Advances in Biochemistry

Volume 8, Issue 2, June 2020

  • Interaction of Extracellular Histones with DNA and Actin Filaments

    Edna Blotnick-Rubin, Andras Muhlrad

    Issue: Volume 8, Issue 2, June 2020
    Pages: 26-37
    Received: 26 March 2020
    Accepted: 13 April 2020
    Published: 14 May 2020
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    Abstract: Histones are located in the cell nucleus. They are positively charged small proteins which became extracellular upon apoptosis, necrosis, and infection – induced cell death. The mixture of extracellular Histones was shown to bundle Actin filaments and digested by bacterial proteases, which was inhibited by DNA and Actin. Here we studied the interac... Show More
  • Manifestation of Functional Defects of Nervous System in Upf3 Mutants Drosophila melanogaster at Larval and Adult Stages

    Sanusi Ahmed Jega, Ahmed Adebowole Adedeji, Marta Vicente-Crespo

    Issue: Volume 8, Issue 2, June 2020
    Pages: 38-44
    Received: 30 March 2020
    Accepted: 13 April 2020
    Published: 14 May 2020
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    Abstract: Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that cleans the system from possible harmful proteins and also regulates up to 10% of normal RNAs. The essential player proteins in the NMD (core NMD factors) are Upf1, Upf2, and Upf3. Mutation of any of these NMD factors cause ranges of effects in the development of various organisms. In... Show More