Synthesis and Microbial Activity of Manganese (II) and Cobalt (III) Complexes of 3-Methoxy-4-Hydroxyphenylmethyelene (2- Hydroxyphenyl) Amine
American Journal of Applied Chemistry
Volume 7, Issue 3, June 2019, Pages: 95-103
Received: Mar. 26, 2019;
Accepted: Apr. 30, 2019;
Published: Jun. 26, 2019
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Belachew Kebede, College of Natural and Computational Sciences, Debre Berhan University, Debre Berhan, Ethiopia
Transition metal complexes of Mnanganese (II) and Cobalt (III) were synthesized from the Schiff’s base ligand, 3-methoxy-4-hydroxyphenylmethyelene (2-hydroxyphenyl) amine which is derived from vanillin and 2-aminohpenol by the reaction of the metal ions. The Structural features of these complexes were obtained from their elemental analyses, magnetic susceptibility, molar conductance, FT-IR, electronic spectra, and Atomic Absorption Spectroscopic studies. In order to study the binding modes of the ligand (Schiff’s base) with metal ions in the complexes, the FT- IR spectrum of the free ligand was compared with the spectra of its complexes. The spectral data suggest the involvement of phenolic oxygen and azomethane nitrogen in coordination to the central metal ions. On the basis of spectral studies and magnetic susceptibility measurements, an octahedral geometry has been assigned for both complexes. The free ligand and its metal complexes were tested in vitro against bacteria (Escherichia coli, Staphylococcus aureus) and fungi (Aspergillus Niger, Colletotricum) in order to assess their antimicrobial activities. And the results indicated that all compounds are effective against both tested bacteria and fungi though their effects are dose dependent. The free ligand showed higher activities than its complexes in both bacteria and fungi case, which suggests the promising potential of the ligand for both bacterial and fungi test.
Synthesis and Microbial Activity of Manganese (II) and Cobalt (III) Complexes of 3-Methoxy-4-Hydroxyphenylmethyelene (2- Hydroxyphenyl) Amine, American Journal of Applied Chemistry.
Vol. 7, No. 3,
2019, pp. 95-103.
Abbas, S. A., Munir M., Fatima A., Naheed S. and Ilyas Z. (2010). Synthesis, Characterization and Biocidal Studies of Some Transition Metal Complexes Containing Tetra Dentate and Neutral Bi Dentate Schiff Base. Electronic—Journal of Life Science, 1, 37-40.
El-Mossalamy, E. H., Al-Thabati S. A., Al-Nowalser F. M. and Al-Sulami Q. A. (2005). Solvent Effects on the Electronic Absorption Spectra and Dissociation Costants of Some Sulfa Drugs. Communications Faculty of Sciences University of Ankara Series B, 51, 21-30.
Ying Li., Yang, Z. S., Zhang, H., Cao, B. J. and Wang, F. D. (2003). Artemisinin Derivatives Bearing Mannich Base Group Synthesis and Antimalarial Activity. Bioorganic & Medicinal Chemistry, 11, 4363-4368.
Kulandaisamy A. (2003). Synthesis, characterization and Electrochemical Behavior of Acetylacetone and P-anisidine and Their Antimicrobial Activity. Indian Acad Sci, chem Sci, 115, 161-167.
Berg J. M. and Lippard S. J. (2004). Principles of Bioinorganic Chemistry. University Science Books, Mill Valley, CA, USA.
Durga N. D., Saveha P N. and Kumar S., (2000). Application of Metal Complexes of Schiff bases. Journal of scientific and industrial research, 68, 181-187.
Kumari G., Kumari D., Singh, Kumari C. A. and V. B. R. (2010). Synthesis, Physical Characterization and Antimicrobial Activity of Trivalent Metal Schiff Base Complexes. J. Serb. Chem. Soc., 75, 629–637.
Dharmalingam V., Ramasamy A. K. and Balasuramanian V. (2011). Synthesis and EPR Studies of Copper Metal Complexes of Dyes Derived from Remazol Red B, Procino Yellow, Fast Green FCF, Brilliant Cresyl Blue with Copper Acetate Monohydrate. E-Journal of Chemistry, 8, 211-224.
Kumar S., Dhar D. N. and Saxena P. N. (2009). Applications of Metal Complexes of Schiff Base. J. Sci. & Indu. Res., 68, 181-187.
Villar R., Encio, I., Migliaccio, M., Gil, M. G. and Martinez M. V. (2004). Synthesis and Cytotoxic Activity of Lipophilic Sulphonamide Derivatives of the Benzo [b] thiophene-1, 1-dioxide. Bioorganic & Medicinal Chemistry, 12, 963-968.
Wang L., Feng, Y., Xue, J. and Li, Y. (2008). Synthesis and Characterization of Novel Porphyrin Schiff Bases. Journal of the Serbian Chemical Society, 73, 1-6.
Wadher S. J., Puranik, M. P., Karande, N. A. and Yeole, P. G. (2009). Synthesis and Biological Evaluation of Schiff base of Dapsone and Their Derivative as Antimicrobial Agents. International Journal of PharmTech Research, 1, 22-33.
Bhat M. A., Imran, M., Khan, S. A. and Siddiqui, N. (2005). Biological Activities of Sulfonamides. Journal of Pharmaceutical Sciences, 67, 151-159.
Prashanthi Y., and Raj S. (2010). Synthesis and Characterization of Transition Metal Complexes with N,O; N,N and S,N-donor Schifff Base Ligands. J. Sci. Res., 2, 114-126.
El-ajaily M. M., Hamil A. M. and Khalifa K. M. (2009). Synthesis, Spectroscopic Investigation and Antibactewrial Activities of Schiff base Complexes of Co (II) and Cu (II) ions. Rasayan Journal of chemistry. 2, 261-266.
Kumar G., Kumar D., Singh C. P., Kumar A. and Rana V. B., (2010). Synthesis, physical characterization and antimicrobial activity of trivalent metal Schiff base complexes. J. Serb. Chem. Soc., 75, 629–637.
El-ajaily M. M., Gweirif B. And Morad F. M. (2007). Antibacterial Activity of Ni (II) with Salicyaldehyde and 2-amino-benzoic Acid Complex. J. of science and its Appl., 1, 72-78.
Mapari A. K., and Mangaonkar K. V. (2011). Synthesis, Characterization and Antimicrobial Activity of Mixed Schiff Base Ligand Complexes of Transition Metal (II) ions. Int. J. Chem. Tech. Res., 3, 477-482.
Prakash A., Singh B. K., Bhojak N. and Adhikari D. (2010). Synthesis and Characterization of Bioactive Zn (II) and Cd (II) Complexes with New Schiff Bases Derived from 4-nitrobenzaldehyde and Acetophenone with Ethylenediamine. Spectrochimica Acta Part A, 76, 356.
Upadhyay R. K. and Sharama S. (2007). Study in Spin-crossover Phenomena in Complexes of Long Chain Ketoanils with Active Methylene group (s) with Fe (III) and Fe (II), Ph.D. thesis, C. C. S., University, Meerut. J. Bioscience, 2, 22-34.
Pandya J. H. and Shah M. K. (2009). Synthesis and Antimicrobial Properties of Transition Metal Complexes of Novel Schiff Base Ligand Derived from 5-bromosalicyldehyde. J. Ind. council. Chem., 26, 109-112.