical treatment and play a positive therapeutic role.
Abstract: Histone deace-tylases (HDACs) are proteases, The main function of HDACs are to modify the structure of chromosomes and regulate gene expression in organisms. HDACs can catalyze the deacetylation of histones, regulate histone acetylation process and deacetylation process in the nucleus, and maintain its dynamic balance state, which is closely relate...
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Progress in Research of miRNA in Multiple Myeloma
Issue:
Volume 3, Issue 1, March 2020
Pages:
5-8
Received:
6 January 2020
Accepted:
15 March 2020
Published:
16 March 2020
Abstract: Objective: Small interfering RNA (miRNA) is a kind of endogenous small RNA with 20-24 nucleotides in length. It is speculated that miRNA regulates one third of human genes. In this paper, the research status and progress of miRNA in the field of multiple myeloma (MM) were summarized to provide data for the follow-up study, and to seek breakthrough points, methods and demonstration basis. Methods: By inputting key words and so on, literatures were searched in the bibliographic databases of Cnki, PubMed, Google, etc., and read online or downloaded to analyze and summarize. Results: 419 related literatures were successfully retrieved, 57 were intensively read and 17 were cited. Conclusion: Abnormally expressed miRNAs promote the occurrence and development in Multiple Myeloma, and have very important role in diagnosis, prognosis and drug resistances in MM.
Abstract: Objective: Small interfering RNA (miRNA) is a kind of endogenous small RNA with 20-24 nucleotides in length. It is speculated that miRNA regulates one third of human genes. In this paper, the research status and progress of miRNA in the field of multiple myeloma (MM) were summarized to provide data for the follow-up study, and to seek breakthrough ...
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