| Peer-Reviewed

Effect of HMB on Phase Angle of Maintenance Hemodialysis Patients

Received: 6 March 2021    Accepted:     Published: 4 June 2021
Views:       Downloads:
Abstract

Objective To observe and evaluate the effect of β- hydroxy-β- methylbutyric acid (HMB) on phase angle (PA) in maintenance hemodialysis (MHD) patients. Methods From March 2018 to August 2019, 64 patients who received maintenance hemodialysis, at Chengdu Fifth People's Hospital, were selected as subjects, and they were divided into experimental group and control group with single center, random, single dose, single blind control design, and 32 patients in each group. HMB intervention was performed in the trial group and placebo in the control group for 12 weeks. Human component analysis (Inbody S770) was performed before and after intervention in the two groups to observe the change of phase angle. Scored Patient-Generated Subjective Global Assessment (SGA) and Malnutrition Inflammatory Score (MIS) were used to assess the nutritional status of MHD patients before and after group entry, to observe the correlation of its numerical change and the phase angle. Results The PA, SGA, MIS of the experimental group was significantly higher (p<0.05) than that of the control group (p<0.05), and the test group increased better than the control group (p<0.05). Positive correlation between PA and SGA, MIS (p<0.05). Conclusions By giving patients complementary HMB, to improve patient nutritional status, to improve the patient phase angle, and improve the patient prognosis.

Published in Science Discovery (Volume 9, Issue 4)
DOI 10.11648/j.sd.20210904.14
Page(s) 150-154
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Phase Angle, β- hydroxy-β-methyl Butyric Acid, Maintenance Hemodialysis

References
[1] Kim EJ, Choi MJ, Lee JH, et al.Extracellular FluidIntracellular Fluid Volume Ratio as a Novel Risk Indicator for All-Cause Mortality and Cardiovascular Disease in Hemodialysis Patients[J].PLOS ONE, 2017, 7(18):17-27.
[2] Rimsevicius L, Gincaite A, Vicka V, et al.Malnutrition assessent in hemodialysis patients: role of bioelectrical impedance analysis phase angle[J].J Ren Nutr, 2016, 26(6):391-395.
[3] Arnaud-Battandier F, Malvy D, Jeandel C, et al.Use of oral supplements in malnourished elderly patients living in the community: a pharmaco-economic study[J].Clin Nutr, 2004, 23(5):1096-1103.
[4] Waal D, Heaslip E, Callas P.Medical Nutrition Therapy for Chronic Kidney Disease Improves Biomarkers and Slows Time to Dialysis[J].J Ren Nutr, 2016, 26(1):1-9.
[5] Wilson JM, Lowery RP, Joy JM, et al.The effects of 12 weeks of beta-hydroxy-beta-methylbutyrate free acid supplementation on muscle mass,strength,and power in resistance-trained individuals: a randomized,double-blind,placebo-controlled study[J].Eur J Appl Physiol, 2014, 114(6):1217-1227.
[6] Fitschen PJ, WilsonGJ, Wilson JM, et al.Efficacy of β-hydroxy-β-methylbutyrate supplementation on elderly and clinical populations[J].Nurition, 2013, 29(1):29-36.
[7] Stegel P, Kozjek NR, Brumen BA, et al.Bioelectrical impedance phase angle as indicator and predictor of cachexia in head and neck cancer patients treated with(chemo) radiotherapy[J].Eur J Clin Nutr, 2016, 70(5):602-626.
[8] Zouridakis A, Simos YV, Verginadis H, et al.Correlation of bioelectrical impedance analysis phase angle with changes in oxidative stress on end-stage renal disease patients, before, during, and after dialysis[J].Ren Fail, 2016, 38(5):738-743.
[9] 黎晓磊.应用生物电阻抗法评估血液透析病人参与肾功能[J].实用医学杂志, 2015, 31(5):770-774。
[10] Nissen S, Sharp R, Ray M, et al.Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training[J].J Appl Physiol, 1996, 81(5):2095-2104.
[11] Fouque D, Kalantar ZK, Kopple J, et al.A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease[J].Kidney Int, 2008, 73(4):391-398.
[12] Popovic V, Zerahn B, Heaf JG.Comparison of dual energy x-ray absorptiometry and bioimpedance in assessing body composition and nutrition in peritoneal dialysis patients[J].J Ren Nutr, 2017, 27(5):355-363.
[13] Kopple JD.Clinical Practice Guidelines for Nutrition in Chronic Renal FailureKDOQI,National Kidney Foundation[J].Am J Kidney Dis, 2000, 35(6 Suppl 2):1-140.
[14] Espahbodi F, Khoddad T, Esmaeili L.Evaluation of Malnutrition and Its Association With Biochemical Parameters in Patients With End Stage Renal Disease Undergoing Hemodialysis Using Subjective Global Assessment[J].Nephrourol Mon, 2014, 6(3):250-321.
[15] Gonzalez OAJ, Arce SCV, Vega VO, et al.Assessment of the Reliability and Consistency of the "Malnutrition Inflammation Score" (MIS) in Mexican Adults With Chronic Kidney Disease for Diagnosis of Protein-Energy Wasting Syndrome (PEW)[J].Nutr Hosp, 2014, 31(3):1352-1358.
[16] Afsar B, Sezer S, Ozdemir FN, et al.Malnutrition-inflammation Score Is a Useful Tool in Peritoneal Dialysis Patients[J].Perit Dial Int, 2006, 26(6):705-711.
[17] Ho LC, Wang HH, Chiang CK, et al.Malnutrition-inflammation Score Independently Determined Cardiovascular and Infection Risk in Peritoneal Dialysis Patients[J].Blood Purif, 2010, 30(1):16-24.
[18] Ruiz-Margain A, Macias-Rodriguez RU, Duarte-Rojo A, et al.Malutrition assessed through phase angle and its relation to prognosis in patients with compensated liver cirrhosis: a prospective cohort study[J].Dig Liver Dis, 2015, 47(4):309-314.
[19] 宁华英, 赵崇法, 齐玉梅, 等.相位角预测手术病人营养风险及住院时间[J].肠外肠内营养, 2017, 24(5):296-300。
[20] Jowko E, Ostaszewski P, Jank M, et al.Creatine and Beta-Hydroxy-Beta-Methylbutyrate (HMB) Additively Increase Lean Body Mass and Muscle Strength During a Weight-Training Program[J].Nutrition, 2001, 17(7-8):558-566.
[21] Hsieh LC, Chien SL, Huang MS, et al.Anti-inflammatory and anticatabolic effects of short-term,beta-hydroxy-beta-methylbutyratesupplementation on chronic obstructive pulmonary disease patients inintensive care unit[J].Asia Pac J Clin Nutr, 2006, 15(14):544-550.
[22] Berk L, James J, Schwartz A, et al.A Randomized,Double-Blind,Placebo-Controlled Trial of a Beta-Hydroxyl Beta-Methyl Butyrate,Glutamine,and Arginine Mixture for the Treatment of Cancer Cachexia (RTOG 0122)[J].Support Care Cancer, 2008, 16(10):1179-1188.
[23] Rathmacher JA, Nissen S, Panton L, et al.Supplementation with a combination of (HMB),arginie,and glutamine is safe and could improve hematological parameters[J].PEN J Parenter Enteral Nutr, 2004, 28(2):65-75.
[24] Lee JY, Kim JS, Yang JW, et al.Serum leptin level is associated with phase angle in CKD5 patients not undergoing dialysis . [J].PLoS ONE, 2018, 13(8):20-25.
[25] Wagner D, Adunka C, Kniepeiss D, et al.Serum albumin,subjective glbal assessment,body mass index and the bioimpedance analysis in the assessment of malnutrition in patients up to 15 years after liver transplantation[J].Clin Transplant, 2011, 25(4):396-400.
[26] Belarmino G, Gonzalez MC, Torrinhas RS, et al.Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis[J].World J Hepatol, 2017, 9(7):401-408.
[27] Varan HD, Bolayir B, Kara O, et al.Phase angle assessment by bioelectrical impedance analysis and its predictive value for malnutrition risk in hospitalized geriatric patients[J].Aging Clin Exp Res, 2016, 28(6):1121-1126.
[28] Peres WA, Lento DF, Baluz K, et al.Phase angle as a nutritional evaluation tool in all stages of chronic liver disease[J].Nutr Hosp, 2012, 27(6):2072-2078.
[29] Gabriela LE, Iván AOP. Phase angle and mid arm circumference as predictors of protein energy wasting in renal replacement therapy patients[J].Nutr Hosp, 2019, 36(3):633-639.
[30] Ceniccola GD, Castro MG, Piovacari SM, et al.Current technologies in body composition assessment: advantages and disadvantages[J].Nutririon, 2019, 62(1):25-31.
[31] Farias CL, Campos DJ, Bonfin CM, et al.Phase angle from BIA as a prognostic and nutritional status stool for children and adolescents undergoning hematopoietic stem cell transplantation[J].Clin Nutr, 2013, 32(3):420-425.
Cite This Article
  • APA Style

    Liang Qingyue, Wang Zhong, Zong Xueping, Diao Yanqing, Cai Ping, et al. (2021). Effect of HMB on Phase Angle of Maintenance Hemodialysis Patients. Science Discovery, 9(4), 150-154. https://doi.org/10.11648/j.sd.20210904.14

    Copy | Download

    ACS Style

    Liang Qingyue; Wang Zhong; Zong Xueping; Diao Yanqing; Cai Ping, et al. Effect of HMB on Phase Angle of Maintenance Hemodialysis Patients. Sci. Discov. 2021, 9(4), 150-154. doi: 10.11648/j.sd.20210904.14

    Copy | Download

    AMA Style

    Liang Qingyue, Wang Zhong, Zong Xueping, Diao Yanqing, Cai Ping, et al. Effect of HMB on Phase Angle of Maintenance Hemodialysis Patients. Sci Discov. 2021;9(4):150-154. doi: 10.11648/j.sd.20210904.14

    Copy | Download

  • @article{10.11648/j.sd.20210904.14,
      author = {Liang Qingyue and Wang Zhong and Zong Xueping and Diao Yanqing and Cai Ping and Li Honglie and Hu Liping},
      title = {Effect of HMB on Phase Angle of Maintenance Hemodialysis Patients},
      journal = {Science Discovery},
      volume = {9},
      number = {4},
      pages = {150-154},
      doi = {10.11648/j.sd.20210904.14},
      url = {https://doi.org/10.11648/j.sd.20210904.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20210904.14},
      abstract = {Objective To observe and evaluate the effect of β- hydroxy-β- methylbutyric acid (HMB) on phase angle (PA) in maintenance hemodialysis (MHD) patients. Methods From March 2018 to August 2019, 64 patients who received maintenance hemodialysis, at Chengdu Fifth People's Hospital, were selected as subjects, and they were divided into experimental group and control group with single center, random, single dose, single blind control design, and 32 patients in each group. HMB intervention was performed in the trial group and placebo in the control group for 12 weeks. Human component analysis (Inbody S770) was performed before and after intervention in the two groups to observe the change of phase angle. Scored Patient-Generated Subjective Global Assessment (SGA) and Malnutrition Inflammatory Score (MIS) were used to assess the nutritional status of MHD patients before and after group entry, to observe the correlation of its numerical change and the phase angle. Results The PA, SGA, MIS of the experimental group was significantly higher (p<0.05) than that of the control group (p<0.05), and the test group increased better than the control group (p<0.05). Positive correlation between PA and SGA, MIS (p<0.05). Conclusions By giving patients complementary HMB, to improve patient nutritional status, to improve the patient phase angle, and improve the patient prognosis.},
     year = {2021}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Effect of HMB on Phase Angle of Maintenance Hemodialysis Patients
    AU  - Liang Qingyue
    AU  - Wang Zhong
    AU  - Zong Xueping
    AU  - Diao Yanqing
    AU  - Cai Ping
    AU  - Li Honglie
    AU  - Hu Liping
    Y1  - 2021/06/04
    PY  - 2021
    N1  - https://doi.org/10.11648/j.sd.20210904.14
    DO  - 10.11648/j.sd.20210904.14
    T2  - Science Discovery
    JF  - Science Discovery
    JO  - Science Discovery
    SP  - 150
    EP  - 154
    PB  - Science Publishing Group
    SN  - 2331-0650
    UR  - https://doi.org/10.11648/j.sd.20210904.14
    AB  - Objective To observe and evaluate the effect of β- hydroxy-β- methylbutyric acid (HMB) on phase angle (PA) in maintenance hemodialysis (MHD) patients. Methods From March 2018 to August 2019, 64 patients who received maintenance hemodialysis, at Chengdu Fifth People's Hospital, were selected as subjects, and they were divided into experimental group and control group with single center, random, single dose, single blind control design, and 32 patients in each group. HMB intervention was performed in the trial group and placebo in the control group for 12 weeks. Human component analysis (Inbody S770) was performed before and after intervention in the two groups to observe the change of phase angle. Scored Patient-Generated Subjective Global Assessment (SGA) and Malnutrition Inflammatory Score (MIS) were used to assess the nutritional status of MHD patients before and after group entry, to observe the correlation of its numerical change and the phase angle. Results The PA, SGA, MIS of the experimental group was significantly higher (p<0.05) than that of the control group (p<0.05), and the test group increased better than the control group (p<0.05). Positive correlation between PA and SGA, MIS (p<0.05). Conclusions By giving patients complementary HMB, to improve patient nutritional status, to improve the patient phase angle, and improve the patient prognosis.
    VL  - 9
    IS  - 4
    ER  - 

    Copy | Download

Author Information
  • Department of Clinical Nutrition, Chengdu Fifth People's Hospital, Chengdu, China

  • Department of Clinical Nutrition, Chengdu Fifth People's Hospital, Chengdu, China

  • Department of Clinical Nutrition, Chengdu Fifth People's Hospital, Chengdu, China

  • Department of Clinical Nutrition, Chengdu Fifth People's Hospital, Chengdu, China

  • Department of Clinical Nutrition, Chengdu Fifth People's Hospital, Chengdu, China

  • Department of Clinical Nutrition, Chengdu Fifth People's Hospital, Chengdu, China

  • Department of Clinical Nutrition, Chengdu Fifth People's Hospital, Chengdu, China

  • Sections